Latest Research

  • Article |

    Expression of α6 integrin enables acute lymphoblastic leukaemia cells to use neural migratory pathways to invade the central nervous system and metastasize to the brain.

    • Hisayuki Yao
    • , Trevor T. Price
    • , Gaia Cantelli
    • , Brandon Ngo
    • , Matthew J. Warner
    • , Lindsey Olivere
    • , Sarah M. Ridge
    • , Elizabeth M. Jablonski
    • , Joseph Therrien
    • , Stacey Tannheimer
    • , Chad M. McCall
    • , Anjen Chenn
    •  & Dorothy A. Sipkins
  • Letter |

    A comprehensive analysis of the thymic medulla identifies a tuft-cell-like thymic epithelial cell population that is necessary for shaping thymic function.

    • Corey N. Miller
    • , Irina Proekt
    • , Jakob von Moltke
    • , Kristen L. Wells
    • , Aparna R. Rajpurkar
    • , Haiguang Wang
    • , Kristin Rattay
    • , Imran S. Khan
    • , Todd C. Metzger
    • , Joshua L. Pollack
    • , Adam C. Fries
    • , Wint W. Lwin
    • , Eric J. Wigton
    • , Audrey V. Parent
    • , Bruno Kyewski
    • , David J. Erle
    • , Kristin A. Hogquist
    • , Lars M. Steinmetz
    • , Richard M. Locksley
    •  & Mark S. Anderson
  • Letter |

    The 53BP1 effector complex shieldin is involved in non-homologous end-joining and immunoglobulin class switching, and acts to protect DNA ends to facilitate the repair of DNA by 53BP1.

    • Sylvie M. Noordermeer
    • , Salomé Adam
    • , Dheva Setiaputra
    • , Marco Barazas
    • , Stephen J. Pettitt
    • , Alexanda K. Ling
    • , Michele Olivieri
    • , Alejandro Álvarez-Quilón
    • , Nathalie Moatti
    • , Michal Zimmermann
    • , Stefano Annunziato
    • , Dragomir B. Krastev
    • , Feifei Song
    • , Inger Brandsma
    • , Jessica Frankum
    • , Rachel Brough
    • , Alana Sherker
    • , Sébastien Landry
    • , Rachel K. Szilard
    • , Meagan M. Munro
    • , Andrea McEwan
    • , Théo Goullet de Rugy
    • , Zhen-Yuan Lin
    • , Traver Hart
    • , Jason Moffat
    • , Anne-Claude Gingras
    • , Alberto Martin
    • , Haico van Attikum
    • , Jos Jonkers
    • , Christopher J. Lord
    • , Sven Rottenberg
    •  & Daniel Durocher
  • Letter |

    Modulation of DNA 5-hydroxymethylcytosine by glucose reveals an AMPK–TET2–5hmC axis that links diabetes to cancer.

    • Di Wu
    • , Di Hu
    • , Hao Chen
    • , Guoming Shi
    • , Irfete S. Fetahu
    • , Feizhen Wu
    • , Kimberlie Rabidou
    • , Rui Fang
    • , Li Tan
    • , Shuyun Xu
    • , Hang Liu
    • , Christian Argueta
    • , Lei Zhang
    • , Fei Mao
    • , Guoquan Yan
    • , Jiajia Chen
    • , Zhaoru Dong
    • , Ruitu Lv
    • , Yufei Xu
    • , Mei Wang
    • , Yong Ye
    • , Shike Zhang
    • , Danielle Duquette
    • , Songmei Geng
    • , Clark Yin
    • , Christine Guo Lian
    • , George F. Murphy
    • , Gail K. Adler
    • , Rajesh Garg
    • , Lydia Lynch
    • , Pengyuan Yang
    • , Yiming Li
    • , Fei Lan
    • , Jia Fan
    • , Yang Shi
    •  & Yujiang Geno Shi
  • Letter |

    A comprehensive characterization of the thymic stroma identifies a tuft-cell-like thymic epithelial cell population that is critical for shaping the immune niche in the thymus.

