Volume 441 Issue 7090, 11 May 2006



  • Editorial |

    Science in the Arctic cries out for better coordination — perhaps modelled on what happens in Antarctica.

  • Editorial |

    Some research centres are more equal than others.

  • Editorial |

    US legislation could fill a gap in drought research.

Research Highlights


News in Brief


News Feature

  • News Feature |

    To correctly ‘play’ the DNA score in our genome, cells must read another notation that overlays it — the epigenetic code. A global effort to decode it is now in the making, reports Jane Qiu.

    • Jane Qiu
  • News Feature |

    The Arctic is the bellwether of climate change, which shows up there first and fastest. Quirin Schiermeier visits ecologists struggling to keep up.

    • Quirin Schiermeier



Spring Books

News & Views

  • News & Views |

    One obstacle to realizing the promise of viral vectors for vaccine delivery is pre-existing immunity to such vectors. An adroit application of structure-based design points to a way around that problem.

    • John R. Mascola
  • News & Views |

    Triton, Neptune's largest moon, was probably part of a two-body object similar to the Pluto–Charon system. This tandem might have been ripped apart when it strayed too close to the planet that Triton is now orbiting.

    • Alessandro Morbidelli
  • News & Views |

    A sharp increase in the concentration of calcium ions in a cell is a key biological signal. Now a vital component of a major route by which calcium ions flow into cells has been identified.

    • Anant B. Parekh
  • News & Views |

    The reactivity of inert hydrocarbons can be transformed by a catalytic double act. With the ability to manipulate the lengths of the resulting carbon chains, this development opens up fresh vistas.

    • Robert H. Crabtree
  • News & Views |

    For a long time it was thought that there are only two types of T helper cell. But it is becoming clear that there may be other lineages that influence inflammatory responses in certain circumstances.

    • Cristina M. Tato
    •  & John J. O'Shea
  • News & Views |

    Phase changes in matter generally occur by building up from small nuclei of the new phase. Scattering experiments and computer simulations reveal the characteristic size of the smallest of these nuclei.

    • Pablo G. Debenedetti
  • News & Views |

    Xenon trapped beneath Earth's crust provides clues to how our planet evolved, but quantifying atmospheric contamination has been impossible. The latest analysis surmounts a barrier to our understanding.

    • Takuya Matsumoto

Brief Communication

  • Brief Communication |

    Underwater backswimmers use their haemoglobin to help them stay stationary while waiting for prey.

    • Philip G. D. Matthews
    •  & Roger S. Seymour






  • Prospects |

    Postdoc organization grades institutions

    • Paul Smaglik

Special Report

  • Special Report |

    They arrive from other disciplines; they spread into distant fields. Toxicology is a voyage of discovery for scientists with diverse skills, including those of communication. Ricki Lewis gets them to open up about it.

    • Ricki Lewis


Recruiters and Academia

Graduate Journal

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