Volume 430 Issue 7002, 19 August 2004


  • Editorial |

    With the death of Francis Crick, biology is mourning one of its deepest thinkers. A work of futurology, published in 1970, reveals the extent of his prescience — and suggests challenges for today's theorists.

  • Editorial |

    Americans should worry less about their neighbour and more about the prestige of regulators who protect public health.


News in Brief


  • News Feature |

    CERN, the centre for particle physics in Europe, has been smashing its way through the subatomic world for the past 50 years. Alison Abbott finds out what's in store for the future.

    • Alison Abbott
  • News Feature |

    Archaeologists have failed to learn the secrets of Mexico's largest ancient monument. Particle physicists might save the day, says Michael Hopkin.

    • Michael Hopkin



  • Commentary |

    How to create a research council that is a Champions League for science.

    • Robert M. May

Books and Arts


    Turning points

News & Views

  • News & Views |

    By taking advantage of the cell's carbohydrate metabolism, reactive sugar analogues can be used to tag specific cells, potentially singling them out for imaging studies or drug delivery.

    • David A. Tirrell
  • News & Views |

    A remarkable set of antimalarial drug candidates has been developed by an international collaboration of scientists, using the age-old Chinese herbal medicine artemisinin as a template.

    • Paul M. O'Neill
  • News & Views |

    In high-temperature superconductors, quantized vortex filaments can be twisted up into a DNA-like double helix. An experiment is proposed to test how easily these vortex lines cut through each other.

    • David R. Nelson
  • News & Views |

    During cell division everything must happen at the right time, or errors occur. A common cellular control device, protein phosphorylation, is now shown to time the assembly of a key part of the division machinery.

    • Bruce Bowerman
  • News & Views |

    During the last glacial period, climatic variation in the Northern and Southern Hemispheres was evidently linked. Modelling work points to freshwater discharge into the North Atlantic as a driving factor.

    • Trond M. Dokken
    •  & Kerim H. Nisancioglu
  • News & Views |

    An atomic picture of how anthrax toxin binds to its host's cells reveals that the toxin commandeers a host receptor protein and tricks it into helping the toxin enter the cell.

    • James G. Bann
    •  & Scott J. Hultgren
  • News & Views |

    Alexander Rich and Charles F. Stevens, respectively an early collaborator of Crick's and a long-standing colleague at the Salk Institute, describe the life and work of one of the great thinkers of twentieth-century biology.

    • Alexander Rich
    •  & Charles F. Stevens

Research Highlights

Brief Communications







  • Outlook |

    “It is high time we addressed the widening inequities that characterize our planet today. We need to focus our energies towards achieving basic healthcare for all.” Pascoal Mocumbi, former prime minister of Mozambique

    • Pascoal Mocumbi
  • Outlook |

    Campaigns against malaria are multiplying, but so are malaria deaths. Brian Greenwood asks what can be done to turn the tide.

    • Brian Greenwood
  • Outlook |

    In Africa, where malaria hits hardest, scientists are crying out for countries to take matters into their own hands, says Declan Butler.

    • Declan Butler
  • Outlook |

    To win the fight against malaria we will need to scale up existing programmes and develop new weapons, say Richard Klausner and Pedro Alonso.

    • Richard Klausner
    •  & Pedro Alonso
  • Outlook |

    International agencies have failed to meet their own malaria performance targets and should be held to account, says Amir Attaran.

    • Amir Attaran
  • Outlook |

    We need to know how bad the malaria situation is before we can make it better, says Robert Snow.

    • Robert W. Snow
  • Outlook |

    The malaria vector is back in scientists' sights, says Janet Hemingway, with insecticides and transgenic insects offering fresh hope.

    • Janet Hemingway
  • Outlook |

    Documentary makers can get as close to the war zones of disease as doctors and researchers — perhaps even closer. Julie Clayton and Declan Butler talk to Kevin Hull about his experiences.

    • Julie Clayton
    •  & Declan Butler
  • Outlook |

    The world must increase collaboration to meet the pressing need for a malaria vaccine, argue Carter Diggs, Sarah Ewart and Melinda Moree.

    • Melinda Moree
    • , Sarah Ewart
    •  & Carter Diggs
  • Outlook |

    Creating a malaria vaccine will be tough. But Africa needs one now more than ever, says Stephen Hoffman.

    • Stephen Hoffman
  • Outlook |

    We have the science to make new antimalarials, say Robert Ridley and Yeya Toure, but we need better mechanisms and resources to develop drugs and deliver them.

    • Robert Ridley
    •  & Yeya Toure
  • Outlook |

    The malaria and mosquito genomes will allow us to find new drug and vaccine targets, says Daniel Carucci.

    • Daniel Carucci



  • Careers and Recruitment

  • Careers and Recruitment |

    Chemical biology, using chemical tools to solve biological problems, is awakening interest among students and creating a new breed of researcher, says Tim Chapman.

    • Tim Chapman



Nature Outlook

  • Nature Outlook |


    Malaria: The long road to a healthy Africa. The Naturezeroes in on the major issues in the war on malaria, with a particular focus on Africa. It analyses the current state of affairs, the major scientific and other obstacles in treatment and control, and the promising areas where substantial progress might be made.

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing