Latest Research

  • Letter |

    Identification and sequencing of circulating tumour DNA in the cerebrospinal fluid of patients with glioma.

    • Alexandra M. Miller
    • , Ronak H. Shah
    • , Elena I. Pentsova
    • , Maryam Pourmaleki
    • , Samuel Briggs
    • , Natalie Distefano
    • , Youyun Zheng
    • , Anna Skakodub
    • , Smrutiben A. Mehta
    • , Carl Campos
    • , Wan-Ying Hsieh
    • , S. Duygu Selcuklu
    • , Lilan Ling
    • , Fanli Meng
    • , Xiaohong Jing
    • , Aliaksandra Samoila
    • , Tejus A. Bale
    • , Dana W. Y. Tsui
    • , Christian Grommes
    • , Agnes Viale
    • , Mark M. Souweidane
    • , Viviane Tabar
    • , Cameron W. Brennan
    • , Anne S. Reiner
    • , Marc Rosenblum
    • , Katherine S. Panageas
    • , Lisa M. DeAngelis
    • , Robert J. Young
    • , Michael F. Berger
    •  & Ingo K. Mellinghoff
  • Letter |

    Earth system models suggest that soil-moisture variability and trends will induce large carbon releases throughout the twenty-first century.

    • Julia K. Green
    • , Sonia I. Seneviratne
    • , Alexis M. Berg
    • , Kirsten L. Findell
    • , Stefan Hagemann
    • , David M. Lawrence
    •  & Pierre Gentine
  • Letter |

    A faint penumbra in a photograph of a diffuse surface enables recovery of the position of the object creating the penumbra and an image of the scene behind it.

    • Charles Saunders
    • , John Murray-Bruce
    •  & Vivek K Goyal
  • Letter |

    Simulations of early galaxy formation suggest that the dynamics of structure formation, rather than the Lyman–Werner flux, drives the formation of massive black holes in the early Universe.

    • John H. Wise
    • , John A. Regan
    • , Brian W. O’Shea
    • , Michael L. Norman
    • , Turlough P. Downes
    •  & Hao Xu
  • Article |

    A consortium of 11 bacterial strains from the healthy human gut microbiota can strongly induce interferon-γ-producing CD8 T cells in the intestine, and enhance both resistance to bacterial infection and the therapeutic efficacy of immune checkpoint inhibitors.

    • Takeshi Tanoue
    • , Satoru Morita
    • , Damian R. Plichta
    • , Ashwin N. Skelly
    • , Wataru Suda
    • , Yuki Sugiura
    • , Seiko Narushima
    • , Hera Vlamakis
    • , Iori Motoo
    • , Kayoko Sugita
    • , Atsushi Shiota
    • , Kozue Takeshita
    • , Keiko Yasuma-Mitobe
    • , Dieter Riethmacher
    • , Tsuneyasu Kaisho
    • , Jason M. Norman
    • , Daniel Mucida
    • , Makoto Suematsu
    • , Tomonori Yaguchi
    • , Vanni Bucci
    • , Takashi Inoue
    • , Yutaka Kawakami
    • , Bernat Olle
    • , Bruce Roberts
    • , Masahira Hattori
    • , Ramnik J. Xavier
    • , Koji Atarashi
    •  & Kenya Honda
  • Article |

    The current phase of subduction of the Nazca slab was established in the Peruvian Andes after a plate reorganization around 80 million years ago and then propagated progressively southwards.

    • Yi-Wei Chen
    • , Jonny Wu
    •  & John Suppe
  • Letter |

    There are no new oligodendrocytes in potentially remyelinated multiple sclerosis shadow plaques, although oligodendrocyte generation is increased in the normal appearing white matter of patients with aggressive disease, informing the development of new therapies.

    • Maggie S. Y. Yeung
    • , Mehdi Djelloul
    • , Embla Steiner
    • , Samuel Bernard
    • , Mehran Salehpour
    • , Göran Possnert
    • , Lou Brundin
    •  & Jonas Frisén
  • Letter |

    In the mouse intestine, pyruvate and lactate produced from bacterial metabolites enhance immune responses through inducing dendrite protrusion, mediated by GPR31, of small intestinal mononuclear cells that express CX3CR1.

