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Volume 612 Issue 7938, 1 December 2022

Holographic wormhole

One challenge that stems from the fundamental incompatibility between general relativity and quantum mechanics is that there is no consensus on a theory of quantum gravity. A way to potentially overcome this is through the holographic principle, which says that a system involving gravity can be described by a lower-dimensional quantum system. In this week’s issue, Maria Spiropulu and her colleagues replicate the dynamics of a traversable holographic wormhole by experimentally realizing the corresponding quantum dynamics in a quantum computer using 9-qubits. This is an early step towards studying theories of quantum gravity in the laboratory. In the same quantum chip, the researchers created two entangled quantum systems. They inserted a qubit into one of them and observed the information emerging from the other exhibiting the expected gravitational properties of the traversable wormhole.

Cover image: inqnet/A. Mueller.

This Week

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News in Focus

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  • News & Views

    • A 67-million-year-old fossil bird found in Europe provides evidence suggesting that scientists should reconsider centuries-old ideas about the nature of the ancestral avian beak.

      • Christopher R. Torres
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    • Seasonal variation in tropical sea surface temperatures doubled during an abrupt warming event 11,700 years ago. This shows that seasonal changes must be considered when inferring past climatic events, and predicting those to come.

      • Alyssa R. Atwood
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    • Mounting evidence suggests that developing neurons and metastatic cancer cells migrate through similar mechanisms. Characterization of a previously unknown complex involved in cell migration confirms this idea.

      • Alain Chédotal
      News & Views
    • Structural insights into a long-studied folate-transport protein provide evidence that might lead to entirely new targeted anticancer treatments, or boost the success of immunotherapy approaches to tackling tumours.

      • Larry H. Matherly
      • Zhanjun Hou
      News & Views
    • A system of nine quantum bits has been used to simulate a state known as a holographic wormhole, a concept that features in attempts to reconcile quantum mechanics with the general theory of relativity.

      • Adam R. Brown
      • Leonard Susskind
      News & Views
  • Perspective

    • The concept of dendrocentric learning artificial intelligence is proposed to replace synaptocentric learning, reducing the energy use requirement and removing the thermal constraint.

      • Kwabena Boahen
  • Articles

    • A sparsified SYK model is constructed using learning techniques and the corresponding traversable wormhole dynamics are observed, representing a step towards a program for studying quantum gravity in the laboratory.

      • Daniel Jafferis
      • Alexander Zlokapa
      • Maria Spiropulu
    • By using Si3N4 photonic integrated circuits on a silicon chip, a continuous-travelling-wave parametric amplifier is shown to yield a parametric gain exceeding both on-chip propagation loss as well as fibre–chip–fibre coupling losses.

      • Johann Riemensberger
      • Nikolai Kuznetsov
      • Tobias J. Kippenberg
    • A meta-imaging sensor detects an extra-fine 4D light field distribution using a vibrating microlens array, enabling high-resolution 3D photography up to a gigapixel with fast aberration correction, demonstrated on a telescope aimed at the Moon.

      • Jiamin Wu
      • Yuduo Guo
      • Qionghai Dai
      Article Open Access
    • A new methodology for the discovery of chalcogenides by tuning the temperature and flux ratios of systems using mixed fluxes is demonstrated, leading to the synthesis of 30 new and unreported compounds or compositions.

      • Xiuquan Zhou
      • Venkata Surya Chaitanya Kolluru
      • Mercouri G. Kanatzidis
    • A molecular ratchet, in which a crown ether is pumped from solution onto an encoded molecular strand by a pulse of chemical fuel, opens the way for the reading of information along molecular tapes.

      • Yansong Ren
      • Romain Jamagne
      • David A. Leigh
    • Mass spectrometry imaging of long-chain alkenones in sediments from the Cariaco Basin shows that average temperatures remained stable during the Younger Dryas to Holocene transition but seasonality more than doubled and interannual variability intensified.

      • Lars Wörmer
      • Jenny Wendt
      • Kai-Uwe Hinrichs
      Article Open Access
    • Single-cell whole-genome sequencing shows that 'foreground' cell-to-cell structural variation and alterations in copy number are associated with genomic diversity and evolution in triple-negative breast and high-grade serous ovarian cancers.

      • Tyler Funnell
      • Ciara H. O’Flanagan
      • Samuel Aparicio
      Article Open Access
    • Medin promotes the formation of vascular aggregates with amyloid-β in mouse models and in human patients with Alzheimer’s disease, and is associated with vascular defects and cognitive decline.

      • Jessica Wagner
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      • Jonas J. Neher
      Article Open Access
    • MYC dissociation from active promoters alters its interactions with proteins involved in transcription termination and RNA processing, influencing DNA repair and thus, potentially, tumour cell growth.

      • Daniel Solvie
      • Apoorva Baluapuri
      • Martin Eilers
    • Cryo-electron microscopy structures of the mouse class M immunoglobulin B cell receptor complex provide insight into B cell receptor subunit assembly, domain architecture and signalling mechanism.

      • Ying Dong
      • Xiong Pi
      • Hao Wu
    • Structural insights into the poly-ADP-ribosyltransferase tankyrase reveal its filamentous architecture and illustrate how assembly controls catalytic and non-catalytic functions.

      • Nisha Pillay
      • Laura Mariotti
      • Sebastian Guettler
      Article Open Access
    • Two cyclic dinucleotide molecules bind within the cavity of human SLC19A1 as a compact dual-molecule unit, whereas folate and antifolate bind to SLC19A1 as a monomer and occupy a distinct pocket of the cavity.

      • Qixiang Zhang
      • Xuyuan Zhang
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  • Matters Arising

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Amendments & Corrections

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Focal Point

  • Drawing on its strengths in life science research and medical innovation, Osaka is creating a world-class hub for biotechnology.

    Focal Point
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