Volume 409 Issue 6822, 15 February 2001

Opinion

  • Opinion |

    The burgeoning commercial sector that is based on genome information poses a challenge to the norms of scientific publication. But it remains to be established that the conditions of access to published sequence data need to change.

News

News in Brief

News Feature

  • News Feature |

    The focus of activity in high-energy physics is about to switch from CERN, near Geneva, to Fermilab in Illinois. Sarah Tomlin sampled the atmosphere, as excited physicists prepared their Tevatron accelerator for action.

    • Sarah Tomlin
  • News Feature |

    The draft human genome sequence published in Nature this week is the culmination of 15 years of work, involving 20 sequencing centres in six countries. Here, we present a reminder of some of the key moments.

  • News Feature |

    If biologists do not adapt to the powerful computational tools needed to exploit huge data sets, says Declan Butler, they could find themselves floundering in the wake of advances in genomics.

    • Declan Butler

Correspondence

Commentary

  • Commentary |

    The present patent system risks becoming a barrier to medical progress.

    • Martin Bobrow
    •  & Sandy Thomas

Book Review

Words

  • Words |

    Biologists must take responsibility for the correct use of language in genetics.

    • Horace Freeland Judson

Concepts

News & Views

  • News & Views |

    The idea of materials that can mend themselves seems far-fetched. But a system that allows composite materials to 'self-heal' has been devised and has passed some early tests.

    • Richard P. Wool
  • News & Views |

    Direct experimental evidence to resolve the conflict between classical and quantum physics has been a long-awaited goal. As the last loophole closes, it seems that quantum mechanics was right all along.

    • Philippe Grangier
  • News & Views |

    Some plants depend on specific animal vectors for the dispersal of their seeds. If the vector comes under threat, there are likely to be adverse consequences for the plant.

    • Peter D. Moore
  • News & Views |

    Our bodies use only 'left-handed' amino acids and 'right-handed' sugars. Hints are now emerging on how this handedness evolved and how cooperativity among like-handed molecular components came about.

    • Jay S. Siegel
  • News & Views |

    Osteopetrosis is a disease characterized by the malfunctioning of bone-resorbing cells. A chloride channel that is crucial for these cells to function has now been identified.

    • Amanda Tromans
  • News & Views |

    Konrad E. Bloch (1912–2000) — research chemist who outlined the path of cholesterol synthesis.

    • Howard Goldfine
    •  & Dennis E. Vance

Brief Communication

Erratum

Article

Letter

Foreword

News & Views

  • News & Views |

    • Peer Bork
    •  &  Richard Copley
  • News & Views |

    The draft sequences of the human genome are remarkable achievements. They provide an outline of the information needed to create a human being and show, for the first time, the overall organization of a vertebrate's DNA.

    • David Baltimore
  • News & Views |

    The public project's sequencing strategy involved producing a map of the human genome, and then pinning sequence to it. This helps to avoid errors in the sequence, especially in repetitive regions.

    • Maynard V. Olson
  • News & Views |

    Two rough drafts of the human genome sequence are now published. Completion of the sequences lies ahead, but the implications for studying human diseases and for biotechnology are already profound.

    • Peer Bork
    •  & Richard Copley
  • News & Views |

    Comparing the human genome sequences with those of other species will not only reveal what makes us genetically different. It may also help us understand what our genes do.

    • Gerald M. Rubin
  • News & Views |

    Single nucleotide polymorphisms are the bread-and-butter of DNA sequence variation. They provide a rich source of information about the evolutionary history of human populations.

    • Mark Stoneking
  • News & Views |

    Single base differences between human genomes underlie differences in susceptibility to, or protection from, a host of diseases. Hence the great potential of such information in medicine.

