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Volume 474 Issue 7350, 9 June 2011

This issue covers some of the hottest topics in stem-cell research. A News and Views article discusses the discovery that induced pluripotent stem (iPS) cells can be immunogenic. Other research articles identify an immune-privileged site in bone-marrow stem cells; a new pathway for the generation of haematopoietic stem cells; and a replacement iPS-cell inducing transcription factor for the cancer-causing c-Myc. And an article published online has identified a peptide that can stimulate progenitor cells to act as a source of new cardiomyocytes. Cover inset: D. Waters/Getty.


  • Editorial |

    National cybersecurity plans should go beyond the cold-war mentality of an arms race and focus more on linking traditional computer security with protections for industrial control systems.

  • Editorial |

    Leaders must end a run of unmet pledges when they meet to discuss sustainable development.

  • Editorial |

    The crisis at Fukushima Daiichi should spark a rethink of nuclear-research programmes.

World View

Research Highlights

Seven Days


News Q&A

  • News Q&A |

    Yusuke Nakamura explains the purpose of his fledgling biomedical office.

    • David Cyranoski


News Feature

  • News Feature |

    David Sloan Wilson is using the lens of evolution to understand life in the struggling city of Binghamton, New York. Next, he wants to improve it.

    • Emma Marris


  • Comment |

    Researchers must collaborate to manage one of the planet's most precious and threatened resources — for food production and much more, says Steve Banwart.

    • Steve Banwart
  • Comment |

    Conservationists should assess organisms on environmental impact rather than on whether they are natives, argue Mark Davis and 18 other ecologists.

    • Mark A. Davis
    • Matthew K. Chew
    • John C. Briggs

Books & Arts

  • Books & Arts |

    A hard-hitting book calls for greater transparency to deter the illegal trade in human blood, organs and eggs, finds Laura Spinney.

    • Laura Spinney
  • Books & Arts |

    From geology to mould, the naturalist's publications form a coherent whole, finds Eugenie Scott.

    • Eugenie Scott
  • Books & Arts |

    Dutch artist Christiaan Zwanikken makes computer-controlled mechanical sculptures, many of which use animal skeletons he has found. As a film about Zwanikken's work and life at an isolated Portuguese convent premieres in Edinburgh, UK, he discusses human relationships with other animals and machines.

    • Jascha Hoffman


News & Views

  • News & Views |

    One mathematical model can account for power-law distributions in a variety of systems. Eschewing system-specific assumptions, it utilizes a shared feature of the observed distributions: they all describe the division of items into groups.

    • Lada Adamic
  • News & Views |

    Induced pluripotent stem cells offer promise for patient-specific regenerative therapy. But a study now cautions that, even when immunologically matched, these cells can be rejected after transplantation. See Letter p.212

    • Effie Apostolou
    • Konrad Hochedlinger
  • News & Views |

    Autism spectrum disorders vary greatly in severity. By including children in regular education who received no special help, an epidemiological study has found these disorders to be up to three times more prevalent than thought.

    • Catherine Lord
  • News & Views |

    A combination of vibrational spectroscopy and molecular calculations reveals that only the surface layer of water at the interface with air has a distinctly different structure from the bulk liquid. See Letter p.192

    • Pavel Jungwirth
  • News & Views |

    Is the fruitfly one of the animals that use visual cues to guide navigation and spatial learning? And if so, how does the simple fly brain support spatial memory formation? Some answers are now emerging. See Letter p.204

    • Troy Zars
  • News & Views |

    The wavefunction is a central mathematical entity in quantum physics. It is used to completely describe the state of a system. A means of probing it directly is now on hand. See Letter p.188

    • Onur Hosten
  • News & Views |

    Cyclin D1 is one of the drivers of the cell cycle, and its deregulation may promote the development of tumours. Surprisingly, this protein also mediates the repair of damaged DNA, a mechanism that commonly prevents cancer. See Letter p.230

    • Jiri Bartek
    • Jiri Lukas






  • Futures |

    A sticky problem.

    • John Frizell

Brief Communications Arising


  • Outlook |

    With two recently approved drugs and dozens more in the pipeline, hepatitis C treatment will improve over the next decade.

    • Jana Schlütter
  • Outlook |

    Can doctors calculate a patient's chance of being cured by searching their DNA? Hepatitis C researchers are starting to make this a reality.

    • Amy Maxmen
  • Outlook |

    The hepatitis C virus is endemic among injection drug users, who could harbour treatment-resistant viruses. We need to adapt to this reality, says Diana Sylvestre

    • Diana Sylvestre
  • Outlook |

    Egypt has the highest prevalence of hepatitis C worldwide. And the epidemic will soon peak. Prevention demands political will, ample funding and a change in mindset.

    • Mohammed Yahia
  • Outlook |

    The hepatitis C virus has a set of cunning ways to evade immunity, but researchers are turning the immune system on it.

    • Michael Eisenstein
  • Outlook |

    Results ready in minutes and more efficacious drugs will help find and treat the hundreds of millions of carriers.

    • Sarah DeWeerdt
  • Outlook |

    The scourge of the hepatitis C virus in the United States is woefully underestimated. Brian R. Edlin reckons it's time the infection is given the priority it demands.

    • Brian R. Edlin

Nature Outlook

  • Nature Outlook |

    Hepatitis C

    Infecting around 120 million people worldwide, hepatitis C virus (HCV) is more common than HIV yet it is a neglected epidemic. Diagnosis is hard, treatment is arduous, and there is no vaccine. However, for the first time in decades, new drugs are about to be launched that could substantially improve treatment and herald a new era of HCV awareness.

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