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Volume 461 Issue 7266, 15 October 2009

Asymmetric division of radial glial progenitors accounts for nearly all neurogenesis in the developing mammalian neocortex. A study of the mouse neocortex shows that this process is regulated by asymmetric inheritance of centrosomes, the main microtubule organizing centres in animal cells, which are intrinsically asymmetrical, made up of older (red in the graphic) and younger (yellow) centrioles. Daughter cells receiving the older of the two centrioles in the main remain in the ventricular zone of the brain’s neocortex to replenish the progenitor pool, while daughter cells receiving the new, duplicated centriole (shown green) tend to migrate into the cortex to differentiate into neurons. Cover graphic: Bokelman & Probst/Xavier Studio.

Authors

Editorial

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Research Highlights

Journal Club

News

News Feature

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Correspondence

Opinion

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    The 'Polymath Project' proved that many minds can work together to solve difficult mathematical problems. Timothy Gowers and Michael Nielsen reflect on the lessons learned for open-source science.

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    • Cameron Neylon

Books & Arts

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    Neuroscientists should worry less about testing abstract qualities such as beauty, and work with art historians towards a concrete understanding of types of viewing, argues Martin Kemp.

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News & Views

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News and Views Q&A

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Editorial

Review Article

Article

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Letter

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Careers Q&A

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Postdoc Journal

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Career Brief

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Insight

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