    • Aravinda Chakravarti

Analysis

Article

  • Article |

    • Eric S. Lander
    • , Lauren M. Linton
    • , Bruce Birren
    • , Chad Nusbaum
    • , Michael C. Zody
    • , Jennifer Baldwin
    • , Keri Devon
    • , Ken Dewar
    • , Michael Doyle
    • , William FitzHugh
    • , Roel Funke
    • , Diane Gage
    • , Katrina Harris
    • , Andrew Heaford
    • , John Howland
    • , Lisa Kann
    • , Jessica Lehoczky
    • , Rosie LeVine
    • , Paul McEwan
    • , Kevin McKernan
    • , James Meldrim
    • , Jill P. Mesirov
    • , Cher Miranda
    • , William Morris
    • , Jerome Naylor
    • , Christina Raymond
    • , Mark Rosetti
    • , Ralph Santos
    • , Andrew Sheridan
    • , Carrie Sougnez
    • , Nicole Stange-Thomann
    • , Nikola Stojanovic
    • , Aravind Subramanian
    • , Dudley Wyman
    • , Jane Rogers
    • , John Sulston
    • , Rachael Ainscough
    • , Stephan Beck
    • , David Bentley
    • , John Burton
    • , Christopher Clee
    • , Nigel Carter
    • , Alan Coulson
    • , Rebecca Deadman
    • , Panos Deloukas
    • , Andrew Dunham
    • , Ian Dunham
    • , Richard Durbin
    • , Lisa French
    • , Darren Grafham
    • , Simon Gregory
    • , Tim Hubbard
    • , Sean Humphray
    • , Adrienne Hunt
    • , Matthew Jones
    • , Christine Lloyd
    • , Amanda McMurray
    • , Lucy Matthews
    • , Simon Mercer
    • , Sarah Milne
    • , James C. Mullikin
    • , Andrew Mungall
    • , Robert Plumb
    • , Mark Ross
    • , Ratna Shownkeen
    • , Sarah Sims
    • , Robert H. Waterston
    • , Richard K. Wilson
    • , LaDeana W. Hillier
    • , John D. McPherson
    • , Marco A. Marra
    • , Elaine R. Mardis
    • , Lucinda A. Fulton
    • , Asif T. Chinwalla
    • , Kymberlie H. Pepin
    • , Warren R. Gish
    • , Stephanie L. Chissoe
    • , Michael C. Wendl
    • , Kim D. Delehaunty
    • , Tracie L. Miner
    • , Andrew Delehaunty
    • , Jason B. Kramer
    • , Lisa L. Cook
    • , Robert S. Fulton
    • , Douglas L. Johnson
    • , Patrick J. Minx
    • , Sandra W. Clifton
    • , Trevor Hawkins
    • , Elbert Branscomb
    • , Paul Predki
    • , Paul Richardson
    • , Sarah Wenning
    • , Tom Slezak
    • , Norman Doggett
    • , Jan-Fang Cheng
    • , Anne Olsen
    • , Susan Lucas
    • , Christopher Elkin
    • , Edward Uberbacher
    • , Marvin Frazier
    • , Richard A. Gibbs
    • , Donna M. Muzny
    • , Steven E. Scherer
    • , John B. Bouck
    • , Erica J. Sodergren
    • , Kim C. Worley
    • , Catherine M. Rives
    • , James H. Gorrell
    • , Michael L. Metzker
    • , Susan L. Naylor
    • , Raju S. Kucherlapati
    • , David L. Nelson
    • , George M. Weinstock
    • , Yoshiyuki Sakaki
    • , Asao Fujiyama
    • , Masahira Hattori
    • , Tetsushi Yada
    • , Atsushi Toyoda
    • , Takehiko Itoh
    • , Chiharu Kawagoe
    • , Hidemi Watanabe
    • , Yasushi Totoki
    • , Todd Taylor
