Volume 585 Issue 7823, 3 September 2020

Seeds of change

The cover shows a silvereye (Zosterops lateralis), a bird native to New Zealand, perched on Chilean rhubarb (Gunnera tinctoria), a species that has been introduced to the country. Trade and transportation have helped to accelerate the introduction of species, both plant and animal, to new regions. In this week’s issue, Evan Fricke and Jens-Christian Svenning analyse the effects such introductions have on the mutualistic networks of fleshy-fruited plants and the animals that eat those fruits and so disperse the seeds. The researchers looked at 410 local networks, encompassing 24,455 unique pair interactions between 1,631 animal and 3,208 plant species. They found that introduced species blur the biogeographical patterns of the global network, and disproportionately facilitate the success of other introduced species. As a result, the researchers say, the resilience of local ecosystems is increasingly at risk from biotic homogenization.

Cover image: Steve Attwood.

This Week

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  • News & Views |

    Volumes of fluid have previously been made to float above air by vibrating the air–fluid system vertically. It now emerges that an ‘antigravity’ effect enables objects to float upside down on the air–fluid interface.

    • Vladislav Sorokin
    •  & Iliya I. Blekhman
  • News & Views |

    A mutation in the C9orf72 gene is the most common genetic cause of two neurodegenerative diseases. A newly identified immunological function for the C9orf72 protein points to a potential therapeutic strategy for these diseases.

    • Olivia Gautier
    •  & Aaron D. Gitler
  • News & Views |

    A cellular condition called oxidative stress can kill cancer cells. The finding that skin cancer cells evade such destruction using lipids acquired while passing through lymphatic vessels reveals a mechanism that boosts cancer spread.

    • Barbara M. Grüner
    •  & Sarah-Maria Fendt
  • Articles

  • Article |

    Penning trap mass spectrometry is used to measure the masses of the deuteron and the HD+ ion with unprecedented precision, reducing the uncertainty of the proton mass reference value.

    • Sascha Rau
    • , Fabian Heiße
    • , Florian Köhler-Langes
    • , Sangeetha Sasidharan
    • , Raphael Haas
    • , Dennis Renisch
    • , Christoph E. Düllmann
    • , Wolfgang Quint
    • , Sven Sturm
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  • Article |

    Manipulation of the effective gravity of an oscillating liquid creates stable buoyancy in the lower surface of a liquid layer levitating above air, allowing bodies to float upside down.

    • Benjamin Apffel
    • , Filip Novkoski
    • , Antonin Eddi
    •  & Emmanuel Fort
  • Article |

    Lead halide-based quasi-two-dimensional perovskite films with different organic cations are used to create stable green lasers under continuous-wave optical pumping in air at room temperature.

    • Chuanjiang Qin
    • , Atula S. D. Sandanayaka
    • , Chenyang Zhao
    • , Toshinori Matsushima
    • , Dezhong Zhang
    • , Takashi Fujihara
    •  & Chihaya Adachi
  • Article |

    The near field of a terahertz wave confined to a scanning probe tip provides femtosecond atomic-scale forces that coherently modulate the switching probability of a molecule between two stable adsorption geometries.

    • Dominik Peller
    • , Lukas Z. Kastner
    • , Thomas Buchner
    • , Carmen Roelcke
    • , Florian Albrecht
    • , Nikolaj Moll
    • , Rupert Huber
    •  & Jascha Repp
  • Article |

    A vanadium-based lithium-rich disordered rock salt oxide is shown to work as a low-potential anode with rapid intercalation kinetics for lithium-ion batteries.

    • Haodong Liu
    • , Zhuoying Zhu
    • , Qizhang Yan
    • , Sicen Yu
    • , Xin He
    • , Yan Chen
    • , Rui Zhang
    • , Lu Ma
    • , Tongchao Liu
    • , Matthew Li
    • , Ruoqian Lin
    • , Yiming Chen
    • , Yejing Li
    • , Xing Xing
    • , Yoonjung Choi
    • , Lucy Gao
    • , Helen Sung-yun Cho
    • , Ke An
    • , Jun Feng
    • , Robert Kostecki
    • , Khalil Amine
    • , Tianpin Wu
    • , Jun Lu
    • , Huolin L. Xin
    • , Shyue Ping Ong
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  • Article |

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    • Wenju Cai
    • , Benjamin Ng
    • , Tao Geng
    • , Lixin Wu
    • , Agus Santoso
    •  & Michael J. McPhaden
  • Article |

    High-coverage, ultra-long-read nanopore sequencing is used to create a new human genome assembly that improves on the coverage and accuracy of the current reference (GRCh38) and includes the gap-free, telomere-to-telomere sequence of the X chromosome.

