Volume 574 Issue 7778, 17 October 2019

Smoke signals

Cigarette smoking dramatically increases the risk of type 2 diabetes, but the mechanisms underlying this effect have remained elusive. In a paper in this issue, Paul Kenny and his colleagues reveal that, in rats, the transcription factor TCF7L2 mediates a signalling circuit that connects neurons in the brain activated by nicotine to blood-glucose regulation by the pancreas. The researchers show that when nicotine activates nicotine acetylcholine receptor (nAChR) proteins expressed on neurons in the medial habenula region of the brain, it also leads to adverse responses to nicotine that limit intake as well as to the release of glucagon and insulin by the pancreas. This in turn raises the levels of blood sugar, which is associated with a higher risk of developing diabetes. In addition, the raised levels of blood sugar create a feedback loop by inhibiting nAChRs expressed by medial habenula neurons, blocking adverse responses to smoking and so helping to establish nicotine dependence. TCF7L2 modulates the entire signalling circuit, thereby linking nicotine addiction with an increased risk of diabetes.

Cover image: Ian Tragen.

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    • , Noah Davidsohn
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    • , Laura Jardine
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    • , Roser Vento-Tormo
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    • , Gary Reynolds
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    • , Corina Moldovan
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  • Letters

  • Letter |

    Three-dimensional gas velocities in the gapped disk around the young star HD 163296 show meridional flows from the surface of the disk towards its midplane at gap locations.

    • Richard Teague
    • , Jaehan Bae
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  • Letter |

    Two distinct compressional oscillation modes are characterized in a dipolar Bose–Einstein condensate; this demonstrates the breaking of two symmetries owing to the coexisting superfluid and crystal properties of a supersolid.

    • L. Tanzi
    • , S. M. Roccuzzo
    • , E. Lucioni
    • , F. Famà
    • , A. Fioretti
    • , C. Gabbanini
    • , G. Modugno
    • , A. Recati
    •  & S. Stringari
  • Letter |

    Observation of the collective mode responding to the superfluid stiffness—the low-energy Goldstone mode—provides direct evidence for phase rigidity, which is a key signature of supersolidity in an ultracold quantum gas.

    • Mingyang Guo
    • , Fabian Böttcher
    • , Jens Hertkorn
    • , Jan-Niklas Schmidt
    • , Matthias Wenzel
    • , Hans Peter Büchler
    • , Tim Langen
    •  & Tilman Pfau
  • Letter |

    A six-coordinate transition-metal complex with a hexagonal planar geometry is isolated and characterized.

    • Martí Garçon
    • , Clare Bakewell
    • , George A. Sackman
    • , Andrew J. P. White
    • , Richard I. Cooper
    • , Alison J. Edwards
    •  & Mark R. Crimmin
  • Letter |

    Widespread formation of new particles from condensable vapours observed in the tropical upper troposphere is an important source of cloud condensation nuclei in the lower troposphere, affecting cloud properties.

    • Christina J. Williamson
    • , Agnieszka Kupc
    • , Duncan Axisa
    • , Kelsey R. Bilsback
    • , ThaoPaul Bui
    • , Pedro Campuzano-Jost
    • , Maximilian Dollner
    • , Karl D. Froyd
    • , Anna L. Hodshire
    • , Jose L. Jimenez
    • , John K. Kodros
    • , Gan Luo
    • , Daniel M. Murphy
    • , Benjamin A. Nault
    • , Eric A. Ray
    • , Bernadett Weinzierl
    • , James C. Wilson
    • , Fangqun Yu
    • , Pengfei Yu
    • , Jeffrey R. Pierce
    •  & Charles A. Brock
  • Letter |

    Aerial sampling in the Sahel of Mali reveals large numbers of windborne malaria mosquitoes that had recently fed on blood and could cover hundreds of kilometres in a single night.

    • Diana L. Huestis
    • , Adama Dao
    • , Moussa Diallo
    • , Zana L. Sanogo
    • , Djibril Samake
    • , Alpha S. Yaro
    • , Yossi Ousman
    • , Yvonne-Marie Linton
    • , Asha Krishna
    • , Laura Veru
    • , Benjamin J. Krajacich
    • , Roy Faiman
    • , Jenna Florio
    • , Jason W. Chapman
    • , Don R. Reynolds
    • , David Weetman
    • , Reed Mitchell
    • , Martin J. Donnelly
    • , Elijah Talamas
    • , Lourdes Chamorro
    • , Ehud Strobach
    •  & Tovi Lehmann
  • Letter |

    CRISPR–Cas9 engineering of the Drosophila Atpα gene (encoding the α-subunit of the sodium pump) is used to study the ability of mutations that evolved independently in several insect orders to confer resistance to keystone plant toxins.

    • Marianthi Karageorgi
    • , Simon C. Groen
    • , Fidan Sumbul
    • , Julianne N. Pelaez
    • , Kirsten I. Verster
    • , Jessica M. Aguilar
    • , Amy P. Hastings
    • , Susan L. Bernstein
    • , Teruyuki Matsunaga
    • , Michael Astourian
    • , Geno Guerra
    • , Felix Rico
    • , Susanne Dobler
    • , Anurag A. Agrawal
    •  & Noah K. Whiteman

    Collection:

  • Letter |

    A genetically encoded fluorescent voltage indicator, SomArchon, is used to image changes in membrane voltage from many neurons simultaneously in multiple brain regions of awake, behaving mice.

