Volume 545 Issue 7655, 25 May 2017

In this issue, Charles Swanton and his colleagues suggest that ‘liquid biopsies’ could be used for the early detection of a relapse after surgery for non-small-cell lung cancer. The researchers assessed the evolutionary dynamics of tumours surgically removed from participants in the TRACERx lung-cancer clinical study. They created phylogenetic trees to show how an individual’s tumour evolved and used that information as the basis for a blood test to look for circulating tumour DNA (ctDNA). This allowed the team to identify recurrence of the tumour around 70 days before it was identified in a routine clinical setting as well as providing insight into the metastatic branched evolutionary process. The results indicate how liquid biopsies might be applied in personalized medicine to improve cancer monitoring. Cover image: Jeroen Claus and Giovanni Panico/Phospho Biomedical Animation.

Editorial

World View

Seven Days

News

Correction

News Feature

Comment

  • Comment |

    The blockchain technology that underpins cryptographic currencies can support sustainability by building trust and avoiding corruption, explains Guillaume Chapron.

    • Guillaume Chapron
  • Comment |

    Mariana Medina-Sánchez and Oliver G. Schmidt set priorities for more realistic tests of tiny machines that could be used to diagnose and treat conditions.

    • Mariana Medina-Sánchez
    •  & Oliver G. Schmidt

Books & Arts

Correspondence

News & Views

  • News & Views |

    The Hubbard model describes the behaviour of interacting quantum particles, but many of its properties remain unknown. A system of ultracold atoms could provide the key to determining the model's underlying physics. See Letter p.462

    • Thierry Giamarchi
  • News & Views |

    Haematopoietic stem cells give rise to all lineages of blood cell, and their production in vitro has been a long-sought goal of stem-cell biology. Two groups now achieve this feat through different means. See Articles p.432 & p.439

    • Carolina Guibentif
    •  & Berthold Göttgens
  • News & Views |

    Genomic analysis of lung-tumour evolution has been used to create personalized blood tests that enable successful clinical monitoring for early signs of cancer relapse — a promising step on the road to precision medicine. See Article p.446

    • Alberto Bardelli

    Nature Outlook:

  • News & Views |

    The neighbourhoods of extremely bright astronomical objects called quasars in the early Universe have been incompletely probed. Observations suggest that these regions harbour some of the most massive known galaxies. See Letter p.457

    • Rychard Bouwens
  • News & Views |

    Plants precisely express some immune regulators by controlling the translation of messenger RNA into protein. This insight enabled a disease-resistant rice to be engineered without compromised productivity. See Letters p.487 & p.491

    • Julia Bailey-Serres
    •  & Wenbo Ma
  • News & Views |

    Reliably measuring global health is a huge challenge. Four papers published in 1997 laid foundations for future global-health estimates, but, despite subsequent advances, better integration of data systems and models is still needed.

    • Peter Byass

Review Article

  • Review Article |

    The use of genetically engineered T cells in the treatment of cancer is reviewed, with particular focus on anti-CD19 chimaeric antigen receptor therapy, providing a summary of past progress and current status, and potential future directions.

    • Michel Sadelain
    • , Isabelle Rivière
    •  & Stanley Riddell

Article

  • Article |

    Haematopoietic stem and progenitor cell conversion of human pluripotent stem cell-derived haemogenic endothelium.

    • Ryohichi Sugimura
    • , Deepak Kumar Jha
    • , Areum Han
    • , Clara Soria-Valles
    • , Edroaldo Lummertz da Rocha
    • , Yi-Fen Lu
    • , Jeremy A. Goettel
    • , Erik Serrao
    • , R. Grant Rowe
    • , Mohan Malleshaiah
    • , Irene Wong
    • , Patricia Sousa
    • , Ted N. Zhu
    • , Andrea Ditadi
    • , Gordon Keller
    • , Alan N. Engelman
    • , Scott B. Snapper
    • , Sergei Doulatov
    •  & George Q. Daley

    Nature Outlook:

  • Article |

    The authors reprogram in vitro endothelial cells from adult mice into engraftable haematopoietic stem cells that display single-cell and multilineage properties, are capable of long-term self-renewal and can reconstitute T cell adaptive immune function.