    • Karen H. Miga
    • , Sergey Koren
    • , Arang Rhie
    • , Mitchell R. Vollger
    • , Ariel Gershman
    • , Andrey Bzikadze
    • , Shelise Brooks
    • , Edmund Howe
    • , David Porubsky
    • , Glennis A. Logsdon
    • , Valerie A. Schneider
    • , Tamara Potapova
    • , Jonathan Wood
    • , William Chow
    • , Joel Armstrong
    • , Jeanne Fredrickson
    • , Evgenia Pak
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    • , Milinn Kremitzki
    • , Christopher Markovic
    • , Valerie Maduro
    • , Amalia Dutra
    • , Gerard G. Bouffard
    • , Alexander M. Chang
    • , Nancy F. Hansen
    • , Amy B. Wilfert
    • , Françoise Thibaud-Nissen
    • , Anthony D. Schmitt
    • , Jon-Matthew Belton
    • , Siddarth Selvaraj
    • , Megan Y. Dennis
    • , Daniela C. Soto
    • , Ruta Sahasrabudhe
    • , Gulhan Kaya
    • , Josh Quick
    • , Nicholas J. Loman
    • , Nadine Holmes
    • , Matthew Loose
    • , Urvashi Surti
    • , Rosa ana Risques
    • , Tina A. Graves Lindsay
    • , Robert Fulton
    • , Ira Hall
    • , Benedict Paten
    • , Kerstin Howe
    • , Winston Timp
    • , Alice Young
    • , James C. Mullikin
    • , Pavel A. Pevzner
    • , Jennifer L. Gerton
    • , Beth A. Sullivan
    • , Evan E. Eichler
    •  & Adam M. Phillippy
  • Article |

    Genetic studies in Drosophila combined with structural analyses show that glypicans bind palmitoylate moieties in Wnt ligands, and thus shield Wnt ligands from their aqueous environments to enable them to signal to their distant receptors.

    • Ian J. McGough
    • , Luca Vecchia
    • , Benjamin Bishop
    • , Tomas Malinauskas
    • , Karen Beckett
    • , Dhira Joshi
    • , Nicola O’Reilly
    • , Christian Siebold
    • , E. Yvonne Jones
    •  & Jean-Paul Vincent
  • Article |

    Retinal pericytes connect via interpericyte tunnelling nanotubes into functional syncytia that regulate microcirculatory blood flow to help to match local blood flow with neuronal activity.

    • Luis Alarcon-Martinez
    • , Deborah Villafranca-Baughman
    • , Heberto Quintero
    • , J. Benjamin Kacerovsky
    • , Florence Dotigny
    • , Keith K. Murai
    • , Alexandre Prat
    • , Pierre Drapeau
    •  & Adriana Di Polo
  • Article |

    Studies of mice and humans suggest a role for loss of the C9orf72 protein in some neurodegenerative disorders: with reduced C9orf72 levels, there is more inflammation mediated by the STING protein in immune and brain cells.

    • Madelyn E. McCauley
    • , Jacqueline Gire O’Rourke
    • , Alberto Yáñez
    • , Janet L. Markman
    • , Ritchie Ho
    • , Xinchen Wang
    • , Shuang Chen
    • , Deepti Lall
    • , Mengyao Jin
    • , A. K. M. G. Muhammad
    • , Shaughn Bell
    • , Jesse Landeros
    • , Viviana Valencia
    • , Matthew Harms
    • , Moshe Arditi
    • , Caroline Jefferies
    •  & Robert H. Baloh
  • Article |

    Germ-free mice co-colonized with two bacterial strains from the small intestinal flora showed increased susceptibility to experimental autoimmune encephalomyelitis, implicating the synergistic effects of these microorganisms in this mouse model of multiple sclerosis.

    • Eiji Miyauchi
    • , Seok-Won Kim
    • , Wataru Suda
    • , Masami Kawasumi
    • , Satoshi Onawa
    • , Naoko Taguchi-Atarashi
    • , Hidetoshi Morita
    • , Todd D. Taylor
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  • Article |

    Results of an exploratory interim analysis from a phase I trial show that an RNA vaccine targeted towards four melanoma-associated antigens produces durable objective responses in patients with melanoma that are accompanied by strong CD4+ and CD8+ T-cell immunity.

    • Ugur Sahin
    • , Petra Oehm
    • , Evelyna Derhovanessian
    • , Robert A. Jabulowsky
    • , Mathias Vormehr
    • , Maike Gold
    • , Daniel Maurus
    • , Doreen Schwarck-Kokarakis
    • , Andreas N. Kuhn
    • , Tana Omokoko
    • , Lena M. Kranz
    • , Mustafa Diken
    • , Sebastian Kreiter
    • , Heinrich Haas
    • , Sebastian Attig
    • , Richard Rae
    • , Katarina Cuk
    • , Alexandra Kemmer-Brück
    • , Andrea Breitkreuz
    • , Claudia Tolliver
    • , Janina Caspar
    • , Juliane Quinkhardt
    • , Lisa Hebich
    • , Malte Stein
    • , Alexander Hohberger
    • , Isabel Vogler
    • , Inga Liebig
    • , Stephanie Renken
    • , Julian Sikorski
    • , Melanie Leierer
    • , Verena Müller
    • , Heidrun Mitzel-Rink
    • , Matthias Miederer
    • , Christoph Huber
    • , Stephan Grabbe
    • , Jochen Utikal
    • , Andreas Pinter
    • , Roland Kaufmann
    • , Jessica C. Hassel
    • , Carmen Loquai
    •  & Özlem Türeci
  • Article |

