Reviews & Analysis

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  • The finding that intestinal viruses can substitute for intestinal bacteria to promote the health of their mammalian hosts raises the possibility that viruses in the gut may be beneficial in some circumstances. See Letter p.94

    • Yao Wang
    • Julie K. Pfeiffer
    News & Views
  • Certain structural elements allow messenger RNAs not usually processed by the protein-synthesis apparatus to be translated. It now seems that they also control the expression of genes involved in embryonic development. See Article p.33

    • Jonathan D. Dinman
    News & Views
  • A new class of fatty acid — found in food and synthesized by mammalian tissues — enhances glucose uptake from the blood and reduces inflammation, suggesting that these fats might be used to treat diabetes.

    • Deborah M. Muoio
    • Christopher B. Newgard
    News & Views
  • An experiment shows that although bank employees behave honestly on average, their dishonesty increases when they make decisions after having been primed to think about their professional identity. See Letter p.86

    • Marie Claire Villeval
    News & Views
  • Following on from affiliated projects in humans and model invertebrates, the Mouse ENCODE Project presents comprehensive data sets on genome regulation in this key mammalian model. See Articles p.355, p.365, p.371 & Letter p.402

    • Piero Carninci
    News & Views
  • An innovative approach to analysing the functions and gene-expression profiles of neural stem cells in developing human and mouse brains sheds light on the differences — and similarities — between the two species. See Letter p.264

    • Forrest O. Gulden
    • Nenad Šestan
    News & Views
  • Chronic stress can cause depression in some individuals, but leaves others untouched. Engagement of a molecular pathway controlling the production of tiny RNA snippets might help to explain the difference. See Article p.51

    • Gerhard Schratt
    News & Views
  • The first crystal structures of bestrophin and lipid scramblase proteins cast light on how these protein families transport very different substrates across membranes, yet are both activated by calcium ions. See Articles p.207 & p.213

    • Matt Whorton
    News & Views
  • Conventional behavioural mouse models of depression are often used to study the disorder, but cannot capture the full picture of the human disease. Here, scientists present two views about the best research strategies to adopt if treatments are to be improved.

    • Lisa M. Monteggia
    • Robert C. Malenka
    • Karl Deisseroth
    News & Views
  • Exquisite control of quantum systems has allowed researchers to connect reality to ideas of how an exotic form of particle transport known as the quantum Hall effect can occur in the absence of a magnetic field. See Letters p.237 & p.241

    • Jonathan Simon
    News & Views
  • Two studies find that an intracellular quality-control mechanism called autophagy is regulated by nuclear receptor proteins that govern the expression of autophagy genes. See Letters p.108 & p.112

    • Carmine Settembre
    • Andrea Ballabio
    News & Views
  • Are you wondering what to prepare for dinner tonight? Data analyses reveal that certain food choices greatly benefit both your health and the environment. But what to do with this evidence remains a challenge to society. See Article p.518

    • Elke Stehfest
    News & Views
  • The detection of unusual 'mirage' energy bands in photoemission spectra of single-atom layers of iron selenide reveals the probable cause of high-temperature superconductivity in these artificial structures. See Letter p.245

    • Jan Zaanen
    News & Views
  • The report of a light-activated catalyst that dictates the three-dimensional shape — the stereochemistry — of molecules formed in an organic reaction suggests a new strategy for controlling such reactions using visible light. See Letter p.100

    • Kazimer L. Skubi
    • Tehshik P. Yoon
    News & Views
  • A newly discovered skull from the Cretaceous period belongs to a mammal that was big, strange and fast-moving. The fossil solves a long-standing mystery, and helps to resolve a controversy about mammalian evolution. See Article p.512

    • Anne Weil
    News & Views
  • A 'plasma afterburner' just 30 centimetres long accelerates electrons hundreds of times faster than giant conventional accelerators. The result may ultimately open up a low-cost technology for particle colliders. See Letter p.92

    • Mike Downer
    • Rafal Zgadzaj
    News & Views
  • Massive stars are rare, but they are sources of some of the most energetic phenomena seen in the Universe today. A high-mass candidate has now been found in a star-forming region that has been observed for more than 50 years.

    • Donald F. Figer
    News & Views
  • An analysis of fruit-fly embryos reveals that receptor proteins of the Toll family direct the oriented cell rearrangements required for the elongation of the head-to-tail axis during development. See Article p.523

    • Ulrich Tepass
    News & Views
  • The high levels of tissue-damaging reactive oxygen species that arise during a stroke or heart attack have been shown to be generated through the accumulation of the metabolic intermediate succinate. See Letter p.431

    • Luke A. J. O'Neill
    News & Views