    • Raphael Lis
    • , Charles C. Karrasch
    • , Michael G. Poulos
    • , Balvir Kunar
    • , David Redmond
    • , Jose G. Barcia Duran
    • , Chaitanya R. Badwe
    • , William Schachterle
    • , Michael Ginsberg
    • , Jenny Xiang
    • , Arash Rafii Tabrizi
    • , Koji Shido
    • , Zev Rosenwaks
    • , Olivier Elemento
    • , Nancy A. Speck
    • , Jason M. Butler
    • , Joseph M. Scandura
    •  & Shahin Rafii

    Nature Outlook:

  • Article |

    Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

    • Christopher Abbosh
    • , Nicolai J. Birkbak
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Tudor Constantin
    • , Raheleh Salari
    • , John Le Quesne
    • , David A. Moore
    • , Selvaraju Veeriah
    • , Rachel Rosenthal
    • , Teresa Marafioti
    • , Eser Kirkizlar
    • , Thomas B. K. Watkins
    • , Nicholas McGranahan
    • , Sophia Ward
    • , Luke Martinson
    • , Joan Riley
    • , Francesco Fraioli
    • , Maise Al Bakir
    • , Eva Grönroos
    • , Francisco Zambrana
    • , Raymondo Endozo
    • , Wenya Linda Bi
    • , Fiona M. Fennessy
    • , Nicole Sponer
    • , Diana Johnson
    • , Joanne Laycock
    • , Seema Shafi
    • , Justyna Czyzewska-Khan
    • , Andrew Rowan
    • , Tim Chambers
    • , Nik Matthews
    • , Samra Turajlic
    • , Crispin Hiley
    • , Siow Ming Lee
    • , Martin D. Forster
    • , Tanya Ahmad
    • , Mary Falzon
    • , Elaine Borg
    • , David Lawrence
    • , Martin Hayward
    • , Shyam Kolvekar
    • , Nikolaos Panagiotopoulos
    • , Sam M. Janes
    • , Ricky Thakrar
    • , Asia Ahmed
    • , Fiona Blackhall
    • , Yvonne Summers
    • , Dina Hafez
    • , Ashwini Naik
    • , Apratim Ganguly
    • , Stephanie Kareht
    • , Rajesh Shah
    • , Leena Joseph
    • , Anne Marie Quinn
    • , Phil A. Crosbie
    • , Babu Naidu
    • , Gary Middleton
    • , Gerald Langman
    • , Simon Trotter
    • , Marianne Nicolson
    • , Hardy Remmen
    • , Keith Kerr
    • , Mahendran Chetty
    • , Lesley Gomersall
    • , Dean A. Fennell
    • , Apostolos Nakas
    • , Sridhar Rathinam
    • , Girija Anand
    • , Sajid Khan
    • , Peter Russell
    • , Veni Ezhil
    • , Babikir Ismail
    • , Melanie Irvin-Sellers
    • , Vineet Prakash
    • , Jason F. Lester
    • , Malgorzata Kornaszewska
    • , Richard Attanoos
    • , Haydn Adams
    • , Helen Davies
    • , Dahmane Oukrif
    • , Ayse U. Akarca
    • , John A. Hartley
    • , Helen L. Lowe
    • , Sara Lock
    • , Natasha Iles
    • , Harriet Bell
    • , Yenting Ngai
    • , Greg Elgar
    • , Zoltan Szallasi
    • , Roland F. Schwarz
    • , Javier Herrero
    • , Aengus Stewart
    • , Sergio A. Quezada
    • , Karl S. Peggs
    • , Peter Van Loo
    • , Caroline Dive
    • , C. Jimmy Lin
    • , Matthew Rabinowitz
    • , Hugo J. W. L. Aerts
    • , Allan Hackshaw
    • , Jacqui A. Shaw
    • , Bernhard G. Zimmermann
    • , Charles Swanton
    • , Mariam Jamal-Hanjani
    • , Christopher Abbosh
    • , Selvaraju Veeriah
    • , Seema Shafi
    • , Justyna Czyzewska-Khan
    • , Diana Johnson
    • , Joanne Laycock
    • , Leticia Bosshard-Carter
    • , Gerald Goh
    • , Rachel Rosenthal
    • , Pat Gorman
    • , Nirupa Murugaesu
    • , Robert E. Hynds
    • , Gareth A. Wilson
    • , Nicolai J. Birkbak
    • , Thomas B. K. Watkins
    • , Nicholas McGranahan
    • , Stuart Horswell
    • , Maise Al Bakir
    • , Eva Grönroos
    • , Richard Mitter
    • , Mickael Escudero
    • , Aengus Stewart
    • , Peter Van Loo
    • , Andrew Rowan
    • , Hang Xu
    • , Samra Turajlic
    • , Crispin Hiley
    • , Jacki Goldman
    • , Richard Kevin Stone
    • , Tamara Denner
    • , Nik Matthews
    • , Greg Elgar
    • , Sophia Ward
    • , Jennifer Biggs
    • , Marta Costa
    • , Sharmin Begum
    • , Ben Phillimore
    • , Tim Chambers
    • , Emma Nye
    • , Sofia Graca
    • , Kroopa Joshi
    • , Andrew Furness
    • , Assma Ben Aissa
    • , Yien Ning Sophia Wong
    • , Andy Georgiou
    • , Sergio A. Quezada
    • , Karl S. Peggs
    • , John A. Hartley
