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Volume 448 Issue 7150, 12 July 2007

Editorial

  • The most suitably qualified person should secure an important post, in almost all instances. But competing interests among nations mean that this is not always the case in Europe.

    Editorial

    Advertisement

  • US research on bioweapons has expanded rapidly, without sufficiently transparent regulation.

    Editorial
  • Is it possible to gauge the true potential of traditional Chinese medicine?

    Editorial
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Research Highlights

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News

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News in Brief

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Column

  • Scientists tend to complain that Congress rarely pays heed to what they have to say. But the issues are often as much about values as they are science, says David Goldston.

    • David Goldston
    Column
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Business

  • As a fast-growing emitter of greenhouse gases, the aviation industry is under intense pressure to improve its fuel efficiency. Kurt Kleiner surveys its options.

    Business
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News Feature

  • Studies of mass extinctions tend to emphasize the sheer scope of the carnage. But subtle differences between the species that died and those that survived can be crucial, finds Nick Lane.

    • Nick Lane
    News Feature
  • Traditional Chinese medicine and Western science face almost irreconcilable differences. Can systems biology bring them together? Jane Qiu reports.

    • Jane Qiu
    News Feature
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Correspondence

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Commentary

  • If scientific culture in the Muslim world has changed since the golden era of Islamic science, so has the practice of Islam. Reintroducing knowledge and creativity requires a revival of both, argues Ziauddin Sardar.

    • Ziauddin Sardar
    Commentary
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Books & Arts

  • Given that humans are here to stay on Earth for some time yet, what can we do to lessen our impact?

    • Stuart L. Pimm
    Books & Arts
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Essay

  • Doctors at the Dutch Trading House on Dejima were a conduit for science into and out of Europe.

    • His Majesty The Emperor of Japan
    Essay
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News & Views

  • Diffraction places a fundamental limit on the smallest scales at which light can be controlled. A nanoscale silver array not only circumvents the barrier, but steers different-coloured light to different places.

    • Niek F. van Hulst
    News & Views
  • During transcription, RNA polymerase catalyses the addition of nucleotides to the growing RNA chain. High-resolution structural snapshots indicate that the polymerase first identifies its substrate, and then incorporates it.

    • Patrick Cramer
    News & Views
  • Is the presence of water a feature common to all gas-giant planets? The first convincing detection of water vapour in the atmosphere of such a planet from outside our Solar System indicates that the answer is yes.

    • Heather A. Knutson
    News & Views
  • Experiments in which related and unrelated plants were grown together reveal the ability of roots to recognize their kin. The ecological and evolutionary implications are tantalizing topics for future studies.

    • Ragan M. Callaway
    • Bruce E. Mahall
    News & Views
  • Perception of cold and hot is one of life's essentials. Three research teams find that, when a temperature-sensing receptor is deleted in mice, the animals lose their response to a range of cold temperatures.

    • Bernd Nilius
    • Thomas Voets
    News & Views
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Article

  • A library of transgenic flies expressing RNAi in a conditional manner, for virtually every gene in the Drosophila melanogaster genome, has been generated. This resource will allow the community to test the function of every gene, in any cell type, at any development stage, or in response to various types of experimental stimulations.

    • Georg Dietzl
    • Doris Chen
    • Barry J. Dickson
    Article
  • Crystal structures of bacterial RNA polymerase elongation complexes bound to NTP substrate analogues with an antibiotic, revealing the mechanism of substrate loading and antibiotic inhibition.

    • Dmitry G. Vassylyev
    • Marina N. Vassylyeva
    • Robert Landick
    Article
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Letter

  • A report of recent observations of the close-in extrasolar giant planet (hot Jupiter) HD 189733b taken during the transit, where the planet passed in front of its parent star. Absorption by water vapour is the most likely cause of the wavelength-dependent variations in the effective radius of the planet.

    • Giovanna Tinetti
    • Alfred Vidal-Madjar
    • Franck Selsis
    Letter
  • A report of the chemical composition of two distinct fragments of comet 73P/Schwassmann–Wachmann 3. The fragments are similar in composition, in contrast to the chemical diversity of comets and contrary to the expectation that short-period comets should show strong compositional variation with depth.

