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Volume 548 Issue 7667, 17 August 2017

The cover image shows a conceptualized view of an individual with multiple cancers that have spread from their primary site, or metastasized. The primary cancers represented include prostate cancer (blue), breast cancer (pink), lung cancer (green) and colon cancer (orange). In this issue, Arul Chinnaiyan and colleagues report sequences of the DNA and RNA of 500 diverse human metastatic cancers as part of the Michigan Oncology Sequencing Program. The researchers characterize the landscape of genomic alterations in the cancers, including some mutations in germline DNA. They also show that clinical RNA sequencing can be used to characterize gene fusions, transcriptional signatures and the immune microenvironment of metastatic cancer. Cover image: Ella Marushchenko and Elina Karimullina (Ella Maru Studio, Inc.)


World View

  • World View |

    The Middle East is freezing out Qatar. A science academy could help — and would set an important precedent for the region, says Ehsan Masood.

    • Ehsan Masood

Seven Days


News Feature


Books & Arts

  • Books & Arts |

    Barbara Kiser reviews five of the week's best science picks.

    • Barbara Kiser


News & Views

  • News & Views |

    Temperature variability in the North Atlantic Ocean is the result of many competing physical processes, but the relative roles of these processes is a source of contention. Here, scientists present two perspectives on the debate.

    • Gabriel A. Vecchi
    • Thomas L. Delworth
    • Ben Booth
  • News & Views |

    Information about taste sensations, such as bitter or sweet, is relayed from the mouse tongue to the brain through taste-specific pathways. It emerges that semaphorin proteins guide the wiring of these pathways. See Letter p.330

    • Jiefu Li
    • Liqun Luo
  • News & Views |

    Sequences of the DNA and RNA of 500 human cancers that have spread from their primary site in the body take us a step closer to the convergence of basic science and patient benefit. See Article p.297

    • G. Steven Bova
  • News & Views |

    The dynamic motion of gas in the outer atmosphere of a red supergiant star has been mapped, providing clues to the mysterious mechanism that causes massive stars to lose mass through stellar winds. See Letter p.310

    • Gail H. Schaefer
  • News & Views |

    Live imaging shows that healthy skin cells surround and expel neighbours that have cancer-promoting mutations, revealing that tissues can recognize and eliminate mutant cells to prevent tumour initiation. See Letter p.334

    • Joseph Burclaff
    • Jason C. Mills


  • Article |

    Maiopatagium, a haramiyid from the Jurassic Tiaojishan Formation (around 160 million years ago) of China was specialised for gliding with a patagium (wing membrane) and a fused wishbone, reminiscent of that of birds.

    • Qing-Jin Meng
    • David M. Grossnickle
    • Zhe-Xi Luo
  • Article |

    Clinical exome and transcriptome sequencing of 500 adult patients with metastatic solid tumours of diverse lineage and biopsy site, as part of the Michigan Oncology Sequencing (MI-ONCOSEQ) Program.

    • Dan R. Robinson
    • Yi-Mi Wu
    • Arul M. Chinnaiyan




  • Q&A |

    A molecular biologist uses his investigative skills to support detectives.

    • Julie Gould


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