Cell Symposia: Biological Assemblies: Phase Transitions and More

Cell Symposia

04 October 2020

Melia Seville Hotel

Registration Deadline

03 August 2020

For many years, our understanding of the organization of major biological activities within the cell was limited to membrane-dependent compartmentalization. However, over the past few years a revolution in thought has been sweeping nearly the entire cell biology community. It is now becoming clear that many complex functions of the cell, and the multiple biochemical complexes that perform them, are highly organized and coordinated in non-membrane-bound molecular compartments. In some cases, we are uncovering the regulation and function of long-mysterious subcellular assemblages. In other cases, we are only beginning to appreciate that known biological activities function through organized structures.

We hope you can join us in Seville, where we will connect researchers across the breadth of cell biology studying the regulation and consequences of organization of large biological complexes throughout the cell. The focus will be on bringing together researchers working across the cell biology spectrum, including the cytoskeleton, stress granules, signaling clusters, the nuclear pore, transcription centers, chromatin, and more. Emerging concepts and technologies with broad applicability will be emphasized to help cross-pollinate new avenues of research for the diverse interests of conference attendees.

Topics within the scope of this meeting include, but are not limited to:

The roles and mechanisms of organizing molecules

   RNA versus protein

   disordered protein regions and multivalent interactions

   phase transitions and hydrogels

Organization in the nucleus

   chromatin and heterochromatin

   paraspeckles and nucleoli

   DNA damage foci

Organization in the cytoplasm and within and around membranes

   Subcellular granules and functional amyloid-like structures

   Signalosomes, cytoskeleton,and nuclear pores

   Synaptic and post-synaptic densities

   Juxta-endomembrane assemblies

Functional and mechanistic dissection of roles in basic cell biology and development

   Autophagy, innate immune and other cell stress responses

   DNA transactions: transcription, DNA repair and genome stability

   Germ cell and embryonic development

Functional and mechanistic dissection of roles in disease

   Cancer

   Neurodegeneration

   Other protein misfolding disorders