Volume 549 Issue 7672, 21 September 2017

When a proliferating population of cells completes mitosis, some of the newly born daughter cells immediately enter the next cell cycle whereas other cells switch to a quiescent state. In this week’s issue, Tobias Meyer and his colleagues reveal how competing memories inherited from the mother cells lead the daughter cells to decide whether to stop or start the subsequent cell cycle. Growth signals cause an accumulation of cyclin D1 messenger RNA in the mother cells, whereas DNA damage leads the cells to contain a higher amount of activated p53. These are passed on to the daughter cells, where the cyclin D1 mRNA is translated into protein and p53 promotes production of the protein p21. Daughter cells that inherit larger amounts of cyclin D1 continue through to the next cell cycle, and those that have a high amount of activated p53 move into quiescence. This results in a system of cell-cycle control that maximizes the health of growing cell populations by preferentially selecting cells with a history of low DNA damage for more frequent proliferation. Cover image: Jeroen Claus/Phospho Biomedical Animation

Editorial

World View

  • World View |

    Monuments to the ‘father of gynaecology’ cannot be defended as historical documents because they hide grave injustices, says Harriet A. Washington.

    • Harriet A. Washington

Seven Days

News

News Feature

Comment

  • Comment |

    Treating cancer with the latest drugs and techniques is costly and will not improve survival globally, warn Richard Sullivan, C. S. Pramesh and Christopher M. Booth.

    • Richard Sullivan
    • , C. S. Pramesh
    •  & Christopher M. Booth
  • Comment |

    Stretchable sensors, circuits and batteries are about to change our relationships with electronics and each other, explain Bryant Chu and colleagues.

    • Bryant Chu
    • , William Burnett
    • , Jong Won Chung
    •  & Zhenan Bao

Books & Arts

Correspondence

News & Views

  • News & Views |

    The idea of nanometre-scale machines that can assemble molecules has long been thought of as the stuff of science fiction. Such a machine has now been built — and might herald a new model for organic synthesis. See Letter p.374

    • T. Ross Kelly
    •  & Marc L. Snapper
  • News & Views |

    Some versions of the MC1R protein are associated with red hair and an increased risk of developing a skin cancer called melanoma. It emerges that a lipid that binds MC1R might provide a target to reduce this risk. See Letter p.399

    • Ian J. Jackson
    •  & E. Elizabeth Patton
  • News & Views |

    Organic materials are potential substitutes for the costly transition-metal oxides used in battery electrodes, but their stability is often poor. A polymer design that uses intermolecular interactions solves this problem.

    • Byungju Lee
    •  & Kisuk Kang
  • News & Views |

    Mutations in embryonic blood-cell precursors called erythro-myeloid progenitors cause abnormal activation of their descendants — immune cells called microglia — leading to neurodegeneration in mice. See Letter p.389

    • Stefan P. Tarnawsky
    •  & Mervin C. Yoder
  • News & Views |

    3D printing could revolutionize manufacturing processes involving metals, but few industrially useful alloys are compatible with the technique. A method has been developed that might open up the 3D printing of all metals. See Letter p.365

    • Iain Todd
  • News & Views |

    Live imaging reveals that whether or not a daughter cell proliferates is influenced by two molecular factors inherited from its mother, providing insight into how the behaviour of a newly born cell can be predetermined. See Letter p.404

    • Katarzyna M. Kedziora
    •  & Jeremy E. Purvis

Article

  • Article |

    A rabies virus-based monosynaptic tracing method is used to show that the external globus pallidus plays a critical role in cocaine-induced behavioural plasticity.

    • Kevin T. Beier
    • , Christina K. Kim
    • , Paul Hoerbelt
    • , Lin Wai Hung
    • , Boris D. Heifets
    • , Katherine E. DeLoach
    • , Timothy J. Mosca
    • , Sophie Neuner
    • , Karl Deisseroth
    • , Liqun Luo
    •  & Robert C. Malenka
  • Article |

    Neuromedin receptor NMUR1 is specifically expressed by a subpopulation of type 2 innate lymphoid cells and promotes the inflammatory response of these cells in response to allergens, indicating the importance of neuro-immune crosstalk in allergic responses.

    • Antonia Wallrapp
    • , Samantha J. Riesenfeld
    • , Patrick R. Burkett
    • , Raja-Elie E. Abdulnour
    • , Jackson Nyman
    • , Danielle Dionne
    • , Matan Hofree
    • , Michael S. Cuoco
    • , Christopher Rodman
    • , Daneyal Farouq
    • , Brian J. Haas
    • , Timothy L. Tickle
    • , John J. Trombetta
    • , Pankaj Baral
    • , Christoph S. N. Klose
    • , Tanel Mahlakõiv
    • , David Artis
    • , Orit Rozenblatt-Rosen
    • , Isaac M. Chiu
    • , Bruce D. Levy
    • , Monika S. Kowalczyk
    • , Aviv Regev
    •  & Vijay K. Kuchroo

Letter

  • Letter |

    Analysis based on high-resolution observations from the Hubble Space Telescope shows that the asteroid 288P is a binary main-belt comet, with properties unlike any known binary asteroid.

    • Jessica Agarwal
    • , David Jewitt
    • , Max Mutchler
    • , Harold Weaver
    •  & Stephen Larson
  • Letter |

    Zirconium nanoparticles introduced into aluminium alloy powders control solidification during 3D printing, enabling the production of crack-free materials with strengths comparable to the corresponding wrought material.

