Volume 568 Issue 7753, 25 April 2019

Caught in the act

The cover shows the inside of the water shield surrounding the XENON1T dark-matter detector at the INFN Gran Sasso National Laboratory near L’Aquila in Italy. In this week’s issue, the XENON Collaboration reveals that the set-up has recorded a type of nuclear decay that is particularly hard to detect. The team has directly observed two-neutrino double electron capture in xenon-124, the half-life of which is roughly a trillion times the age of the Universe. The XENON1T detector contains 3.2 tonnes of ultra-pure xenon, and allowed the researchers to detect the X-rays emitted when xenon-124 decays into tellurium-124. They measured the half-life of this decay to be 1.8 × 10^22 years, which is in line with predictions. The team says that this detection is a useful step on the road to detecting neutrinoless double electron capture processes, which could provide a deeper understanding of the neutrino.

Cover image: XENON Collaboration

This Week

News in Focus

Comment

Technology

Careers

Futures

Research

    News & Views

  • News & Views |

    A detector that was designed to probe dark matter, the ‘missing’ mass in the Universe, has seen an elusive nuclear decay called two-neutrino double electron capture — with implications for nuclear and particle physics.

    • Jouni Suhonen
  • News & Views |

    Cancer cells often have mutations in anticancer genes that make their survival dependent on other genes. The gene-editing approach CRISPR–Cas9 offers a way to identify such vulnerabilities.

    • Felix Y. Feng
    •  & Luke A. Gilbert
  • News & Views |

    Ammonia is vital to society, but its manufacture is energy intensive, has a large carbon footprint and requires high initial capital outlays. An intriguing reaction now suggests that energy-efficient alternatives are possible.

    • Máté J. Bezdek
    •  & Paul J. Chirik
  • News & Views |

    A brain–computer interface device synthesizes speech using the neural signals that control lip, tongue, larynx and jaw movements, and could be a stepping stone to restoring speech function in individuals unable to speak.

    • Chethan Pandarinath
    •  & Yahia H. Ali
  • News & Views |

    Crosslinked polymer networks known as thermoset plastics have many applications, but can’t be reshaped or recycled. A thermoset with reorganizable crosslinks retains its useful properties, but has recyclability built in.

    • Coralie Jehanno
    •  & Haritz Sardon
  • Reviews

  • Review Article |

    Understanding the behaviour of the machines powered by artificial intelligence that increasingly mediate our social, cultural, economic and political interactions is essential to our ability to control the actions of these intelligent machines, reap their benefits and minimize their harms.

    • Iyad Rahwan
    • , Manuel Cebrian
    • , Nick Obradovich
    • , Josh Bongard
    • , Jean-François Bonnefon
    • , Cynthia Breazeal
    • , Jacob W. Crandall
    • , Nicholas A. Christakis
    • , Iain D. Couzin
    • , Matthew O. Jackson
    • , Nicholas R. Jennings
    • , Ece Kamar
    • , Isabel M. Kloumann
    • , Hugo Larochelle
    • , David Lazer
    • , Richard McElreath
    • , Alan Mislove
    • , David C. Parkes
    • , Alex ‘Sandy’ Pentland
    • , Margaret E. Roberts
    • , Azim Shariff
    • , Joshua B. Tenenbaum
    •  & Michael Wellman

    Collection:

  • Articles

  • Article |

    In the forearc regions of Costa Rica, helium and carbon isotope data reveal that about 20 per cent less carbon is being transported into the deep mantle than previously thought.

    • P. H. Barry
    • , J. M. de Moor
    • , D. Giovannelli
    • , M. Schrenk
    • , D. R. Hummer
    • , T. Lopez
    • , C. A. Pratt
    • , Y. Alpízar Segura
    • , A. Battaglia
    • , P. Beaudry
    • , G. Bini
    • , M. Cascante
    • , G. d’Errico
    • , M. di Carlo
    • , D. Fattorini
    • , K. Fullerton
    • , E. Gazel
    • , G. González
    • , S. A. Halldórsson
    • , K. Iacovino
    • , J. T. Kulongoski
    • , E. Manini
    • , M. Martínez
    • , H. Miller
    • , M. Nakagawa
    • , S. Ono
    • , S. Patwardhan
    • , C. J. Ramírez
    • , F. Regoli
    • , F. Smedile
    • , S. Turner
    • , C. Vetriani
    • , M. Yücel
    • , C. J. Ballentine
    • , T. P. Fischer
    • , D. R. Hilton
    •  & K. G. Lloyd
  • Article |

    A neural decoder uses kinematic and sound representations encoded in human cortical activity to synthesize audible sentences, which are readily identified and transcribed by listeners.