    • Chamutal Bornstein
    • , Shir Nevo
    • , Amir Giladi
    • , Noam Kadouri
    • , Marie Pouzolles
    • , François Gerbe
    • , Eyal David
    • , Alice Machado
    • , Anna Chuprin
    • , Beáta Tóth
    • , Ori Goldberg
    • , Shalev Itzkovitz
    • , Naomi Taylor
    • , Philippe Jay
    • , Valérie S. Zimmermann
    • , Jakub Abramson
    •  & Ido Amit
  • Letter |

    A comparative metabolomics approach is used to identify succinate as a key activator of thermogenesis in brown adipose tissue.

    • Evanna L. Mills
    • , Kerry A. Pierce
    • , Mark P. Jedrychowski
    • , Ryan Garrity
    • , Sally Winther
    • , Sara Vidoni
    • , Takeshi Yoneshiro
    • , Jessica B. Spinelli
    • , Gina Z. Lu
    • , Lawrence Kazak
    • , Alexander S. Banks
    • , Marcia C. Haigis
    • , Shingo Kajimura
    • , Michael P. Murphy
    • , Steven P. Gygi
    • , Clary B. Clish
    •  & Edward T. Chouchani
  • Letter |

    A sensitive T cell tracking assay reveals immunogenic activity of specific catabolized peptide fragments of insulin and their effects on T cell activity in lymph nodes, highlighting communication between pancreatic islets and lymphoid tissue.

    • Xiaoxiao Wan
    • , Bernd H. Zinselmeyer
    • , Pavel N. Zakharov
    • , Anthony N. Vomund
    • , Ruth Taniguchi
    • , Laura Santambrogio
    • , Mark S. Anderson
    • , Cheryl F. Lichti
    •  & Emil R. Unanue
  • Article |

    Combining an electron microscope pixel-array detector that collects the entire distribution of scattered electrons with full-field ptychography greatly improves image resolution and contrast compared to traditional techniques, even at low beam energies.

    • Yi Jiang
    • , Zhen Chen
    • , Yimo Han
    • , Pratiti Deb
    • , Hui Gao
    • , Saien Xie
    • , Prafull Purohit
    • , Mark W. Tate
    • , Jiwoong Park
    • , Sol M. Gruner
    • , Veit Elser
    •  & David A. Muller
  • Letter |

    The outer membrane of Gram-negative bacteria is shown to be at least as stiff as the cell wall, and this property enables it to protect cells from mechanical pertubations.

    • Enrique R. Rojas
    • , Gabriel Billings
    • , Pascal D. Odermatt
    • , George K. Auer
    • , Lillian Zhu
    • , Amanda Miguel
    • , Fred Chang
    • , Douglas B. Weibel
    • , Julie A. Theriot
    •  & Kerwyn Casey Huang
  • Letter |

    Triple oxygen isotope measurements of 1.4-billion-year-old sedimentary sulfates reveal a unique mid-Proterozoic atmosphere and demonstrate that gross primary productivity in the mid-Proterozoic was between 6% and 41% of pre-anthropogenic levels.

    • Peter W. Crockford
    • , Justin A. Hayles
    • , Huiming Bao
    • , Noah J. Planavsky
    • , Andrey Bekker
    • , Philip W. Fralick
    • , Galen P. Halverson
    • , Thi Hao Bui
    • , Yongbo Peng
    •  & Boswell A. Wing
  • Article |

    Analysis of more than 1,500 microbial genomes sheds light on the processing of carbon released as permafrost thaws.

