Volume 557 Issue 7703, 3 May 2018

Lifeline for livers

A key limiting factor for successful liver transplants is the availability and quality of donor organs. In this issue, David Nasralla, Constantin Coussios, Peter Friend and colleagues report the outcomes from a trial investigating a new method of liver preservation prior to transplantation. Normally, a donor liver is preserved in ice, but this can cause damage to the organ. The researchers tackled this problem by deploying a technique called normothermic machine perfusion (NMP). This maintains the donor organs at body temperature and takes deoxygenated blood from the liver into a machine where it is oxygenated and bolstered with crucial nutrients before being pumped back into the liver. The technique allowed more donor livers to be transplanted having been preserved up to 54% longer and, despite this, reduced graft injury by 50% compared with organs preserved on ice. The team hopes that NMP could increase the number of viable organs available for transplant operations.

Cover image: AXS Studio, Inc.

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  • Articles

  • Article | | open

    Analyses of genetic variation and population structure based on over 3,000 cultivated rice (Oryza sativa) genomes reveal subpopulations that correlate with geographic location and patterns of introgression consistent with multiple rice domestication events.

    • Wensheng Wang
    • , Ramil Mauleon
    • , Zhiqiang Hu
    • , Dmytro Chebotarov
    • , Shuaishuai Tai
    • , Zhichao Wu
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  • Article |

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  • Article |

    SAMHD1 has an essential role in the replication stress response and prevents inflammation by activating the MRE11 nuclease to degrade nascent DNA strands at stalled replication forks, thus enabling replication.

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  • Letters

  • Letter |

    A detection of helium absorption at 10,833 Å on the exoplanet WASP-107b reveals that its atmosphere is extended and eroding, and demonstrates a new way to study upper exoplanetary atmospheres.

    • J. J. Spake
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    • , A. Oklopčić
    • , V. Bourrier
    • , L. Kreidberg
    • , B. V. Rackham
    • , J. Irwin
    • , D. Ehrenreich
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    • , H. R. Wakeford
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    • , M. H. Williamson
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    • , D. R. Anderson
    • , C. Hellier
    • , D. Charbonneau
    • , S. Udry
    •  & N. Madhusudhan
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    The shape of the spectral line and the resonance frequency of the 1S–2S transition in antihydrogen agree very well with those of hydrogen.

    • M. Ahmadi
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    • F. Langer
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    • Daryl T. Spencer
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    • , Daron Westly
    • , B. Robert Ilic
    • , Aaron Bluestone
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    • , Erik Norberg
    • , Luke Theogarajan
    • , Kerry Vahala
    • , Nathan R. Newbury
    • , Kartik Srinivasan
    • , John E. Bowers
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    • Ling Zhang
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    • Jamie Hicks
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    • , Jose M. Goicoechea
    •  & Simon Aldridge
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    • , Michael Hanson
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    • , Jun A. Ebersole
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  • Letter |

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    • , Judith Vivié
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    •  & Niels Geijsen
  • Letter |

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    • Nieves Peltzer
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    • , Peter Draber
    • , Helena Draberova
    • , Sebastian Kupka
    • , Eva Rieser
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    • , Lucia Taraborrelli
    • , Torsten Hartwig
    • , Elodie Lafont
    • , Tobias L. Haas
    • , Yutaka Shimizu
    • , Charlotta Böiers
    • , Aida Sarr
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    • , Michael T. Ashworth
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    • , Dong-Hua Chen
    • , Daniel Barrero
    • , Lauren Madigan
    • , Joseph D. Puglisi
    • , Georgios Skiniotis
    •  & Elisabetta Viani Puglisi
  • Letter |

    The structure of alternative complex III, a key enzyme in the bacterial electron transport chain, is reported both alone and as a supercomplex with an aa3-type cytochrome c oxidase.

    • Chang Sun
    • , Samir Benlekbir
    • , Padmaja Venkatakrishnan
    • , Yuhang Wang
    • , Sangjin Hong
    • , Jonathan Hosler
    • , Emad Tajkhorshid
    • , John L. Rubinstein
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