    • Naoki Morita
    • , Eiji Umemoto
    • , Setsuko Fujita
    • , Akio Hayashi
    • , Junichi Kikuta
    • , Ikuo Kimura
    • , Takeshi Haneda
    • , Toshio Imai
    • , Asuka Inoue
    • , Hitomi Mimuro
    • , Yuichi Maeda
    • , Hisako Kayama
    • , Ryu Okumura
    • , Junken Aoki
    • , Nobuhiko Okada
    • , Toshiyuki Kida
    • , Masaru Ishii
    • , Ryusuke Nabeshima
    •  & Kiyoshi Takeda
  • Author Correction |

    • Govinda Adhikari
    • , Pushparaj Adhikari
    • , Estella Barbosa de Souza
    • , Nelson Carlin
    • , Seonho Choi
    • , Mitra Djamal
    • , Anthony C. Ezeribe
    • , Chang Hyon Ha
    • , Insik Hahn
    • , Antonia J. F. Hubbard
    • , Eunju Jeon
    • , Jay Hyun Jo
    • , Hanwool Joo
    • , Woon Gu Kang
    • , Woosik Kang
    • , Matthew Kauer
    • , Bonghee Kim
    • , Hongjoo Kim
    • , Hyounggyu Kim
    • , Kyungwon Kim
    • , Nam Young Kim
    • , Sun Kee Kim
    • , Yeongduk Kim
    • , Yong-Hamb Kim
    • , Young Ju Ko
    • , Vitaly A. Kudryavtsev
    • , Hyun Su Lee
    • , Jaison Lee
    • , Jooyoung Lee
    • , Moo Hyun Lee
    • , Douglas S. Leonard
    • , Warren A. Lynch
    • , Reina H. Maruyama
    • , Frederic Mouton
    • , Stephen L. Olsen
    • , Byungju Park
    • , Hyang Kyu Park
    • , Hyeonseo Park
    • , Jungsic Park
    • , Kangsoon Park
    • , Walter C. Pettus
    • , Hafizh Prihtiadi
    • , Sejin Ra
    • , Carsten Rott
    • , Andrew Scarff
    • , Keon Ah Shin
    • , Neil J. C. Spooner
    • , William G. Thompson
    • , Liang Yang
    •  & Seok Hyun Yong
  • Letter |

    The thermal vibrations of a carbon nanotube are directly measured in real time with high displacement sensitivity and fine time resolution, revealing dynamics undetected by previous time-averaged measurements.

    • Arthur W. Barnard
    • , Mian Zhang
    • , Gustavo S. Wiederhecker
    • , Michal Lipson
    •  & Paul L. McEuen
  • Author Correction |

    • Serena Nik-Zainal
    • , Helen Davies
    • , Johan Staaf
    • , Manasa Ramakrishna
    • , Dominik Glodzik
    • , Xueqing Zou
    • , Inigo Martincorena
    • , Ludmil B. Alexandrov
    • , Sancha Martin
    • , David C. Wedge
    • , Peter Van Loo
    • , Young Seok Ju
    • , Marcel Smid
    • , Arie B. Brinkman
    • , Sandro Morganella
    • , Miriam R. Aure
    • , Ole Christian Lingjærde
    • , Anita Langerød
    • , Markus Ringnér
    • , Sung-Min Ahn
    • , Sandrine Boyault
    • , Jane E. Brock
    • , Annegien Broeks
    • , Adam Butler
    • , Christine Desmedt
    • , Luc Dirix
    • , Serge Dronov
    • , Aquila Fatima
    • , John A. Foekens
    • , Moritz Gerstung
    • , Gerrit K. J. Hooijer
    • , Se Jin Jang
    • , David R. Jones
    • , Hyung-Yong Kim
    • , Tari A. King
    • , Savitri Krishnamurthy
    • , Hee Jin Lee
    • , Jeong-Yeon Lee
    • , Yilong Li
    • , Stuart McLaren
    • , Andrew Menzies
    • , Ville Mustonen
    • , Sarah O’Meara
    • , Iris Pauporté
    • , Xavier Pivot
    • , Colin A. Purdie
    • , Keiran Raine
    • , Kamna Ramakrishnan
    • , F. Germán Rodríguez-González
    • , Gilles Romieu
    • , Anieta M. Sieuwerts
    • , Peter T. Simpson
    • , Rebecca Shepherd
    • , Lucy Stebbings
    • , Olafur A. Stefansson
    • , Jon Teague
    • , Stefania Tommasi
    • , Isabelle Treilleux
    • , Gert G. Van den Eynden
    • , Peter Vermeulen
    • , Anne Vincent-Salomon
    • , Lucy Yates
    • , Carlos Caldas
    • , Laura van’t Veer
    • , Andrew Tutt
    • , Stian Knappskog
    • , Benita Kiat Tee Tan
    • , Jos Jonkers
    • , Åke Borg
    • , Naoto T. Ueno
    • , Christos Sotiriou
    • , Alain Viari
    • , P. Andrew Futreal
    • , Peter J. Campbell
    • , Paul N. Span
    • , Steven Van Laere
    • , Sunil R. Lakhani
    • , Jorunn E. Eyfjord
    • , Alastair M. Thompson
    • , Ewan Birney
    • , Hendrik G. Stunnenberg
    • , Marc J. van de Vijver
    • , John W. M. Martens
    • , Anne-Lise Børresen-Dale
    • , Andrea L. Richardson
    • , Gu Kong
    • , Gilles Thomas
    •  & Michael R. Stratton
  • Letter |

