Volume 583 Issue 7818, 30 July 2020

ENCODE

This week marks the publication of results from phase three of the Encyclopedia of DNA Elements (ENCODE) project. Nine articles in this issue of Nature, along with papers published online and in several other journals, examine the most comprehensive catalogue yet of the candidate functional elements in the human and mouse genomes. In an overview paper, the ENCODE Project Consortium offers a summary of the new elements in the encyclopedia, which have been compiled with data sets from some 6,000 experiments. Much of the work published in this issue examines DNA regions called candidate cis-regulatory elements (cCREs), which may regulate gene transcription. Three papers — from Joseph Ecker, Bing Ren, Barbara Wold and their colleagues — look at cCREs during embryonic development in the mouse. Two papers from Wouter Meuleman, Jeff Vierstra, John Stamatoyannopoulos and colleagues map cCREs and transcription factor footprints in hundreds of human cell and tissue types. Michael Snyder and colleagues map chromatin loops in 24 human cell types; Eric Mendenhall and co-workers map the genome-wide binding of almost one-quarter of all chromatin-associated proteins active in a human liver cell line; and Brenton Graveley and colleagues integrate multiple assays to produce a comprehensive analysis of RNA-binding proteins and their functional elements. Finally, in a Perspective article, the project team puts the multiple phases of ENCODE in context.

Cover image: StoryTK

This Week

News in Focus

Books & Arts

Opinion

Work

Research

    News & Views

  • News & Views |

    A clinical trial has tested the use of gene-sequencing results for lung cancer to match patients to targeted therapies. Some paired treatments were a good fit, but others did not succeed, for reasons that will require further exploration.

    • Alexander Drilon
    •  & Matthew D. Hellmann
  • News & Views |

    The prolonged cold of winter is required for the flowering of many plants. Now the identification of a previously unknown long-term cold-sensing mechanism helps to reveal how plants are able to time their flowering correctly.

