Supplements

Proteins to proteomes

Vol. 450, No. 7172 pp 963–1009

In this supplement

• Editorial
• Reviews

Proteins are the most diverse and versatile set of biological macromolecules, having crucial roles in all biological processes. Now that researchers have identified whole complements of proteins (proteomes) for many cell types, they are pushing the frontiers of protein science: from the regulation and function of single protein dynamics to the evolution and inhibition of protein–protein interactions.

Editorial

Proteins to proteomes

Tanguy Chouard & Joshua Finkelstein

doi:10.1038/450963a

Full Text | PDF (66KB)

Reviews

Dynamic personalities of proteins

Katherine Henzler-Wildman & Dorothee Kern

doi:10.1038/nature06522

Abstract | Full Text | PDF (663KB)

The molecular sociology of the cell

Carol V. Robinson, Andrej Sali & Wolfgang Baumeister

doi:10.1038/nature06523

Abstract | Full Text | PDF (1,007KB)

The origin of protein interactions and allostery in colocalization

John Kuriyan & David Eisenberg

doi:10.1038/nature06524

Abstract | Full Text | PDF (867KB)

The biological impact of mass-spectrometry-based proteomics

Benjamin F. Cravatt, Gabriel M. Simon & John R. Yates III

doi:10.1038/nature06525

Abstract | Full Text | PDF (4,064KB)

Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

James A. Wells & Christopher L. McClendon

doi:10.1038/nature06526

Abstract | Full Text | PDF (533KB) | Supplementary information