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Volume 633 Issue 8030, 19 September 2024

Jumbo jets

Powerful jets of radiation and particles generated by supermassive black holes can affect the distribution of matter and magnetism in the cosmic web — the large-scale structure of the Universe. In this week’s issue, Martijn Oei and colleagues report the discovery of the largest known jet structure originating from a black hole. Identified from radio images, the jets in the structure extend for about 7 megaparsecs (23 million light years), putting it on a truly cosmological scale. Named Porphyrion by the researchers, the structure is captured on the cover in an artist’s impression that shows Porphyrion emerging from a filament of the cosmic web and shooting its jets into the surrounding voids.

Cover image: Erik Wernquist/Dylan Nelson (IllustrisTNG Collaboration)/Martijn Oei

This Week

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Research

  • News & Views

    • By mining large-population genetic data sets, researchers identify the key factors controlling menopause timing, and reveal a close connection between reproductive longevity, cancer risk and new mutations in children.

      • Anne Goriely
      News & Views
    • By smashing protons together at blinding speeds, scientists have shown that pairs of quarks display the phenomenon of quantum entanglement. The result could lead to fresh insight about one of the forces holding nuclei together.

      • Martin Hentschinski
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    • Boosting the heart’s natural countermeasures against poor function is one way to treat heart failure, but existing therapies need to be given frequently. An antibody with enduring effects could offer a solution.

      • John C. Burnett Jr
      News & Views
  • Articles

    • Radio images reveal distant black hole jets of cosmological length, suggesting that the environmental impact of supermassive black holes extends further in space and time than previously thought.

      • Martijn S. S. L. Oei
      • Martin J. Hardcastle
      • S. G. Djorgovski
      Article
    • Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb−1.

      • G. Aad
      • B. Abbott
      • L. Zwalinski
      Article Open Access
    • The emergent electrodynamics induced by skyrmion lattice motion in Gd2PdSi3 is facilitated by its giant topological Hall effect dynamic transition, and implies the emergent Galilean relativity of current-driven skyrmions.

      • Max T. Birch
      • Ilya Belopolski
      • Yoshinori Tokura
      Article
    • A molecular aggregate formed in a two-dimensional organic–inorganic hybrid perovskite superlattice with a near-equilibrium distance is shown to have a near-unity photoluminescence quantum yield like that of single molecules, despite being in an aggregated state.

      • Kang Wang
      • Zih-Yu Lin
      • Letian Dou
      Article
    • A polymer-like ultrahigh-strength TiNi alloy was fabricated by a simple three-step process to give a combination of a polymer-like ultralow elastic modulus and a steel-like ultrahigh yield strength over a wide temperature range, and such exotic properties arise from a unique strain glass state.

      • Zhizhi Xu
      • Yuanchao Ji
      • Xiaobing Ren
      Article Open Access
    • Rapid ocean deoxygenation during the Early Cretaceous OAE1a is shown to provide evidence for a strong link between volcanic CO2 emissions, weathering and ocean oxygen content that is characterized by a climate threshold.

      • Kohen W. Bauer
      • N. Ryan McKenzie
      • Sean A. Crowe
      Article
    • In situ experimental findings from six contrasting oceanic regimes, at multiple mesopelagic depths, are used to determine the mechanisms that drive microbially mediated carbon flux attenuation in the oceanic biological pump.

      • M. Bressac
      • E. C. Laurenceau-Cornec
      • P. W. Boyd
      Article Open Access
    • A newly identified emergent constraint applied to a key drought metric reduces uncertainty in future predictions of the longest annual dry spells, revealing that their increase due to climate change will be 40–50% greater than climate models project at present.

      • Irina Y. Petrova
      • Diego G. Miralles
      • Margot Bador
      Article Open Access
    • We conduct experiments in a wave tank and show that waves with realistic three-dimensional spreading can become two times steeper than two-dimensional waves before breaking, with three breaking regimes identified.

      • M. L. McAllister
      • S. Draycott
      • T. S. van den Bremer
      Article Open Access
    • Precision functional mapping shows that the frontostriatal salience network occupies nearly twice as much of the cortex in people with depression, and this was unaffected by mood changes and detected in children before onset of symptoms.

      • Charles J. Lynch
      • Immanuel G. Elbau
      • Conor Liston
      Article Open Access
    • A comprehensive cell atlas of the aged prefrontal cortex identifies two distinct cellular trajectories of ageing driven by specific glial and neuronal subpopulations, some of which are associated with clinicopathologic traits that define Alzheimer’s disease.

      • Gilad Sahar Green
      • Masashi Fujita
      • Philip L. De Jager
      Article
    • Nitrospira inopinata and probably most other comammox microorganisms can grow on the non-conventional substrate guanidine as the sole source of energy, reductant and nitrogen.

      • Marton Palatinszky
      • Craig W. Herbold
      • Michael Wagner
      Article Open Access
    • Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

      • Michael E. Dunn
      • Aaron Kithcart
      • Lori Morton
      Article Open Access
    • A technique for threading long protein strands through a nanopore by electrophoresis and back using a protein unfoldase motor, ClpX, enables single protein molecules to be analyzed multiple times with single-amino-acid sensitivity.

      • Keisuke Motone
      • Daphne Kontogiorgos-Heintz
      • Jeff Nivala
      Article Open Access
    • We show that target-induced proximity labelling enables isolation of first-division CD8 chimeric antigen receptor T cells that asymmetrically distribute their surface proteome and transcriptome, resulting in distinct phenotypic, metabolic and functional profiles in proximal and distal daughter cells.

      • Casey S. Lee
      • Sisi Chen
      • Christoph T. Ellebrecht
      Article Open Access
    • Combined phylogenetic analyses and glycoprotein structure prediction across the Flaviviridae reveals divergent membrane fusion systems and provides insights into the complex evolutionary history within this family of viruses.

      • Jonathon C. O. Mifsud
      • Spyros Lytras
      • Joe Grove
      Article Open Access
    • Structural studies of a homodimeric arrangement of hepatitis C virus envelope E1/E2 heterodimers reveals the molecular basis of intracomplex interactions and  provides mechanistic insights into neutralizing antibody evasion and membrane fusion with host cells.

      • Elias Honerød Augestad
      • Christina Holmboe Olesen
      • Jannick Prentoe
      Article
    • Structural comparison of predicted viral protein structures with known protein structures suggests taxonomic relationships and functions for up to 25% of unannotated viral proteins, including many with putative functions in host immune evasion.

      • Jason Nomburg
      • Erin E. Doherty
      • Jennifer A. Doudna
      Article Open Access
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Nature Index

  • The rapid adoption of chatbots such as ChatGPT in mainstream society have placed artificial intelligence (AI) front and centre of the public debate on science in the past two years.

    Nature Index
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