Reviews & Analysis

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  • Ten years since the discovery of the Higgs boson, the exploration of the Higgs sector, as this overview shows, has progressed far beyond original expectations, but many research questions still remain open.

    • Gavin P. Salam
    • Lian-Tao Wang
    • Giulia Zanderighi
  • A simple method for incorporating molecules into the gaps of stacked semimetallic materials through immersion offers an efficient way of filtering electrons, which could be useful for information-storage technologies.

    • Xi Ling
    News & Views
  • We charted the genetic history of the grey wolf over the past 100,000 years by analysing 72 ancient genomes. Placing dogs into this history, we found that they derive ancestry from at least two separate wolf populations.

    Research Briefing
  • The discovery that gut viruses can be transmitted from mouse pups to their mothers in saliva during breastfeeding reveals previously unrecognized sites of viral replication and means of viral transmission.

    • Elizabeth A. Kennedy
    • Megan T. Baldridge
    News & Views
  • A compound made by plants used in traditional medicine has been prepared by chemical synthesis, providing enough for biological testing. The unexpected finding that it acts at opioid receptors raises prospects for drug discovery.

    • Nicholas P. R. Onuska
    • Joshua G. Pierce
    News & Views
  • How a bacterium coordinates the assembly of its outer layers, and couples the formation of this envelope to cell growth and division, is not fully understood. Assessing the role of peptidoglycan molecules provides some answers.

    • Michaël Deghelt
    • Jean-François Collet
    News & Views
  • An experiment firing helium-8 nuclei at a proton target has generated evidence that four neutrons can exist transiently without any other matter. But doubts remain, because the existence of such systems is at odds with theory.

    • Lee G. Sobotka
    • Maria Piarulli
    News & Views
  • The deadly spread of cancer occurs predominantly during sleep, as revealed by an analysis of migrating human tumour cells in the bloodstream. What are the implications of this finding for the treatment of cancer?

    • Harrison Ball
    • Sunitha Nagrath
    News & Views
  • DNA from more than 1,000 marine microbial communities around the world was used to reconstruct around 26,000 genomes. The analyses identified a highly biosynthetically diverse family of bacteria in the open ocean, as well as new enzymes and biochemical compounds.

    Research Briefing
  • The sensation of touch-evoked itch is common in people who have chronic itch conditions. Evidence in mice now suggests that the mechanoreceptor protein Piezo1 underlies this sensation.

    • Taylor Follansbee
    • Xinzhong Dong
    News & Views
  • Membranes made from metal–organic frameworks contain modular pores that can separate mixtures of gas. By changing the shape of these pores to improve molecular separation, we produced a membrane that could remove nitrogen and carbon dioxide from natural gas in an energy-efficient and cost-effective way.

    Research Briefing
  • Two-dimensional materials made of carbon have been limited to monolayers of atoms, such as graphene. Sheets composed of connected buckyballs — spherical clusters of atoms — have now been made by peeling layers from a crystal.

    • J. Michael Gottfried
    News & Views
  • A high-precision comparison of the magnetic moments of two isotopically different neon ions opens a path to the search for elusive particles that could explain the unexpectedly low observed mass of the Higgs boson.

    • Gerald Gwinner
    • Roshani Silwal
    News & Views
  • A metabolite called Lac-Phe is associated with exercise-induced ‘muscle burn’. This molecule has now been shown to reduce food intake after exercise in mice, racehorses and humans, and to trigger weight loss in obese mice.

    • Tahnbee Kim
    • Scott M. Sternson
    News & Views
  • Systematic editing of yeast genes to generate thousands of mutations indicates that, overall, the mutations have similar effects on yeast fitness regardless of whether they change the protein sequences encoded by the mutated genes.

    • Nathaniel Sharp
    News & Views