    • , Jean Weissenbach
    • , Roland Heilig
    • , William Saurin
    • , Francois Artiguenave
    • , Philippe Brottier
    • , Thomas Bruls
    • , Eric Pelletier
    • , Catherine Robert
    • , Patrick Wincker
    • , André Rosenthal
    • , Matthias Platzer
    • , Gerald Nyakatura
    • , Stefan Taudien
    • , Andreas Rump
    • , Douglas R. Smith
    • , Lynn Doucette-Stamm
    • , Marc Rubenfield
    • , Keith Weinstock
    • , Hong Mei Lee
    • , JoAnn Dubois
    • , Huanming Yang
    • , Jun Yu
    • , Jian Wang
    • , Guyang Huang
    • , Jun Gu
    • , Leroy Hood
    • , Lee Rowen
    • , Anup Madan
    • , Shizen Qin
    • , Ronald W. Davis
    • , Nancy A. Federspiel
    • , A. Pia Abola
    • , Michael J. Proctor
    • , Bruce A. Roe
    • , Feng Chen
    • , Huaqin Pan
    • , Juliane Ramser
    • , Hans Lehrach
    • , Richard Reinhardt
    • , W. Richard McCombie
    • , Melissa de la Bastide
    • , Neilay Dedhia
    • , Helmut Blöcker
    • , Klaus Hornischer
    • , Gabriele Nordsiek
    • , Richa Agarwala
    • , L. Aravind
    • , Jeffrey A. Bailey
    • , Alex Bateman
    • , Serafim Batzoglou
    • , Ewan Birney
    • , Peer Bork
    • , Daniel G. Brown
    • , Christopher B. Burge
    • , Lorenzo Cerutti
    • , Hsiu-Chuan Chen
    • , Deanna Church
    • , Michele Clamp
    • , Richard R. Copley
    • , Tobias Doerks
    • , Sean R. Eddy
    • , Evan E. Eichler
    • , Terrence S. Furey
    • , James Galagan
    • , James G. R. Gilbert
    • , Cyrus Harmon
    • , Yoshihide Hayashizaki
    • , David Haussler
    • , Henning Hermjakob
    • , Karsten Hokamp
    • , Wonhee Jang
    • , L. Steven Johnson
    • , Thomas A. Jones
    • , Simon Kasif
    • , Arek Kaspryzk
    • , Scot Kennedy
    • , W. James Kent
    • , Paul Kitts
    • , Eugene V. Koonin
    • , Ian Korf
    • , David Kulp
    • , Doron Lancet
    • , Todd M. Lowe
    • , Aoife McLysaght
    • , Tarjei Mikkelsen
    • , John V. Moran
    • , Nicola Mulder
    • , Victor J. Pollara
    • , Chris P. Ponting
    • , Greg Schuler
    • , Jörg Schultz
    • , Guy Slater
    • , Arian F. A. Smit
    • , Elia Stupka
    • , Joseph Szustakowki
    • , Danielle Thierry-Mieg
    • , Jean Thierry-Mieg
    • , Lukas Wagner
    • , John Wallis
    • , Raymond Wheeler
    • , Alan Williams
    • , Yuri I. Wolf
    • , Kenneth H. Wolfe
    • , Shiaw-Pyng Yang
    • , Ru-Fang Yeh
    • , Francis Collins
    • , Mark S. Guyer
    • , Jane Peterson
    • , Adam Felsenfeld
    • , Kris A. Wetterstrand
    • , Richard M. Myers
    • , Jeremy Schmutz
    • , Mark Dickson
    • , Jane Grimwood
    • , David R. Cox
    • , Maynard V. Olson
    • , Rajinder Kaul
    • , Christopher Raymond
    • , Nobuyoshi Shimizu
    • , Kazuhiko Kawasaki
    • , Shinsei Minoshima
    • , Glen A. Evans
    • , Maria Athanasiou
    • , Roger Schultz
    • , Aristides Patrinos
    •  & Michael J. Morgan
  • Article |