    Melanoma cells undergo less oxidative stress and less ferroptosis in lymph than in blood, owing to higher levels of oleic acid in lymph, and thus exposure to the lymphatic environment increases subsequent metastasis through blood.

    • Jessalyn M. Ubellacker
    • , Alpaslan Tasdogan
    • , Vijayashree Ramesh
    • , Bo Shen
    • , Evann C. Mitchell
    • , Misty S. Martin-Sandoval
    • , Zhimin Gu
    • , Michael L. McCormick
    • , Alison B. Durham
    • , Douglas R. Spitz
    • , Zhiyu Zhao
    • , Thomas P. Mathews
    •  & Sean J. Morrison
  • Article |

    In a study performed in Schizosaccharomyces pombe, ‘closed mitosis’ is shown to occur via local disassembly of the nuclear envelope within the narrow bridge connecting segregating daughter nuclei, and a key role is identified for Les1, which restricts nuclear envelope breakdown to the bridge.

    • Gautam Dey
    • , Siân Culley
    • , Scott Curran
    • , Uwe Schmidt
    • , Ricardo Henriques
    • , Wanda Kukulski
    •  & Buzz Baum
  • Article |

    An approach for the design of protein pores is demonstrated by the computational design and subsequent experimental expression of both an ion-selective and a large transmembrane pore.

    • Chunfu Xu
    • , Peilong Lu
    • , Tamer M. Gamal El-Din
    • , Xue Y. Pei
    • , Matthew C. Johnson
    • , Atsuko Uyeda
    • , Matthew J. Bick
    • , Qi Xu
    • , Daohua Jiang
    • , Hua Bai
    • , Gabriella Reggiano
    • , Yang Hsia
    • , T J Brunette
    • , Jiayi Dou
    • , Dan Ma
    • , Eric M. Lynch
    • , Scott E. Boyken
    • , Po-Ssu Huang
    • , Lance Stewart
    • , Frank DiMaio
    • , Justin M. Kollman
    • , Ben F. Luisi
    • , Tomoaki Matsuura
    • , William A. Catterall
    •  & David Baker
  • Article |

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    • Kaiwen Liu
    • , Lijie Wu
    • , Shuguang Yuan
    • , Meng Wu
    • , Yueming Xu
    • , Qianqian Sun
    • , Shu Li
    • , Suwen Zhao
    • , Tian Hua
    •  & Zhi-Jie Liu
  • Article |

    Electrophiles activate the transient receptor potential ion channel TRPA1 by a two-step cysteine modification mechanism, which stabilizes a cytoplasmic loop that controls gating and calcium permeability.

    • Jianhua Zhao
    • , John V. Lin King
    • , Candice E. Paulsen
    • , Yifan Cheng
    •  & David Julius

Amendments & Corrections

  • Publisher Correction |

    • Neil J. Gemmell
    • , Kim Rutherford
    • , Stefan Prost
    • , Marc Tollis
    • , David Winter
    • , J. Robert Macey
    • , David L. Adelson
    • , Alexander Suh
    • , Terry Bertozzi
    • , José H. Grau
    • , Chris Organ
    • , Paul P. Gardner
    • , Matthieu Muffato
    • , Mateus Patricio
    • , Konstantinos Billis
    • , Fergal J. Martin
    • , Paul Flicek
    • , Bent Petersen
    • , Lin Kang
    • , Pawel Michalak
    • , Thomas R. Buckley
    • , Melissa Wilson
    • , Yuanyuan Cheng
    • , Hilary Miller
    • , Ryan K. Schott
    • , Melissa D. Jordan
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    • , José Ignacio Arroyo
    • , Nicole Valenzuela
    • , Tim A. Hore
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    • , Shawn M. Rupp
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    • , Helen Taylor
    • , Hideaki Abe
    • , Donna M. Bond
    • , James M. Paterson
    • , Daniel G. Mulcahy
    • , Vanessa L. Gonzalez
    • , Charles G. Barbieri
    • , Dustin P. DeMeo
    • , Stephan Pabinger
    • , Tracey Van Stijn
    • , Shannon Clarke
    • , Oliver Ryder
    • , Scott V. Edwards
    • , Steven L. Salzberg
    • , Lindsay Anderson
    • , Nicola Nelson
    • , Clive Stone
    • , Jim Smillie
    •  & Haydn Edmonds
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