    • Gopala K. Anumanchipalli
    • , Josh Chartier
    •  & Edward F. Chang
  • Article | | open

    The known species repertoire of the collective human gut microbiota is substantially expanded with the discovery of 1,952 uncultured bacterial species that greatly improve classification of understudied African and South American samples.

    • Alexandre Almeida
    • , Alex L. Mitchell
    • , Miguel Boland
    • , Samuel C. Forster
    • , Gregory B. Gloor
    • , Aleksandra Tarkowska
    • , Trevor D. Lawley
    •  & Robert D. Finn
  • Article | | open

    Draft prokaryotic genomes from faecal metagenomes of diverse human populations enrich our understanding of the human gut microbiome by identifying over two thousand new species-level taxa that have numerous disease associations.

    • Stephen Nayfach
    • , Zhou Jason Shi
    • , Rekha Seshadri
    • , Katherine S. Pollard
    •  & Nikos C. Kyrpides
  • Article |

    In a screen of 324 human cancer cell lines and utilising a systematic target prioritization framework, the Werner syndrome ATP-dependent helicase is shown to be a synthetic lethal target in tumours from multiple cancer types with microsatellite instability, providing a new target for cancer drug development.

    • Fiona M. Behan
    • , Francesco Iorio
    • , Gabriele Picco
    • , Emanuel Gonçalves
    • , Charlotte M. Beaver
    • , Giorgia Migliardi
    • , Rita Santos
    • , Yanhua Rao
    • , Francesco Sassi
    • , Marika Pinnelli
    • , Rizwan Ansari
    • , Sarah Harper
    • , David Adam Jackson
    • , Rebecca McRae
    • , Rachel Pooley
    • , Piers Wilkinson
    • , Dieudonne van der Meer
    • , David Dow
    • , Carolyn Buser-Doepner
    • , Andrea Bertotti
    • , Livio Trusolino
    • , Euan A. Stronach
    • , Julio Saez-Rodriguez
    • , Kosuke Yusa
    •  & Mathew J. Garnett
  • Letters

  • Letter |

    Highly sensitive measurements of the atmosphere of Mars with the ExoMars Trace Gas Orbiter do not detect any methane over a range of latitudes in both hemispheres, in contrast to previous local or remote detections.

    • Oleg Korablev
    • , Ann Carine Vandaele
    • , Franck Montmessin
    • , Anna A. Fedorova
    • , Alexander Trokhimovskiy
    • , François Forget
    • , Franck Lefèvre
    • , Frank Daerden
    • , Ian R. Thomas
    • , Loïc Trompet
    • , Justin T. Erwin
    • , Shohei Aoki
    • , Séverine Robert
    • , Lori Neary
    • , Sébastien Viscardy
    • , Alexey V. Grigoriev
    • , Nikolay I. Ignatiev
    • , Alexey Shakun
    • , Andrey Patrakeev
    • , Denis A. Belyaev
    • , Jean-Loup Bertaux
    • , Kevin S. Olsen
    • , Lucio Baggio
    • , Juan Alday
    • , Yuriy S. Ivanov
    • , Bojan Ristic
    • , Jon Mason
    • , Yannick Willame
    • , Cédric Depiesse
    • , Laszlo Hetey
    • , Sophie Berkenbosch
    • , Roland Clairquin
    • , Claudio Queirolo
    • , Bram Beeckman
    • , Eddy Neefs
    • , Manish R. Patel
    • , Giancarlo Bellucci
    • , Jose-Juan López-Moreno
    • , Colin F. Wilson
    • , Giuseppe Etiope
    • , Lev Zelenyi
    • , Håkan Svedhem
    • , Jorge L. Vago
    • , Gustavo Alonso-Rodrigo
    • , Francesca Altieri
    • , Konstantin Anufreychik
    • , Gabriele Arnold
    • , Sophie Bauduin
    • , David Bolsée
    • , Giacomo Carrozzo
    • , R. Todd Clancy
    • , Edward Cloutis
    • , Matteo Crismani
    • , Fabiana Da Pieve
    • , Emiliano D’Aversa
    • , Natalia Duxbury
    • , Therese Encrenaz
    • , Thierry Fouchet
    • , Bernd Funke
    • , Didier Fussen
    • , Maia Garcia-Comas
    • , Jean-Claude Gérard
    • , Marco Giuranna
    • , Leo Gkouvelis
    • , Francisco Gonzalez-Galindo
    • , Davide Grassi
    • , Sandrine Guerlet
    • , Paul Hartogh
    • , James Holmes
    • , Benoît Hubert
    • , Jacek Kaminski
    • , Ozgur Karatekin
    • , Yasumasa Kasaba
    • , David Kass
    • , Igor Khatuntsev
    • , Armin Kleinböhl
    • , Nikita Kokonkov
    • , Vladimir Krasnopolsky
    • , Ruslan Kuzmin
    • , Gaétan Lacombe
    • , Orietta Lanciano
    • , Emmanuel Lellouch
    • , Stephen Lewis
    • , Mikhail Luginin
    • , Giuliano Liuzzi
    • , Manuel López-Puertas
    • , Miguel López-Valverde
    • , Anni Määttänen
    • , Arnaud Mahieux
    • , Emmanuel Marcq
    • , Javier Martin-Torres
    • , Igor Maslov
    • , Alexander Medvedev
    • , Ehouarn Millour
    • , Boris Moshkin
    • , Michael J. Mumma
    • , Hiromu Nakagawa
    • , Robert E. Novak
    • , Fabrizio Oliva
    • , Dmitry Patsaev
    • , Arianna Piccialli
    • , Cathy Quantin-Nataf
    • , Etienne Renotte
    • , Birgit Ritter
    • , Alexander Rodin
    • , Frédéric Schmidt
    • , Nick Schneider
    • , Valery Shematovich
    • , Michael D. Smith
    • , Nicholas A. Teanby
    • , Ed Thiemann
    • , Nicolas Thomas
    • , Jean Vander Auwera
    • , Luis Vazquez
    • , Geronimo Villanueva
    • , Matthieu Vincendon
    • , James Whiteway
    • , Valérie Wilquet
    • , Michael J. Wolff
    • , Paulina Wolkenberg
    • , Roger Yelle
    • , Roland Young
    • , Ludmila Zasova
    •  & Maria Paz Zorzano
  • Letter |