    • D. D. Shoemaker
    • , E. E. Schadt
    • , C. D. Armour
    • , Y. D. He
    • , P. Garrett-Engele
    • , P. D. McDonagh
    • , P. M. Loerch
    • , A. Leonardson
    • , P. Y. Lum
    • , G. Cavet
    • , L. F. Wu
    • , S. J. Altschuler
    • , S. Edwards
    • , J. King
    • , J. S. Tsang
    • , G. Schimmack
    • , J. M. Schelter
    • , J. Koch
    • , M. Ziman
    • , M. J. Marton
    • , B. Li
    • , P. Cundiff
    • , T. Ward
    • , J. Castle
    • , M. Krolewski
    • , M. R. Meyer
    • , M. Mao
    • , J. Burchard
    • , M. J. Kidd
    • , H. Dai
    • , J. W. Phillips
    • , P. S. Linsley
    • , R. Stoughton
    • , S. Scherer
    •  & M. S. Boguski
  • Article |

    • Ravi Sachidanandam
    • , David Weissman
    • , Steven C. Schmidt
    • , Jerzy M. Kakol
    • , Lincoln D. Stein
    • , Gabor Marth
    • , Steve Sherry
    • , James C. Mullikin
    • , Beverley J. Mortimore
    • , David L. Willey
    • , Sarah E. Hunt
    • , Charlotte G. Cole
    • , Penny C. Coggill
    • , Catherine M. Rice
    • , Zemin Ning
    • , Jane Rogers
    • , David R. Bentley
    • , Pui-Yan Kwok
    • , Elaine R. Mardis
    • , Raymond T. Yeh
    • , Brian Schultz
    • , Lisa Cook
    • , Ruth Davenport
    • , Michael Dante
    • , Lucinda Fulton
    • , LaDeana Hillier
    • , Robert H. Waterston
    • , John D. McPherson
    • , Brian Gilman
    • , Stephen Schaffner
    • , William J. Van Etten
    • , David Reich
    • , John Higgins
    • , Mark J. Daly
    • , Brendan Blumenstiel
    • , Jennifer Baldwin
    • , Nicole Stange-Thomann
    • , Michael C. Zody
    • , Lauren Linton
    • , Eric S. Lander
    •  & David Altshuler
  • Article |

    • John D. McPherson
    • , Marco Marra
    • , LaDeana Hillier
    • , Robert H. Waterston
    • , Asif Chinwalla
    • , John Wallis
    • , Mandeep Sekhon
    • , Kristine Wylie
    • , Elaine R. Mardis
    • , Richard K. Wilson
    • , Robert Fulton
    • , Tamara A. Kucaba
    • , Caryn Wagner-McPherson
    • , William B. Barbazuk
    • , Simon G. Gregory
    • , Sean J. Humphray
    • , Lisa French
    • , Richard S. Evans
    • , Graeme Bethel
    • , Adam Whittaker
    • , Jane L. Holden
    • , Owen T. McCann
    • , Andrew Dunham
    • , Carol Soderlund
    • , Carol E. Scott
    • , David R. Bentley
    • , Gregory Schuler
    • , Hsiu-Chuan Chen
    • , Wonhee Jang
    • , Eric D. Green
    • , Jacquelyn R. Idol
    • , Valerie V. Braden Maduro
    • , Kate T. Montgomery
    • , Eunice Lee
    • , Ashley Miller
    • , Suzanne Emerling
    • , Raju Kucherlapati
    • , Richard Gibbs
    • , Steve Scherer
    • , J. Harley Gorrell
    • , Erica Sodergren
    • , Kerstin Clerc-Blankenburg
    • , Paul Tabor
    • , Susan Naylor
    • , Dawn Garcia
    • , Pieter J. de Jong
    • , Joseph J. Catanese
    • , Norma Nowak
    • , Kazutoyo Osoegawa
    • , Shizhen Qin
    • , Lee Rowen
    • , Anuradha Madan
    • , Monica Dors
    • , Leroy Hood
    • , Barbara Trask
    • , Cynthia Friedman
    • , Hillary Massa
    • , Vivian G. Cheung
    • , Ilan R. Kirsch
    • , Thomas Reid
    • , Raluca Yonescu
    • , Jean Weissenbach
    • , Thomas Bruls
    • , Roland Heilig
    • , Elbert Branscomb
    • , Anne Olsen
    • , Norman Doggett
    • , Jan-Fang Cheng
    • , Trevor Hawkins
    • , Richard M. Myers
    • , Jin Shang
    • , Lucia Ramirez
    • , Jeremy Schmutz
    • , Olivia Velasquez
    • , Kami Dixon
    • , Nancy E. Stone
    • , David R. Cox
    • , David Haussler
    • , W. James Kent
    • , Terrence Furey
    • , Sanja Rogic
    • , Scot Kennedy
    • , Steven Jones
    • , André Rosenthal
    • , Gaiping Wen
    • , Markus Schilhabel
    • , Gernot Gloeckner
    • , Gerald Nyakatura
    • , Reiner Siebert
    • , Brigitte Schlegelberger
    • , Julie Korenberg
    • , Xiao-Ning Chen
    • , Asao Fujiyama
    • , Masahira Hattori
    • , Atsushi Toyoda
    • , Tetsushi Yada
    • , Hong-Seok Park
    • , Yoshiyuki Sakaki
    • , Nobuyoshi Shimizu
    • , Shuichi Asakawa
    • , Kazuhiko Kawasaki
    • , Takashi Sasaki
    • , Ai Shintani
    • , Atsushi Shimizu
    • , Kazunori Shibuya
    • , Jun Kudoh
    • , Shinsei Minoshima
    • , Juliane Ramser
    • , Peter Seranski
    • , Celine Hoff
    • , Annemarie Poustka
    • , Richard Reinhardt
    •  & Hans Lehrach

