Volume 517 Issue 7535, 22 January 2015

The Esquel pallasite � arguably the most beautiful meteorite ever discovered � consists of centimetre-scale gem-quality crystals of the silicate mineral olivine embedded in a metallic matrix of iron-nickel alloy. The pallasites are thought to originate from a ~200 km radius parent body that separated into a liquid metal core surrounded by a rocky silicate mantle shortly after the birth of the Solar System. High-resolution magnetic imaging of the iron–nickel matrix of two pallasites (Esquel and Imilac) by James Bryson et al. reveals a time-series record of magnetic activity on the pallasite parent body, encoded within nanoscale intergrowths of iron-rich and nickel-rich phases. This record captures the dying moments of the magnetic field generated as the liquid core solidified, providing evidence for a long-lasting magnetic dynamo driven by compositional convection. (Esquel image from Natural History Museum, London.)

Editorial

  • Editorial |

    A vital dependence of genetically modified organisms on an artificial nutrient could be a means of preventing their escape into the environment.

  • Editorial |

    A concerted focus on soils will benefit society in untold ways and should be embraced.

  • Editorial |

    The discovery of Beagle 2 on Mars should spur the search for other items lost to science.

World View

Research Highlights

Social Selection

Seven Days

News

Correction

News Feature

  • News Feature |

    By splicing animals together, scientists have shown that young blood rejuvenates old tissues. Now, they are testing whether it works for humans.

    • Megan Scudellari
  • News Feature |

    By firing lasers into the sky, Claire Max has transformed the capabilities of current — and future — telescopes.

    • Ann Finkbeiner

    Special:

Comment

Books & Arts

  • Books & Arts |

    Steven Aftergood appraises a study on the hidden impacts of personal data collection.

    • Steven Aftergood
  • Books & Arts |

    Monya Baker reviews a documentary film profiling two scientists bent on longevity.

    • Monya Baker
  • Books & Arts |

    Barbara Kiser reviews five of the week's best science picks.

    • Barbara Kiser

Correspondence

News & Views

  • News & Views |

    Gold in the +3 oxidation state is scarcely used in catalysis, because the oxidants employed to generate it can damage reactants. An oxidant-free route to gold(III) catalysts reveals their potential. See Article p.449

    • Christopher M. B. K. Kourra
    •  & Nicolai Cramer
  • News & Views |

    The discovery and functional analysis of the protein MEIKIN in mice leads to an evolutionarily conserved model of how chromosome segregation is regulated during a specialized type of cell division called meiosis I. See Article p.466

    • Kikuë Tachibana-Konwalski
  • News & Views |

    A screen of 10,000 bacterial strains, cultured in their normal soil, has uncovered an antibiotic with broad and potent activity. And because the compound targets lipid molecules, developing resistance is probably difficult. See Article p.455

    • Gerard Wright
  • News & Views |

    It emerges that most of the elements heavier than helium are not found in galaxies, where they can be mixed into future stars and planets. Instead, these elements largely reside far from galaxies in ionized gas and dust particles.

    • Molly S. Peeples
  • News & Views |

    A simplified global climate model that keeps track of water as it moves through Earth's water cycle throws fresh light on how the Asian summer monsoon has varied during the past 150,000 years.

    • Bronwen Konecky
  • News & Views |

    Endocytosis is a process by which molecules gain access to a cell. An unusual mode of endocytosis has now been shown to regulate cell signalling, and to be highjacked by bacterial toxins. See Article p.460 & Letter p.493

    • Volker Haucke

Article

  • Article |

    The facile synthesis of a stable Au(III) cationic complex is described; this gold catalyst exhibits hard, oxophilic Lewis acidity, enabling selective conjugate additions and a [2 + 2] cycloaddition reaction.

    • Chung-Yeh Wu
    • , Takahiro Horibe
    • , Christian Borch Jacobsen
    •  & F. Dean Toste
  • Article |

    From a new species of β-proteobacteria, an antibiotic called teixobactin that does not generate resistance has been characterized; the antibiotic has two different lipid targets in different bacterial cell wall synthesis components, which may explain why resistance was not observed.

    • Losee L. Ling
    • , Tanja Schneider
    • , Aaron J. Peoples
    • , Amy L. Spoering
    • , Ina Engels
    • , Brian P. Conlon
    • , Anna Mueller
    • , Till F. Schäberle
    • , Dallas E. Hughes
    • , Slava Epstein
    • , Michael Jones
    • , Linos Lazarides
    • , Victoria A. Steadman
    • , Douglas R. Cohen
    • , Cintia R. Felix
    • , K. Ashley Fetterman
    • , William P. Millett
    • , Anthony G. Nitti
    • , Ashley M. Zullo
    • , Chao Chen
    •  & Kim Lewis
  • Article |

    This study describes a fast, clathrin-independent endocytic pathway mediated by endophilin, dynamin and actin; the pathway is activated by ligand binding to a variety of cargo receptors, and endophilin-mediated endocytosis occurs primarily at the leading edges of cells where lamellipodin and the lipid PtdIns(3,4)P2 ensure endophilin targeting.

    • Emmanuel Boucrot
    • , Antonio P. A. Ferreira
    • , Leonardo Almeida-Souza
    • , Sylvain Debard
    • , Yvonne Vallis
    • , Gillian Howard
    • , Laetitia Bertot
    • , Nathalie Sauvonnet
    •  & Harvey T. McMahon
  • Article |

    The long elusive mammalian meiosis-specific kinetochore factor has been identified in mice; MEIKIN—which plays an equivalent role to the yeast proteins Spo13 and Moa1—ensures mono-orientation, protects sister chromatid cohesion and recruits the kinase PLK1 to the kinetochores.

    • Jihye Kim
    • , Kei-ichiro Ishiguro
    • , Aya Nambu
    • , Bungo Akiyoshi
    • , Shihori Yokobayashi
    • , Ayano Kagami
    • , Tadashi Ishiguro
    • , Alberto M. Pendas
    • , Naoki Takeda
    • , Yogo Sakakibara
    • , Tomoya S. Kitajima
    • , Yuji Tanno
    • , Takeshi Sakuno
    •  & Yoshinori Watanabe

Letter

  • Letter |

    Nanomagnetic imaging has been used to obtain a palaeomagnetic time series of two pallasite meteorites, revealing that their convection was driven by core solidification, which would have caused long-lived magnetic fields in the cores of early Solar System planetary bodies.

    • James F. J. Bryson
    • , Claire I. O. Nichols
    • , Julia Herrero-Albillos
    • , Florian Kronast
    • , Takeshi Kasama
    • , Hossein Alimadadi
    • , Gerrit van der Laan
    • , Francis Nimmo
    •  & Richard J. Harrison
  • Letter |

    Inorganic–organic lead halide perovskite could be efficient when used as the light-harvesting component of solar cells; here incorporation of methylammonium lead bromide into formamidinium lead iodide stabilizes the perovskite and improves the power conversion efficiency of the solar cell up to 17.9 per cent.

    • Nam Joong Jeon
    • , Jun Hong Noh
    • , Woon Seok Yang
    • , Young Chan Kim
    • , Seungchan Ryu
    • , Jangwon Seo
    •  & Sang Il Seok
  • Letter |

    A statistical reassessment of the tide gauge record concludes that sea level rose at a rate of about 1.2 millimetres per year from 1901 to 1990, slightly lower than prior estimates and now consistent with estimates based on individual contributions to sea-level change; the estimates reported here from 1990 onwards are consistent with other work, suggesting that the recent acceleration in sea-level rise is greater than previously thought.

    • Carling C. Hay
    • , Eric Morrow
    • , Robert E. Kopp
    •  & Jerry X. Mitrovica
  • Letter |

    The Ichthyopterygia appeared in the fossil record as fully evolved, aquatic creatures, with nothing known about their transition from land to water, but now some light is shed on this transition by a fossil from the Lower Triassic of southern China of a small, primitive and possibly amphibious ichthyosaur-like creature, close to the common ancestry of ichthyosaurs and the obscure Hupehsuchia, a group of extinct aquatic reptiles known only from southern China.