    High-resolution measurements of Martian atmospheric dust, water and semiheavy water, obtained by the ExoMars Trace Gas Orbiter during a global dust storm on Mars, are reported.

    • Ann Carine Vandaele
    • , Oleg Korablev
    • , Frank Daerden
    • , Shohei Aoki
    • , Ian R. Thomas
    • , Francesca Altieri
    • , Miguel López-Valverde
    • , Geronimo Villanueva
    • , Giuliano Liuzzi
    • , Michael D. Smith
    • , Justin T. Erwin
    • , Loïc Trompet
    • , Anna A. Fedorova
    • , Franck Montmessin
    • , Alexander Trokhimovskiy
    • , Denis A. Belyaev
    • , Nikolay I. Ignatiev
    • , Mikhail Luginin
    • , Kevin S. Olsen
    • , Lucio Baggio
    • , Juan Alday
    • , Jean-Loup Bertaux
    • , Daria Betsis
    • , David Bolsée
    • , R. Todd Clancy
    • , Edward Cloutis
    • , Cédric Depiesse
    • , Bernd Funke
    • , Maia Garcia-Comas
    • , Jean-Claude Gérard
    • , Marco Giuranna
    • , Francisco Gonzalez-Galindo
    • , Alexey V. Grigoriev
    • , Yuriy S. Ivanov
    • , Jacek Kaminski
    • , Ozgur Karatekin
    • , Franck Lefèvre
    • , Stephen Lewis
    • , Manuel López-Puertas
    • , Arnaud Mahieux
    • , Igor Maslov
    • , Jon Mason
    • , Michael J. Mumma
    • , Lori Neary
    • , Eddy Neefs
    • , Andrey Patrakeev
    • , Dmitry Patsaev
    • , Bojan Ristic
    • , Séverine Robert
    • , Frédéric Schmidt
    • , Alexey Shakun
    • , Nicholas A. Teanby
    • , Sébastien Viscardy
    • , Yannick Willame
    • , James Whiteway
    • , Valérie Wilquet
    • , Michael J. Wolff
    • , Giancarlo Bellucci
    • , Manish R. Patel
    • , Jose-Juan López-Moreno
    • , François Forget
    • , Colin F. Wilson
    • , Håkan Svedhem
    • , Jorge L. Vago
    • , Daniel Rodionov
    • , Ann Carine Vandaele
    • , Jose-Juan López-Moreno
    • , Giancarlo Bellucci
    • , Manish R. Patel
    • , Gustavo Alonso-Rodrigo
    • , Shohei Aoki
    • , Francesca Altieri
    • , Sophie Bauduin
    • , David Bolsée
    • , Giacomo Carrozzo
    • , R. Todd Clancy
    • , Edward Cloutis
    • , Matteo Crismani
    • , Frank Daerden
    • , Fabiana Da Pieve
    • , Emiliano D’Aversa
    • , Cédric Depiesse
    • , Justin T. Erwin
    • , Giuseppe Etiope
    • , Anna A. Fedorova
    • , Bernd Funke
    • , Didier Fussen
    • , Maia Garcia-Comas
    • , Anna Geminale
    • , Jean-Claude Gérard
    • , Marco Giuranna
    • , Leo Gkouvelis
    • , Francisco Gonzalez-Galindo
    • , James Holmes
    • , Benoît Hubert
    • , Nicolay I. Ignatiev