    • , Helen L. Lowe
    • , Javier Herrero
    • , David Lawrence
    • , Martin Hayward
    • , Nikolaos Panagiotopoulos
    • , Shyam Kolvekar
    • , Mary Falzon
    • , Elaine Borg
    • , Teresa Marafioti
    • , Celia Simeon
    • , Gemma Hector
    • , Amy Smith
    • , Marie Aranda
    • , Marco Novelli
    • , Dahmane Oukrif
    • , Ayse U. Akarca
    • , Sam M. Janes
    • , Ricky Thakrar
    • , Martin D. Forster
    • , Tanya Ahmad
    • , Siow Ming Lee
    • , Dionysis Papadatos-Pastos
    • , Dawn Carnell
    • , Ruheena Mendes
    • , Jeremy George
    • , Neal Navani
    • , Asia Ahmed
    • , Magali Taylor
    • , Junaid Choudhary
    • , Yvonne Summers
    • , Raffaele Califano
    • , Paul Taylor
    • , Rajesh Shah
    • , Piotr Krysiak
    • , Kendadai Rammohan
    • , Eustace Fontaine
    • , Richard Booton
    • , Matthew Evison
    • , Phil A. Crosbie
    • , Stuart Moss
    • , Faiza Idries
    • , Leena Joseph
    • , Paul Bishop
    • , Anshuman Chaturvedi
    • , Anne Marie Quinn
    • , Helen Doran
    • , Angela Leek
    • , Phil Harrison
    • , Katrina Moore
    • , Rachael Waddington
    • , Juliette Novasio
    • , Fiona Blackhall
    • , Jane Rogan
    • , Elaine Smith
    • , Caroline Dive
    • , Jonathan Tugwood
    • , Ged Brady
    • , Dominic G. Rothwell
    • , Francesca Chemi
    • , Jackie Pierce
    • , Sakshi Gulati
    • , Babu Naidu
    • , Gerald Langman
    • , Simon Trotter
    • , Mary Bellamy
    • , Hollie Bancroft
    • , Amy Kerr
    • , Salma Kadiri
    • , Joanne Webb
    • , Gary Middleton
    • , Madava Djearaman
    • , Dean A. Fennell
    • , Jacqui A. Shaw
    • , John Le Quesne
    • , David A. Moore
    • , Anne Thomas
    • , Harriet Walter
    • , Joan Riley
    • , Luke Martinson
    • , Apostolos Nakas
    • , Sridhar Rathinam
    • , William Monteiro
    • , Hilary Marshall
    • , Louise Nelson
    • , Jonathan Bennett
    • , Lindsay Primrose
    • , Girija Anand
    • , Sajid Khan
    • , Anita Amadi
    • , Marianne Nicolson
    • , Keith Kerr
    • , Shirley Palmer
    • , Hardy Remmen
    • , Joy Miller
    • , Keith Buchan
    • , Mahendran Chetty
    • , Lesley Gomersall
    • , Jason F. Lester
    • , Alison Edwards
    • , Fiona Morgan
    • , Haydn Adams
    • , Helen Davies
    • , Malgorzata Kornaszewska
    • , Richard Attanoos
    • , Sara Lock
    • , Azmina Verjee
    • , Mairead MacKenzie
    • , Maggie Wilcox
    • , Harriet Bell
    • , Natasha Iles
    • , Allan Hackshaw
    • , Yenting Ngai
    • , Sean Smith
    • , Nicole Gower
    • , Christian Ottensmeier
    • , Serena Chee
    • , Benjamin Johnson
    • , Aiman Alzetani
    • , Emily Shaw
    • , Eric Lim
    • , Paulo De Sousa
    • , Monica Tavares Barbosa
    • , Alex Bowman
    • , Simon Jordan
    • , Alexandra Rice
    • , Hilgardt Raubenheimer
    • , Chiara Proli
    • , Maria Elena Cufari
    • , John Carlo Ronquillo
    • , Angela Kwayie
    • , Harshil Bhayani
    • , Morag Hamilton
    • , Yusura Bakar
    • , Natalie Mensah
    • , Lyn Ambrose
    • , Anand Devaraj
    • , Silviu Buderi
    • , Jonathan Finch
    • , Leire Azcarate
    • , Hema Chavan
    • , Sophie Green
    • , Hillaria Mashinga
    • , Andrew G. Nicholson
    • , Kelvin Lau
    • , Michael Sheaff
    • , Peter Schmid
    • , John Conibear
    • , Veni Ezhil
    • , Babikir Ismail
    • , Melanie Irvin-Sellers
    • , Vineet Prakash
    • , Peter Russell
    • , Teresa Light
    • , Tracey Horey
    • , Sarah Danson
    • , Jonathan Bury
    • , John Edwards
    • , Jennifer Hill
    • , Sue Matthews
    • , Yota Kitsanta
    • , Kim Suvarna
    • , Patricia Fisher
    • , Allah Dino Keerio
    • , Michael Shackcloth
    • , John Gosney
    • , Pieter Postmus
    • , Sarah Feeney
    • , Julius Asante-Siaw
    • , Tudor Constantin
    • , Raheleh Salari
    • , Nicole Sponer
    • , Ashwini Naik
    • , Bernhard G. Zimmermann
    • , Matthew Rabinowitz
    • , Hugo J. W. L. Aerts
    • , Stefan Dentro
    • , Christophe Dessimoz
    •  & Charles Swanton
  • Article |