Letters to Nature

  • Letters to Nature |

    • D. R. Bentley
    • , P. Deloukas
    • , A. Dunham
    • , L. French
    • , S. G. Gregory
    • , S. J. Humphray
    • , A. J. Mungall
    • , M. T. Ross
    • , N. P. Carter
    • , I. Dunham
    • , C. E. Scott
    • , K. J. Ashcroft
    • , A. L. Atkinson
    • , K. Aubin
    • , D. M. Beare
    • , G. Bethel
    • , N. Brady
    • , J. C. Brook
    • , D. C. Burford
    • , W. D. Burrill
    • , C. Burrows
    • , A. P. Butler
    • , C. Carder
    • , J. J. Catanese
    • , C. M. Clee
    • , S. M. Clegg
    • , V. Cobley
    • , A. J. Coffey
    • , C. G. Cole
    • , J. E. Collins
    • , J. S. Conquer
    • , R. A. Cooper
    • , K. M. Culley
    • , E. Dawson
    • , F. L. Dearden
    • , R. M. Durbin
    • , P. J. de Jong
    • , P. D. Dhami
    • , M. E. Earthrowl
    • , C. A. Edwards
    • , R. S. Evans
    • , C. J. Gillson
    • , J. Ghori
    • , L. Green
    • , R. Gwilliam
    • , K. S. Halls
    • , S. Hammond
    • , G. L. Harper
    • , R. W. Heathcott
    • , J. L. Holden
    • , E. Holloway
    • , B. L. Hopkins
    • , P. J. Howard
    • , G. R. Howell
    • , E. J. Huckle
    • , J. Hughes
    • , P. J. Hunt
    • , S. E. Hunt
    • , M. Izmajlowicz
    • , C. A. Jones
    • , S. S. Joseph
    • , G. Laird
    • , C. F. Langford
    • , M. H. Lehvaslaiho
    • , M. A. Leversha
    • , O. T. McCann
    • , L. M. McDonald
    • , J. McDowall
    • , G. L. Maslen
    • , D. Mistry
    • , N. K. Moschonas
    • , V. Neocleous
    • , D. M. Pearson
    • , K. J. Phillips
    • , K. M. Porter
    • , S. R. Prathalingam
    • , Y. H. Ramsey
    • , S. A. Ranby
    • , C. M. Rice
    • , J. Rogers
    • , L. J. Rogers
    • , T. Sarafidou
    • , D. J. Scott
    • , G. J. Sharp
    • , C. J. Shaw-Smith
    • , L. J. Smink
    • , C. Soderlund
    • , E. C. Sotheran
    • , H. E. Steingruber
    • , J. E. Sulston
    • , A. Taylor
    • , R. G. Taylor
    • , A. A. Thorpe
    • , E. Tinsley
    • , G. L. Warry
    • , A. Whittaker
    • , P. Whittaker
    • , S. H. Williams
    • , T. E. Wilmer
    • , R. Wooster
    •  & C. L. Wright
  • Letters to Nature |