    • , Jacek Kaminski
    • , Ozgur Karatekin
    • , Yasumasa Kasaba
    • , David Kass
    • , Armin Kleinböhl
    • , Orietta Lanciano
    • , Franck Lefèvre
    • , Stephen Lewis
    • , Giuliano Liuzzi
    • , Manuel López-Puertas
    • , Miguel López-Valverde
    • , Arnaud Mahieux
    • , Jon Mason
    • , Michael J. Mumma
    • , Hiromu Nakagawa
    • , Lori Neary
    • , Eddy Neefs
    • , Robert E. Novak
    • , Fabrizio Oliva
    • , Arianna Piccialli
    • , Etienne Renotte
    • , Birgit Ritter
    • , Séverine Robert
    • , Frédéric Schmidt
    • , Nick Schneider
    • , Giuseppe Sindoni
    • , Michael D. Smith
    • , Nicholas A. Teanby
    • , Ed Thiemann
    • , Ian R. Thomas
    • , Alexander Trokhimovskiy
    • , Loïc Trompet
    • , Jean Vander Auwera
    • , Geronimo Villanueva
    • , Sébastien Viscardy
    • , James Whiteway
    • , Valerie Wilquet
    • , Yannick Willame
    • , Michael J. Wolff
    • , Paulina Wolkenberg
    • , Roger Yelle
    • , Juan Alday
    • , Francesca Altieri
    • , Konstantin Anufreychik
    • , Gabriele Arnold
    • , Lucio Baggio
    • , Denis A. Belyaev
    • , Jean-Loup Bertaux
    • , Natalia Duxbury
    • , Anna A. Fedorova
    • , François Forget
    • , Thierry Fouchet
    • , Davide Grassi
    • , Alexey V. Grigoriev
    • , Sandrine Guerlet
    • , Paul Hartogh
    • , Nikolay I. Ignatiev
    • , Yasumasa Kasaba
    • , Igor Khatuntsev
    • , Nikita Kokonkov
    • , Oleg Korablev
    • , Vladimir Krasnopolsky
    • , Ruslan Kuzmin
    • , Gaétan Lacombe
    • , Franck Lefèvre
    • , Emmanuel Lellouch
    • , Miguel López-Valverde
    • , Igor Maslov
    • , Mikhail Luginin
    • , Anni Määttänen
    • , Emmanuel Marcq
    • , Javier Martin-Torres
    • , Alexander Medvedev
    • , Ehouarn Millour
    • , Franck Montmessin
    • , Boris Moshkin
    • , Kevin S. Olsen
    • , Manish R. Patel
    • , Andrey Patrakeev
    • , Dmitry Patsaev
    • , Cathy Quantin-Nataf
    • , Daniel Rodionov
    • , Alexander Rodin
    • , Alexey Shakun
    • , Valery Shematovich
    • , Ian R. Thomas
    • , Nicolas Thomas
    • , Alexander Trokhimovsky
    • , Luis Vazquez
    • , Matthieu Vincendon
    • , Valérie Wilquet
    • , Colin F. Wilson
    • , Roland Young
    • , Ludmila Zasova
    • , Lev Zelenyi
    •  & Maria Paz Zorzano
  • Letter |

    Two-neutrino double electron capture is observed experimentally in 124Xe with the XENON1T detector, yielding a half-life of 1.8 × 1022 years.

