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Volume 473 Issue 7348, 26 May 2011

A suite of News Features, Comment pieces and research papers in this issue focuses on vaccines and vaccination. In a Perspective , Rino Rappuoli and Alan Aderem present a vision for 2020, by which time rationally designed vaccines should be capable of tackling the triple problem of HIV/AIDS, malaria and tuberculosis. In Comment, Julie Leask asks how a greater acceptance of vaccination can be achieved in developed societies (page 443), and Heidi Larson and Isaac Ghinai outline the lessons to be learned from the long battle against polio in the developing world (page 446). In News Features, Roberta Kwok examines recent vaccine safety problems (page 436) and Corie Lok profiles immunologist Bruce Walker and his attempts to overhaul the field of HIV vaccines (page 439). Cover illustration: Serge Bloch.

Volume 473 Issue 7348

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Editorial

  • Graphene is not a miracle material, just a very promising one. It will take restraint and sustained interest to deliver its potential.

    Editorial

    Advertisement

  • A slow university investigation into serious accusations of misconduct benefits no one.

    Editorial

  • The great achievements of vaccines are not consigned to the past.

    Editorial
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World View

  • The European Framework programme, one of the world's largest science funders, has improved its reputation. Not by enough, says Colin Macilwain

    • Colin Macilwain
    World View
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Research Highlights

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Seven Days

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News

  • Researchers drawn by 'mega-grants' find rewards and frustrations in equal measure.

    • Quirin Schiermeier
    News

  • Critics call for restructuring of world health body, together with greater focus on fewer issues.

    • Declan Butler
    News

  • Drug development loses momentum as patients shun clinical trials for tried and tested treatments. Could payment for participation be the answer?

    • Heidi Ledford
    News
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News Feature

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Comment

  • Past waves of vaccine rejection in industrialized nations have a lot to teach us about preventing future ones, argues Julie Leask.

    • Julie Leask
    Comment

  • Ridding the world of polio requires a global initiative that tailors strategies to communities, say Heidi J. Larson and Isaac Ghinai.

    • Heidi J. Larson
    • Isaac Ghinai
    Comment
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Books & Arts

  • Genetics and artificial intelligence figure prominently in an unsettling Dublin exhibition, discovers Anthony King.

    • Anthony King
    Books & Arts
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Correspondence

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News & Views

  • What makes a queen honeybee? The proposal of a definitive answer to this long-standing question offers much royal food for thought for those studying the evolution of social traits and insect genomes. See Article p.478

    • Gene E. Robinson
    News & Views

  • X-rays were discovered more than 100 years ago. They have since become a staple tool for medicine and science, so researchers are continuing their efforts to find innovative ways to produce them.

    • Stefan Kneip
    News & Views

  • Developing AIDS vaccines has been a frustrating business. A vaccine that triggers immune responses that effectively control early infection by the simian counterpart of HIV in macaques seems promising. See Letter p.523

    • R. Paul Johnson
    News & Views

  • The synthesis of conolidine, a scarce, naturally occurring compound, has enabled the first studies of its pharmacological properties to be carried out. Excitingly, conolidine is a painkiller that seems to have an unusual mechanism of action.

    • Sarah E. Reisman
    News & Views

  • One might think that physicists know everything about the electron. But the latest measurement of its shape could alter expectations for results at high-energy particle accelerators. See Letter p.493

    • Aaron E. Leanhardt
    News & Views

  • It seems that Mars had grown to near its present size by 2 million to 4 million years after the Solar System began to form. Such rapid growth explains why the planet is much smaller than Earth and Venus. See Letter p.489

    • Alan Brandon
    News & Views

  • An innovative marriage of techniques, combining the principles of common protein pull-down assays with single-molecule fluorescence microscopy, opens up new ways of visualizing cellular protein complexes. See Article p.484

    • Philip Tinnefeld
    News & Views
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Perspective

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Review Article

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Article

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Letter

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Corrigendum

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Feature

  • A good technician can be vital to a successful lab. But how to become one, and how to select the best in a diverse market?

    • Heidi Ledford
    Feature
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News

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Career Brief

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Futures

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