    • Ben J. Woodcroft
    • , Caitlin M. Singleton
    • , Joel A. Boyd
    • , Paul N. Evans
    • , Joanne B. Emerson
    • , Ahmed A. F. Zayed
    • , Robert D. Hoelzle
    • , Timothy O. Lamberton
    • , Carmody K. McCalley
    • , Suzanne B. Hodgkins
    • , Rachel M. Wilson
    • , Samuel O. Purvine
    • , Carrie D. Nicora
    • , Changsheng Li
    • , Steve Frolking
    • , Jeffrey P. Chanton
    • , Patrick M. Crill
    • , Scott R. Saleska
    • , Virginia I. Rich
    •  & Gene W. Tyson
  • Publisher Correction |

    • Xuchu Que
    • , Ming-Yow Hung
    • , Calvin Yeang
    • , Ayelet Gonen
    • , Thomas A. Prohaska
    • , Xiaoli Sun
    • , Cody Diehl
    • , Antti Määttä
    • , Dalia E. Gaddis
    • , Karen Bowden
    • , Jennifer Pattison
    • , Jeffrey G. MacDonald
    • , Seppo Ylä-Herttuala
    • , Pamela L. Mellon
    • , Catherine C. Hedrick
    • , Klaus Ley
    • , Yury I. Miller
    • , Christopher K. Glass
    • , Kirk L. Peterson
    • , Christoph J. Binder
    • , Sotirios Tsimikas
    •  & Joseph L. Witztum
  • Letter |

    DNA origami is used as a template to produce complex geometric shapes of nanoscale silica hybrid materials.

    • Xiaoguo Liu
    • , Fei Zhang
    • , Xinxin Jing
    • , Muchen Pan
    • , Pi Liu
    • , Wei Li
    • , Bowen Zhu
    • , Jiang Li
    • , Hong Chen
    • , Lihua Wang
    • , Jianping Lin
    • , Yan Liu
    • , Dongyuan Zhao
    • , Hao Yan
    •  & Chunhai Fan
  • Letter |

    Sediment-core and modelling analyses suggest that, during distinct cold periods known as Heinrich Stadials, changes in ocean circulation in the North Atlantic triggered discharge of freshwater from the Cordilleran Ice Sheet into the North Pacific.

    • E. Maier
    • , X. Zhang
    • , A. Abelmann
    • , R. Gersonde
    • , S. Mulitza
    • , M. Werner
    • , M. Méheust
    • , J. Ren
    • , B. Chapligin
    • , H. Meyer
    • , R. Stein
    • , R. Tiedemann
    •  & G. Lohmann
  • Letter |

    Histidine metabolism influences the sensitivity of cancer cells to methotrexate, with mice bearing leukaemia xenografts showing increased response to the drug upon histidine supplementation.

    • Naama Kanarek
    • , Heather R. Keys
    • , Jason R. Cantor
    • , Caroline A. Lewis
    • , Sze Ham Chan
    • , Tenzin Kunchok
    • , Monther Abu-Remaileh
    • , Elizaveta Freinkman
    • , Lawrence D. Schweitzer
    •  & David M. Sabatini
  • Letter |

    Half-integer quantization of the thermal Hall effect in a Kitaev spin liquid reveals chiral currents of charge-neutral Majorana fermions around the edges of the sample, produced by strong electronic correlations.

    • Y. Kasahara
    • , T. Ohnishi
    • , Y. Mizukami
    • , O. Tanaka
    • , Sixiao Ma
    • , K. Sugii
    • , N. Kurita
    • , H. Tanaka
    • , J. Nasu
    • , Y. Motome
    • , T. Shibauchi
    •  & Y. Matsuda
  • Letter |

    An Early Pleistocene artefact assemblage from the Chinese Loess Plateau indicates that hominins had left Africa by at least 2.1 million years ago, and occupied the Loess Plateau repeatedly for a long time.

    • Zhaoyu Zhu
    • , Robin Dennell
    • , Weiwen Huang
    • , Yi Wu
    • , Shifan Qiu
    • , Shixia Yang
    • , Zhiguo Rao
    • , Yamei Hou
    • , Jiubing Xie
    • , Jiangwei Han
    •  & Tingping Ouyang