Reviews & Analysis

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  • Transposase proteins mediate the movement of ‘parasitic’ DNA segments in genomes. A series of structures of a transposase catches it in action, and highlights how these proteins evolved for use in immune systems.

    • Orsolya Barabas
    News & Views
  • A review of drug resistance in cancer analyses each biological determinant of resistance separately and discusses existing and new therapeutic strategies to combat the problem as a whole.

    • Neil Vasan
    • José Baselga
    • David M. Hyman
    Review Article
  • How Nature reported historic changes in medical practice in 1919, and call for doctors and nurses to receive computer training in 1969.

    News & Views
  • The ability of birds to learn a song depends not on their genes alone, but also on whether their genetic make-up is well matched to that of their singing teacher. This discovery sheds light on how gene–environment interactions affect learning.

    • Ofer Tchernichovski
    • Dalton Conley
    News & Views
  • A molecule has now been characterized that acts to inhibit a cancer-causing form of KRAS protein and stimulate the immune system. The inhibitor is one of the first of its kind to show anticancer activity in the clinic.

    • Roy S. Herbst
    • Joseph Schlessinger
    News & Views
  • Arrays of nanoscale magnets have been constructed to form the magnetized panels of microscopic robots — thus allowing magnetic fields to be used to control the robots’ shape and movement.

    • Xuanhe Zhao
    • Yoonho Kim
    News & Views
  • Approximately 11.6-million-year-old fossils reveal an ape with arms suited to hanging in trees but human-like legs, suggesting a form of locomotion that might push back the timeline for when walking on two feet evolved.

    • Tracy L. Kivell
    News & Views
  • A previously unknown bacterial toxin has now been characterized. The protein is secreted into neighbouring cells, depleting them of essential energy-carrying molecules and so leading to the cells’ demise.

    • Brent W. Anderson
    • Jue D. Wang
    News & Views
  • Atomic physicists and nuclear physicists have each made a refined measurement of the radius of the proton. Both values agree with a hotly debated result obtained by spectroscopy of an exotic form of hydrogen called muonic hydrogen.

    • Jean-Philippe Karr
    • Dominique Marchand
    News & Views
  • Bacteria move along gradients of chemical attractants. Two studies find that, in nutrient-rich environments, bacteria can grow rapidly by following a non-nutritious attractant — but expanding too fast leaves them vulnerable.

    • Henry Mattingly
    • Thierry Emonet
    News & Views
  • An overview of the effects of vaccines on global morbidity and mortality, vaccine safety issues, and the hurdles involved in proceeding from vaccine discovery to successful implementation.

    • Peter Piot
    • Heidi J. Larson
    • Beate Kampmann
    Review Article
  • Structural metals enable improved energy efficiency through their reduced mass, higher thermal stability and better mechanical properties; here, methods of improving the sustainability of structural metals, from recycling to contaminant tolerance, are described.

    • Dierk Raabe
    • C. Cem Tasan
    • Elsa A. Olivetti
    Review Article
  • This Perspective examines the global production ecosystem through the lenses of connectivity, diversity and feedback, and proposes measures that will increase its stability and sustainability.

    • M. Nyström
    • J.-B. Jouffray
    • C. Folke
  • The authors discuss the potential for sex and gender analysis to foster scientific discovery, improve experimental efficiency and enable social equality.

    • Cara Tannenbaum
    • Robert P. Ellis
    • Londa Schiebinger
  • Genetic strategies for improving the yield and sustainability of agricultural crops, and the resilience of crops in the face of biotic and abiotic stresses contingent on projected climate change, are evaluated.

    • Julia Bailey-Serres
    • Jane E. Parker
    • Julian I. Schroeder
    Review Article
  • Aphorisms by Goethe — the opening article of the first issue of Nature, 4 November 1869.

    News & Views