    Epigenetic programming of T cells in solid tumours from a functional to a dysfunctional state occurs in two phases, and only the first phase is reversible.

    • Mary Philip
    • , Lauren Fairchild
    • , Liping Sun
    • , Ellen L. Horste
    • , Steven Camara
    • , Mojdeh Shakiba
    • , Andrew C. Scott
    • , Agnes Viale
    • , Peter Lauer
    • , Taha Merghoub
    • , Matthew D. Hellmann
    • , Jedd D. Wolchok
    • , Christina S. Leslie
    •  & Andrea Schietinger

Letter

  • Letter |

    Four galaxies discovered near quasars at redshifts exceeding 6 have star-formation rates that are high enough to explain the massive elliptical galaxies known to exist at redshifts of about 4.

    • R. Decarli
    • , F. Walter
    • , B. P. Venemans
    • , E. Bañados
    • , F. Bertoldi
    • , C. Carilli
    • , X. Fan
    • , E. P. Farina
    • , C. Mazzucchelli
    • , D. Riechers
    • , H.-W. Rix
    • , M. A. Strauss
    • , R. Wang
    •  & Y. Yang
  • Letter |

    An antiferromagnet with a correlation length that encompasses the whole system is created with the aid of quantum gas microscopy of cold atoms in an optical lattice.

    • Anton Mazurenko
    • , Christie S. Chiu
    • , Geoffrey Ji
    • , Maxwell F. Parsons
    • , Márton Kanász-Nagy
    • , Richard Schmidt
    • , Fabian Grusdt
    • , Eugene Demler
    • , Daniel Greif
    •  & Markus Greiner
  • Letter |

    Across markets accounting for 80 per cent of global diesel vehicle sales, more than a third of diesel nitrogen oxide emissions are in excess of certification limits, causing many deaths.

    • Susan C. Anenberg
    • , Joshua Miller
    • , Ray Minjares
    • , Li Du
    • , Daven K. Henze
    • , Forrest Lacey
    • , Christopher S. Malley
    • , Lisa Emberson
    • , Vicente Franco
    • , Zbigniew Klimont
    •  & Chris Heyes
  • Letter |

    Identification of sleep-active and sleep-promoting neurons in the preoptic area of the hypothalamus using neural projection tracing tools to target this population among a group of intermingled neurons, all with various functions.