    • Hiroyuki Iida
    •  & Ari Pekka Mähönen
  • ENCODE 3

  • Perspective |

    The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • , Reyes Acosta
    • , Nicholas J. Addleman
    • , Jessika Adrian
    • , Veena Afzal
    • , Bronwen Aken
    • , Jennifer A. Akiyama
    • , Omar Al Jammal
    • , Henry Amrhein
    • , Stacie M. Anderson
    • , Gregory R. Andrews
    • , Igor Antoshechkin
    • , Kristin G. Ardlie
    • , Joel Armstrong
    • , Matthew Astley
    • , Budhaditya Banerjee
    • , Amira A. Barkal
    • , If H. A. Barnes
    • , Iros Barozzi
    • , Daniel Barrell
    • , Gemma Barson
    • , Daniel Bates
    • , Ulugbek K. Baymuradov
    • , Cassandra Bazile
    • , Michael A. Beer
    • , Samantha Beik
    • , M. A. Bender
    • , Ruth Bennett
    • , Louis Philip Benoit Bouvrette
    • , Bradley E. Bernstein
    • , Andrew Berry
    • , Anand Bhaskar
    • , Alexandra Bignell
    • , Steven M. Blue
    • , David M. Bodine
    • , Carles Boix
    • , Nathan Boley
    • , Tyler Borrman
    • , Beatrice Borsari
    • , Alan P. Boyle
    • , Laurel A. Brandsmeier
    • , Alessandra Breschi
    • , Emery H. Bresnick
    • , Jason A. Brooks
    • , Michael Buckley
    • , Christopher B. Burge
    • , Rachel Byron
    • , Eileen Cahill
    • , Lingling Cai
    • , Lulu Cao
    • , Mark Carty
    • , Rosa G. Castanon
    • , Andres Castillo
    • , Hassan Chaib
    • , Esther T. Chan
    • , Daniel R. Chee
    • , Sora Chee
    • , Hao Chen
    • , Huaming Chen
    • , Jia-Yu Chen
    • , Songjie Chen
    • , J. Michael Cherry
    • , Surya B. Chhetri
    • , Jyoti S. Choudhary
    • , Jacqueline Chrast
    • , Dongjun Chung
    • , Declan Clarke
    • , Neal A. L. Cody
    • , Candice J. Coppola
    • , Julie Coursen
    • , Anthony M. D’Ippolito
    • , Stephen Dalton
    • , Cassidy Danyko
    • , Claire Davidson
    • , Jose Davila-Velderrain
    • , Carrie A. Davis
    • , Job Dekker
    • , Alden Deran
    • , Gilberto DeSalvo
    • , Gloria Despacio-Reyes
    • , Colin N. Dewey
    • , Diane E. Dickel
    • , Morgan Diegel
    • , Mark Diekhans
    • , Vishnu Dileep
    • , Bo Ding
    • , Sarah Djebali
    • , Alexander Dobin
    • , Daniel Dominguez
    • , Sarah Donaldson
    • , Jorg Drenkow
    • , Timothy R. Dreszer
    • , Yotam Drier
    • , Michael O. Duff
    • , Douglass Dunn
    • , Catharine Eastman
    • , Joseph R. Ecker
    • , Matthew D. Edwards
    • , Nicole El-Ali
    • , Shaimae I. Elhajjajy
    • , Keri Elkins
    • , Andrew Emili
    • , Charles B. Epstein
    • , Rachel C. Evans
    • , Iakes Ezkurdia
    • , Kaili Fan
    • , Peggy J. Farnham
    • , Nina Farrell
    • , Elise A. Feingold
    • , Anne-Maud Ferreira
    • , Katherine Fisher-Aylor
    • , Stephen Fitzgerald
    • , Paul Flicek
    • , Chuan Sheng Foo
    • , Kevin Fortier
    • , Adam Frankish
    • , Peter Freese
    • , Shaliu Fu
    • , Xiang-Dong Fu
    • , Yu Fu
    • , Yoko Fukuda-Yuzawa
    • , Mariateresa Fulciniti
    • , Alister P. W. Funnell
    • , Idan Gabdank
    • , Timur Galeev
    • , Mingshi Gao
    • , Carlos Garcia Giron
    • , Tyler H. Garvin
    • , Chelsea Anne Gelboin-Burkhart
    • , Grigorios Georgolopoulos
    • , Mark B. Gerstein
    • , Belinda M. Giardine
    • , David K. Gifford
    • , David M. Gilbert
    • , Daniel A. Gilchrist
    • , Shawn Gillespie
    • , Thomas R. Gingeras
    • , Peng Gong
    • , Alvaro Gonzalez
    • , Jose M. Gonzalez
    • , Peter Good
    • , Alon Goren
    • , David U. Gorkin
    • , Brenton R. Graveley
    • , Michael Gray
    • , Jack F. Greenblatt
    • , Ed Griffiths
    • , Mark T. Groudine
    • , Fabian Grubert
    • , Mengting Gu
    • , Roderic Guigó
    • , Hongbo Guo
    • , Yu Guo
    • , Yuchun Guo
    • , Gamze Gursoy
    • , Maria Gutierrez-Arcelus
    • , Jessica Halow
    • , Ross C. Hardison
    • , Matthew Hardy
    • , Manoj Hariharan
    • , Arif Harmanci
    • , Anne Harrington
    • , Jennifer L. Harrow
    • , Tatsunori B. Hashimoto
    • , Richard D. Hasz
    • , Meital Hatan
    • , Eric Haugen
    • , James E. Hayes
    • , Peng He
    • , Yupeng He
    • , Nastaran Heidari
    • , David Hendrickson
    • , Elisabeth F. Heuston
    • , Jason A. Hilton
    • , Benjamin C. Hitz
    • , Abigail Hochman
    • , Cory Holgren
    • , Lei Hou
    • , Shuyu Hou
    • , Yun-Hua E. Hsiao
    • , Shanna Hsu
    • , Hui Huang
    • , Tim J. Hubbard
    • , Jack Huey
    • , Timothy R. Hughes
    • , Toby Hunt
    • , Sean Ibarrientos
    • , Robbyn Issner
    • , Mineo Iwata
    • , Osagie Izuogu
    • , Tommi Jaakkola
    • , Nader Jameel
    • , Camden Jansen
    • , Lixia Jiang
    • , Peng Jiang
    • , Audra Johnson
    • , Rory Johnson
    • , Irwin Jungreis
    • , Madhura Kadaba
    • , Maya Kasowski
    • , Mary Kasparian
    • , Momoe Kato
    • , Rajinder Kaul
    • , Trupti Kawli
    • , Michael Kay
    • , Judith C. Keen
    • , Sunduz Keles
    • , Cheryl A. Keller
    • , David Kelley
    • , Manolis Kellis
    • , Pouya Kheradpour
    • , Daniel Sunwook Kim
    • , Anthony Kirilusha
    • , Robert J. Klein
    • , Birgit Knoechel
    • , Samantha Kuan
    • , Michael J. Kulik
    • , Sushant Kumar
    • , Anshul Kundaje
    • , Tanya Kutyavin
    • , Julien Lagarde
    • , Bryan R. Lajoie
    • , Nicole J. Lambert
    • , John Lazar
    • , Ah Young Lee
    • , Donghoon Lee
    • , Elizabeth Lee
    • , Jin Wook Lee
    • , Kristen Lee
    • , Christina S. Leslie
    • , Shawn Levy
    • , Bin Li
    • , Hairi Li
    • , Nan Li
    • , Xiangrui Li
    • , Yang I. Li
    • , Ying Li
    • , Yining Li
    • , Yue Li
    • , Jin Lian
    • , Maxwell W. Libbrecht
    • , Shin Lin
    • , Yiing Lin
    • , Dianbo Liu
    • , Jason Liu
    • , Peng Liu
    • , Tingting Liu
    • , X. Shirley Liu
    • , Yan Liu
    • , Yaping Liu
    • , Maria Long
    • , Shaoke Lou
    • , Jane Loveland
    • , Aiping Lu
    • , Yuheng Lu
    • , Eric Lécuyer
    • , Lijia Ma
    • , Mark Mackiewicz
    • , Brandon J. Mannion
    • , Michael Mannstadt
    • , Deepa Manthravadi
    • , Georgi K. Marinov
    • , Fergal J. Martin
    • , Eugenio Mattei
    • , Kenneth McCue
    • , Megan McEown
    • , Graham McVicker
    • , Sarah K. Meadows
    • , Alex Meissner
    • , Eric M. Mendenhall
    • , Christopher L. Messer
    • , Wouter Meuleman
    • , Clifford Meyer
    • , Steve Miller
    • , Matthew G. Milton
    • , Tejaswini Mishra
    • , Dianna E. Moore
    • , Helen M. Moore
    • , Jill E. Moore
    • , Samuel H. Moore
    • , Jennifer Moran
    • , Ali Mortazavi
    • , Jonathan M. Mudge
    • , Nikhil Munshi
    • , Rabi Murad
    • , Richard M. Myers
    • , Vivek Nandakumar
    • , Preetha Nandi
    • , Anil M. Narasimha
    • , Aditi K. Narayanan
    • , Hannah Naughton
    • , Fabio C. P. Navarro
    • , Patrick Navas
    • , Jurijs Nazarovs
    • , Jemma Nelson
    • , Shane Neph
    • , Fidencio Jun Neri
    • , Joseph R. Nery
    • , Amy R. Nesmith
    • , J. Scott Newberry
    • , Kimberly M. Newberry
    • , Vu Ngo
    • , Rosy Nguyen
    • , Thai B. Nguyen
    • , Tung Nguyen
    • , Andrew Nishida
    • , William S. Noble
    • , Catherine S. Novak
    • , Eva Maria Novoa
    • , Briana Nuñez
    • , Charles W. O’Donnell
    • , Sara Olson
    • , Kathrina C. Onate
    • , Ericka Otterman
    • , Hakan Ozadam
    • , Michael Pagan
    • , Tsultrim Palden
    • , Xinghua Pan
    • , Yongjin Park
    • , E. Christopher Partridge
    • , Benedict Paten
    • , Florencia Pauli-Behn
    • , Michael J. Pazin
    • , Baikang Pei
    • , Len A. Pennacchio
    • , Alexander R. Perez
    • , Emily H. Perry
    • , Dmitri D. Pervouchine
    • , Nishigandha N. Phalke
    • , Quan Pham
    • , Doug H. Phanstiel
    • , Ingrid Plajzer-Frick
    • , Gabriel A. Pratt
    • , Henry E. Pratt
    • , Sebastian Preissl
    • , Jonathan K. Pritchard
    • , Yuri Pritykin
    • , Michael J. Purcaro
    • , Qian Qin
    • , Giovanni Quinones-Valdez
    • , Ines Rabano
    • , Ernest Radovani
    • , Anil Raj
    • , Nisha Rajagopal
    • , Oren Ram
    • , Lucia Ramirez
    • , Ricardo N. Ramirez
    • , Dylan Rausch
    • , Soumya Raychaudhuri
    • , Joseph Raymond
    • , Rozita Razavi
    • , Timothy E. Reddy
    • , Thomas M. Reimonn
    • , Bing Ren
    • , Alexandre Reymond
    • , Alex Reynolds
    • , Suhn K. Rhie
    • , John Rinn
    • , Miguel Rivera
    • , Juan Carlos Rivera-Mulia
    • , Brian Roberts
    • , Jose Manuel Rodriguez
    • , Joel Rozowsky
    • , Russell Ryan
    • , Eric Rynes
    • , Denis N. Salins
    • , Richard Sandstrom
    • , Takayo Sasaki
    • , Shashank Sathe
    • , Daniel Savic
    • , Alexandra Scavelli
    • , Jonathan Scheiman
    • , Christoph Schlaffner
    • , Jeffery A. Schloss
    • , Frank W. Schmitges
    • , Lei Hoon See
    • , Anurag Sethi
    • , Manu Setty
    • , Anthony Shafer
    • , Shuo Shan
    • , Eilon Sharon
    • , Quan Shen
    • , Yin Shen
    • , Richard I. Sherwood
    • , Minyi Shi
    • , Sunyoung Shin
    • , Noam Shoresh
    • , Kyle Siebenthall
    • , Cristina Sisu
    • , Teri Slifer
    • , Cricket A. Sloan
    • , Anna Smith
    • , Valentina Snetkova
    • , Michael P. Snyder
    • , Damek V. Spacek
    • , Sharanya Srinivasan
    • , Rohith Srivas
    • , George Stamatoyannopoulos
    • , John A. Stamatoyannopoulos
    • , Rebecca Stanton
    • , Dave Steffan
    • , Sandra Stehling-Sun
    • , J. Seth Strattan
    • , Amanda Su
    • , Balaji Sundararaman
    • , Marie-Marthe Suner
    • , Tahin Syed
    • , Matt Szynkarek
    • , Forrest Y. Tanaka
    • , Danielle Tenen
    • , Mingxiang Teng
    • , Jeffrey A. Thomas
    • , Dave Toffey
    • , Michael L. Tress
    • , Diane E. Trout
    • , Gosia Trynka
    • , Junko Tsuji
    • , Sean A. Upchurch
    • , Oana Ursu
    • , Barbara Uszczynska-Ratajczak
    • , Mia C. Uziel
    • , Alfonso Valencia
    • , Benjamin Van Biber
    • , Arjan G. van der Velde
    • , Eric L. Van Nostrand
    • , Yekaterina Vaydylevich
    • , Jesus Vazquez
    • , Alec Victorsen
    • , Jost Vielmetter
    • , Jeff Vierstra
    • , Axel Visel
    • , Anna Vlasova
    • , Christopher M. Vockley
    • , Simona Volpi
    • , Shinny Vong
    • , Hao Wang
    • , Mengchi Wang
    • , Qin Wang
    • , Ruth Wang
    • , Tao Wang
    • , Wei Wang
    • , Xiaofeng Wang
    • , Yanli Wang
    • , Nathaniel K. Watson
    • , Xintao Wei
    • , Zhijie Wei
    • , Hendrik Weisser
    • , Sherman M. Weissman
    • , Rene Welch
    • , Robert E. Welikson
    • , Zhiping Weng
    • , Harm-Jan Westra
    • , John W. Whitaker
    • , Collin White
    • , Kevin P. White
    • , Andre Wildberg
    • , Brian A. Williams
    • , David Wine
    • , Heather N. Witt
    • , Barbara Wold
    • , Maxim Wolf
    • , James Wright
    • , Rui Xiao
    • , Xinshu Xiao
    • , Jie Xu
    • , Jinrui Xu
    • , Koon-Kiu Yan
    • , Yongqi Yan
    • , Hongbo Yang
    • , Xinqiong Yang
    • , Yi-Wen Yang
    • , Galip Gürkan Yardımcı
    • , Brian A. Yee
    • , Gene W. Yeo
    • , Taylor Young
    • , Tianxiong Yu
    • , Feng Yue
    • , Chris Zaleski
    • , Chongzhi Zang
    • , Haoyang Zeng
    • , Weihua Zeng
    • , Daniel R. Zerbino
    • , Jie Zhai
    • , Lijun Zhan
    • , Ye Zhan
    • , Bo Zhang
    • , Jialing Zhang
    • , Jing Zhang
    • , Kai Zhang
    • , Lijun Zhang
    • , Peng Zhang
    • , Qi Zhang
    • , Xiao-Ou Zhang
    • , Yanxiao Zhang
    • , Zhizhuo Zhang
    • , Yuan Zhao
    • , Ye Zheng
    • , Guoqing Zhong
    • , Xiao-Qiao Zhou
    • , Yun Zhu
    • , Jared Zimmerman
    • , Michael P. Snyder
    • , Thomas R. Gingeras
    • , Jill E. Moore
    • , Zhiping Weng
    • , Mark B. Gerstein
    • , Bing Ren
    • , Ross C. Hardison
    • , John A. Stamatoyannopoulos
    • , Brenton R. Graveley
    • , Elise A. Feingold
    • , Michael J. Pazin
    • , Michael Pagan
    • , Daniel A. Gilchrist
    • , Benjamin C. Hitz
    • , J. Michael Cherry
    • , Bradley E. Bernstein
    • , Eric M. Mendenhall
    • , Daniel R. Zerbino
    • , Adam Frankish
    • , Paul Flicek
    •  & Richard M. Myers

