Volume 435 Issue 7038, 5 May 2005

Volume 435 Issue 7038

Editorials

  • Editorial |

    The study of functioning groups of molecules is an important frontier of biology at reductionist and holistic levels. Central to the long-term goals of scientific research, it brings its own challenges of infrastructure and evaluation.

News

News in Brief

Features

  • News Feature |

    Are wafers of silicon that support cells cultured from vital organs the future of drug testing and toxicology? Roxanne Khamsi talks to the pioneers creating model animals — and humans — on a chip.

    • Roxanne Khamsi
  • News Feature |

    Growing numbers of people are being implanted with electronic devices that can automatically restart a failing heart. But have the risks and benefits been adequately assessed? Duncan Graham-Rowe investigates.

    • Duncan Graham-Rowe

Correspondence

Spring Books

News & Views

  • News & Views |

    Lurking in the rivers of Botswana are the remnants of a diverse flock of cichlid fishes, whose origins can be traced to a lake that vanished more than 2,000 years ago.

    • Thomas D. Kocher
  • News & Views |

    Morphogen proteins guide the development of many tissues in animals, but how are these insoluble proteins ferried around the body? A well-known group of lipid transporters might be the answer.

    • Richard S. Mann
    •  & Joaquim Culi
  • News & Views |

    Data from the Cassini–Huygens mission provide convincing evidence that the saturnian moon Phoebe formed elsewhere in the Solar System, and was only later captured by Saturn's gravitational pull.

    • J. Brad Dalton
  • News & Views |

    A short delay in the attachment of embryos to the wall of the womb during early pregnancy adversely affects later developmental processes. New evidence reinforces the need for lipids to regulate this event.

    • S. K. Dey
  • News & Views |

    The topology of amorphous glasses has generally been considered only at the level of atoms and their nearest neighbours. A larger-scale view gives a fresh perspective on the structure and formation of these glasses.

    • Paul Madden
  • News & Views |

    In one example of a feedback mechanism in mammals, cells switch cholesterol synthesis on or off depending on the availability of sterol. A rewired version of this pathway in yeast acts instead as an oxygen sensor.

    • Renee M. Garza
    •  & Randolph Y. Hampton

Research Highlights

Brief Communications

Articles

  • Article |

    • L. Eichinger
    • , J. A. Pachebat
    • , G. Glöckner
    • , M.-A. Rajandream
    • , R. Sucgang
    • , M. Berriman
    • , J. Song
    • , R. Olsen
    • , K. Szafranski
    • , Q. Xu
    • , B. Tunggal
    • , S. Kummerfeld
    • , M. Madera
    • , B. A. Konfortov
    • , F. Rivero
    • , A. T. Bankier
    • , R. Lehmann
    • , N. Hamlin
    • , R. Davies
    • , P. Gaudet
    • , P. Fey
    • , K. Pilcher
    • , G. Chen
    • , D. Saunders
    • , E. Sodergren
    • , P. Davis
    • , A. Kerhornou
    • , X. Nie
    • , N. Hall
    • , C. Anjard
    • , L. Hemphill
    • , N. Bason
    • , P. Farbrother
    • , B. Desany
    • , E. Just
    • , T. Morio
    • , R. Rost
    • , C. Churcher
    • , J. Cooper
    • , S. Haydock
    • , N. van Driessche
    • , A. Cronin
    • , I. Goodhead
    • , D. Muzny
    • , T. Mourier
    • , A. Pain
    • , M. Lu
    • , D. Harper
    • , R. Lindsay
    • , H. Hauser
    • , K. James
    • , M. Quiles
    • , M. Madan Babu
    • , T. Saito
    • , C. Buchrieser
    • , A. Wardroper
    • , M. Felder
    • , M. Thangavelu
    • , D. Johnson
    • , A. Knights
    • , H. Loulseged
    • , K. Mungall
    • , K. Oliver
    • , C. Price
    • , M. A. Quail
    • , H. Urushihara
    • , J. Hernandez
    • , E. Rabbinowitsch
    • , D. Steffen
    • , M. Sanders
    • , J. Ma
    • , Y. Kohara
    • , S. Sharp
    • , M. Simmonds
    • , S. Spiegler
    • , A. Tivey
    • , S. Sugano
    • , B. White
    • , D. Walker
    • , J. Woodward
    • , T. Winckler
    • , Y. Tanaka
    • , G. Shaulsky
    • , M. Schleicher
    • , G. Weinstock
    • , A. Rosenthal
    • , E. C. Cox
    • , R. L. Chisholm
    • , R. Gibbs
    • , W. F. Loomis
    • , M. Platzer
    • , R. R. Kay
    • , J. Williams
    • , P. H. Dear
    • , A. A. Noegel
    • , B. Barrell
    •  & A. Kuspa

Letters

Naturejobs

Futures

  • Futures |

    A growth industry.

    • Paul McAuley

Corrigendum

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing