Volume 430 Issue 7003, 26 August 2004


  • Editorial |

    The US National Institutes of Health is toughening its funding rules to persuade researchers to share materials more widely. The move is commendable but it raises critical questions that urgently require resolution.

  • Editorial |

    The biotech industry's top lobbyist faces a problem he was quick to raise as a Congressman: apparent conflict of interest.


News in Brief


  • News Feature |

    Hiroaki Serizawa's promising US academic career was ruined when a favour to a friend led to him being charged with economic espionage on behalf of Japan. He tells his story to David Cyranoski.

    • David Cyranoski
  • News Feature |

    Ever woken up with the answer to a problem that had seemed insoluble the night before, or able to perform a task that had previously taxed your skills? We may soon know why, says Laura Nelson.

    • Laura Nelson


Books and Arts



  • Essay |

    Reversible computation: how feasible is a computer that is both logically and physically reversible?

    • Seth Lloyd

News & Views

  • News & Views |

    A protein has been identified that enables cells to survive when dislodged from their substrate, and to migrate to new sites in the body. Such a mechanism might give cancer cells a significant advantage.

    • Lance A. Liotta
    •  & Elise Kohn
  • News & Views |

    Silicon carbide is a highly desirable material for high-power electronic devices — more desirable even than silicon. And now the problem of producing large, pure wafers of the carbide could be solved.

    • Roland Madar
  • News & Views |

    Kinship fosters the evolution of cooperation. However, a once-heretical theory and an unconventional social organism show that the cooperation-enhancing effect of kinship is sometimes negated.

    • David C. Queller
  • News & Views |

    The future for intracellular imaging looks bright with the development of fluorescent probes made entirely of RNA. The cunning design exploits structural attributes of RNA to detect a variety of small molecules.

    • Michael Famulok
  • News & Views |

    Whether a protein can transmit disease in mammals has been an open question for some time. The latest test of this idea provides some strong evidence in favour, but is unlikely to end the debate.

    • Herman K. Edskes
    •  & Reed B. Wickner
  • News & Views |

    Which came first, the stars and gas that make up a galaxy, or the giant black hole at its centre? Observations of a distant galaxy, caught as it forms, could help solve this chicken-and-egg problem.

    • Zoltán Haiman
  • News & Views |

    Activation-induced deaminase catalyses two processes that diversify antibodies. But this enzyme need not work alone: a partner links it to its substrate — single-stranded DNA — and to DNA-repair molecules.

    • Almudena R. Ramiro
    •  & Michel C. Nussenzweig

Research Highlights

Brief Communications






  • Careers and Recruitment

  • Careers and Recruitment |

    As Western lifestyles spread around the world, diabetes has become an epidemic. Improved treatments are desperately needed, and the funding is there for those who may be able to help, says Ricki Lewis.

    • Ricki Lewis



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