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Volume 480 Issue 7376, 8 December 2011

The metre-long swimming invertebrate Anomalocaris was the top predator in the Cambrian ocean more than 500 million years ago. Recent discoveries of fly-like compound eyes attributable to this creature confirm suggestions that it is related to the arthropods — jointed-limbed creatures such as insects, crustaceans and trilobites — and show that compound eyes evolved before hardened exoskeletons. The superbly preserved fossils from South Australia show that Anomalocaris had exceptional vision. Its compound eyes are among the largest and most acute to have ever existed; each eye is up to 3 centimetres long and contains more than 16,000 lenses. The existence of highly visual hunters during the Cambrian would have accelerated the pace of the predator–prey 'arms race' then under way. Illustration: Katrina Kenny/University of Adelaide.

Editorial

  • With the Leveson inquiry scrutinizing journalistic practice in the United Kingdom, scientists should take the opportunity to fight back against agenda-driven reporting.

    Editorial

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  • Protected areas are only the start of the road to reforming our relationship with the seas.

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  • There are bigger things in the Universe than our earthly worries. Much bigger.

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World View

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Seven Days

  • The week in science: Europe’s €80-billion research budget; Brazilian deforestation falls to record low; and Kepler finds a potentially habitable planet outside our Solar System.

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Comment

  • Greater global cooperation is needed to avert the risk of further militarization, says James Clay Moltz.

    • James Clay Moltz
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  • Social media hold a treasure trove of information. But the secretive methods of ethics review boards are hindering their analysis, says Alexander Halavais.

    • Alexander Halavais
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Books & Arts

  • Chris Loss savours a wide-ranging exploration of flavour that takes in evolution and physiology — and suggests it could be key to a healthier future.

    • Chris Loss
    Books & Arts
  • Theoretical chemist, poet and playwright Roald Hoffmann won a Nobel prize in 1981 for his work on how molecules change as they react. As the International Year of Chemistry comes to a close and he releases two books, Hoffmann talks about language, ethics and the sublime.

    • Jascha Hoffman
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  • Compounds containing the trifluoromethyl group have many uses, but their isomers must often be made using different multi-step routes. Two studies now show how several isomers can be made by the same route. See Letter p.224

    • Andrew T. Parsons
    • Stephen L. Buchwald
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  • The molecular clock machinery regulates organisms' responses to daily variations in the environment. One unexpected response seems to be temporal fine-tuning of stem-cell behaviour in the skin. See Article p.209

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    • Paolo Sassone-Corsi
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  • A combination of ground-based and spacecraft observations has uncovered two black holes of 10 billion solar masses in the nearby Universe. The finding sheds light on how these cosmic monsters co-evolve with galaxies. See Letter p.215

    • Michele Cappellari
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  • The idea that gene variants alone control an organism's traits is overly simple. A study of the effects of gene interactions on the outcomes of random variation in gene expression reveals the complex reality. See Letter p.250

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    • Jonathan S. Weissman
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  • Will a sense of touch similar to that of humans ever be developed in robots? Results on the physics of friction for fingerprint-like ridges sliding across textured surfaces may lead the way to tactile robotic sensors.

    • C. Mathew Mate
    • Robert W. Carpick
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  • Cancer cells ignore oxygen availability, opting for less efficient, anaerobic ways of generating energy. The wisdom behind this choice seems to be in preventing the accumulation of reactive oxygen species, and so oxidative damage.

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    • Markus Ralser
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Correction

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Review Article

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Article

  • A meta-analysis of genome-wide association studies in more than 66,000 individuals identifies 68 new genomic loci that reliably associate with platelet count and volume, and reveals new gene functions.

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    • Aparna Radhakrishnan
    • Nicole Soranzo
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  • The circadian clock fine-tunes the activation state of epidermal stem cells by regulating their ability to respond to their microenvironment; perturbation of this clock affects long-term tissue homeostasis and predisposition to tumorigenesis.

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    • Gloria Pascual
    • Salvador Aznar Benitah
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  • Europe's largest economy is boosting research on alternative energy sources and generating job opportunities.

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  • There is something to be said for letting go of the mantle of expert, argues Peter Fiske.

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Career Brief

  • Number of US doctorates awarded falls for first time in eight years.

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Futures

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Brief Communications Arising

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Outlook

  • Richard Webby studies the ecology of influenza, trying to better understand how certain strains of influenza can leap across the species divide from animals to people. Nature Outlook sat down with him to learn more about his research.

    • Richard Webby
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  • As researchers map the stable parts of the proteins that stud the surface of influenza, the decades-long quest for a universal flu vaccine is showing signs of progress.

    • Jana Schlütter
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  • Antiviral treatments are a critical component of an effective healthcare response to influenza, but drug resistance to the treatment-of-choice has public health officials searching for other options.

    • Roxanne Palmer
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  • The 2009 pandemic arrived suddenly and lethally, exposing our plans to reality. Are we now better prepared?

    • Laura Vargas Parada
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  • Some people get horribly sick from the flu, and even die. Others just rest for a few days. What's behind this fateful variation?

    • Christine Junge
    Outlook
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Nature Outlook

  • Our centuries-old battle against influenza occasionally erupts into mass death — the 1918 pandemic alone killed at least 50 million people. What makes this virus such a tough foe is its ability to mutate so that vaccines and drugs quickly become obsolete. Can new research offer hope for defeating this pathogen for good?

    Nature Outlook
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