Volume 577 Issue 7788, 2 January 2020

Keeping track

One hundred and ninety-three countries have committed to the United Nations’ 17 Sustainable Development Goals (SDGs). These goals cover a range of issues including poverty, gender equality and climate change. To date, it has been difficult to assess spatio-temporal progress towards achieving the SDGs. In this week’s issue, Jianguo Liu and his colleagues present systematic methods that can be used to quantify progress towards the goals at multiple organizational levels over time. The researchers demonstrate their methods using China as a test case, finding that the scores for 13 of the 17 goals had improved nationally over the period 2000 to 2015, while revealing regional differences within the country.

Cover image: K. Krause/Nature (photo: Grand Warszawski/Shutterstock)

This Week

News in Focus

Books & Arts

Opinion

Work

    Feature

  • Where I Work

  • Where I Work |

    Paul Nurse, director of the Francis Crick Institute in London, likes to think amid the hustle and bustle of the institute’s bright and lively atrium.

    • Josie Glausiusz

Research

    News & Views

  • News & Views |

    A widely used vaccine against tuberculosis has now been shown to provide almost complete protection when injected intravenously. This is a striking improvement over vaccination through the typical intradermal route.

    • Samuel M. Behar
    •  & Chris Sassetti
  • News & Views |

    Knowing how dietary fibre nourishes gut microorganisms might suggest ways to boost health-promoting bacteria. A method developed to pinpoint bacteria that consume particular types of dietary fibre could advance such efforts.

    • Nathalie M. Delzenne
    •  & Laure B. Bindels
  • News & Views |

    The reliance of infrared spectroscopy on light transmission limits the sensitivity of many analytical applications. An approach that depends on the emission of infrared radiation from molecules promises to solve this problem.

    • Andreas Barth
  • News & Views |

    Could artificial intelligence improve the accuracy of screening for breast cancer? A comparison of the diagnostic performance of expert physicians and computers suggests so, but the clinical implications are as yet uncertain.

    • Etta D. Pisano
  • News & Views |

    Observations of a distant cluster of galaxies suggest that star formation began there only 370 million years after the Big Bang. The results provide key details about where and when the first stars and galaxies emerged in the Universe.

    • Nina A. Hatch
  • Articles

  • Article |

    The redshift of a seemingly mature galaxy cluster has been confirmed spectroscopically to be about 2 and photometry indicates that star formation began in the galaxies of the cluster at a redshift of about 12.

    • J. P. Willis
    • , R. E. A. Canning
    • , E. S. Noordeh
    • , S. W. Allen
    • , A. L. King
    • , A. Mantz
    • , R. G. Morris
    • , S. A. Stanford
    •  & G. Brammer
  • Article |

    A superposition of tunable photonic lattices is used to create optical moiré patterns and demonstrate the resulting localization of light waves through a mechanism based on flat-band physics.

    • Peng Wang
    • , Yuanlin Zheng
    • , Xianfeng Chen
    • , Changming Huang
    • , Yaroslav V. Kartashov
    • , Lluis Torner
    • , Vladimir V. Konotop
    •  & Fangwei Ye
  • Article |

    The labyrinthine domain patterns formed in ultrathin films of ferroelectric oxides by subcritical quenching undergo an inverse phase transition to the less-symmetric parallel-stripe domain structure upon increasing temperature.

    • Y. Nahas
    • , S. Prokhorenko
    • , J. Fischer
    • , B. Xu
    • , C. Carrétéro
    • , S. Prosandeev
    • , M. Bibes
    • , S. Fusil
    • , B. Dkhil
    • , V. Garcia
    •  & L. Bellaiche
  • Article |

    A vibrational spectroscopy technique that measures the electric field emitted from organic molecules following infrared illumination allows their molecular fingerprints to be separated from the excitation background, even in complex biological samples.