    • Kiryl D. Piatkevich
    • , Seth Bensussen
    • , Hua-an Tseng
    • , Sanaya N. Shroff
    • , Violeta Gisselle Lopez-Huerta
    • , Demian Park
    • , Erica E. Jung
    • , Or A. Shemesh
    • , Christoph Straub
    • , Howard J. Gritton
    • , Michael F. Romano
    • , Emma Costa
    • , Bernardo L. Sabatini
    • , Zhanyan Fu
    • , Edward S. Boyden
    •  & Xue Han
  • Letter |

    Species comparisons using single-cell transcriptomics and accessible chromatin profiling in stem cell-derived cerebral organoids are used to map dynamic gene-regulatory changes that are unique to humans.

    • Sabina Kanton
    • , Michael James Boyle
    • , Zhisong He
    • , Malgorzata Santel
    • , Anne Weigert
    • , Fátima Sanchís-Calleja
    • , Patricia Guijarro
    • , Leila Sidow
    • , Jonas Simon Fleck
    • , Dingding Han
    • , Zhengzong Qian
    • , Michael Heide
    • , Wieland B. Huttner
    • , Philipp Khaitovich
    • , Svante Pääbo
    • , Barbara Treutlein
    •  & J. Gray Camp
  • Letter |

    The histidine–aspartate kinase Sln1 acts as a molecular sensor of turgor in appressoria of the rice blast fungus Magnaporthe oryzae, enabling penetration of the host leaf cuticle and plant infection.

    • Lauren S. Ryder
    • , Yasin F. Dagdas
    • , Michael J. Kershaw
    • , Chandrasekhar Venkataraman
    • , Anotida Madzvamuse
    • , Xia Yan
    • , Neftaly Cruz-Mireles
    • , Darren M. Soanes
    • , Miriam Oses-Ruiz
    • , Vanessa Styles
    • , Jan Sklenar
    • , Frank L. H. Menke
    •  & Nicholas J. Talbot
  • Letter |

    A range of SF3B1 mutations promote tumorigenesis through the repression of BRD9, a core component of the non-canonical BAF complex, and correcting BRD9 mis-splicing in these SF3B1-mutant cells suppresses tumour growth.

    • Daichi Inoue
    • , Guo-Liang Chew
    • , Bo Liu
    • , Brittany C. Michel
    • , Joseph Pangallo
    • , Andrew R. D’Avino
    • , Tyler Hitchman
    • , Khrystyna North
    • , Stanley Chun-Wei Lee
    • , Lillian Bitner
    • , Ariele Block
    • , Amanda R. Moore
    • , Akihide Yoshimi
    • , Luisa Escobar-Hoyos
    • , Hana Cho
    • , Alex Penson
    • , Sydney X. Lu
    • , Justin Taylor
    • , Yu Chen
    • , Cigall Kadoch
    • , Omar Abdel-Wahab
    •  & Robert K. Bradley

Amendments & Corrections

  • Author Correction |

    • Samuel S. Myers
    • , Antonella Zanobetti
    • , Itai Kloog
    • , Peter Huybers
    • , Andrew D. B. Leakey
    • , Arnold J. Bloom
    • , Eli Carlisle
    • , Lee H. Dietterich
    • , Glenn Fitzgerald
    • , Toshihiro Hasegawa
    • , N. Michele Holbrook
    • , Randall L. Nelson
    • , Michael J. Ottman
    • , Victor Raboy
    • , Hidemitsu Sakai
    • , Karla A. Sartor
    • , Joel Schwartz
    • , Saman Seneweera
    • , Michael Tausz
    •  & Yasuhiro Usui
  • Publisher Correction |

    • Moises Exposito-Alonso
    • , Moises Exposito-Alonso
    • , Rocío Gómez Rodríguez
    • , Cristina Barragán
    • , Giovanna Capovilla
    • , Eunyoung Chae
    • , Jane Devos
    • , Ezgi S. Dogan
    • , Claudia Friedemann
    • , Caspar Gross
    • , Patricia Lang
    • , Derek Lundberg
    • , Vera Middendorf
    • , Jorge Kageyama
    • , Talia Karasov
    • , Sonja Kersten
    • , Sebastian Petersen
    • , Leily Rabbani
    • , Julian Regalado
    • , Lukas Reinelt
    • , Beth Rowan
    • , Danelle K. Seymour
    • , Efthymia Symeonidi
    • , Rebecca Schwab
    • , Diep Thi Ngoc Tran
    • , Kavita Venkataramani
    • , Anna-Lena Van de Weyer
    • , François Vasseur
    • , George Wang
    • , Ronja Wedegärtner
    • , Frank Weiss
    • , Rui Wu
    • , Wanyan Xi
    • , Maricris Zaidem
    • , Wangsheng Zhu
    • , Fernando García-Arenal
    • , Hernán A. Burbano
    • , Oliver Bossdorf
    • , Detlef Weigel
    • , Hernán A. Burbano
    • , Oliver Bossdorf
    • , Rasmus Nielsen
    •  & Detlef Weigel

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