    Organoids derived from human stem cells recapitulate the structure and functions of human blood vessels, and can be used to model and identify regulators of diabetic vasculopathy.

    • Reiner A. Wimmer
    • , Alexandra Leopoldi
    • , Martin Aichinger
    • , Nikolaus Wick
    • , Brigitte Hantusch
    • , Maria Novatchkova
    • , Jasmin Taubenschmid
    • , Monika Hämmerle
    • , Christopher Esk
    • , Joshua A. Bagley
    • , Dominik Lindenhofer
    • , Guibin Chen
    • , Manfred Boehm
    • , Chukwuma A. Agu
    • , Fengtang Yang
    • , Beiyuan Fu
    • , Johannes Zuber
    • , Juergen A. Knoblich
    • , Dontscho Kerjaschki
    •  & Josef M. Penninger
  • Letter |

    Cell-labelling experiments are used to demonstrate that the hindgut in the chick embryo is formed by cells moving through the stationary caudal intestinal portal as a result of a contractile force gradient directed by fibroblast growth factor signalling.

    • Nandan L. Nerurkar
    • , ChangHee Lee
    • , L. Mahadevan
    •  & Clifford J. Tabin
  • Article |

    Inspired by the enhanced mechanical strength of microstructured metals, damage-tolerant architected materials are developed in which the internal structure is granular, with different regions having different lattice orientations.

    • Minh-Son Pham
    • , Chen Liu
    • , Iain Todd
    •  & Jedsada Lertthanasarn
  • Letter |

    A magnetic contribution to the spin Hall effect is observed in the non-collinear antiferromagnet Mn3Sn, which is attributed to momentum-dependent spin splitting produced by non-collinear magnetic order.

    • Motoi Kimata
    • , Hua Chen
    • , Kouta Kondou
    • , Satoshi Sugimoto
    • , Prasanta K. Muduli
    • , Muhammad Ikhlas
    • , Yasutomo Omori
    • , Takahiro Tomita
    • , Allan. H. MacDonald
    • , Satoru Nakatsuji
    •  & Yoshichika Otani
  • Article |

    Transcriptomic and genetic analyses of a deletion set of all known introns in genes of the budding yeast Saccharomyces cerevisiae indicate that introns promote resistance to starvation.

    • Julie Parenteau
    • , Laurine Maignon
    • , Mélodie Berthoumieux
    • , Mathieu Catala
    • , Vanessa Gagnon
    •  & Sherif Abou Elela
  • Letter |

    Distinct but partially overlapping subsets of neurons in the orbitofrontal cortex of mice respond to feeding and/or social stimuli and, when optogenetically stimulated at single-cell resolution, specifically regulate reward-seeking behaviours.

