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Volume 555 Issue 7696, 15 March 2018

The cover features a false-colour scanning electron microscopy image of the fungus Aspergillus fumigatus showing the specialized branches that produce its spores. In this issue, Gordon Brown and his colleagues examine the way in which mammals are able to detect melanin in the cell wall of these fungal spores. They identify a new cell receptor called MelLec that senses DHN-melanin and triggers an immune response which plays a key role in protecting the host against Aspergillus infection. Cover image: Kevin Mackenzie and Mark Stappers


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  • Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

    • Susanne N. Gröbner
    • Barbara C. Worst
    • Stefan M. Pfister
    Article Open Access
  • The high-resolution structure of the entire eukaryotic oligosaccharyltransferase complex is determined, revealing the role of membrane lipids in mediating inter-subunit interactions, and the mechanism by which the complex enables protein N-glycosylation.

    • Lin Bai
    • Tong Wang
    • Huilin Li
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