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Volume 578 Issue 7793, 6 February 2020

Cancer catalogued

In this week’s issue, the Pan-Cancer Analysis of Whole Genomes (PCAWG) consortium presents the integrative analysis of more than 2,600 whole cancer genomes and their matching normal tissues across 38 tumour types. In a collection of six papers, members of PCAWG examine the evolution and structural variation of cancer genomes. They review genetic events that drive cancer and catalogue mutational signatures. And they report integrative analyses of structural variation, evolutionary trajectories and transcriptome data for many of the genomes and tumour types. Taken together, these papers offer a fresh perspective on the genetic complexity of cancer and provide a valuable resource for the exploration of the biological changes that drive the development of tumours.

Cover image: Nik Spencer/Nature

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