Volume 520 Issue 7547, 16 April 2015

Cultured cell lines, including many cancer cell lines, are essential tools not only in biological research but also other areas of science. Unfortunately, it has been long known that many cell lines are contaminated, mislabelled or incorrectly annotated. Richard Neve and colleagues now present an analysis providing unambiguous authentication and annotation for more than 3,500 cell lines. This resource offers a reference point for both short tandem repeats (STR) and single nucleotide polymorphism (SNP) profiles as genetic methods of cell annotation, combined with suggested standards for nomenclature using a controlled vocabulary. In a parallel development, we present on page 307 a new publication policy designed to increase the scrutiny around cell line identity problems. Cover: AXS Biomedical Animation Studio

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    Brief Communications Arising

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  • News & Views

  • News & Views |

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  • News & Views |

    Experimental results suggest that if Earth initially grew by the accumulation of highly chemically reduced material, its core could contain enough uranium to drive the planet's magnetic field throughout Earth's history. See Letter p.337

    • Richard W. Carlson
  • News & Views |

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    • Mary J. C. Hendrix
  • News & Views |

    Drug manufacture can benefit from flow synthesis, in which raw materials are fed into a sequence of reactors, producing the drug as a continuous output. A flow strategy that capitalizes on solid catalysts has now been realized. See Letter p.329

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  • News & Views |

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    • Nicholas K. Dulvy
    •  & Holly K. Kindsvater
  • Analysis

  • Analysis |

    It has been long known that many cultured cell lines, an essential tool not only in biological research but also other areas of science, are contaminated, mislabelled or incorrectly annotated; here an analysis covering over 3,500 cell lines and their unambiguous authentication and annotation offers the community a reference point for both STR and SNP profiles as genetic methods of cell authentication, combined with suggested standards for nomenclature using a controlled vocabulary.

    • Mamie Yu
    • , Suresh K. Selvaraj
    • , May M. Y. Liang-Chu
    • , Sahar Aghajani
    • , Matthew Busse
    • , Jean Yuan
    • , Genee Lee
    • , Franklin Peale
    • , Christiaan Klijn
    • , Richard Bourgon
    • , Joshua S. Kaminker
    •  & Richard M. Neve
  • Articles

  • Article |

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    • Hiroaki Tanabe
    • , Yoshifumi Fujii
    • , Miki Okada-Iwabu
    • , Masato Iwabu
    • , Yoshihiro Nakamura
    • , Toshiaki Hosaka
    • , Kanna Motoyama
    • , Mariko Ikeda
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    • , Takaho Terada
    • , Noboru Ohsawa
    • , Masakatsu Hato
    • , Satoshi Ogasawara
    • , Tomoya Hino
    • , Takeshi Murata
    • , So Iwata
    • , Kunio Hirata
    • , Yoshiaki Kawano
    • , Masaki Yamamoto
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  • Article |

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    • Dandan Zhang
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    • , Kaihua Zhang
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    • , Limin Ma
    • , Wenru Zhang
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    • , Hong Liu
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  • Letters

  • Letter |

    Observations of CK Vulpeculae reveal that it is surrounded by molecular gas and dust whose large mass and chemical composition cannot have come from a nova; the best explanation is that this object is the remnant of the merger of two stars.

    • Tomasz Kamiński
    • , Karl M. Menten
    • , Romuald Tylenda
    • , Marcin Hajduk
    • , Nimesh A. Patel
    •  & Alexander Kraus
  • Letter |

    An aluminium-ion battery is reported that can charge within one minute, and offers improved cycle life compared to previous devices; it operates through the electrochemical deposition and dissolution of aluminium at the anode, and the intercalation/de-intercalation of chloroaluminate anions into a novel graphitic-foam cathode.

