Volume 554 Issue 7691, 8 February 2018

In a basket trial design, the efficacy of the pan-HER kinase inhibitor neratinib is tested in patients with 21 different tumour types, and responses are determined by mutation and tissue type, and are restricted to HER2-mutant cancers.

A kinetic model is proposed to predict the probability of dG•dT misincorporation across different polymerases, and provides mechanisms for sequence-dependent misincorporation.

Cryo-electron microscopy and single-molecule studies reveal that the adaptors BICDR1 and HOOK3 recruit two dynein molecules to dynactin and thereby increase the force and speed of the dynein–dynactin microtubule motor.

The observed electromagnetic emission from GW170817 suggests that a ‘cocoon’ of mildly relativistic material was released as a jet transferred its energy to the neutron-rich dynamical ejecta from the merger.

Measurements and modelling of a large confined eruption on the Sun show that its evolution is controlled by a multilayer magnetic cage containing a twisted flux rope, which can sometimes be ejective.

Experimental evidence is presented for isomer depletion through nuclear excitation by electron capture in molybdenum-93 nuclei.

Many-body two- and three-string states are realized experimentally in the antiferromagnetic Heisenberg–Ising chain SrCo₂V₂O₈ in strong longitudinal magnetic fields.

A process is described for the transformation of bulk wood into a low-cost, strong, tough, lightweight structural material, by the partial removal of lignin and hemicellulose followed by hot-pressing to densify the natural wood.

Contrary to the hopes of policymakers, fossil fuel subsidy removal would have only a small impact on global energy demand and carbon dioxide emissions and would not increase renewable energy use by 2030.

A dated phylogeny and spatial distribution data for Chinese angiosperms show that eastern China has tended to act as a refugium for older taxa whereas western China has acted as a centre for their evolutionary diversification.

Gene enhancer knockout phenotypes and analysis of enhancer activity patterns show that developmental genes are regulated by multiple redundant enhancers in mouse embryos.

The activity of dopamine neurons in the substantia nigra pars compacta before movement initiation affects the probability and vigour of future movements.

Measurement of human plasma amyloid-β biomarkers using immunoprecipitation coupled with mass spectrometry reliably predicts individual brain amyloid-β status and has potential clinical utility.

Distinct populations of lymphocytes act sequentially during development to direct maturation of the mammalian gut microbiota.

Analysis at high temporal and spatial resolution shows that the number and dynamics of SNARE proteins available during exocytosis determines the size and stability of fusion pores.