    • Ioachim Pupeza
    • , Marinus Huber
    • , Michael Trubetskov
    • , Wolfgang Schweinberger
    • , Syed A. Hussain
    • , Christina Hofer
    • , Kilian Fritsch
    • , Markus Poetzlberger
    • , Lenard Vamos
    • , Ernst Fill
    • , Tatiana Amotchkina
    • , Kosmas V. Kepesidis
    • , Alexander Apolonski
    • , Nicholas Karpowicz
    • , Vladimir Pervak
    • , Oleg Pronin
    • , Frank Fleischmann
    • , Abdallah Azzeer
    • , Mihaela Žigman
    •  & Ferenc Krausz
  • Article |

    Real-space imaging of the edge structures and growth of a two-dimensional ice on a gold substrate is achieved using noncontact atomic-force microscopy with a carbon monoxide tip.

    • Runze Ma
    • , Duanyun Cao
    • , Chongqin Zhu
    • , Ye Tian
    • , Jinbo Peng
    • , Jing Guo
    • , Ji Chen
    • , Xin-Zheng Li
    • , Joseph S. Francisco
    • , Xiao Cheng Zeng
    • , Li-Mei Xu
    • , En-Ge Wang
    •  & Ying Jiang
  • Article |

    The pore space in the metal–organic framework Zr6O4(OH)4(bpydc)6 can be used as a scaffold to grow precisely defined atomically thick sheets of metal halide materials, taking advantage of multiple binding sites to direct complexation of the metal ions; these metal halide nanosheets fill the size gap between discrete molecular magnets and bulk magnetic materials, with potentially unusual magnetic properties arising from this size regime.

    • Miguel I. Gonzalez
    • , Ari B. Turkiewicz
    • , Lucy E. Darago
    • , Julia Oktawiec
    • , Karen Bustillo
    • , Fernande Grandjean
    • , Gary J. Long
    •  & Jeffrey R. Long
  • Article |

    An analysis based on Landsat imagery shows that the extent of river ice has declined extensively over past decades and that this trend will continue under future global warming.

    • Xiao Yang
    • , Tamlin M. Pavelsky
    •  & George H. Allen
  • Article |

    Systematic methods for evaluating progress towards the 17 United Nations Sustainable Development Goals are developed and tested using 119 indicators at China’s national and subnational levels during 2000–2015, showing improvement overall.

    • Zhenci Xu
    • , Sophia N. Chau
    • , Xiuzhi Chen
    • , Jian Zhang
    • , Yingjie Li
    • , Thomas Dietz
    • , Jinyan Wang
    • , Julie A. Winkler
    • , Fan Fan
    • , Baorong Huang
    • , Shuxin Li
    • , Shaohua Wu
    • , Anna Herzberger
    • , Ying Tang
    • , Dequ Hong
    • , Yunkai Li
    •  & Jianguo Liu
  • Article | | Open Access

    The genome of the tropical blue-petal water lily Nymphaea colorata and the transcriptomes from 19 other Nymphaeales species provide insights into the early evolution of angiosperms.

    • Liangsheng Zhang
    • , Fei Chen
    • , Xingtan Zhang
    • , Zhen Li
    • , Yiyong Zhao
    • , Rolf Lohaus
    • , Xiaojun Chang
    • , Wei Dong
    • , Simon Y. W. Ho
    • , Xing Liu
    • , Aixia Song
    • , Junhao Chen
    • , Wenlei Guo
    • , Zhengjia Wang
    • , Yingyu Zhuang
    • , Haifeng Wang
    • , Xuequn Chen
    • , Juan Hu
    • , Yanhui Liu
    • , Yuan Qin
    • , Kai Wang
    • , Shanshan Dong
    • , Yang Liu
    • , Shouzhou Zhang
    • , Xianxian Yu
    • , Qian Wu
    • , Liangsheng Wang
    • , Xueqing Yan
    • , Yuannian Jiao
    • , Hongzhi Kong
    • , Xiaofan Zhou
    • , Cuiwei Yu
    • , Yuchu Chen
    • , Fan Li
    • , Jihua Wang
    • , Wei Chen
    • , Xinlu Chen
    • , Qidong Jia
    • , Chi Zhang
    • , Yifan Jiang
    • , Wanbo Zhang
    • , Guanhua Liu
    • , Jianyu Fu
    • , Feng Chen
    • , Hong Ma
    • , Yves Van de Peer
    •  & Haibao Tang
  • Article |

    RITF1, a newly identified plant transcription factor, links signalling through the peptide hormone RGF1 to the balance of reactive oxygen species and thereby enhances the stability of another transcription factor, PLETHORA2, a master regulator of root stem cells.

