Volume 550 Issue 7676, 19 October 2017

The workplace is changing. Dramatic shifts in labour are reshaping society, the environment and the political landscape. Around the globe, computers and robots are poised to replace people in a wide variety of jobs. In this issue, Nature asks: what light is research shedding on the future of work and how will these changes affect scientists’ working world? A News Feature explores three of the most studied questions about the future of work: what jobs are most at risk of automation? Do shifts to a decentralized ‘gig economy’ make good on their promise to democratize work around the world? And what kinds of programmes are best preparing workers for the coming changes? A Careers Feature examines the gig economy in more detail, revealing how freelance opportunities are remodelling what it means to be a researcher. And in three Comment pieces, Robert Allen provides a historical perspective on the relationship between wages and productivity; Yuval Noah Harari seeks new socio-economic models and a revolution in education; and Ian Goldin suggests that our era has more parallels with the Renaissance than the Industrial Revolution. Cover image: Chris Malbon

This Week

News In Focus

Comment

Careers

Specials

Research

    News & Views

  • News & Views |

    An artificial-intelligence program called AlphaGo Zero has mastered the game of Go without any human data or guidance. A computer scientist and two members of the American Go Association discuss the implications. See Article p.354

    • Satinder Singh
    • , Andy Okun
    •  & Andrew Jackson
  • News & Views |

    Tumour cells can develop intrinsic adaptations that make them less susceptible to chemotherapy. It emerges that extrinsic bacterial action can also enable tumour cells to escape the effects of drug treatment.

    • Christian Jobin
  • News & Views |

    A technique that combines machine learning and quantum computing has been used to identify the particles known as Higgs bosons. The method could find applications in many areas of science. See Letter p.375

    • Steven Schramm
  • News & Views |

    A pro-inflammatory response, the senescence-associated secretory phenotype, can affect development, ageing and cancer. It emerges that one trigger for this response is the presence of DNA in the cytoplasm. See Letter p.402

    • Neil T. Umbreit
    •  & David Pellman
  • News & Views |

    Repair of broken DNA is vital for genome stability and to prevent the development of cancer. Research shows how the tumour-suppressor protein BRCA1 promotes a DNA-repair pathway called homologous recombination. See Article p.360

    • Petr Cejka
  • News & Views |

    Rett syndrome is a brain disorder caused by disrupted forms of the protein MECP2, but how MECP2 loss affects the brain is unknown. A mouse study now implicates key domains of the protein and offers therapeutic insights. See Letter p.398

    • Anne E. West
  • Review

  • Review Article |

    The history and future potential of DNA sequencing, including the development of the underlying technologies and the expansion of its areas of application, are reviewed.

    • Jay Shendure
    • , Shankar Balasubramanian
    • , George M. Church
    • , Walter Gilbert
    • , Jane Rogers
    • , Jeffery A. Schloss
    •  & Robert H. Waterston
  • Articles

  • Article |

    Starting from zero knowledge and without human data, AlphaGo Zero was able to teach itself to play Go and to develop novel strategies that provide new insights into the oldest of games.

    • David Silver
    • , Julian Schrittwieser
    • , Karen Simonyan
    • , Ioannis Antonoglou
    • , Aja Huang
    • , Arthur Guez
    • , Thomas Hubert
    • , Lucas Baker
    • , Matthew Lai
    • , Adrian Bolton
    • , Yutian Chen
    • , Timothy Lillicrap
    • , Fan Hui
    • , Laurent Sifre
    • , George van den Driessche
    • , Thore Graepel
    •  & Demis Hassabis
  • Article |

    The tumour suppressor complex BRCA1–BARD1, which facilitates the generation of a single-stranded DNA template during homologous recombination, also binds to the recombinase RAD51 and enhances its function.

    • Weixing Zhao
    • , Justin B. Steinfeld
    • , Fengshan Liang
    • , Xiaoyong Chen
    • , David G. Maranon
    • , Chu Jian Ma
    • , Youngho Kwon
    • , Timsi Rao
    • , Weibin Wang
    • , Chen Sheng
    • , Xuemei Song
    • , Yanhong Deng
    • , Judit Jimenez-Sainz
    • , Lucy Lu
    • , Ryan B. Jensen
    • , Yong Xiong
    • , Gary M. Kupfer
    • , Claudia Wiese
    • , Eric C. Greene
    •  & Patrick Sung
  • Letters

  • Letter | | open

    The magnetic moment of the antiproton is measured at the parts-per-billion level, improving on previous measurements by a factor of about 350.

    • C. Smorra
    • , S. Sellner
    • , M. J. Borchert
    • , J. A. Harrington
    • , T. Higuchi
    • , H. Nagahama
    • , T. Tanaka
    • , A. Mooser
    • , G. Schneider
    • , M. Bohman
    • , K. Blaum
    • , Y. Matsuda
    • , C. Ospelkaus
    • , W. Quint
    • , J. Walz
    • , Y. Yamazaki
    •  & S. Ulmer
  • Letter |

    Cations are used to control the interlayer spacing of graphene oxide membranes, enabling efficient and selective sieving of hydrated cations.

