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Volume 546 Issue 7658, 15 June 2017

Three papers in this issue provide a plethora of new genome sequences for the Zika virus and offer insights into its genetic epidemiology. On page 401, Kristian Anderson and his colleagues reveal 39 new genome sequences obtained from infected patients and Aedes aegypti mosquitoes. Using phylogenetic analysis they conclude that the virus has been introduced to Florida on multiple separate occasions and that most of these events were linked to travel from the Caribbean. Their work also suggests that Zika transmission chains in Florida are unlikely to persist, indicating that future outbreaks would depend on transmission dynamics in the Americas. On page 406, Nuno Faria and his colleagues provide 54 new virus genomes, mostly from northeast Brazil, several sequenced in real time using portable DNA sequencers and a mobile genomics laboratory. Using these and other available sequences they trace the spatial origins and spread of the virus in Brazil and the Americas, revealing that northeast Brazil played a crucial role in establishing the epidemic and the spread of the virus on the continent. And on page 411, Bronwyn MacInnis and her colleagues analyse 110 Zika virus genomes derived from clinical and mosquito samples from ten countries and territories. Their work affirms the rapid expansion of the epidemic within Brazil and multiple introductions to other geographical regions. They also describe the ongoing evolution of the virus and look at how the accumulation of mutations might affect the future performance of diagnostic tests. Cover image: Jasiek Krzysztofiak/Nature

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    Most state-of-the-art methods of wireless energy delivery are inherently limited to static devices. An approach based on fundamental physics could overcome this limitation, opening up a wealth of applications. See Letter p.387

    • Geoffroy Lerosey
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    Evolutionary trees constructed using both newly sequenced and previously available Zika virus genomes reveal how the recent outbreak arose in Brazil and spread across the Americas. See Letters p.401 , p.406 & p.411

    • Michael Worobey
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    Cell division requires the action of key regulator proteins called cyclins and CDKs. It emerges that a cyclin–CDK complex can regulate cell metabolism, and targeting this metabolic regulation causes tumour regression in mice. See Letter p.426

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    Rubber sheets that reversibly bind and release substrates have been made by copying a subtlety in the shape of octopus suckers. The findings reveal how macro-scale biological structures can influence function. See Letter p.396

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    A paper that analysed genetic variants in 14,000 people to identify disease-associated regions set the standard for collaborative genome-wide association studies and provided methodological advances whose effects are still felt today.

    • Teri A. Manolio
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    Production of the metabolite acetyl-CoA near specific regions of DNA modulates gene expression in mouse neurons during cellular differentiation and memory formation. See Article p.381

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    How to live happily ever after.

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