    Special:

  • Article |

    The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • , Reyes Acosta
    • , Nicholas J. Addleman
    • , Jessika Adrian
    • , Veena Afzal
    • , Bronwen Aken
    • , Jennifer A. Akiyama
    • , Omar Al Jammal
    • , Henry Amrhein
    • , Stacie M. Anderson
    • , Gregory R. Andrews
    • , Igor Antoshechkin
    • , Kristin G. Ardlie
    • , Joel Armstrong
    • , Matthew Astley
    • , Budhaditya Banerjee
    • , Amira A. Barkal
    • , If H. A. Barnes
    • , Iros Barozzi
    • , Daniel Barrell
    • , Gemma Barson
    • , Daniel Bates
    • , Ulugbek K. Baymuradov
    • , Cassandra Bazile
    • , Michael A. Beer
    • , Samantha Beik
    • , M. A. Bender
    • , Ruth Bennett
    • , Louis Philip Benoit Bouvrette
    • , Bradley E. Bernstein
    • , Andrew Berry
    • , Anand Bhaskar
    • , Alexandra Bignell
    • , Steven M. Blue
    • , David M. Bodine
    • , Carles Boix
    • , Nathan Boley
    • , Tyler Borrman
    • , Beatrice Borsari
    • , Alan P. Boyle
    • , Laurel A. Brandsmeier
    • , Alessandra Breschi
    • , Emery H. Bresnick
    • , Jason A. Brooks
    • , Michael Buckley
    • , Christopher B. Burge
    • , Rachel Byron
    • , Eileen Cahill
    • , Lingling Cai
    • , Lulu Cao
    • , Mark Carty
    • , Rosa G. Castanon
    • , Andres Castillo
    • , Hassan Chaib
    • , Esther T. Chan
    • , Daniel R. Chee
    • , Sora Chee
    • , Hao Chen
    • , Huaming Chen
    • , Jia-Yu Chen
    • , Songjie Chen
    • , J. Michael Cherry
    • , Surya B. Chhetri
    • , Jyoti S. Choudhary
    • , Jacqueline Chrast
    • , Dongjun Chung
    • , Declan Clarke
    • , Neal A. L. Cody
    • , Candice J. Coppola
    • , Julie Coursen
    • , Anthony M. D’Ippolito
    • , Stephen Dalton
    • , Cassidy Danyko
    • , Claire Davidson
    • , Jose Davila-Velderrain
    • , Carrie A. Davis
    • , Job Dekker
    • , Alden Deran
    • , Gilberto DeSalvo
    • , Gloria Despacio-Reyes
    • , Colin N. Dewey
    • , Diane E. Dickel
    • , Morgan Diegel
    • , Mark Diekhans
    • , Vishnu Dileep
    • , Bo Ding
    • , Sarah Djebali
    • , Alexander Dobin
    • , Daniel Dominguez
    • , Sarah Donaldson
    • , Jorg Drenkow
    • , Timothy R. Dreszer
    • , Yotam Drier
    • , Michael O. Duff
    • , Douglass Dunn
    • , Catharine Eastman
    • , Joseph R. Ecker
    • , Matthew D. Edwards
    • , Nicole El-Ali
    • , Shaimae I. Elhajjajy
    • , Keri Elkins
    • , Andrew Emili
    • , Charles B. Epstein
    • , Rachel C. Evans
    • , Iakes Ezkurdia
    • , Kaili Fan
    • , Peggy J. Farnham
    • , Nina P. Farrell
    • , Elise A. Feingold
    • , Anne-Maud Ferreira
    • , Katherine Fisher-Aylor
    • , Stephen Fitzgerald
    • , Paul Flicek
    • , Chuan Sheng Foo
    • , Kevin Fortier
    • , Adam Frankish
    • , Peter Freese
    • , Shaliu Fu
    • , Xiang-Dong Fu
    • , Yu Fu
    • , Yoko Fukuda-Yuzawa
    • , Mariateresa Fulciniti
    • , Alister P. W. Funnell
    • , Idan Gabdank
    • , Timur Galeev
    • , Mingshi Gao
    • , Carlos Garcia Giron
    • , Tyler H. Garvin
    • , Chelsea Anne Gelboin-Burkhart
    • , Grigorios Georgolopoulos
    • , Mark B. Gerstein
    • , Belinda M. Giardine
    • , David K. Gifford
    • , David M. Gilbert
    • , Daniel A. Gilchrist
    • , Shawn Gillespie
    • , Thomas R. Gingeras
    • , Peng Gong
    • , Alvaro Gonzalez
    • , Jose M. Gonzalez
    • , Peter Good
    • , Alon Goren
    • , David U. Gorkin
    • , Brenton R. Graveley
    • , Michael Gray
    • , Jack F. Greenblatt
    • , Ed Griffiths
    • , Mark T. Groudine
    • , Fabian Grubert
    • , Mengting Gu
    • , Roderic Guigó
    • , Hongbo Guo
    • , Yu Guo
    • , Yuchun Guo
    • , Gamze Gursoy
    • , Maria Gutierrez-Arcelus
    • , Jessica Halow
    • , Ross C. Hardison
    • , Matthew Hardy
    • , Manoj Hariharan
    • , Arif Harmanci
    • , Anne Harrington
    • , Jennifer L. Harrow
    • , Tatsunori B. Hashimoto
    • , Richard D. Hasz
    • , Meital Hatan
    • , Eric Haugen
    • , James E. Hayes
    • , Peng He
    • , Yupeng He
    • , Nastaran Heidari
    • , David Hendrickson
    • , Elisabeth F. Heuston
    • , Jason A. Hilton
    • , Benjamin C. Hitz
    • , Abigail Hochman
    • , Cory Holgren
    • , Lei Hou
    • , Shuyu Hou
    • , Yun-Hua E. Hsiao
    • , Shanna Hsu
    • , Hui Huang
    • , Tim J. Hubbard
    • , Jack Huey
    • , Timothy R. Hughes
    • , Toby Hunt
    • , Sean Ibarrientos
    • , Robbyn Issner
    • , Mineo Iwata
    • , Osagie Izuogu
    • , Tommi Jaakkola
    • , Nader Jameel
    • , Camden Jansen
    • , Lixia Jiang
    • , Peng Jiang
    • , Audra Johnson
    • , Rory Johnson
    • , Irwin Jungreis
    • , Madhura Kadaba
    • , Maya Kasowski
    • , Mary Kasparian
    • , Momoe Kato
    • , Rajinder Kaul
    • , Trupti Kawli
    • , Michael Kay
    • , Judith C. Keen
    • , Sunduz Keles
    • , Cheryl A. Keller
    • , David Kelley
    • , Manolis Kellis
    • , Pouya Kheradpour
    • , Daniel Sunwook Kim
    • , Anthony Kirilusha
    • , Robert J. Klein
    • , Birgit Knoechel
    • , Samantha Kuan
    • , Michael J. Kulik
    • , Sushant Kumar
    • , Anshul Kundaje
    • , Tanya Kutyavin
    • , Julien Lagarde
    • , Bryan R. Lajoie
    • , Nicole J. Lambert
    • , John Lazar
    • , Ah Young Lee
    • , Donghoon Lee
    • , Elizabeth Lee
    • , Jin Wook Lee
    • , Kristen Lee
    • , Christina S. Leslie
    • , Shawn Levy
    • , Bin Li
    • , Hairi Li
    • , Nan Li
    • , Xiangrui Li
    • , Yang I. Li
    • , Ying Li
    • , Yining Li
    • , Yue Li
    • , Jin Lian
    • , Maxwell W. Libbrecht
    • , Shin Lin
    • , Yiing Lin
    • , Dianbo Liu
    • , Jason Liu
    • , Peng Liu
    • , Tingting Liu
    • , X. Shirley Liu
    • , Yan Liu
    • , Yaping Liu
    • , Maria Long
    • , Shaoke Lou
    • , Jane Loveland
    • , Aiping Lu
    • , Yuheng Lu
    • , Eric Lécuyer
    • , Lijia Ma
    • , Mark Mackiewicz
    • , Brandon J. Mannion
    • , Michael Mannstadt
    • , Deepa Manthravadi
    • , Georgi K. Marinov
    • , Fergal J. Martin
    • , Eugenio Mattei
    • , Kenneth McCue
    • , Megan McEown
    • , Graham McVicker
    • , Sarah K. Meadows
    • , Alex Meissner
    • , Eric M. Mendenhall
    • , Christopher L. Messer
    • , Wouter Meuleman
    • , Clifford Meyer
    • , Steve Miller
    • , Matthew G. Milton
    • , Tejaswini Mishra
    • , Dianna E. Moore
    • , Helen M. Moore
    • , Jill E. Moore
    • , Samuel H. Moore
    • , Jennifer Moran
