Volume 554 Issue 7692, 15 February 2018

Letter

  • Letter |

    In a mouse model of breast cancer, asparagine bioavailability strongly influences metastasis and this is correlated with the production of proteins that regulate the epithelial-to-mesenchymal transition, which provides at least one potential mechanism for how a single amino acid could regulate metastatic progression.

    • Simon R. V. Knott
    • , Elvin Wagenblast
    • , Showkhin Khan
    • , Sun Y. Kim
    • , Mar Soto
    • , Michel Wagner
    • , Marc-Olivier Turgeon
    • , Lisa Fish
    • , Nicolas Erard
    • , Annika L. Gable
    • , Ashley R. Maceli
    • , Steffen Dickopf
    • , Evangelia K. Papachristou
    • , Clive S. D’Santos
    • , Lisa A. Carey
    • , John E. Wilkinson
    • , J. Chuck Harrell
    • , Charles M. Perou
    • , Hani Goodarzi
    • , George Poulogiannis
    •  & Gregory J. Hannon
  • Letter |

    Freezing on a spherical surface is shown to proceed by the sequestration of defects into 12 icosahedrally coordinated ‘seas’ that enable the formation of a crystalline ‘continent’ with long-range orientational order.

    • Rodrigo E. Guerra
    • , Colm P. Kelleher
    • , Andrew D. Hollingsworth
    •  & Paul M. Chaikin
  • Letter |

    A crystal structure of DNMT3A and its regulatory partner DNMT3L bound to DNA reveals the mechanistic basis for DNMT3A-mediated DNA methylation and establishes its aetiological link to human disease.

    • Zhi-Min Zhang
    • , Rui Lu
    • , Pengcheng Wang
    • , Yang Yu
    • , Dongliang Chen
    • , Linfeng Gao
    • , Shuo Liu
    • , Debin Ji
    • , Scott B Rothbart
    • , Yinsheng Wang
    • , Gang Greg Wang
    •  & Jikui Song
  • Letter |

    A quantum-liquid state of spin–orbital-entangled magnetic moments is observed in the 5d-electron honeycomb iridate H3LiIr2O6, evidenced by the absence of magnetic ordering down to 0.05 kelvin.

    • K. Kitagawa
    • , T. Takayama
    • , Y. Matsumoto
    • , A. Kato
    • , R. Takano
    • , Y. Kishimoto
    • , S. Bette
    • , R. Dinnebier
    • , G. Jackeli
    •  & H. Takagi
  • Letter |

    The transcription factor c-MAF is required for the generation of Helicobacter-specific regulatory T cells that selectively restrain pro-inflammatory TH17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease.

    • Mo Xu
    • , Maria Pokrovskii
    • , Yi Ding
    • , Ren Yi
    • , Christy Au
    • , Oliver J. Harrison
    • , Carolina Galan
    • , Yasmine Belkaid
    • , Richard Bonneau
    •  & Dan R. Littman
  • Letter |

    A method for modelling time-varying dynamic stability in a natural marine fish community finds that seasonal patterns in community stability are driven by species diversity and interspecific interactions.

    • Masayuki Ushio
    • , Chih-hao Hsieh
    • , Reiji Masuda
    • , Ethan R Deyle
    • , Hao Ye
    • , Chun-Wei Chang
    • , George Sugihara
    •  & Michio Kondoh
  • Letter |

    High-angular-resolution measurements allow the direct observation of the scattering of energetic electrons by chorus waves in the magnetosphere, which causes quasiperiodic electron precipitation that gives rise to pulsating aurorae.

    • S. Kasahara
    • , Y. Miyoshi
    • , S. Yokota
    • , T. Mitani
    • , Y. Kasahara
    • , S. Matsuda
    • , A. Kumamoto
    • , A. Matsuoka
    • , Y. Kazama
    • , H. U. Frey
    • , V. Angelopoulos
    • , S. Kurita
    • , K. Keika
    • , K. Seki
    •  & I. Shinohara

Corrigendum

Erratum

Article

  • Article | | open

    The origin, evolution and domestication of Citrus and the genealogy of the most important wild and cultivated citrus varieties.

    • Guohong Albert Wu
    • , Javier Terol
    • , Victoria Ibanez
    • , Antonio López-García
    • , Estela Pérez-Román
    • , Carles Borredá
    • , Concha Domingo
    • , Francisco R. Tadeo
    • , Jose Carbonell-Caballero
    • , Roberto Alonso
    • , Franck Curk
    • , Dongliang Du
    • , Patrick Ollitrault
    • , Mikeal L. Roose
    • , Joaquin Dopazo
    • , Frederick G. Gmitter
    • , Daniel S. Rokhsar
    •  & Manuel Talon
  • Article |

    The transmembrane protein teneurin-3 is expressed in multiple topographically interconnected areas of the hippocampal region and acts in both projection and target neurons to control wiring specificity from CA1 to the subiculum.

    • Dominic S. Berns
    • , Laura A. DeNardo
    • , Daniel T. Pederick
    •  & Liqun Luo
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