    • Liang Chen
    • , Guosheng Shi
    • , Jie Shen
    • , Bingquan Peng
    • , Bowu Zhang
    • , Yuzhu Wang
    • , Fenggang Bian
    • , Jiajun Wang
    • , Deyuan Li
    • , Zhe Qian
    • , Gang Xu
    • , Gongping Liu
    • , Jianrong Zeng
    • , Lijuan Zhang
    • , Yizhou Yang
    • , Guoquan Zhou
    • , Minghong Wu
    • , Wanqin Jin
    • , Jingye Li
    •  & Haiping Fang
  • Letter |

    A blend of two organic molecules excited by a simple LED light source can release the stored excitation energy slowly as ‘long persistent luminescence’ over periods of up to an hour.

    • Ryota Kabe
    •  & Chihaya Adachi
  • Letter |

    Interactions with male and female intruders activated overlapping neuronal populations in the ventromedial hypothalamus of inexperienced adult male mice, and these ensembles gradually separated as the mice acquired social and sexual experience with conspecifics.

    • Ryan Remedios
    • , Ann Kennedy
    • , Moriel Zelikowsky
    • , Benjamin F. Grewe
    • , Mark J. Schnitzer
    •  & David J. Anderson
  • Letter |

    Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.

    • Jian Yang
    • , David J. Ryan
    • , Wei Wang
    • , Jason Cheuk-Ho Tsang
    • , Guocheng Lan
    • , Hideki Masaki
    • , Xuefei Gao
    • , Liliana Antunes
    • , Yong Yu
    • , Zhexin Zhu
    • , Juexuan Wang
    • , Aleksandra A. Kolodziejczyk
    • , Lia S. Campos
    • , Cui Wang
    • , Fengtang Yang
    • , Zhen Zhong
    • , Beiyuan Fu
    • , Melanie A. Eckersley-Maslin
    • , Michael Woods
    • , Yosuke Tanaka
    • , Xi Chen
    • , Adam C. Wilkinson
    • , James Bussell
    • , Jacqui White
    • , Ramiro Ramirez-Solis
    • , Wolf Reik
    • , Berthold Göttgens
    • , Sarah A. Teichmann
    • , Patrick P. L. Tam
    • , Hiromitsu Nakauchi
    • , Xiangang Zou
    • , Liming Lu
    •  & Pentao Liu
  • Letter |

    Analysis of the minimal functional unit for MeCP2 protein shows that its function is to recruit the NCoR/SMRT co-repressor complex to methylated sites on chromatin, which may have use in designing strategies for gene therapy of Rett syndrome.

    • Rebekah Tillotson
    • , Jim Selfridge
    • , Martha V. Koerner
    • , Kamal K. E. Gadalla
    • , Jacky Guy
    • , Dina De Sousa
    • , Ralph D. Hector
    • , Stuart R. Cobb
    •  & Adrian Bird
  • Letter |

    Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.

    • Zhixun Dou
    • , Kanad Ghosh
    • , Maria Grazia Vizioli
    • , Jiajun Zhu
    • , Payel Sen
    • , Kirk J. Wangensteen
    • , Johayra Simithy
    • , Yemin Lan
    • , Yanping Lin
    • , Zhuo Zhou
    • , Brian C. Capell
    • , Caiyue Xu
    • , Mingang Xu
    • , Julia E. Kieckhaefer
    • , Tianying Jiang
    • , Michal Shoshkes-Carmel
    • , K. M. Ahasan Al Tanim
    • , Glen N. Barber
    • , John T. Seykora
    • , Sarah E. Millar
    • , Klaus H. Kaestner
    • , Benjamin A. Garcia
    • , Peter D. Adams
    •  & Shelley L. Berger
  • Letter |

    A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target.

    • Janice S. Chen
    • , Yavuz S. Dagdas
    • , Benjamin P. Kleinstiver
    • , Moira M. Welch
    • , Alexander A. Sousa
    • , Lucas B. Harrington
    • , Samuel H. Sternberg
    • , J. Keith Joung
    • , Ahmet Yildiz
    •  & Jennifer A. Doudna

    Collection:

  • Letter |

    The structure of mouse transient receptor potential mucolipin 1 (TRPML1), a cation channel located within endosomal and lysosomal membranes, is resolved using single-particle electron cryo-microscopy.

    • Qingfeng Chen
    • , Ji She
    • , Weizhong Zeng
    • , Jiangtao Guo
    • , Haoxing Xu
    • , Xiao-chen Bai
    •  & Youxing Jiang
Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing