Reviews & Analysis

Filter By:

Article Type
  • Increased expression of sirtuin proteins has been shown to enhance lifespan in several organisms. New data indicate that some of the reported effects may have been due to confounding factors in experimental design. Here, experts discuss the significance of these data for research into ageing. See Letter p.482

    • David B. Lombard
    • Scott D. Pletcher
    • Johan Auwerx
    News & Views Forum
  • Variation in a genomic region that contains the cancer-associated gene ATM affects a patient's response to the diabetes drug metformin. Two experts discuss the implications for understanding diabetes and the link to cancer.

    • Morris J. Birnbaum
    • Reuben J. Shaw
    News & Views Forum
  • Two approaches have emerged for creating libraries of compounds for use in biological screening assays for drug discovery — fragment-based ligand design and diversity-oriented synthesis. Advocates of each approach discuss their favoured strategy.

    • Philip J. Hajduk
    • Warren R. J. D. Galloway
    • David R. Spring
    News & Views Forum
  • A growing body of literature deals with the application of theories developed in other disciplines to financial institutions, to which a paper in this issue now adds. As outlined here, however, views differ as to its relevance. See Perspective p.351

    • Neil Johnson
    • Thomas Lux
    News & Views Forum
  • Many scientists now use the power of computer models to advance their subjects. But there is a choice: to simplify complex systems or to include more detail. Modelling the intricate processes of sedimentary geology is a case in point.

    • Chris Paola
    • Mike Leeder
    News & Views Forum