    • , Ali Mortazavi
    • , Jonathan M. Mudge
    • , Nikhil Munshi
    • , Rabi Murad
    • , Richard M. Myers
    • , Vivek Nandakumar
    • , Preetha Nandi
    • , Anil M. Narasimha
    • , Aditi K. Narayanan
    • , Hannah Naughton
    • , Fabio C. P. Navarro
    • , Patrick Navas
    • , Jurijs Nazarovs
    • , Jemma Nelson
    • , Shane Neph
    • , Fidencio Jun Neri
    • , Joseph R. Nery
    • , Amy R. Nesmith
    • , J. Scott Newberry
    • , Kimberly M. Newberry
    • , Vu Ngo
    • , Rosy Nguyen
    • , Thai B. Nguyen
    • , Tung Nguyen
    • , Andrew Nishida
    • , William S. Noble
    • , Catherine S. Novak
    • , Eva Maria Novoa
    • , Briana Nuñez
    • , Charles W. O’Donnell
    • , Sara Olson
    • , Kathrina C. Onate
    • , Ericka Otterman
    • , Hakan Ozadam
    • , Michael Pagan
    • , Tsultrim Palden
    • , Xinghua Pan
    • , Yongjin Park
    • , E. Christopher Partridge
    • , Benedict Paten
    • , Florencia Pauli-Behn
    • , Michael J. Pazin
    • , Baikang Pei
    • , Len A. Pennacchio
    • , Alexander R. Perez
    • , Emily H. Perry
    • , Dmitri D. Pervouchine
    • , Nishigandha N. Phalke
    • , Quan Pham
    • , Doug H. Phanstiel
    • , Ingrid Plajzer-Frick
    • , Gabriel A. Pratt
    • , Henry E. Pratt
    • , Sebastian Preissl
    • , Jonathan K. Pritchard
    • , Yuri Pritykin
    • , Michael J. Purcaro
    • , Qian Qin
    • , Giovanni Quinones-Valdez
    • , Ines Rabano
    • , Ernest Radovani
    • , Anil Raj
    • , Nisha Rajagopal
    • , Oren Ram
    • , Lucia Ramirez
    • , Ricardo N. Ramirez
    • , Dylan Rausch
    • , Soumya Raychaudhuri
    • , Joseph Raymond
    • , Rozita Razavi
    • , Timothy E. Reddy
    • , Thomas M. Reimonn
    • , Bing Ren
    • , Alexandre Reymond
    • , Alex Reynolds
    • , Suhn K. Rhie
    • , John Rinn
    • , Miguel Rivera
    • , Juan Carlos Rivera-Mulia
    • , Brian S. Roberts
    • , Jose Manuel Rodriguez
    • , Joel Rozowsky
    • , Russell Ryan
    • , Eric Rynes
    • , Denis N. Salins
    • , Richard Sandstrom
    • , Takayo Sasaki
    • , Shashank Sathe
    • , Daniel Savic
    • , Alexandra Scavelli
    • , Jonathan Scheiman
    • , Christoph Schlaffner
    • , Jeffery A. Schloss
    • , Frank W. Schmitges
    • , Lei Hoon See
    • , Anurag Sethi
    • , Manu Setty
    • , Anthony Shafer
    • , Shuo Shan
    • , Eilon Sharon
    • , Quan Shen
    • , Yin Shen
    • , Richard I. Sherwood
    • , Minyi Shi
    • , Sunyoung Shin
    • , Noam Shoresh
    • , Kyle Siebenthall
    • , Cristina Sisu
    • , Teri Slifer
    • , Cricket A. Sloan
    • , Anna Smith
    • , Valentina Snetkova
    • , Michael P. Snyder
    • , Damek V. Spacek
    • , Sharanya Srinivasan
    • , Rohith Srivas
    • , George Stamatoyannopoulos
    • , John A. Stamatoyannopoulos
    • , Rebecca Stanton
    • , Dave Steffan
    • , Sandra Stehling-Sun
    • , J. Seth Strattan
    • , Amanda Su
    • , Balaji Sundararaman
    • , Marie-Marthe Suner
    • , Tahin Syed
    • , Matt Szynkarek
    • , Forrest Y. Tanaka
    • , Danielle Tenen
    • , Mingxiang Teng
    • , Jeffrey A. Thomas
    • , Dave Toffey
    • , Michael L. Tress
    • , Diane E. Trout
    • , Gosia Trynka
    • , Junko Tsuji
    • , Sean A. Upchurch
    • , Oana Ursu
    • , Barbara Uszczynska-Ratajczak
    • , Mia C. Uziel
    • , Alfonso Valencia
    • , Benjamin Van Biber
    • , Arjan G. van der Velde
    • , Eric L. Van Nostrand
    • , Yekaterina Vaydylevich
    • , Jesus Vazquez
    • , Alec Victorsen
    • , Jost Vielmetter
    • , Jeff Vierstra
    • , Axel Visel
    • , Anna Vlasova
    • , Christopher M. Vockley
    • , Simona Volpi
    • , Shinny Vong
    • , Hao Wang
    • , Mengchi Wang
    • , Qin Wang
    • , Ruth Wang
    • , Tao Wang
    • , Wei Wang
    • , Xiaofeng Wang
    • , Yanli Wang
    • , Nathaniel K. Watson
    • , Xintao Wei
    • , Zhijie Wei
    • , Hendrik Weisser
    • , Sherman M. Weissman
    • , Rene Welch
    • , Robert E. Welikson
    • , Zhiping Weng
    • , Harm-Jan Westra
    • , John W. Whitaker
    • , Collin White
    • , Kevin P. White
    • , Andre Wildberg
    • , Brian A. Williams
    • , David Wine
    • , Heather N. Witt
    • , Barbara Wold
    • , Maxim Wolf
    • , James Wright
    • , Rui Xiao
    • , Xinshu Xiao
    • , Jie Xu
    • , Jinrui Xu
    • , Koon-Kiu Yan
    • , Yongqi Yan
    • , Hongbo Yang
    • , Xinqiong Yang
    • , Yi-Wen Yang
    • , Galip Gürkan Yardımcı
    • , Brian A. Yee
    • , Gene W. Yeo
    • , Taylor Young
    • , Tianxiong Yu
    • , Feng Yue
    • , Chris Zaleski
    • , Chongzhi Zang
    • , Haoyang Zeng
    • , Weihua Zeng
    • , Daniel R. Zerbino
    • , Jie Zhai
    • , Lijun Zhan
    • , Ye Zhan
    • , Bo Zhang
    • , Jialing Zhang
    • , Jing Zhang
    • , Kai Zhang
    • , Lijun Zhang
    • , Peng Zhang
    • , Qi Zhang
    • , Xiao-Ou Zhang
    • , Yanxiao Zhang
    • , Zhizhuo Zhang
    • , Yuan Zhao
    • , Ye Zheng
    • , Guoqing Zhong
    • , Xiao-Qiao Zhou
    • , Yun Zhu
    • , Jared Zimmerman
    • , Jill E. Moore
    • , Michael J. Purcaro
    • , Henry E. Pratt
    • , Charles B. Epstein
    • , Noam Shoresh
    • , Jessika Adrian
    • , Trupti Kawli
    • , Carrie A. Davis
    • , Alexander Dobin
    • , Rajinder Kaul
    • , Jessica Halow
    • , Eric L. Van Nostrand
    • , Peter Freese
    • , David U. Gorkin
    • , Yin Shen
    • , Yupeng He
    • , Mark Mackiewicz
    • , Florencia Pauli-Behn
    • , Brian A. Williams
    • , Ali Mortazavi
    • , Cheryl A. Keller
    • , Xiao-Ou Zhang
    • , Shaimae I. Elhajjajy
    • , Jack Huey
    • , Diane E. Dickel
    • , Valentina Snetkova
    • , Xintao Wei
    • , Xiaofeng Wang
    • , Juan Carlos Rivera-Mulia
    • , Joel Rozowsky
    • , Jing Zhang
    • , Surya B. Chhetri
    • , Jialing Zhang
    • , Alec Victorsen
    • , Kevin P. White
    • , Axel Visel
    • , Gene W. Yeo
    • , Christopher B. Burge
    • , Eric Lécuyer
    • , David M. Gilbert
    • , Job Dekker
    • , John Rinn
    • , Eric M. Mendenhall
    • , Joseph R. Ecker
    • , Manolis Kellis
    • , Robert J. Klein
    • , William S. Noble
    • , Anshul Kundaje
    • , Roderic Guigó
    • , Peggy J. Farnham
    • , J. Michael Cherry
    • , Richard M. Myers
    • , Bing Ren
    • , Brenton R. Graveley
    • , Mark B. Gerstein
    • , Len A. Pennacchio
    • , Michael P. Snyder
    • , Bradley E. Bernstein
    • , Barbara Wold
    • , Ross C. Hardison
    • , Thomas R. Gingeras
    • , John A. Stamatoyannopoulos
    •  & Zhiping Weng