    • Meng-Chang Lin
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    • , Bingan Lu
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    • , Di-Yan Wang
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    • , Jiang Yang
    • , Bing-Joe Hwang
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  • Letter |

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    • Stephen Barker
    • , James Chen
    • , Xun Gong
    • , Lukas Jonkers
    • , Gregor Knorr
    •  & David Thornalley
  • Letter |

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    • , Nicholas A. J. Graham
    • , Joshua E. Cinner
    • , Shaun K. Wilson
    • , Ivor D. Williams
    • , Joseph Maina
    • , Steven Newman
    • , Alan M. Friedlander
    • , Stacy Jupiter
    • , Nicholas V. C. Polunin
    •  & Tim R. McClanahan

    Special:

  • Letter |

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    • , Barbara Kremeyer
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    • , Heini M. L. Kallio
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    • , Kati Kivinummi
    • , Victoria Goody
    • , Calli Latimer
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    • , Mar Soto
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    • , Annika L. Gable
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    • , Nicolas Erard
    • , Alissa M. Williams
    • , Sun Y. Kim
    • , Steffen Dickopf
    • , J. Chuck Harrell
    • , Andrew D. Smith
    • , Charles M. Perou
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    •  & Simon R. V. Knott
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    • Dohoon Kim
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    • , Kivanc Birsoy
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    • , Jason R. Cantor
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    • , Dan Y. Gui
    • , Manjae Kwon
    • , Shakti H. Ramkissoon
    • , Keith L. Ligon
    • , Seong Woo Kang
    • , Matija Snuderl
    • , Matthew G. Vander Heiden
    •  & David M. Sabatini
  • Letter |

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    • Anna C. Obenauf
    • , Yilong Zou
    • , Andrew L. Ji
    • , Sakari Vanharanta
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    • , Andrew J. Rech
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    • , Erietta Stelekati
    • , Joseph L. Benci
    • , Bihui Xu
    • , Hannah Dada
    • , Pamela M. Odorizzi
    • , Ramin S. Herati
    • , Kathleen D. Mansfield
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    • , Lynn M. Schuchter
    • , Hemant Ishwaran
    • , Rosemarie Mick
    • , Daniel A. Pryma
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    • , Michael D. Feldman
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  • Letter |

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    • J. Marsolier
    • , M. Perichon
    • , J. D. DeBarry
    • , B. O. Villoutreix
    • , J. Chluba
    • , T. Lopez
    • , C. Garrido
    • , X. Z. Zhou
    • , K. P. Lu
    • , L. Fritsch
    • , S. Ait-Si-Ali
    • , M. Mhadhbi
    • , S. Medjkane
    •  & J. B. Weitzman

Corrections

    Corrigenda

  • Corrigendum |

    • Fiona Cuskin
    • , Elisabeth C. Lowe
    • , Max J. Temple
    • , Yanping Zhu
    • , Elizabeth A. Cameron
    • , Nicholas A. Pudlo
    • , Nathan T. Porter
    • , Karthik Urs
    • , Andrew J. Thompson
    • , Alan Cartmell
    • , Artur Rogowski
    • , Brian S. Hamilton
    • , Rui Chen
    • , Thomas J. Tolbert
    • , Kathleen Piens
    • , Debby Bracke
    • , Wouter Vervecken
    • , Zalihe Hakki
    • , Gaetano Speciale
    • , Jose L. Munōz-Munōz
    • , Andrew Day
    • , Maria J. Peña
    • , Richard McLean
    • , Michael D. Suits
    • , Alisdair B. Boraston
    • , Todd Atherly
    • , Cherie J. Ziemer
    • , Spencer J. Williams
    • , Gideon J. Davies
    • , D. Wade Abbott
    • , Eric C. Martens
    •  & Harry J. Gilbert
  • Erratum

  • Erratum |

    • Losee L. Ling
    • , Tanja Schneider
    • , Aaron J. Peoples
    • , Amy L. Spoering
    • , Ina Engels
    • , Brian P. Conlon
    • , Anna Mueller
    • , Till F. Schäberle
    • , Dallas E. Hughes
    • , Slava Epstein
    • , Michael Jones
    • , Linos Lazarides
    • , Victoria A. Steadman
    • , Douglas R. Cohen
    • , Cintia R. Felix
    • , K. Ashley Fetterman
    • , William P. Millett
    • , Anthony G. Nitti
    • , Ashley M. Zullo
    • , Chao Chen
    •  & Kim Lewis
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