Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 617 Issue 7960, 11 May 2023

Human pangenome

The human reference genome has been the backbone of human genomics since the release of the draft sequence in 2001. But it has its limitations: one genome cannot hope to capture the diversity of the human species. In this week’s issue, the Human Pangenome Reference Consortium presents the first draft human pangenome, which combines genetic material from 47 genetically diverse individuals to provide a more complete picture of the human genome. Two additional papers use this new resource to study regions of the genome that include repetitive DNA: one looking at segmental duplications, the other at the short arms of acrocentric chromosomes. These results come from an early stage in the pangenome project, which ultimately aims to capture the genetic diversity of at least 350 individuals. The cover shows the pangenome wrapping a globe and uses a sequence tube map rendering of a pangenome graph relating ten haplotypes within the highly variable HLA-A locus on chromosome 6 created by Adam Novak at the University of California, Santa Cruz.

Cover image: Darryl Leja/NHGR

This Week

Top of page ⤴

News in Focus

Top of page ⤴

Books & Arts

Top of page ⤴


Top of page ⤴


Top of page ⤴


  • News & Views

    • The human brain’s motor cortex is often regarded as a linear map with discrete sections, each controlling different parts of the body. The discovery that portions of the motor cortex have other functions points to a different type of map.

      • David A. Leopold
      News & Views
    • Superconducting quantum bits, a promising platform for future quantum computers, have been entangled over a separation of 30 metres, with a performance that enabled the demonstration of a milestone in quantum physics.

      • Marissa Giustina
      News & Views
    • Analysis of microfossils in marine sediments spanning the past 1.2 million years suggests that increased intrusion of highly saline waters from the Indian Ocean into the South Atlantic propelled Earth’s deglaciations during this period.

      • Kaustubh Thirumalai
      News & Views
  • Articles

    • Investigation of the physical conditions of the circumgalactic medium led to detection of two compact [C ii]-emitting galaxies with narrow linewidths at a redshift of 5.7, associated with a complex, high-ionization C iv absorption system.

      • Daichi Kashino
      • Simon J. Lilly
      • Anna-Christina Eilers
    • A loophole-free violation of Bell’s inequality with superconducting circuits shows that non-locality is a viable new resource in quantum information technology realized with superconducting circuits, promising many potential applications.

      • Simon Storz
      • Josua Schär
      • Andreas Wallraff
      Article Open Access
    • A new transfer method for microLEDs fabrication based on fluidic self-assembly technology combining magnetic and dielectrophoresis forces is described, achieving a very high simultaneous RGB LED transfer yield and over large areas.

      • Wonjae Chang
      • Jungsub Kim
      • Jeong Soo Lee
    • The authors report a high-throughput combinatorial printing method capable of fabricating materials with compositional gradients at microscale spatial resolution, demonstrating a variety of high-throughput printing strategies and applications in combinatorial doping, functional grading and chemical reaction.

      • Minxiang Zeng
      • Yipu Du
      • Yanliang Zhang
      Article Open Access
    • Salinity reconstructions show that Indian Ocean surface salinity increased during glacial periods and that the release of this water via the Agulhas Leakage during deglaciation can trigger abrupt changes in the Atlantic Meridional Overturning Circulation.

      • Sophie Nuber
      • James W. B. Rae
      • Stephen Barker
    • An initial draft of the human pangenome is presented and made publicly available by the Human Pangenome Reference Consortium; the draft contains 94 de novo haplotype assemblies from 47 ancestrally diverse individuals.

      • Wen-Wei Liao
      • Mobin Asri
      • Benedict Paten
      Article Open Access
    • A study shows that, although the number of incarcerated people in the USA decreased during the first year of the COVID-19 pandemic, the fraction of incarcerated Black and Latino individuals increased.

      • Brennan Klein
      • C. Brandon Ogbunugafor
      • Elizabeth Hinton
      Article Open Access
    • A new encoding method, CEBRA, jointly uses behavioural and neural data in a (supervised) hypothesis- or (self-supervised) discovery-driven manner to produce both consistent and high-performance latent spaces.

      • Steffen Schneider
      • Jin Hwa Lee
      • Mackenzie Weygandt Mathis
      Article Open Access
    • Combining genome-wide CRISPR screens with massively parallel analyses of human and random DNA sequences reveal a unified mechanism for the surveillance and evolution of translation products from annotated noncoding DNA.

      • Jordan S. Kesner
      • Ziheng Chen
      • Xuebing Wu
    • The α-diazoester azaserine can be produced by Streptomyces albus engineered with a biosynthetic gene cluster and act as the carbene precursor for coupling with intracellularly produced styrene to generate unnatural amino acids containing a cyclopropyl group.

      • Jing Huang
      • Andrew Quest
      • Jay D. Keasling
    • A cryo-electron microscopy reconstruction of the virus ΦcrAss001 provides insights into the functions of the viral gene products in capsid assembly and infection.

      • Oliver W. Bayfield
      • Andrey N. Shkoporov
      • Alfred A. Antson
      Article Open Access
    • Active-state structures of the κ-opioid receptor in complexes with the G-protein heterotrimers Gi1, GoA, Gz and Gg provide insights into the actions of hallucinogenic opioids and G-protein-coupling specificity at the κ-opioid receptor.

      • Jianming Han
      • Jingying Zhang
      • Tao Che
      Article Open Access
  • Matters Arising

Top of page ⤴

Amendments & Corrections

Top of page ⤴
Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing


Quick links