    • Joshua H. Jennings
    • , Christina K. Kim
    • , James H. Marshel
    • , Misha Raffiee
    • , Li Ye
    • , Sean Quirin
    • , Sally Pak
    • , Charu Ramakrishnan
    •  & Karl Deisseroth
  • Letter |

    Quantitative explorations using biomechanics and robotics of the gait of Orobates, a stem amniote, indicate that the development of relatively erect, power-saving and balanced locomotion preceded the diversification of crown amniotes

    • John A. Nyakatura
    • , Kamilo Melo
    • , Tomislav Horvat
    • , Kostas Karakasiliotis
    • , Vivian R. Allen
    • , Amir Andikfar
    • , Emanuel Andrada
    • , Patrick Arnold
    • , Jonas Lauströer
    • , John R. Hutchinson
    • , Martin S. Fischer
    •  & Auke J. Ijspeert
  • Letter |

    Increased glutamine metabolism caused by unregulated HIF-1α signalling in mouse chondrocytes results in increased post-translational modification of collagen and skeletal dysplasia, demonstrating that strict regulation of HIF-1α signalling in chondrocytes is essential for normal bone growth.

    • Steve Stegen
    • , Kjell Laperre
    • , Guy Eelen
    • , Gianmarco Rinaldi
    • , Peter Fraisl
    • , Sophie Torrekens
    • , Riet Van Looveren
    • , Shauni Loopmans
    • , Geert Bultynck
    • , Stefan Vinckier
    • , Filip Meersman
    • , Patrick H. Maxwell
    • , Jyoti Rai
    • , MaryAnn Weis
    • , David R. Eyre
    • , Bart Ghesquière
    • , Sarah-Maria Fendt
    • , Peter Carmeliet
    •  & Geert Carmeliet
  • Letter |

    A kiwellin protein in maize is found to inhibit the activity of the secreted enzyme chorismate mutase from a maize-infecting pathogenic fungus, suggesting a role for kiwellins in plant immunity.

    • Xiaowei Han
    • , Florian Altegoer
    • , Wieland Steinchen
    • , Lynn Binnebesel
    • , Jan Schuhmacher
    • , Timo Glatter
    • , Pietro I. Giammarinaro
    • , Armin Djamei
    • , Stefan A. Rensing
    • , Stefanie Reissmann
    • , Regine Kahmann
    •  & Gert Bange
  • Article |

    A set of 34 excised introns in Saccharomyces cerevisiae, characterized by having a short distance between the lariat branch point and the 3′ splice site, have a biological function within the TOR growth-signalling network.

    • Jeffrey T. Morgan
    • , Gerald R. Fink
    •  & David P. Bartel
  • Letter |

    Photoredox transformations are achieved with infrared light by using triplet fusion upconversion that converts infrared into visible light, enabling the use of photoredox chemistry on larger scales and through barriers that are impenetrable by visible light.

    • Benjamin D. Ravetz
    • , Andrew B. Pun
    • , Emily M. Churchill
    • , Daniel N. Congreve
    • , Tomislav Rovis
    •  & Luis M. Campos
  • Letter |

    Multi-epoch observations of a supernova associated with a γ-ray burst reveal spectral features at extremely high expansion velocities within the first day after the burst, indicative of a choked jet.

    • L. Izzo
    • , A. de Ugarte Postigo
    • , K. Maeda
    • , C. C. Thöne
    • , D. A. Kann
    • , M. Della Valle
    • , A. Sagues Carracedo
    • , M. J. Michałowski
    • , P. Schady
    • , S. Schmidl
    • , J. Selsing
    • , R. L. C. Starling
    • , A. Suzuki
    • , K. Bensch
    • , J. Bolmer
    • , S. Campana
    • , Z. Cano
    • , S. Covino
    • , J. P. U. Fynbo
    • , D. H. Hartmann
    • , K. E. Heintz
    • , J. Hjorth
    • , J. Japelj
    • , K. Kamiński
    • , L. Kaper
    • , C. Kouveliotou
    • , M. Krużyński
    • , T. Kwiatkowski
    • , G. Leloudas
    • , A. J. Levan
    • , D. B. Malesani
    • , T. Michałowski
    • , S. Piranomonte
    • , G. Pugliese
    • , A. Rossi
    • , R. Sánchez-Ramírez
    • , S. Schulze
    • , D. Steeghs
    • , N. R. Tanvir
    • , K. Ulaczyk
    • , S. D. Vergani
    •  & K. Wiersema
  • Author Correction |