    • Shinjae Chung
    • , Franz Weber
    • , Peng Zhong
    • , Chan Lek Tan
    • , Thuc Nghi Nguyen
    • , Kevin T. Beier
    • , Nikolai Hörmann
    • , Wei-Cheng Chang
    • , Zhe Zhang
    • , Johnny Phong Do
    • , Shenqin Yao
    • , Michael J. Krashes
    • , Bosiljka Tasic
    • , Ali Cetin
    • , Hongkui Zeng
    • , Zachary A. Knight
    • , Liqun Luo
    •  & Yang Dan
  • Letter |

    A mutation that increases the secretion of Zika virus non-structural protein 1 (NS1) in infected hosts enhances the ability of the virus to infect its mosquito vector Aedes aegypti and might have contributed to the recent Zika epidemic.

    • Yang Liu
    • , Jianying Liu
    • , Senyan Du
    • , Chao Shan
    • , Kaixiao Nie
    • , Rudian Zhang
    • , Xiao-Feng Li
    • , Renli Zhang
    • , Tao Wang
    • , Cheng-Feng Qin
    • , Penghua Wang
    • , Pei-Yong Shi
    •  & Gong Cheng
  • Letter |

    Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis in vivo, decreases tumour burden and increases survival of mice.

    • Sydney R. Gordon
    • , Roy L. Maute
    • , Ben W. Dulken
    • , Gregor Hutter
    • , Benson M. George
    • , Melissa N. McCracken
    • , Rohit Gupta
    • , Jonathan M. Tsai
    • , Rahul Sinha
    • , Daniel Corey
    • , Aaron M. Ring
    • , Andrew J. Connolly
    •  & Irving L. Weissman

    Nature Outlook:

  • Letter |

    BCAT1, a cytosolic aminotransferase for branched-chain amino acids (BCAAs), is aberrantly activated and functionally required for disease progression in chronic myeloid leukaemia.

    • Ayuna Hattori
    • , Makoto Tsunoda
    • , Takaaki Konuma
    • , Masayuki Kobayashi
    • , Tamas Nagy
    • , John Glushka
    • , Fariba Tayyari
    • , Daniel McSkimming
    • , Natarajan Kannan
    • , Arinobu Tojo
    • , Arthur S. Edison
    •  & Takahiro Ito
  • Letter |

    Affinity purification–mass spectrometry elucidates protein interaction networks and co-complexes to build, to our knowledge, the largest experimentally derived human protein interaction network so far, termed BioPlex 2.0.

    • Edward L. Huttlin
    • , Raphael J. Bruckner
    • , Joao A. Paulo
    • , Joe R. Cannon
    • , Lily Ting
    • , Kurt Baltier
    • , Greg Colby
    • , Fana Gebreab
    • , Melanie P. Gygi
    • , Hannah Parzen
    • , John Szpyt
    • , Stanley Tam
    • , Gabriela Zarraga
    • , Laura Pontano-Vaites
    • , Sharan Swarup
    • , Anne E. White
    • , Devin K. Schweppe
    • , Ramin Rad
    • , Brian K. Erickson
    • , Robert A. Obar
    • , K. G. Guruharsha
    • , Kejie Li
    • , Spyros Artavanis-Tsakonas
    • , Steven P. Gygi
    •  & J. Wade Harper

Corrigendum

Technology Feature

  • Technology Feature |

    Microfluidic devices filled with intricate channels that exploit fluid behaviour promise to make it easier to diagnose genetic disease.

    • Amber Dance

    Collection:

Feature

Career Brief

  • Career Brief |

    US science PhD programmes still attract more men than women, except in biology and agricultural sciences.

Correction

Futures

Nature Index

Advertisement Feature

  • Advertisement Feature |

    QScience Highlights

    QScience.com is an open access, peer-reviewed publishing platform from Hamad Bin Khalifa University Press in Qatar with a portfolio of journals that showcase research and reviews from the natural and social sciences. This supplement offers a glimpse into the diversity that Qscience.com boasts, by showcasing research highlights of ten of the online portal’s research articles.

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