    • E. Aprile
    • , J. Aalbers
    • , F. Agostini
    • , M. Alfonsi
    • , L. Althueser
    • , F. D. Amaro
    • , M. Anthony
    • , V. C. Antochi
    • , F. Arneodo
    • , L. Baudis
    • , B. Bauermeister
    • , M. L. Benabderrahmane
    • , T. Berger
    • , P. A. Breur
    • , A. Brown
    • , A. Brown
    • , E. Brown
    • , S. Bruenner
    • , G. Bruno
    • , R. Budnik
    • , C. Capelli
    • , J. M. R. Cardoso
    • , D. Cichon
    • , D. Coderre
    • , A. P. Colijn
    • , J. Conrad
    • , J. P. Cussonneau
    • , M. P. Decowski
    • , P. de Perio
    • , P. Di Gangi
    • , A. Di Giovanni
    • , S. Diglio
    • , A. Elykov
    • , G. Eurin
    • , J. Fei
    • , A. D. Ferella
    • , A. Fieguth
    • , W. Fulgione
    • , A. Gallo Rosso
    • , M. Galloway
    • , F. Gao
    • , M. Garbini
    • , L. Grandi
    • , Z. Greene
    • , C. Hasterok
    • , E. Hogenbirk
    • , J. Howlett
    • , M. Iacovacci
    • , R. Itay
    • , F. Joerg
    • , B. Kaminsky
    • , S. Kazama
    • , A. Kish
    • , G. Koltman
    • , A. Kopec
    • , H. Landsman
    • , R. F. Lang
    • , L. Levinson
    • , Q. Lin
    • , S. Lindemann
    • , M. Lindner
    • , F. Lombardi
    • , J. A. M. Lopes
    • , E. López Fune
    • , C. Macolino
    • , J. Mahlstedt
    • , A. Manfredini
    • , F. Marignetti
    • , T. Marrodán Undagoitia
    • , J. Masbou
    • , D. Masson
    • , S. Mastroianni
    • , M. Messina
    • , K. Micheneau
    • , K. Miller
    • , A. Molinario
    • , K. Morå
    • , M. Murra
    • , J. Naganoma
    • , K. Ni
    • , U. Oberlack
    • , K. Odgers
    • , B. Pelssers
    • , R. Peres
    • , F. Piastra
    • , J. Pienaar
    • , V. Pizzella
    • , G. Plante
    • , R. Podviianiuk
    • , N. Priel
    • , H. Qiu
    • , D. Ramírez García
    • , S. Reichard
    • , B. Riedel
    • , A. Rizzo
    • , A. Rocchetti
    • , N. Rupp
    • , J. M. F. dos Santos
    • , G. Sartorelli
    • , N. Šarčević
    • , M. Scheibelhut
    • , S. Schindler
    • , J. Schreiner
    • , D. Schulte
    • , M. Schumann
    • , L. Scotto Lavina
    • , M. Selvi
    • , P. Shagin
    • , E. Shockley
    • , M. Silva
    • , H. Simgen
    • , C. Therreau
    • , D. Thers
    • , F. Toschi
    • , G. Trinchero
    • , C. Tunnell
    • , N. Upole
    • , M. Vargas
    • , O. Wack
    • , H. Wang
    • , Z. Wang
    • , Y. Wei
    • , C. Weinheimer
    • , D. Wenz
    • , C. Wittweg
    • , J. Wulf
    • , J. Ye
    • , Y. Zhang
    • , T. Zhu
    •  & J. P. Zopounidis
  • Letter |

    Multinucleated osteoclasts required for normal bone development and tooth eruption in the mouse originate from embryonic erythro-myeloid progenitors and are maintained after birth by fusion with circulating monocytes.

    • Christian E. Jacome-Galarza
    • , Gulce I. Percin
    • , James T. Muller
    • , Elvira Mass
    • , Tomi Lazarov
    • , Jiri Eitler
    • , Martina Rauner
    • , Vijay K. Yadav
    • , Lucile Crozet
    • , Mathieu Bohm
    • , Pierre-Louis Loyher
    • , Gerard Karsenty
    • , Claudia Waskow
    •  & Frederic Geissmann
  • Letter |

    Geometrically defined microenvironments are used to show that leukocytes migrate along chemokine gradients using the nucleus as a mechanical gauge to sample potential paths and identify the path of least resistance.

    • Jörg Renkawitz
    • , Aglaja Kopf
    • , Julian Stopp
    • , Ingrid de Vries
    • , Meghan K. Driscoll
    • , Jack Merrin
    • , Robert Hauschild
    • , Erik S. Welf
    • , Gaudenz Danuser
    • , Reto Fiolka
    •  & Michael Sixt
  • Letter |

    Depletion of the DNA helicase WRN induced double-stranded DNA breaks, and promoted apoptosis and cell cycle arrest selectively in cancers with microsatellite instability, indicating that WRN is a promising drug target for the treatment of these cancers.