    • N. Dello Russo
    • R. J. Vervack
    • C. M. Lisse
    Letter
  • A powerful new spectroscopic technique (high-resolution time-domain capacitance spectroscopy) for detailed exploration of the energy structure of two-dimensional electron systems (2DES) gives a quantitative and precise view of electron–electron interactions in a 2DES, and reveals several phenomena at energies that cannot be reached with other techniques.

    • O. E. Dial
    • R. C. Ashoori
    • K. W. West
    Letter
  • Marine sediments can switch from being a net sink to a net source of nitrogen. Mesocosm and core incubation experiments, together with a historic data set of mean annual chlorophyll production, suggest that a climate-induced decrease in primary production has led to a decrease in organic matter deposition to the benthos and the observed reversal of the net sediment nitrogen flux.

    • R. W. Fulweiler
    • S. W. Nixon
    • S. L. Granger
    Letter
  • Gravity and bathymetry data from transform fault systems associated with mid-ocean ridges that are spreading at different rates indicates that crustal thickening may occur under transform faults associated with intermediate- and fast-spreading ridges. If confirmed, this observation would require a change in our understanding of how magma accretion occurs along rapidly spreading mid-ocean ridges.

    • Patricia M. Gregg
    • Jian Lin
    • Laurent G. J. Montési
    Letter
  • An analysis of published data from grassland biodiversity experiments looks at the relationship between biodiversity and multiple ecological processes (ecosystem multifunctionality). Different species often influence different ecosystem functions, suggesting that studies considering single ecosystem services in isolation may severely underestimate the levels of biodiversity required for fully functioning ecosystems.

    • Andy Hector
    • Robert Bagchi
    Letter
  • A study revealing that pluripotent stem cells (EpiSCs) can be derived from the late epiblast layer of post-implantation mouse and rat embryos. To achieve this, a chemically defined, activin-containing culture medium known to be sufficient for long-term maintenance of human embryonic stem cells is used. These findings will help to understand the biological provenance of human embryonic stem cells.

    • I. Gabrielle M. Brons
    • Lucy E. Smithers
    • Ludovic Vallier
    Letter
  • Mouse and human embryonic stem (ES) cells use different signalling pathways to maintain their pluripotent status. Now, a new kind of pluripotent ES cell is described. This cell type is derived from mouse embryos after they implant in the wall of the uterus, and shares many defining features with human ES cells, including signalling responses that control differentiation to somatic fates.

    • Paul J. Tesar
    • Josh G. Chenoweth
    • Ronald D. G. McKay
    Letter
  • Membrane ion channels of the P2X class, which are gated by extracellular ATP, have been thought to be an exclusivity of multicellular organisms. Now, a functional P2X receptor in the social amoeba Dictyostelium discoideum has been found. It helps D. discoideum to adapt its cell volume to conditions of salinity. This discovery suggests vastly expanded modes of action for this important class of membrane receptors.

    • Samuel J. Fountain
    • Katie Parkinson
    • R. Alan North
    Letter
  • The identity of the transduction molecules underlying cold sensation has long been a mystery in sensory physiology. Now, using a combination of electrophysiological recording, calcium imaging and behavioural analysis, TRPM8 is shown to have a major role in normal cold transduction in mice.

    • Diana M. Bautista
    • Jan Siemens
    • David Julius
    Letter
  • A report on single topoisomerase molecules in action, showing that topoisomerase inhibitors don't just stabilize an intermediate but actually affect the ability of topoisomerase to relax DNA supercoiling, suggesting a new mechanism by which these drugs cause cytotoxicity.

    • Daniel A. Koster
    • Komaraiah Palle
    • Nynke H. Dekker
    Letter
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Prospects

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Special Report

  • Emerging from scandal and reorganization, Los Alamos National Laboratory hopes to retain talent and remain at the cutting edge. Karen Fox reports.

    • Karen Fox
    Special Report
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Movers

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Networks and Support

  • Everyday workplace culture might be keeping women out of science, engineering and technology fields in Britain.

    • Roger Livesey
    Networks and Support
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Career View

  • Composing a manuscript is a laborious task. Could there be a better way some day?

    • Peter Jordan
    Career View
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Futures

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Authors

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