Supplements

The ubiquitin system

Vol. 458, No. 7237 pp 421–467

In this supplement

• Editorial
• Reviews

The central role of ubiquitin in cell-cycle regulation, DNA repair, cell growth, signalling and immune function is starting to become clear right down to the molecular level. Identifying irregularities in the system has opened up opportunities in drug discovery, and in diagnostics and treatment for a range of disorders, from cancer to neurodegeneration.

Editorial

The ubiquitin system free access

Deepa Nath & Sadaf Shadan

doi:10.1038/458421a

Full Text | PDF (986KB)

Reviews

Origin and function of ubiquitin-like proteins

Mark Hochstrasser

doi:10.1038/nature07958

Abstract | Full Text | PDF (2,362KB)

Ubiquitylation in innate and adaptive immunity

Vijay G. Bhoj & Zhijian J. Chen

doi:10.1038/nature07959

Abstract | Full Text | PDF (6,072KB)

Targeting the ubiquitin system in cancer therapy

Daniela Hoeller & Ivan Dikic

doi:10.1038/nature07960

Abstract | Full Text | PDF (3,493KB)

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

Camilla Raiborg & Harald Stenmark

doi:10.1038/nature07961

Abstract | Full Text | PDF (5,530KB)

The ubiquitylation machinery of the endoplasmic reticulum

Christian Hirsch, Robert Gauss, Sabine C. Horn, Oliver Neuber & Thomas Sommer

doi:10.1038/nature07962

Abstract | Full Text | PDF (3,062KB)

Principles of ubiquitin and SUMO modifications in DNA repair

Steven Bergink & Stefan Jentsch

doi:10.1038/nature07963

Abstract | Full Text | PDF (5,233KB)