Volume 555 Issue 7696, 15 March 2018

Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

The high-resolution structure of the entire eukaryotic oligosaccharyltransferase complex is determined, revealing the role of membrane lipids in mediating inter-subunit interactions, and the mechanism by which the complex enables protein N-glycosylation.

Fourteen stars from stellar overdensities above and below the Galactic disk have the same elemental abundances as disk stars, suggesting that these stars originated in the disk, perhaps being removed during interaction with passing dwarf galaxies.

A confocal scanning technique solves the reconstruction problem of non-line-of-sight imaging to give fast and high-quality reconstructions of hidden objects.

A two-dimensional phononic quadrupole topological insulator is demonstrated experimentally using mechanical metamaterials, which has both the one-dimensional edge states and the zero-dimensional corner states predicted by theory.

A quantized quadrupole topological insulator composed of capacitively coupled microwave resonators has corner states that are protected by bulk topology and exhibit exceptional robustness against edge deformation.

High-resolution nuclear magnetic resonance spectroscopy at the scale of single cells is achieved by combining a magnetometer consisting of an ensemble of nitrogen–vacancy centres with a narrowband synchronized readout protocol.

Redox conditions and associated defect chemistry rather than water content, as previously thought, strongly influence the seismic properties of olivine, the main constituent mineral of Earth’s upper mantle.

A derivation of Hamilton’s rule that considers explicit environmental stochasticity can predict when organisms should pay a cost to influence the variance in the reproductive success of their relatives, formalizing the link between bet-hedging and altruism.

Millions of Chinese smallholder farmers were persuaded to adopt enhanced management practices, which led to a greater yield, reduced nitrogen fertilizer use and improved environmental performance throughout China.

In lowland tropical forests in Panama, widespread species-level phosphorus limitation of tree growth is not reflected in community-wide growth or biomass owing to the presence of a few species tolerant of low phosphorus availability.

Analysis of the genomes, exomes and transcriptomes of 1,699 childhood cancers identifies 142 driver genes.

Recruitment of young neurons to the hippocampus decreases rapidly during the first years of life, and neurogenesis does not continue, or is extremely rare, in the adult human brain.

The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.

The EWS–FLI1 fusion protein, expressed in Ewing sarcoma, increases global transcription, causes accumulation of R loops and replication stress, and impairs BRCA1-mediated repair.

Gonadal germline epigenetic reprogramming involves an interplay between DNA methylation, the polycomb complex and Tet1 in both DNA methylation dependent and independent roles, to ensure the activation of a specific subset of genes critical for progression of gametogenesis.

X-ray and cryo-electron microscopy structures of the acid-sensing ion channel ASIC1a reveal the molecular mechanisms of channel gating and desensitization.