    • Edmond M. Chan
    • , Tsukasa Shibue
    • , James M. McFarland
    • , Benjamin Gaeta
    • , Mahmoud Ghandi
    • , Nancy Dumont
    • , Alfredo Gonzalez
    • , Justine S. McPartlan
    • , Tianxia Li
    • , Yanxi Zhang
    • , Jie Bin Liu
    • , Jean-Bernard Lazaro
    • , Peili Gu
    • , Cortt G. Piett
    • , Annie Apffel
    • , Syed O. Ali
    • , Rebecca Deasy
    • , Paula Keskula
    • , Raymond W. S. Ng
    • , Emma A. Roberts
    • , Elizaveta Reznichenko
    • , Lisa Leung
    • , Maria Alimova
    • , Monica Schenone
    • , Mirazul Islam
    • , Yosef E. Maruvka
    • , Yang Liu
    • , Jatin Roper
    • , Srivatsan Raghavan
    • , Marios Giannakis
    • , Yuen-Yi Tseng
    • , Zachary D. Nagel
    • , Alan D’Andrea
    • , David E. Root
    • , Jesse S. Boehm
    • , Gad Getz
    • , Sandy Chang
    • , Todd R. Golub
    • , Aviad Tsherniak
    • , Francisca Vazquez
    •  & Adam J. Bass
  • Letter |

    The stress-activated kinase p38γ has a role in regulating entry into the cell cycle; in the liver, it can induce cellular proliferation during regeneration and promote the development of hepatocellular carcinoma.

    • Antonia Tomás-Loba
    • , Elisa Manieri
    • , Bárbara González-Terán
    • , Alfonso Mora
    • , Luis Leiva-Vega
    • , Ayelén M. Santamans
    • , Rafael Romero-Becerra
    • , Elena Rodríguez
    • , Aránzazu Pintor-Chocano
    • , Ferran Feixas
    • , Juan Antonio López
    • , Beatriz Caballero
    • , Marianna Trakala
    • , Óscar Blanco
    • , Jorge L. Torres
    • , Lourdes Hernández-Cosido
    • , Valle Montalvo-Romeral
    • , Nuria Matesanz
    • , Marta Roche-Molina
    • , Juan Antonio Bernal
    • , Hannah Mischo
    • , Marta León
    • , Ainoa Caballero
    • , Diego Miranda-Saavedra
    • , Jesús Ruiz-Cabello
    • , Yulia A. Nevzorova
    • , Francisco Javier Cubero
    • , Jerónimo Bravo
    • , Jesús Vázquez
    • , Marcos Malumbres
    • , Miguel Marcos
    • , Sílvia Osuna
    •  & Guadalupe Sabio
  • Letter |

    Disease-causing microduplications can be corrected by harnessing an endogenous double-stranded break DNA repair pathway.

    • Sukanya Iyer
    • , Sneha Suresh
    • , Dongsheng Guo
    • , Katelyn Daman
    • , Jennifer C. J. Chen
    • , Pengpeng Liu
    • , Marina Zieger
    • , Kevin Luk
    • , Benjamin P. Roscoe
    • , Christian Mueller
    • , Oliver D. King
    • , Charles P. Emerson Jr
    •  & Scot A. Wolfe
  • Letter |

    The structure of human ATP-citrate lyase, in complex with a newly developed small-molecule inhibitor, shows extensive conformational changes that reveal an allosteric site for the inhibitor to bind and indirectly compete with the citrate substrate.

    • Jia Wei
    • , Silvana Leit
    • , Jun Kuai
    • , Eric Therrien
    • , Salma Rafi
    • , H. James Harwood Jr
    • , Byron DeLaBarre
    •  & Liang Tong
  • Letter |

    Crystal structures of ATP citrate lyase from bacteria, archaea and humans unravel how the enzyme directs the formation of the central metabolite acetyl-CoA, and shed light onto the evolutionary origins of the Krebs cycle.

    • Koen H. G. Verschueren
    • , Clement Blanchet
    • , Jan Felix
    • , Ann Dansercoer
    • , Dirk De Vos
    • , Yehudi Bloch
    • , Jozef Van Beeumen
    • , Dmitri Svergun
    • , Irina Gutsche
    • , Savvas N. Savvides
    •  & Kenneth Verstraete

Amendments & Corrections

Spotlight

  • Spotlight |

    Canada

    Canada’s scientists are learning politics.

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