    Special:

  • Article |

    A combination of five assays is used to produce a catalogue of RNA elements to which RNA-binding proteins bind in human cells.

    • Eric L. Van Nostrand
    • , Peter Freese
    • , Gabriel A. Pratt
    • , Xiaofeng Wang
    • , Xintao Wei
    • , Rui Xiao
    • , Steven M. Blue
    • , Jia-Yu Chen
    • , Neal A. L. Cody
    • , Daniel Dominguez
    • , Sara Olson
    • , Balaji Sundararaman
    • , Lijun Zhan
    • , Cassandra Bazile
    • , Louis Philip Benoit Bouvrette
    • , Julie Bergalet
    • , Michael O. Duff
    • , Keri E. Garcia
    • , Chelsea Gelboin-Burkhart
    • , Myles Hochman
    • , Nicole J. Lambert
    • , Hairi Li
    • , Michael P. McGurk
    • , Thai B. Nguyen
    • , Tsultrim Palden
    • , Ines Rabano
    • , Shashank Sathe
    • , Rebecca Stanton
    • , Amanda Su
    • , Ruth Wang
    • , Brian A. Yee
    • , Bing Zhou
    • , Ashley L. Louie
    • , Stefan Aigner
    • , Xiang-Dong Fu
    • , Eric Lécuyer
    • , Christopher B. Burge
    • , Brenton R. Graveley
    •  & Gene W. Yeo

    Special:

  • Article |

    ChIP–seq and CETCh–seq data are used to analyse binding maps for 208 transcription factors and other chromatin-associated proteins in a single human cell type, providing a comprehensive catalogue of the transcription factor landscape and gene regulatory networks in these cells.

    • E. Christopher Partridge
    • , Surya B. Chhetri
    • , Jeremy W. Prokop
    • , Ryne C. Ramaker
    • , Camden S. Jansen
    • , Say-Tar Goh
    • , Mark Mackiewicz
    • , Kimberly M. Newberry
    • , Laurel A. Brandsmeier
    • , Sarah K. Meadows
    • , C. Luke Messer
    • , Andrew A. Hardigan
    • , Candice J. Coppola
    • , Emma C. Dean
    • , Shan Jiang
    • , Daniel Savic
    • , Ali Mortazavi
    • , Barbara J. Wold
    • , Richard M. Myers
    •  & Eric M. Mendenhall

    Special:

  • Article |

    A high-density DNase I cleavage map from 243 human cell and tissue types provides a genome-wide, nucleotide-resolution map of human transcription factor footprints.

    • Jeff Vierstra
    • , John Lazar
    • , Richard Sandstrom
    • , Jessica Halow
    • , Kristen Lee
    • , Daniel Bates
    • , Morgan Diegel
    • , Douglas Dunn
    • , Fidencio Neri
    • , Eric Haugen
    • , Eric Rynes
    • , Alex Reynolds
    • , Jemma Nelson
    • , Audra Johnson
    • , Mark Frerker
    • , Michael Buckley
    • , Rajinder Kaul
    • , Wouter Meuleman
    •  & John A. Stamatoyannopoulos

    Special:

  • Article |

    A map of cohesin-mediated chromatin loops in 24 types of human cells identifies loops that show cell-type-specific variation, indicating that chromatin loops may help to specify cell-specific gene expression programs and functions.

    • Fabian Grubert
    • , Rohith Srivas
    • , Damek  V Spacek
    • , Maya Kasowski
    • , Mariana Ruiz-Velasco
    • , Nasa Sinnott-Armstrong
    • , Peyton Greenside
    • , Anil Narasimha
    • , Qing Liu
    • , Benjamin Geller
    • , Akshay Sanghi
    • , Michael Kulik
    • , Silin Sa
    • , Marlene Rabinovitch
    • , Anshul Kundaje
    • , Stephen Dalton
    • , Judith B. Zaugg
    •  & Michael Snyder

    Special:

  • Article |

    Analysis of chromatin state and accessibility in mouse tissues from twelve sites and eight developmental stages provides a comprehensive view of chromatin dynamics.

    • David U. Gorkin
    • , Iros Barozzi
    • , Yuan Zhao
    • , Yanxiao Zhang
    • , Hui Huang
    • , Ah Young Lee
    • , Bin Li
    • , Joshua Chiou
    • , Andre Wildberg
    • , Bo Ding
    • , Bo Zhang
    • , Mengchi Wang
    • , J. Seth Strattan
    • , Jean M. Davidson
    • , Yunjiang Qiu
    • , Veena Afzal
    • , Jennifer A. Akiyama
    • , Ingrid Plajzer-Frick
    • , Catherine S. Novak
    • , Momoe Kato
    • , Tyler H. Garvin
    • , Quan T. Pham
    • , Anne N. Harrington
    • , Brandon J. Mannion
    • , Elizabeth A. Lee
    • , Yoko Fukuda-Yuzawa
    • , Yupeng He
    • , Sebastian Preissl
    • , Sora Chee
    • , Jee Yun Han
    • , Brian A. Williams
    • , Diane Trout
    • , Henry Amrhein
    • , Hongbo Yang
    • , J. Michael Cherry
    • , Wei Wang
    • , Kyle Gaulton
    • , Joseph R. Ecker
    • , Yin Shen
    • , Diane E. Dickel
    • , Axel Visel
    • , Len A. Pennacchio
    •  & Bing Ren

    Special:

  • Article |

    Analysis of 168 methylomes from 12 mouse tissues at 9 developmental stages sheds light on the epigenetic and regulatory landscape during mammalian fetal development.

    • Yupeng He
    • , Manoj Hariharan
    • , David U. Gorkin
    • , Diane E. Dickel
    • , Chongyuan Luo
    • , Rosa G. Castanon
    • , Joseph R. Nery
    • , Ah Young Lee
    • , Yuan Zhao
    • , Hui Huang
    • , Brian A. Williams
    • , Diane Trout
    • , Henry Amrhein
    • , Rongxin Fang
    • , Huaming Chen
    • , Bin Li
    • , Axel Visel
    • , Len A. Pennacchio
    • , Bing Ren
    •  & Joseph R. Ecker

    Special:

  • Article |

    RNA expression is quantified at a tissue level in seventeen mouse tissues across embryonic development, and at the single-cell level in the developing limb.