    • Belén Fadrique
    • , Selene Báez
    • , Álvaro Duque
    • , Agustina Malizia
    • , Cecilia Blundo
    • , Julieta Carilla
    • , Oriana Osinaga-Acosta
    • , Lucio Malizia
    • , Miles Silman
    • , William Farfán-Ríos
    • , Yadvinder Malhi
    • , Kenneth R. Young
    • , Cuesta C. Francisco
    • , Jurgen Homeier
    • , Manuel Peralvo
    • , Esteban Pinto
    • , Oswaldo Jadan
    • , Nikolay Aguirre
    • , Zhofre Aguirre
    •  & Kenneth J. Feeley
  • Letter |

    Imaging steady-state negative capacitance in SrTiO3/PbTiO3 superlattices with atomic resolution provides solid microscale support for this phenomenon.

    • Ajay K. Yadav
    • , Kayla X. Nguyen
    • , Zijian Hong
    • , Pablo García-Fernández
    • , Pablo Aguado-Puente
    • , Christopher T. Nelson
    • , Sujit Das
    • , Bhagawati Prasad
    • , Daewoong Kwon
    • , Suraj Cheema
    • , Asif I. Khan
    • , Chenming Hu
    • , Jorge Íñiguez
    • , Javier Junquera
    • , Long-Qing Chen
    • , David A. Muller
    • , Ramamoorthy Ramesh
    •  & Sayeef Salahuddin
  • Letter |

    A ferroelectric thin film that behaves as a single domain is found to exhibit both negative capacitance and the predicted double-well polarization–energy relationship.

    • Michael Hoffmann
    • , Franz P. G. Fengler
    • , Melanie Herzig
    • , Terence Mittmann
    • , Benjamin Max
    • , Uwe Schroeder
    • , Raluca Negrea
    • , Pintilie Lucian
    • , Stefan Slesazeck
    •  & Thomas Mikolajick
  • Letter |

    A three-dimensional photonic topological insulator is presented, made of split-ring resonators with strong magneto-electric coupling, which has an extremely wide topological bandgap, forbidding light propagation.

    • Yihao Yang
    • , Zhen Gao
    • , Haoran Xue
    • , Li Zhang
    • , Mengjia He
    • , Zhaoju Yang
    • , Ranjan Singh
    • , Yidong Chong
    • , Baile Zhang
    •  & Hongsheng Chen
  • Letter |

    A second repeating fast radio burst is detected, showing behaviour similar to that of the first, and demonstrating that repeaters are unlikely to be rare.

    • M. Amiri
    • , K. Bandura
    • , M. Bhardwaj
    • , P. Boubel
    • , M. M. Boyce
    • , P. J. Boyle
    • , C. Brar
    • , M. Burhanpurkar
    • , T. Cassanelli
    • , P. Chawla
    • , J. F. Cliche
    • , D. Cubranic
    • , M. Deng
    • , N. Denman
    • , M. Dobbs
    • , M. Fandino
    • , E. Fonseca
    • , B. M. Gaensler
    • , A. J. Gilbert
    • , A. Gill
    • , U. Giri
    • , D. C. Good
    • , M. Halpern
    • , D. S. Hanna
    • , A. S. Hill
    • , G. Hinshaw
    • , C. Höfer
    • , A. Josephy
    • , V. M. Kaspi
    • , T. L. Landecker
    • , D. A. Lang
    • , H.-H. Lin
    • , K. W. Masui
    • , R. Mckinven
    • , J. Mena-Parra
    • , M. Merryfield
    • , D. Michilli
    • , N. Milutinovic
    • , C. Moatti
    • , A. Naidu
    • , L. B. Newburgh
    • , C. Ng
    • , C. Patel
    • , U.-L. Pen
    • , T. Pinsonneault-Marotte
    • , Z. Pleunis
    • , M. Rafiei-Ravandi
    • , M. Rahman
    • , S. M. Ransom
    • , A. Renard
    • , P. Scholz
    • , J. R. Shaw
    • , S. R. Siegel
    • , K. M. Smith
    • , I. H. Stairs
    • , S. P. Tendulkar
    • , I. Tretyakov
    • , K. Vanderlinde
    •  & P. Yadav
  • Letter |

    Photometry and parallax data from the Gaia satellite provide direct observational evidence of a theoretically predicted pile-up in the cooling sequence of white dwarfs, which is associated with core crystallization.

    • Pier-Emmanuel Tremblay
    • , Gilles Fontaine
    • , Nicola Pietro Gentile Fusillo
    • , Bart H. Dunlap
    • , Boris T. Gänsicke
    • , Mark A. Hollands
    • , J. J. Hermes
    • , Thomas R. Marsh
    • , Elena Cukanovaite
    •  & Tim Cunningham
  • Letter |

    Radial growth in the roots of Arabidopsis, which is mediated by gene expression activated by the mobile PEAR1 and PEAR2 transcription factors, is initiated around protophloem-sieve-element cell files of procambial tissue.

    • Shunsuke Miyashima
    • , Pawel Roszak
    • , Iris Sevilem
    • , Koichi Toyokura
    • , Bernhard Blob
    • , Jung-ok Heo
    • , Nathan Mellor
    • , Hanna Help-Rinta-Rahko
    • , Sofia Otero
    • , Wouter Smet
    • , Mark Boekschoten
    • , Guido Hooiveld
    • , Kayo Hashimoto
    • , Ondřej Smetana
    • , Riccardo Siligato
    • , Eva-Sophie Wallner
    • , Ari Pekka Mähönen
    • , Yuki Kondo
    • , Charles W. Melnyk
    • , Thomas Greb
    • , Keiji Nakajima
    • , Rosangela Sozzani
    • , Anthony Bishopp
    • , Bert De Rybel
    •  & Ykä Helariutta
  • Letter |

    Specific ablation of mitochondrial complex III subunits in Treg cells in mice results in inflammatory disease, altered Treg gene expression and defective Treg function, indicating a key functional role for mitochondrial complex III in Treg cells.

    • Samuel E. Weinberg
    • , Benjamin D. Singer
    • , Elizabeth M. Steinert
    • , Carlos A. Martinez
    • , Manan M. Mehta
    • , Inmaculada Martínez-Reyes
    • , Peng Gao
    • , Kathryn A. Helmin
    • , Hiam Abdala-Valencia
    • , Laura A. Sena
    • , Paul T. Schumacker
    • , Laurence A. Turka
    •  & Navdeep S. Chandel
  • Letter |

    In the roots of Arabidopsis thaliana, cells with xylem identity and high levels of auxin signalling function as organizer cells that direct neighbouring vascular cambial cells to act as stem cells.

    • Ondřej Smetana
    • , Riikka Mäkilä
    • , Munan Lyu
    • , Ali Amiryousefi
    • , Filomeno Sánchez Rodríguez
    • , Miin-Feng Wu
    • , Anna Solé-Gil
    • , Marina Leal Gavarrón
    • , Riccardo Siligato
    • , Shunsuke Miyashima
    • , Pawel Roszak
    • , Tiina Blomster
    • , Jason W. Reed
    • , Suvi Broholm
    •  & Ari Pekka Mähönen
  • Letter |

    A frequently recurring nova is surrounded by an enormous cavity in space, produced as the nova’s ejecta ‘sweeps up’ the interstellar medium around the star after each eruption.

    • M. J. Darnley
    • , R. Hounsell
    • , T. J. O’Brien
    • , M. Henze
    • , P. Rodríguez-Gil
    • , A. W. Shafter
    • , M. M. Shara
    • , N. M. H. Vaytet
    • , M. F. Bode
    • , R. Ciardullo
    • , B. D. Davis
    • , R. Galera-Rosillo
    • , D. J. Harman
    • , E. J. Harvey
    • , M. W. Healy
    • , J.-U. Ness
    • , V. A. R. M. Ribeiro
    •  & S. C. Williams
  • Letter |

    A new metal–organic framework has several conformational degrees of freedom that can be modified by the external chemical environment to change the structure and trigger the uptake of a guest molecule.

    • Alexandros P. Katsoulidis
    • , Dmytro Antypov
    • , George F. S. Whitehead
    • , Elliot J. Carrington
    • , Dave J. Adams
    • , Neil G. Berry
    • , George R. Darling
    • , Matthew S. Dyer
    •  & Matthew J. Rosseinsky