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Volume 571 Issue 7764, 11 July 2019

Snooze report

What is sleep like for fish? That is the question addressed in this week’s issue by Philippe Mourrain, Louis Leung and their colleagues. Although various stages of sleep have been identified and defined in mammals, birds and reptiles, it was not clear if the same held true for other vertebrates such as fish. Using non-invasive molecular, imaging and physiological tools, the Stanford researchers observed neural signatures in zebrafish that can be identified as at least two different sleep states. These states bear similarities to the slow-wave sleep and rapid eye movement sleep states seen in other organisms. The identification of such signatures in fish suggests that these sleep states may have emerged in the vertebrate brain more than 450 million years ago.

Cover image of a sleeping white spotted pufferfish: Tunatura/Shutterstock

This Week

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News in Focus

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  • News & Views

    • Thick foot calluses develop naturally when walking barefoot. It emerges that they preserve foot sensitivity while offering protection, thus avoiding the trade-off between the two that occurs with cushioned shoes.

      • Kristiaan D’Août
      News & Views
    • Simulations demonstrate that the Moon’s ability to retain material from striking impactors is lower than was previously assumed. This finding helps to explain the scarcity of precious metals in the Moon relative to Earth.

      • James M. D. Day
      News & Views
    • How Nature reported a resource of animal sounds in 1969, and an analysis of psychiatric disorders in 1919.

      News & Views
    • If an animal’s body shape is specialized in a way that aids feeding on specific organisms, does this restrict what the animal can prey on? An observation of fishes feeding in the wild might now help to settle this question.

      • Sebastian Kruppert
      • Adam P. Summers
      News & Views
  • Reviews

  • Analysis

    • Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of climate–conflict linkages remain uncertain.

      • Katharine J. Mach
      • Caroline M. Kraan
      • Nina von Uexkull
  • Articles

    • Fluorescence-based polysomnography in zebrafish reveals two major sleep signatures that share features with those of amniotes, which suggests that common neural sleep signatures emerged in the vertebrate brain over 450 million years ago.

      • Louis C. Leung
      • Gordon X. Wang
      • Philippe Mourrain
    • Single-cell transcriptomic analysis of neurogenic niches in young and old mice reveals that T cells infiltrate the neurogenic niches of old mice and inhibit the proliferation of neural stem cells, in part through expression of interferon-γ.

      • Ben W. Dulken
      • Matthew T. Buckley
      • Anne Brunet
    • A programmable transposase integrates donor DNA at user-defined genomic target sites with high fidelity, revealing a new approach for genetic engineering that obviates the need for DNA double-strand breaks and homologous recombination. 

      • Sanne E. Klompe
      • Phuc L. H. Vo
      • Samuel H. Sternberg
  • Letters

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Amendments & Corrections

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