    • Ryosuke Motani
    • , Da-Yong Jiang
    • , Guan-Bao Chen
    • , Andrea Tintori
    • , Olivier Rieppel
    • , Cheng Ji
    •  & Jian-Dong Huang
  • Letter |

    Whole-exome sequencing is used to compare the mutational landscape of adenomas from three mouse models of non-small-cell lung cancer, induced either by exposure to carcinogens or by genetic mutation of Kras; the results reveal that the two types of tumour have different mutational profiles and adopt different routes to tumour development.

    • Peter M. K. Westcott
    • , Kyle D. Halliwill
    • , Minh D. To
    • , Mamunur Rashid
    • , Alistair G. Rust
    • , Thomas M. Keane
    • , Reyno Delrosario
    • , Kuang-Yu Jen
    • , Kay E. Gurley
    • , Christopher J. Kemp
    • , Erik Fredlund
    • , David A. Quigley
    • , David J. Adams
    •  & Allan Balmain
  • Letter |

    Endophilin-A2 (endoA2) is shown to mediate clathrin-independent endocytosis of Shiga and cholera toxins, and to function in parallel with dynamin and actin in the pulling-force-driven scission of Shiga-toxin-induced tubular structures.

    • Henri-François Renard
    • , Mijo Simunovic
    • , Joël Lemière
    • , Emmanuel Boucrot
    • , Maria Daniela Garcia-Castillo
    • , Senthil Arumugam
    • , Valérie Chambon
    • , Christophe Lamaze
    • , Christian Wunder
    • , Anne K. Kenworthy
    • , Anne A. Schmidt
    • , Harvey T. McMahon
    • , Cécile Sykes
    • , Patricia Bassereau
    •  & Ludger Johannes
  • Letter |

    The mTORC1 complex has been implicated in tumorigenesis owing partially to its ability to increase protein translation; now, mTORC1 activity in the mouse intestine is shown not to be required for normal homeostasis but to be necessary for the triggering of tumorigenesis by APC mutations, suggesting that it could be a good target for the prevention of colorectal cancer in high-risk patients.

    • William J. Faller
    • , Thomas J. Jackson
    • , John R. P. Knight
    • , Rachel A. Ridgway
    • , Thomas Jamieson
    • , Saadia A. Karim
    • , Carolyn Jones
    • , Sorina Radulescu
    • , David J. Huels
    • , Kevin B. Myant
    • , Kate M. Dudek
    • , Helen A. Casey
    • , Alessandro Scopelliti
    • , Julia B. Cordero
    • , Marcos Vidal
    • , Mario Pende
    • , Alexey G. Ryazanov
    • , Nahum Sonenberg
    • , Oded Meyuhas
    • , Michael N. Hall
    • , Martin Bushell
    • , Anne E. Willis
    •  & Owen J. Sansom
  • Letter |

    Here, the predominant murine immunoglobulin G subclass, IgG1, which is a poor activator of effector mechanisms, is shown to have a regulatory function, protecting against the development of IgG3 immune-complex-driven renal disease by competing with IgG3 for antigen and increasing immune complex solubility.

    • Richard T. Strait
    • , Monica T. Posgai
    • , Ashley Mahler
    • , Nathaniel Barasa
    • , Chaim O. Jacob
    • , Jörg Köhl
    • , Marc Ehlers
    • , Keith Stringer
    • , Shiva Kumar Shanmukhappa
    • , David Witte
    • , Md Monir Hossain
    • , Marat Khodoun
    • , Andrew B. Herr
    •  & Fred D. Finkelman
  • Letter |

    X-ray crystallography and EPR spectroscopy are used to characterize a soluble, oxygen-tolerant reductive dehalogenase from Nitratireductor pacificus pht-3B; the data suggest that the cobalt in the cobalamin cofactor ligates the halogen atom of the substrate, directly abstracting the halogen atom via an oxidative addition.

    • Karl A. P. Payne
    • , Carolina P. Quezada
    • , Karl Fisher
    • , Mark S. Dunstan
    • , Fraser A. Collins
    • , Hanno Sjuts
    • , Colin Levy
    • , Sam Hay
    • , Stephen E. J. Rigby
    •  & David Leys

Feature

Q&A

Futures

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