    • Charles A. Tilford
    • , Tomoko Kuroda-Kawaguchi
    • , Helen Skaletsky
    • , Steve Rozen
    • , Laura G. Brown
    • , Michael Rosenberg
    • , John D. McPherson
    • , Kristine Wylie
    • , Mandeep Sekhon
    • , Tamara A. Kucaba
    • , Robert H. Waterston
    •  & David C. Page
  • Letters to Nature |

    • Kate T. Montgomery
    • , Eunice Lee
    • , Ashley Miller
    • , Stephanie Lau
    • , Cecilia Shim
    • , Jeremy Decker
    • , Denise Chiu
    • , Suzanne Emerling
    • , Mandeep Sekhon
    • , Rachel Kim
    • , Jack Lenz
    • , Jinghua Han
    • , Ilya Ioshikhes
    • , Beatrice Renault
    • , Ivonne Marondel
    • , Sung-Joo Kim Yoon
    • , Kyuyoung Song
    • , V. V. V. S. Murty
    • , Steven Scherer
    • , Raluca Yonescu
    • , Ilan R. Kirsch
    • , Thomas Ried
    • , John McPherson
    • , Richard Gibbs
    •  & Raju Kucherlapati
  • Letters to Nature |

    • Thomas Brüls
    • , Gabor Gyapay
    • , Jean-Louis Petit
    • , François Artiguenave
    • , Virginie Vico
    • , Shizen Qin
    • , Aye Mon Tin-Wollam
    • , Corinne Da Silva
    • , Delphine Muselet
    • , Delphine Mavel
    • , Eric Pelletier
    • , Michael Levy
    • , Asao Fujiyama
    • , Fumihiko Matsuda
    • , Richard Wilson
    • , Lee Rowen
    • , Leroy Hood
    • , Jean Weissenbach
    • , William Saurin
    •  & Roland Heilig
  • Letters to Nature |

    • The BAC Resource Consortium
    • , V. G. Cheung
    • , N. Nowak
    • , W. Jang
    • , I. R. Kirsch
    • , S. Zhao
    • , X.-N. Chen
    • , T. S. Furey
    • , U.-J. Kim
    • , W.-L. Kuo
    • , M. Olivier
    • , J. Conroy
    • , A. Kasprzyk
    • , H. Massa
    • , R. Yonescu
    • , S. Sait
    • , C. Thoreen
    • , A. Snijders
    • , E. Lemyre
    • , J. A. Bailey
    • , A. Bruzel
    • , W. D. Burrill
    • , S. M. Clegg
    • , S. Collins
    • , P. Dhami
    • , C. Friedman
    • , C. S. Han
    • , S. Herrick
    • , J. Lee
    • , A. H. Ligon
    • , S. Lowry
    • , M. Morley
    • , S. Narasimhan
    • , K. Osoegawa
    • , Z. Peng
    • , I. Plajzer-Frick
    • , B. J. Quade
    • , D. Scott
    • , K. Sirotkin
    • , A. A. Thorpe
    • , J. W. Gray
    • , J. Hudson
    • , D. Pinkel
    • , T. Ried
    • , L. Rowen
    • , G. L. Shen-Ong
    • , R. L. Strausberg
    • , E. Birney
    • , D. F. Callen
    • , J.-F. Cheng
    • , D. R. Cox
    • , N. A. Doggett
    • , N. P. Carter
    • , E. E. Eichler
    • , D. Haussler
    • , J. R. Korenberg
    • , C. C. Morton
    • , D. Albertson
    • , G. Schuler
    • , P. J. de Jong
    •  & B. J. Trask

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