    • Peng He
    • , Brian A. Williams
    • , Diane Trout
    • , Georgi K. Marinov
    • , Henry Amrhein
    • , Libera Berghella
    • , Say-Tar Goh
    • , Ingrid Plajzer-Frick
    • , Veena Afzal
    • , Len A. Pennacchio
    • , Diane E. Dickel
    • , Axel Visel
    • , Bing Ren
    • , Ross C. Hardison
    • , Yu Zhang
    •  & Barbara J. Wold

    Special:

  • Articles

  • Article |

    The Phoenix stream in the Milky Way halo is shown to be a tidally disrupted remnant of an unusually metal-poor globular cluster, which was possibly destroyed during Galactic evolution.

    • Zhen Wan
    • , Geraint F. Lewis
    • , Ting S. Li
    • , Jeffrey D. Simpson
    • , Sarah L. Martell
    • , Daniel B. Zucker
    • , Jeremy R. Mould
    • , Denis Erkal
    • , Andrew B. Pace
    • , Dougal Mackey
    • , Alexander P. Ji
    • , Sergey E. Koposov
    • , Kyler Kuehn
    • , Nora Shipp
    • , Eduardo Balbinot
    • , Joss Bland-Hawthorn
    • , Andrew R. Casey
    • , Gary S. Da Costa
    • , Prajwal Kafle
    • , Sanjib Sharma
    •  & Gayandhi M. De Silva
  • Article |

    The night-time seeing (the extent to which a star’s light is blurred by the atmosphere) at Dome A, the highest part on the Antarctic plateau, can be as good as 0.13 arcseconds above a height of only 8 metres.

    • Bin Ma
    • , Zhaohui Shang
    • , Yi Hu
    • , Keliang Hu
    • , Yongjiang Wang
    • , Xu Yang
    • , Michael C. B. Ashley
    • , Paul Hickson
    •  & Peng Jiang
  • Article |

    Superconducting giant atoms are realized in a waveguide by coupling small atoms to the waveguide at multiple discrete locations, producing tunable atom–waveguide coupling and enabling decoherence-free interactions.

    • Bharath Kannan
    • , Max J. Ruckriegel
    • , Daniel L. Campbell
    • , Anton Frisk Kockum
    • , Jochen Braumüller
    • , David K. Kim
    • , Morten Kjaergaard
    • , Philip Krantz
    • , Alexander Melville
    • , Bethany M. Niedzielski
    • , Antti Vepsäläinen
    • , Roni Winik
    • , Jonilyn L. Yoder
    • , Franco Nori
    • , Terry P. Orlando
    • , Simon Gustavsson
    •  & William D. Oliver
  • Article |

    Photons and plasmons hybridize into polaritons in three-dimensional crystals of plasmonic nanoparticles, leading to deep strong light–matter coupling and the breakdown of the Purcell effect.

    • Niclas S. Mueller
    • , Yu Okamura
    • , Bruno G. M. Vieira
    • , Sabrina Juergensen
    • , Holger Lange
    • , Eduardo B. Barros
    • , Florian Schulz
    •  & Stephanie Reich
  • Article |

    A spin–orbit-entangled exciton state in the van der Waals material NiPS3 is observed, and found to arise from many-body states of a Zhang–Rice singlet.

    • Soonmin Kang
    • , Kangwon Kim
    • , Beom Hyun Kim
    • , Jonghyeon Kim
    • , Kyung Ik Sim
    • , Jae-Ung Lee
    • , Sungmin Lee
    • , Kisoo Park
    • , Seokhwan Yun
    • , Taehun Kim
    • , Abhishek Nag
    • , Andrew Walters
    • , Mirian Garcia-Fernandez
    • , Jiemin Li
    • , Laurent Chapon
    • , Ke-Jin Zhou
    • , Young-Woo Son
    • , Jae Hoon Kim
    • , Hyeonsik Cheong
    •  & Je-Geun Park
  • Article |

    A solution-based lithography-assisted epitaxial-growth-and-transfer method is used to fabricate single-crystal hybrid perovskites on any surface, with precise control of the thickness, area and chemical composition gradient.

    • Yusheng Lei
    • , Yimu Chen
    • , Ruiqi Zhang
    • , Yuheng Li
    • , Qizhang Yan
    • , Seunghyun Lee
    • , Yugang Yu
    • , Hsinhan Tsai
    • , Woojin Choi
    • , Kaiping Wang
    • , Yanqi Luo
    • , Yue Gu
    • , Xinran Zheng
    • , Chunfeng Wang
    • , Chonghe Wang
    • , Hongjie Hu
    • , Yang Li
    • , Baiyan Qi
    • , Muyang Lin
    • , Zhuorui Zhang
    • , Shadi A. Dayeh
    • , Matt Pharr
    • , David P. Fenning
    • , Yu-Hwa Lo
    • , Jian Luo
    • , Kesong Yang
    • , Jinkyoung Yoo
    • , Wanyi Nie
    •  & Sheng Xu
  • Article |

    Current models are too noisy to predict climate usefully on decadal timescales, but two-stage post-processing of model outputs greatly improves predictions of decadal variations in North Atlantic winter climate.

    • D. M. Smith
    • , A. A. Scaife
    • , R. Eade
    • , P. Athanasiadis
    • , A. Bellucci
    • , I. Bethke
    • , R. Bilbao
    • , L. F. Borchert
    • , L.-P. Caron
    • , F. Counillon
    • , G. Danabasoglu
    • , T. Delworth
    • , F. J. Doblas-Reyes
    • , N. J. Dunstone
    • , V. Estella-Perez
    • , S. Flavoni
    • , L. Hermanson
    • , N. Keenlyside
    • , V. Kharin
    • , M. Kimoto
    • , W. J. Merryfield
    • , J. Mignot
    • , T. Mochizuki
    • , K. Modali
    • , P.-A. Monerie
    • , W. A. Müller
    • , D. Nicolí
    • , P. Ortega
    • , K. Pankatz
    • , H. Pohlmann
    • , J. Robson
    • , P. Ruggieri
    • , R. Sospedra-Alfonso
    • , D. Swingedouw
    • , Y. Wang
    • , S. Wild
    • , S. Yeager
    • , X. Yang
    •  & L. Zhang
  • Article |

    Fishing has had a profound impact on global reef shark populations, and the absence or presence of sharks is strongly correlated with national socio-economic conditions and reef governance.

    • M. Aaron MacNeil
    • , Demian D. Chapman
    • , Michelle Heupel
    • , Colin A. Simpfendorfer
    • , Michael Heithaus
    • , Mark Meekan
    • , Euan Harvey
    • , Jordan Goetze
    • , Jeremy Kiszka
    • , Mark E. Bond
    • , Leanne M. Currey-Randall
    • , Conrad W. Speed
    • , C. Samantha Sherman
    • , Matthew J. Rees
    • , Vinay Udyawer
    • , Kathryn I. Flowers
    • , Gina Clementi
    • , Jasmine Valentin-Albanese
    • , Taylor Gorham
    • , M. Shiham Adam
    • , Khadeeja Ali
    • , Fabián Pina-Amargós
    • , Jorge A. Angulo-Valdés
    • , Jacob Asher
    • , Laura García Barcia
    • , Océane Beaufort
    • , Cecilie Benjamin
    • , Anthony T. F. Bernard
    • , Michael L. Berumen
    • , Stacy Bierwagen
    • , Erika Bonnema
    • , Rosalind M. K. Bown
    • , Darcey Bradley
    • , Edd Brooks
    • , J. Jed Brown
    • , Dayne Buddo
    • , Patrick Burke
    • , Camila Cáceres
    • , Diego Cardeñosa
    • , Jeffrey C. Carrier
    • , Jennifer E. Caselle
    • , Venkatesh Charloo
    • , Thomas Claverie
    • , Eric Clua
    • , Jesse E. M. Cochran
    • , Neil Cook
    • , Jessica Cramp
    • , Brooke D’Alberto
    • , Martin de Graaf
    • , Mareike Dornhege
    • , Andy Estep
    • , Lanya Fanovich
    • , Naomi F. Farabough
    • , Daniel Fernando
    • , Anna L. Flam
    • , Camilla Floros
    • , Virginia Fourqurean
    • , Ricardo Garla
    • , Kirk Gastrich
    • , Lachlan George
    • , Rory Graham
    • , Tristan Guttridge
    • , Royale S. Hardenstine
    • , Stephen Heck
    • , Aaron C. Henderson
    • , Heidi Hertler
    • , Robert Hueter
    • , Mohini Johnson
    • , Stacy Jupiter
    • , Devanshi Kasana
    • , Steven T. Kessel
    • , Benedict Kiilu
    • , Taratu Kirata
    • , Baraka Kuguru
    • , Fabian Kyne
    • , Tim Langlois
    • , Elodie J. I. Lédée
    • , Steve Lindfield
    • , Andrea Luna-Acosta
    • , Jade Maggs
    • , B. Mabel Manjaji-Matsumoto
    • , Andrea Marshall
    • , Philip Matich
    • , Erin McCombs
    • , Dianne McLean
    • , Llewelyn Meggs
    • , Stephen Moore
    • , Sushmita Mukherji
    • , Ryan Murray
    • , Muslimin Kaimuddin
    • , Stephen J. Newman
    • , Josep Nogués
    • , Clay Obota
    • , Owen O’Shea
    • , Kennedy Osuka
    • , Yannis P. Papastamatiou
    • , Nishan Perera
    • , Bradley Peterson
    • , Alessandro Ponzo
    • , Andhika Prasetyo
    • , L. M. Sjamsul Quamar
    • , Jessica Quinlan
    • , Alexei Ruiz-Abierno
    • , Enric Sala
    • , Melita Samoilys
    • , Michelle Schärer-Umpierre
    • , Audrey Schlaff
    • , Nikola Simpson
    • , Adam N. H. Smith
    • , Lauren Sparks
    • , Akshay Tanna
    • , Rubén Torres
    • , Michael J. Travers
    • , Maurits van Zinnicq Bergmann
    • , Laurent Vigliola
    • , Juney Ward
    • , Alexandra M. Watts
    • , Colin Wen
    • , Elizabeth Whitman
    • , Aaron J. Wirsing
    • , Aljoscha Wothke
    • , Esteban Zarza-Gonzâlez
    •  & Joshua E. Cinner
  • Article |

    Current outcomes are reported from the ongoing National Lung Matrix Trial, an umbrella trial for the treatment of non-small-cell lung cancer in which patients are triaged according to their tumour genotype and matched with targeted therapeutic agents.

    • Gary Middleton
    • , Peter Fletcher
    • , Sanjay Popat
    • , Joshua Savage
    • , Yvonne Summers
    • , Alastair Greystoke
    • , David Gilligan
    • , Judith Cave
    • , Noelle O’Rourke
    • , Alison Brewster
    • , Elizabeth Toy
    • , James Spicer
    • , Pooja Jain
    • , Adam Dangoor
    • , Melanie Mackean
    • , Martin Forster
    • , Amanda Farley
    • , Dee Wherton
    • , Manita Mehmi
    • , Rowena Sharpe
    • , Tara C. Mills
    • , Maria Antonietta Cerone
    • , Timothy A. Yap
    • , Thomas B. K. Watkins
    • , Emilia Lim
    • , Charles Swanton
    •  & Lucinda Billingham
  • Article |

    In the thalamic reticular nucleus there are two neuron types that are segregated into central and edge zones and receive inputs from different thalamocortical nuclei, creating subcircuits with distinct dynamics.

    • Rosa I. Martinez-Garcia
    • , Bettina Voelcker
    • , Julia B. Zaltsman
    • , Saundra L. Patrick
    • , Tanya R. Stevens
    • , Barry W. Connors
    •  & Scott J. Cruikshank
  • Article |

    A study integrating single-cell RNA-sequencing and electrophysiology data shows that in mouse, the cellular repertoire of the thalamic reticular nucleus is characterized by a transcriptomic gradient defined at its extremes by mutually exclusive expression of Spp1 and Ecel1, providing insights into the organizational principles underlying the divergent functions of this brain region.

    • Yinqing Li
    • , Violeta G. Lopez-Huerta
    • , Xian Adiconis
    • , Kirsten Levandowski
    • , Soonwook Choi
    • , Sean K. Simmons
    • , Mario A. Arias-Garcia
    • , Baolin Guo
    • , Annie Y. Yao
    • , Timothy R. Blosser
    • , Ralf D. Wimmer
    • , Tomomi Aida
    • , Alexander Atamian
    • , Tina Naik
    • , Xuyun Sun
    • , Dasheng Bi
    • , Diya Malhotra
    • , Cynthia C. Hession
    • , Reut Shema
    • , Marcos Gomes
    • , Taibo Li
    • , Eunjin Hwang
    • , Alexandra Krol
    • , Monika Kowalczyk
    • , João Peça
    • , Gang Pan
    • , Michael M. Halassa
    • , Joshua Z. Levin
    • , Zhanyan Fu
    •  & Guoping Feng
  • Article |

    The authors find that slow plant growth at low temperatures during winter reduces dilution of the transcription factor NTL8, which allows slow accumulation of NTL8 and thus the gradual increase in transcription of VIN3—a gene involved in memory of cold exposure.

    • Yusheng Zhao
    • , Rea L. Antoniou-Kourounioti
    • , Grant Calder
    • , Caroline Dean
    •  & Martin Howard
  • Article |

    Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

    • Linlin Bao
    • , Wei Deng
    • , Baoying Huang
    • , Hong Gao
    • , Jiangning Liu
    • , Lili Ren
    • , Qiang Wei
    • , Pin Yu
    • , Yanfeng Xu
    • , Feifei Qi
    • , Yajin Qu
    • , Fengdi Li
    • , Qi Lv
    • , Wenling Wang
    • , Jing Xue
    • , Shuran Gong
    • , Mingya Liu
    • , Guanpeng Wang
    • , Shunyi Wang
    • , Zhiqi Song
    • , Linna Zhao
    • , Peipei Liu
    • , Li Zhao
    • , Fei Ye
    • , Huijuan Wang
    • , Weimin Zhou
    • , Na Zhu
    • , Wei Zhen
    • , Haisheng Yu
    • , Xiaojuan Zhang
    • , Li Guo
    • , Lan Chen
    • , Conghui Wang
    • , Ying Wang
    • , Xinming Wang
    • , Yan Xiao
    • , Qiangming Sun
    • , Hongqi Liu
    • , Fanli Zhu
    • , Chunxia Ma
    • , Lingmei Yan
    • , Mengli Yang
    • , Jun Han
    • , Wenbo Xu
    • , Wenjie Tan
    • , Xiaozhong Peng
    • , Qi Jin
    • , Guizhen Wu
    •  & Chuan Qin
  • Article |

    The pathogenicity and transmissibility of SARS-CoV-2 in golden (Syrian) hamsters resemble features of COVID-19 in human patients, suggesting that these hamsters could be used to model this disease.

    • Sin Fun Sia
    • , Li-Meng Yan
    • , Alex W. H. Chin
    • , Kevin Fung
    • , Ka-Tim Choy
    • , Alvina Y. L. Wong
    • , Prathanporn Kaewpreedee
    • , Ranawaka A. P. M. Perera
    • , Leo L. M. Poon
    • , John M. Nicholls
    • , Malik Peiris
    •  & Hui-Ling Yen
  • Article |

    The authors show that leptin signalling regulates the plasticity of sympathetic architecture of adipose tissue via a top-down neural pathway that is crucial for energy homeostasis.

    • Putianqi Wang
    • , Ken H. Loh
    • , Michelle Wu
    • , Donald A. Morgan
    • , Marc Schneeberger
    • , Xiaofei Yu
    • , Jingyi Chi
    • , Christin Kosse
    • , Damian Kim
    • , Kamal Rahmouni
    • , Paul Cohen
    •  & Jeffrey Friedman
  • Article |

    Analysis of B-cell leukaemia samples reveals that oncogenic mutations do not cause malignant transformation unless they converge on the same signalling pathway, and that it may be possible clinically to combine inhibition of the principal oncogenic driver with reactivation of divergent pathways.

