Reviews & Analysis

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  • Disease-causing microorganisms can invade plants through leaf pores called stomata, which close rapidly in a calcium-dependent manner on detecting such danger. The calcium channels involved have now finally been identified.

    • Keiko Yoshioka
    • Wolfgang Moeder
    News & Views
  • The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

    • Nikolaus Rajewsky
    • Geneviève Almouzni
    • Frauke Zipp
    Perspective
  • A light-sensitive receptor protein expressed in neurons deep in the mouse brain has been shown to be stimulated by violet light, and to activate a pathway that reduces heat production in brown fat.

    • Gary J. Schwartz
    News & Views
  • Volumes of fluid have previously been made to float above air by vibrating the air–fluid system vertically. It now emerges that an ‘antigravity’ effect enables objects to float upside down on the air–fluid interface.

    • Vladislav Sorokin
    • Iliya I. Blekhman
    News & Views
  • Yeast has been engineered to convert simple sugars and amino acids into drugs that inhibit a neurotransmitter molecule. The work marks a step towards making the production of these drugs more reliable and sustainable.

    • José Montaño López
    • José L. Avalos
    News & Views
  • Skin cancers resulting from distinct mutations have characteristic tissue forms and different disease outcomes. Analysing the architecture of benign and aggressive tumours reveals how mechanical forces drive these patterns.

    • Karolina Punovuori
    • Sara A. Wickström
    News & Views
  • Temperature determines the geographical distribution of plants and their rate of growth and development, but how they sense high temperatures to mount a response was unclear. Now a process underlying this responsiveness is known.

    • Simon Alberti
    News & Views
  • Tiny devices have been developed that can act as the legs of laser-controlled microrobots. The compatibility of these devices with microelectronics systems suggests a path to the mass manufacture of autonomous microrobots.

    • Allan M. Brooks
    • Michael S. Strano
    News & Views
  • In a few people living with HIV, the virus remains under control without antiretroviral therapy. It emerges that, in these people, the viral DNA that is integrated into the host genome is in a deeply transcriptionally repressed state.

    • Nicolas Chomont
    News & Views
  • This Review explores the role of viscoelasticity of tissues and extracellular matrices in cell–matrix interactions and mechanotransduction and the potential utility of viscoelastic biomaterials in regenerative medicine.

    • Ovijit Chaudhuri
    • Justin Cooper-White
    • Vivek B. Shenoy
    Review Article
  • A mutation in the C9orf72 gene is the most common genetic cause of two neurodegenerative diseases. A newly identified immunological function for the C9orf72 protein points to a potential therapeutic strategy for these diseases.

    • Olivia Gautier
    • Aaron D. Gitler
    News & Views
  • Diodes are devices that conduct electric current mainly in one direction. An electrically polar film that acts as a diode for superconducting current could lead to electronic devices that have ultralow power consumption.

    • Toshiya Ideue
    • Yoshihiro Iwasa
    News & Views
  • A cellular condition called oxidative stress can kill cancer cells. The finding that skin cancer cells evade such destruction using lipids acquired while passing through lymphatic vessels reveals a mechanism that boosts cancer spread.

    • Barbara M. Grüner
    • Sarah-Maria Fendt
    News & Views
  • A molecule produced by the metabolism of proteins and fats has been found to accumulate in the blood of older people, and to endow cancer cells with the ability to spread from one site in the body to others.

    • Hai Wang
    • Xiang H.-F. Zhang
    News & Views
  • It is unclear why people’s immune response to the SARS-CoV-2 coronavirus varies so widely. Tracking patient responses over time sheds light on this issue, and has implications for efforts to predict disease severity.

    • Stanley Perlman
    News & Views