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Nature Insight: Skin Biology

Vol. 445, No. 7130 pp 833-880

Skin is the largest organ of the body and performs many functions. It helps us sense our surroundings and provides a barrier to environmental insults. Greater understanding of the mechanisms of skin development and the molecular interactions within and between skin cells and other cell types is leading to new therapeutics and laboratory-engineered skin with which to treat skin disease and injury.

In this supplement

• Editorial
• Reviews

Editorial

Skin Biology

Barbara Marte, Joshua Finkelstein and Lesley Anson

doi:10.1038/445833a

Full Text | PDF (104KB)

Reviews

Scratching the surface of skin development

Elaine Fuchs

doi:10.1038/nature05659

Abstract | Full Text | PDF (2,253KB)

Melanocyte biology and skin pigmentation

Jennifer Y. Lin and David E. Fisher

doi:10.1038/nature05660

Abstract | Full Text | PDF (791KB)

Melanoma biology and new targeted therapy

Vanessa Gray-Schopfer, Claudia Wellbrock and Richard Marais

doi:10.1038/nature05661

Abstract | Full Text | PDF (805KB)

Mechanisms of sensory transduction in the skin

Ellen A. Lumpkin and Michael J. Caterina

doi:10.1038/nature05662

Abstract | Full Text | PDF (2,313KB)

Pathogenesis and therapy of psoriasis

Michelle A. Lowes, Anne M. Bowcock and James G. Krueger

doi:10.1038/nature05663

Abstract | Full Text | PDF (1,183KB)

Progress and opportunities for tissue-engineered skin

Sheila MacNeil

doi:10.1038/nature05664

Abstract | Full Text | PDF (1,026KB)