    • Masashi Yamada
    • , Xinwei Han
    •  & Philip N. Benfey
  • Article |

    An artificial intelligence (AI) system performs as well as or better than radiologists at detecting breast cancer from mammograms, and using a combination of AI and human inputs could help to improve screening efficiency.

    • Scott Mayer McKinney
    • , Marcin Sieniek
    • , Varun Godbole
    • , Jonathan Godwin
    • , Natasha Antropova
    • , Hutan Ashrafian
    • , Trevor Back
    • , Mary Chesus
    • , Greg S. Corrado
    • , Ara Darzi
    • , Mozziyar Etemadi
    • , Florencia Garcia-Vicente
    • , Fiona J. Gilbert
    • , Mark Halling-Brown
    • , Demis Hassabis
    • , Sunny Jansen
    • , Alan Karthikesalingam
    • , Christopher J. Kelly
    • , Dominic King
    • , Joseph R. Ledsam
    • , David Melnick
    • , Hormuz Mostofi
    • , Lily Peng
    • , Joshua Jay Reicher
    • , Bernardino Romera-Paredes
    • , Richard Sidebottom
    • , Mustafa Suleyman
    • , Daniel Tse
    • , Kenneth C. Young
    • , Jeffrey De Fauw
    •  & Shravya Shetty
  • Article | | Open Access

    The delivery route and dose of the BCG vaccine profoundly alters the protective outcome after Mycobacterium tuberculosis challenge in non-human primates.

    • Patricia A. Darrah
    • , Joseph J. Zeppa
    • , Pauline Maiello
    • , Joshua A. Hackney
    • , Marc H. Wadsworth II
    • , Travis K. Hughes
    • , Supriya Pokkali
    • , Phillip A. Swanson II
    • , Nicole L. Grant
    • , Mark A. Rodgers
    • , Megha Kamath
    • , Chelsea M. Causgrove
    • , Dominick J. Laddy
    • , Aurelio Bonavia
    • , Danilo Casimiro
    • , Philana Ling Lin
    • , Edwin Klein
    • , Alexander G. White
    • , Charles A. Scanga
    • , Alex K. Shalek
    • , Mario Roederer
    • , JoAnne L. Flynn
    •  & Robert A. Seder
  • Article |

    Heterozygous mutateons in the caspase-8 cleavage site of RIPK1 cause a range of autoinflammatory symptoms in humans, and caspase-8 cleavage of RIPK1 in a mouse model limits TNF-induced cell death and inflammation.

    • Najoua Lalaoui
    • , Steven E. Boyden
    • , Hirotsugu Oda
    • , Geryl M. Wood
    • , Deborah L. Stone
    • , Diep Chau
    • , Lin Liu
    • , Monique Stoffels
    • , Tobias Kratina
    • , Kate E. Lawlor
    • , Kristien J. M. Zaal
    • , Patrycja M. Hoffmann
    • , Nima Etemadi
    • , Kristy Shield-Artin
    • , Christine Biben
    • , Wanxia Li Tsai
    • , Mary D. Blake
    • , Hye Sun Kuehn
    • , Dan Yang
    • , Holly Anderton
    • , Natasha Silke
    • , Laurens Wachsmuth
    • , Lixin Zheng
    • , Natalia Sampaio Moura
    • , David B. Beck
    • , Gustavo Gutierrez-Cruz
    • , Amanda K. Ombrello
    • , Gineth P. Pinto-Patarroyo
    • , Andrew J. Kueh
    • , Marco J. Herold
    • , Cathrine Hall
    • , Hongying Wang
    • , Jae Jin Chae
    • , Natalia I. Dmitrieva
    • , Mark McKenzie
    • , Amanda Light
    • , Beverly K. Barham
    • , Anne Jones
    • , Tina M. Romeo
    • , Qing Zhou
    • , Ivona Aksentijevich
    • , James C. Mullikin
    • , Andrew J. Gross
    • , Anthony K. Shum
    • , Edwin D. Hawkins
    • , Seth L. Masters
    • , Michael J. Lenardo
    • , Manfred Boehm
    • , Sergio D. Rosenzweig
    • , Manolis Pasparakis
    • , Anne K. Voss
    • , Massimo Gadina
    • , Daniel L. Kastner
    •  & John Silke
  • Article |

