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Volume 440 Issue 7082, 16 March 2006


  • Editorial |

    In Italy's election campaign, opposition parties have pledged research reform — but nothing will change until agency chiefs start playing by the rules.

  • Editorial |

    The lack of an accessible store of information is undermining the fight against avian flu.

  • Editorial |

    Nature celebrates a discipline's unheralded achievements.

Research Highlights


News in Brief

News Feature

  • News Feature |

    A series of mental challenges is helping physicists to prepare for the strange data they may get when the next particle accelerator goes live. Jenny Hogan joins the work-out.

    • Jenny Hogan
  • News Feature |

    Studies of medical literature are confirming what many suspected — reporters of clinical trials do not always play straight. Jim Giles talks to those pushing for a fairer deal.

    • Jim Giles
  • News Feature |

    Alison Abbott talks to the man who wants theoretical chemistry to ease political strife in the Middle East.

    • Alison Abbott


  • Business |

    Cases involving long-term users of Vioxx will, as Meredith Wadman reports, determine the true cost to Merck and the drug industry of the painkiller's withdrawal.


Books & Arts

News & Views

  • News & Views |

    When it comes to making shapes out of DNA, the material is there, and its properties are understood. What was missing was a convincing, universal design scheme to allow our capabilities to unfold to the full.

    • Lloyd M. Smith
  • News & Views |

    Abnormal protein clumps of many varieties build up in the brains of individuals with Alzheimer's disease. But which types actually cause memory deficits? The behaviour of model mice might help to find out.

    • Richard Morris
    • Lennart Mucke
  • News & Views |

    A cleverly engineered molecule uses light to generate a charge-separated state and so cause one of its components to move. It's the latest study of a molecular machine that exploits nature's most plentiful energy source.

    • Euan R. Kay
    • David A. Leigh
  • News & Views |

    A fossil dinosaur that ‘nests’ with feathered relations in the dinosaur phylogenetic tree did not, it seems, have feathers. The discovery will encourage a re-evaluation of feather evolution.

    • Xing Xu
  • News & Views |

    Quantum bodies that can't settle down together in pairs get on fine in a cosy threesome. This startling claim about the private life of particles has just seen its first experimental confirmation.

    • Brett D. Esry
    • Chris H. Greene
  • News & Views |

    Pharmacist and natural-products chemist, who devised widely used treatments for cancer.

    • François Chast

News and Views Feature

  • News and Views Feature |

    How did dinosaurs stand and move? Computer simulation and other methods have told us much about how dinosaurs did and did not move, but they have not yet reached their full potential.

    • John R. Hutchinson
    • Stephen M. Gatesy

Brief Communication

  • Brief Communication |

    Enhancing catalytic performance holds promise for hydrogen production by water splitting in sunlight.

    • Kazuhiko Maeda
    • Kentaro Teramura
    • Kazunari Domen


  • Article |

    A robust, versatile, one-pot bottom-up nanotechnology fabrication method uses a few-hundred short DNA strands to 'staple' a very long strand into two-dimensional structures of 100 nm in diameter and resembling any desired shape, such as squares, 'nanofaces' and stars.

    • Paul W. K. Rothemund
  • Article |

    A combination of mutant phenotype analysis, genome comparisons and proteomics has elucidated the metabolic network of Salmonella during typhoid fever and enteritis infections. Owing to many redundant pathways, Salmonella metabolism is surprisingly robust, thus severely limiting the number of new drug targets.

    • Daniel Becker
    • Matthias Selbach
    • Dirk Bumann



  • Prospects |

    Technicians' roles deserve a closer look.

    • Paul Smaglik

Special Report

  • Special Report |

    Industry's need to reduce waste and deal with the environmental concerns of consumers is creating demand for cleaner catalysis, says Virginia Gewin.

    • Virginia Gewin


Recruiters and Academia

Graduate Journal



  • Authors |

    Four years' hard labour earned a picture of gene activity in single cells.

Brief Communications Arising

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