    • Lai N. Chan
    • , Mark A. Murakami
    • , Mark E. Robinson
    • , Rebecca Caeser
    • , Teresa Sadras
    • , Jaewoong Lee
    • , Kadriye Nehir Cosgun
    • , Kohei Kume
    • , Vishal Khairnar
    • , Gang Xiao
    • , Mohamed A. Ahmed
    • , Eamon Aghania
    • , Gauri Deb
    • , Christian Hurtz
    • , Seyedmehdi Shojaee
    • , Chao Hong
    • , Petri Pölönen
    • , Matthew A. Nix
    • , Zhengshan Chen
    • , Chun Wei Chen
    • , Jianjun Chen
    • , Andreas Vogt
    • , Merja Heinäniemi
    • , Olli Lohi
    • , Arun P. Wiita
    • , Shai Izraeli
    • , Huimin Geng
    • , David M. Weinstock
    •  & Markus Müschen
  • Article |

    The histone variant H3.3 is phosphorylated at Ser31 in induced genes, and this selective mark stimulates the histone methyltransferase SETD2 and ejects the ZMYND11 repressor, thus revealing a role for histone phosphorylation in amplifying de novo transcription.

    • Anja Armache
    • , Shuang Yang
    • , Alexia Martínez de Paz
    • , Lexi E. Robbins
    • , Ceyda Durmaz
    • , Jin Q. Cheong
    • , Arjun Ravishankar
    • , Andrew W. Daman
    • , Dughan J. Ahimovic
    • , Thaís Klevorn
    • , Yuan Yue
    • , Tanja Arslan
    • , Shu Lin
    • , Tanya Panchenko
    • , Joel Hrit
    • , Miao Wang
    • , Samuel Thudium
    • , Benjamin A. Garcia
    • , Erica Korb
    • , Karim-Jean Armache
    • , Scott B. Rothbart
    • , Sandra B. Hake
    • , C. David Allis
    • , Haitao Li
    •  & Steven Z. Josefowicz
  • Article |

    Single-molecule fluorescence resonance energy transfer and real-time confocal laser tracking with fluorescence correlation spectroscopy together characterize how individual lac repressor molecules bypass operator sites while exploring the DNA surface at microsecond timescales.

    • Emil Marklund
    • , Brad van Oosten
    • , Guanzhong Mao
    • , Elias Amselem
    • , Kalle Kipper
    • , Anton Sabantsev
    • , Andrew Emmerich
    • , Daniel Globisch
    • , Xuan Zheng
    • , Laura C. Lehmann
    • , Otto G. Berg
    • , Magnus Johansson
    • , Johan Elf
    •  & Sebastian Deindl
  • Article |

    A cryo-electron microscopy structure of the β1-adrenoceptor coupled to β-arrestin 1 and activated by the biased agonist formoterol, as well as the crystal structure of a related formoterol-bound adrenoreceptor, provide insights into biased signalling in these systems.

    • Yang Lee
    • , Tony Warne
    • , Rony Nehmé
    • , Shubhi Pandey
    • , Hemlata Dwivedi-Agnihotri
    • , Madhu Chaturvedi
    • , Patricia C. Edwards
    • , Javier García-Nafría
    • , Andrew G. W. Leslie
    • , Arun K. Shukla
    •  & Christopher G. Tate

Amendments & Corrections

  • Author Correction |

    • Jinseo Park
    • , Ziao Fu
    • , Aurel Frangaj
    • , Jonathan Liu
    • , Lidia Mosyak
    • , Tong Shen
    • , Vesna N. Slavkovich
    • , Kimberly M. Ray
    • , Jaume Taura
    • , Baohua Cao
    • , Yong Geng
    • , Hao Zuo
    • , Yongjun Kou
    • , Robert Grassucci
    • , Shaoxia Chen
    • , Zheng Liu
    • , Xin Lin
    • , Justin P. Williams
    • , William J. Rice
    • , Edward T. Eng
    • , Rick K. Huang
    • , Rajesh K. Soni
    • , Brian Kloss
    • , Zhiheng Yu
    • , Jonathan A. Javitch
    • , Wayne A. Hendrickson
    • , Paul A. Slesinger
    • , Matthias Quick
    • , Joseph Graziano
    • , Hongtao Yu
    • , Oliver Fiehn
    • , Oliver B. Clarke
    • , Joachim Frank
    •  & Qing R. Fan
  • Author Correction |

    • Guo-Qiang Zhang
    • , Ke-Wei Liu
    • , Zhen Li
    • , Rolf Lohaus
    • , Yu-Yun Hsiao
    • , Shan-Ce Niu
    • , Jie-Yu Wang
    • , Yao-Cheng Lin
    • , Qing Xu
    • , Li-Jun Chen
    • , Kouki Yoshida
    • , Sumire Fujiwara
    • , Zhi-Wen Wang
    • , Yong-Qiang Zhang
    • , Nobutaka Mitsuda
    • , Meina Wang
    • , Guo-Hui Liu
    • , Lorenzo Pecoraro
    • , Hui-Xia Huang
    • , Xin-Ju Xiao
    • , Min Lin
    • , Xin-Yi Wu
    • , Wan-Lin Wu
    • , You-Yi Chen
    • , Song-Bin Chang
    • , Shingo Sakamoto
    • , Masaru Ohme-Takagi
    • , Masafumi Yagi
    • , Si-Jin Zeng
    • , Ching-Yu Shen
    • , Chuan-Ming Yeh
    • , Yi-Bo Luo
    • , Wen-Chieh Tsai
    • , Yves Van de Peer
    •  & Zhong-Jian Liu
  • Publisher Correction |

    • Peter Plavchan
    • , Thomas Barclay
    • , Jonathan Gagné
    • , Peter Gao
    • , Bryson Cale
    • , William Matzko
    • , Diana Dragomir
    • , Sam Quinn
    • , Dax Feliz
    • , Keivan Stassun
    • , Ian J. M. Crossfield
    • , David A. Berardo
    • , David W. Latham
    • , Ben Tieu
    • , Guillem Anglada-Escudé
    • , George Ricker
    • , Roland Vanderspek
    • , Sara Seager
    • , Joshua N. Winn
    • , Jon M. Jenkins
    • , Stephen Rinehart
    • , Akshata Krishnamurthy
    • , Scott Dynes
    • , John Doty
    • , Fred Adams
    • , Dennis A. Afanasev
    • , Chas Beichman
    • , Mike Bottom
    • , Brendan P. Bowler
    • , Carolyn Brinkworth
    • , Carolyn J. Brown
    • , Andrew Cancino
    • , David R. Ciardi
    • , Mark Clampin
    • , Jake T. Clark
    • , Karen Collins
    • , Cassy Davison
    • , Daniel Foreman-Mackey
    • , Elise Furlan
    • , Eric J. Gaidos
    • , Claire Geneser
    • , Frank Giddens
    • , Emily Gilbert
    • , Ryan Hall
    • , Coel Hellier
    • , Todd Henry
    • , Jonathan Horner
    • , Andrew W. Howard
    • , Chelsea Huang
    • , Joseph Huber
    • , Stephen R. Kane
    • , Matthew Kenworthy
    • , John Kielkopf
    • , David Kipping
    • , Chris Klenke
    • , Ethan Kruse
    • , Natasha Latouf
    • , Patrick Lowrance
    • , Bertrand Mennesson
    • , Matthew Mengel
    • , Sean M. Mills
    • , Tim Morton
    • , Norio Narita
    • , Elisabeth Newton
    • , America Nishimoto
    • , Jack Okumura
    • , Enric Palle
    • , Joshua Pepper
    • , Elisa V. Quintana
    • , Aki Roberge
    • , Veronica Roccatagliata
    • , Joshua E. Schlieder
    • , Angelle Tanner
    • , Johanna Teske
    • , C. G. Tinney
    • , Andrew Vanderburg
    • , Kaspar von Braun
    • , Bernie Walp
    • , Jason Wang
    • , Sharon Xuesong Wang
    • , Denise Weigand
    • , Russel White
    • , Robert A. Wittenmyer
    • , Duncan J. Wright
    • , Allison Youngblood
    • , Hui Zhang
    •  & Perri Zilberman
  • Publisher Correction |

    • X. Wu
    • , M. Delbianco
    • , K. Anggara
    • , T. Michnowicz
    • , A. Pardo-Vargas
    • , P. Bharate
    • , S. Sen
    • , M. Pristl
    • , S. Rauschenbach
    • , U. Schlickum
    • , S. Abb
    • , P. H. Seeberger
    •  & K. Kern

Nature Outlook

  • Nature Outlook |

    Cystic fibrosis

    New therapies are turning cystic fibrosis, an inherited disorder that causes a vicious cycle of mucus build-up, infection and inflammation, into a more manageable condition that people can survive into adulthood.

Sign up for the Nature Briefing newsletter for a daily update on COVID-19 science.
Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Quick links