    • John H. Martin
    • , Brennan D. Yahata
    • , Jacob M. Hundley
    • , Justin A. Mayer
    • , Tobias A. Schaedler
    •  & Tresa M. Pollock
  • Letter |

    A molecular machine that can be programmed to position a substrate at one of two directing sites on a molecule, which control the stereochemistry of addition to the substrate, demonstrates complexity, precision and function previously only observed in nature.

    • Salma Kassem
    • , Alan T. L. Lee
    • , David A. Leigh
    • , Vanesa Marcos
    • , Leoni I. Palmer
    •  & Simone Pisano
  • Letter | | Open Access

    WebComparing the whole genome sequence of Apostasia shenzhenica with transcriptome and genome data from five orchid subfamilies permits the reconstruction of an ancestral gene toolkit, providing insight into orchid origins, evolution and diversification.

    • Guo-Qiang Zhang
    • , Ke-Wei Liu
    • , Zhen Li
    • , Rolf Lohaus
    • , Yu-Yun Hsiao
    • , Shan-Ce Niu
    • , Jie-Yu Wang
    • , Yao-Cheng Lin
    • , Qing Xu
    • , Li-Jun Chen
    • , Kouki Yoshida
    • , Sumire Fujiwara
    • , Zhi-Wen Wang
    • , Yong-Qiang Zhang
    • , Nobutaka Mitsuda
    • , Meina Wang
    • , Guo-Hui Liu
    • , Lorenzo Pecoraro
    • , Hui-Xia Huang
    • , Xin-Ju Xiao
    • , Min Lin
    • , Xin-Yi Wu
    • , Wan-Lin Wu
    • , You-Yi Chen
    • , Song-Bin Chang
    • , Shingo Sakamoto
    • , Masaru Ohme-Takagi
    • , Masafumi Yagi
    • , Si-Jin Zeng
    • , Ching-Yu Shen
    • , Chuan-Ming Yeh
    • , Yi-Bo Luo
    • , Wen-Chieh Tsai
    • , Yves Van de Peer
    •  & Zhong-Jian Liu
  • Letter |

    Surface diffusion of AMPA receptors, from extra-synaptic to synaptic sites at the plasma membrane, is essential for full long-term potentiation in hippocampal neurons and for fear conditioning in living mice.

    • A. C. Penn
    • , C. L. Zhang
    • , F. Georges
    • , L. Royer
    • , C. Breillat
    • , E. Hosy
    • , J. D. Petersen
    • , Y. Humeau
    •  & D. Choquet
  • Letter |

    Braf V600E expression in resident macrophage progenitors leads to clonal expansion of ERK-activated microglia, which causes synaptic and neuronal loss in the brain and results in lethal neurodegenerative disease in adult mice.

    • Elvira Mass
    • , Christian E. Jacome-Galarza
    • , Thomas Blank
    • , Tomi Lazarov
    • , Benjamin H. Durham
    • , Neval Ozkaya
    • , Alessandro Pastore
    • , Marius Schwabenland
    • , Young Rock Chung
    • , Marc K. Rosenblum
    • , Marco Prinz
    • , Omar Abdel-Wahab
    •  & Frederic Geissmann
  • Letter |

    A molecular mechanism for the sensitive detection of long and U-turn DNA by cyclic GMP–AMP synthase (cGAS) both in vitro and in human cells.

    • Liudmila Andreeva
    • , Björn Hiller
    • , Dirk Kostrewa
    • , Charlotte Lässig
    • , Carina C. de Oliveira Mann
    • , David Jan Drexler
    • , Andreas Maiser
    • , Moritz Gaidt
    • , Heinrich Leonhardt
    • , Veit Hornung
    •  & Karl-Peter Hopfner
  • Letter |

    The protein modification palmitoylation increases the ability of variant forms of the melanocortin-1 receptor (MC1R) to induce pigmentation, and this is linked to reduced development of melanomas.

    • Shuyang Chen
    • , Bo Zhu
    • , Chengqian Yin
    • , Wei Liu
    • , Changpeng Han
    • , Baoen Chen
    • , Tongzheng Liu
    • , Xin Li
    • , Xiang Chen
    • , Chunying Li
    • , Limin Hu
    • , Jun Zhou
    • , Zhi-Xiang Xu
    • , Xiumei Gao
    • , Xu Wu
    • , Colin R. Goding
    •  & Rutao Cui
  • Letter |

    Mother cells transmit mitogen-induced CCND1 mRNA and DNA damage-induced p53 protein to newly born daughter cells, where synthesized cyclin D1 and the p53-regulated CDK inhibitor p21 directly compete to decide between proliferation and quiescence.

    • Hee Won Yang
    • , Mingyu Chung
    • , Takamasa Kudo
    •  & Tobias Meyer
  • Letter |

    Combining ancestral protein reconstruction with deep mutational scanning to characterize alternative histories in the sequence space around an ancient transcription factor reveals hundreds of alternative protein sequences that use diverse biochemical mechanisms to perform the derived function at least as well as the historical outcome.

    • Tyler N. Starr
    • , Lora K. Picton
    •  & Joseph W. Thornton
  • Letter |

    The cryo-electron microscopy structure of the ten-subunit human transcription factor IIH, revealing the molecular architecture of the TFIIH core complex, the detailed structures of its constituent XPB and XPD ATPases, and how the core and kinase subcomplexes of TFIIH are connected.

    • Basil J. Greber
    • , Thi Hoang Duong Nguyen
    • , Jie Fang
    • , Pavel V. Afonine
    • , Paul D. Adams
    •  & Eva Nogales

Erratum

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