    A dominantly inherited human autoinflammatory disease caused by mutations in RIPK1 is identified, and RIPK1 mutations that prevent caspase-8 cleavage sensitize cells to apoptosis, necroptosis and inflammation.

    • Panfeng Tao
    • , Jinqiao Sun
    • , Zheming Wu
    • , Shihao Wang
    • , Jun Wang
    • , Wanjin Li
    • , Heling Pan
    • , Renkui Bai
    • , Jiahui Zhang
    • , Ying Wang
    • , Pui Y. Lee
    • , Wenjing Ying
    • , Qinhua Zhou
    • , Jia Hou
    • , Wenjie Wang
    • , Bijun Sun
    • , Mi Yang
    • , Danru Liu
    • , Ran Fang
    • , Huan Han
    • , Zhaohui Yang
    • , Xin Huang
    • , Haibo Li
    • , Natalie Deuitch
    • , Yuan Zhang
    • , Dilan Dissanayake
    • , Katrina Haude
    • , Kirsty McWalter
    • , Chelsea Roadhouse
    • , Jennifer J. MacKenzie
    • , Ronald M. Laxer
    • , Ivona Aksentijevich
    • , Xiaomin Yu
    • , Xiaochuan Wang
    • , Junying Yuan
    •  & Qing Zhou
  • Article |

    Differences in MCT1 function among melanoma cells confer differences in oxidative stress resistance and metastatic potential.

    • Alpaslan Tasdogan
    • , Brandon Faubert
    • , Vijayashree Ramesh
    • , Jessalyn M. Ubellacker
    • , Bo Shen
    • , Ashley Solmonson
    • , Malea M. Murphy
    • , Zhimin Gu
    • , Wen Gu
    • , Misty Martin
    • , Stacy Y. Kasitinon
    • , Travis Vandergriff
    • , Thomas P. Mathews
    • , Zhiyu Zhao
    • , Dirk Schadendorf
    • , Ralph J. DeBerardinis
    •  & Sean J. Morrison
  • Article |

    The histone-acetylation-reader protein ENL is mutated in a paediatric kidney cancer in such a way that it clusters at target genes, increasing the recruitment of the transcriptional machinery, enhancing transcription and deregulating cell fate during development.

    • Liling Wan
    • , Shasha Chong
    • , Fan Xuan
    • , Angela Liang
    • , Xiaodong Cui
    • , Leah Gates
    • , Thomas S. Carroll
    • , Yuanyuan Li
    • , Lijuan Feng
    • , Guochao Chen
    • , Shu-Ping Wang
    • , Michael V. Ortiz
    • , Sara K. Daley
    • , Xiaolu Wang
    • , Hongwen Xuan
    • , Alex Kentsis
    • , Tom W. Muir
    • , Robert G. Roeder
    • , Haitao Li
    • , Wei Li
    • , Robert Tjian
    • , Hong Wen
    •  & C. David Allis
  • Article |

    Chaperones interact with a canonical motif in α-synuclein, which can be prevented by phosphorylation of α-synuclein at Tyr39, whereas inhibition of this interaction leads to the localization of α-synuclein to the mitochondria and aggregate formation.

    • Björn M. Burmann
    • , Juan A. Gerez
    • , Irena Matečko-Burmann
    • , Silvia Campioni
    • , Pratibha Kumari
    • , Dhiman Ghosh
    • , Adam Mazur
    • , Emelie E. Aspholm
    • , Darius Šulskis
    • , Magdalena Wawrzyniuk
    • , Thomas Bock
    • , Alexander Schmidt
    • , Stefan G. D. Rüdiger
    • , Roland Riek
    •  & Sebastian Hiller
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