Latest Research

  • Letter |

    Belief in moralizing gods followed the expansion of human societies and may have been preceded by doctrinal rituals that contributed to the initial rise of social complexity.

    • Harvey Whitehouse
    • , Pieter François
    • , Patrick E. Savage
    • , Thomas E. Currie
    • , Kevin C. Feeney
    • , Enrico Cioni
    • , Rosalind Purcell
    • , Robert M. Ross
    • , Jennifer Larson
    • , John Baines
    • , Barend ter Haar
    • , Alan Covey
    •  & Peter Turchin
  • Letter |

    Angle-resolved photoemission spectroscopy measurements in CoSi reveal the presence of unconventional chiral fermions near the Fermi level, with giant surface Fermi arcs and one pair of well separated chiral nodes.

    • Zhicheng Rao
    • , Hang Li
    • , Tiantian Zhang
    • , Shangjie Tian
    • , Chenghe Li
    • , Binbin Fu
    • , Cenyao Tang
    • , Le Wang
    • , Zhilin Li
    • , Wenhui Fan
    • , Jiajun Li
    • , Yaobo Huang
    • , Zhehong Liu
    • , Youwen Long
    • , Chen Fang
    • , Hongming Weng
    • , Youguo Shi
    • , Hechang Lei
    • , Yujie Sun
    • , Tian Qian
    •  & Hong Ding
  • Letter |

    Crystal structures of a five-protein complex comprising the inner-membrane components of the bacterial lipopolysaccharide transporter provide insight into the mechanism of extraction of lipopolysaccharide from the inner membrane and its transport to the outer membrane.

    • Tristan W. Owens
    • , Rebecca J. Taylor
    • , Karanbir S. Pahil
    • , Blake R. Bertani
    • , Natividad Ruiz
    • , Andrew C. Kruse
    •  & Daniel Kahne
  • Letter |

    A stochastic robotic system shows deterministic behaviour—such as locomotion, object transport and phototaxis—from the collective motion of many loosely coupled disk-shaped ‘particles’ that perform only volumetric oscillations.

    • Shuguang Li
    • , Richa Batra
    • , David Brown
    • , Hyun-Dong Chang
    • , Nikhil Ranganathan
    • , Chuck Hoberman
    • , Daniela Rus
    •  & Hod Lipson
  • Letter |

    Angle-resolved photoemission spectroscopy measurements reveal that CoSi and RhSi are nearly ideal topological conductors, with structural chirality and surface helicoid arcs of topological charge ±2 arising from bulk multifold chiral states.

    • Daniel S. Sanchez
    • , Ilya Belopolski
    • , Tyler A. Cochran
    • , Xitong Xu
    • , Jia-Xin Yin
    • , Guoqing Chang
    • , Weiwei Xie
    • , Kaustuv Manna
    • , Vicky Süß
    • , Cheng-Yi Huang
    • , Nasser Alidoust
    • , Daniel Multer
    • , Songtian S. Zhang
    • , Nana Shumiya
    • , Xirui Wang
    • , Guang-Qiang Wang
    • , Tay-Rong Chang
    • , Claudia Felser
    • , Su-Yang Xu
    • , Shuang Jia
    • , Hsin Lin
    •  & M. Zahid Hasan
  • Article |

    Cryo-electron microscopy structures of LptB2FGC, in nucleotide-free and vanadate-trapped states, reveal the mechanism of lipopolysaccharide extraction from the inner membrane of Gram-negative bacteria and a role for LptC in efficient lipopolysaccharide transport.

    • Yanyan Li
    • , Benjamin J. Orlando
    •  & Maofu Liao
  • Article |

    RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.

    • Rachel Rosenthal
    • , Elizabeth Larose Cadieux
    • , Roberto Salgado
    • , Maise Al Bakir
    • , David A. Moore
    • , Crispin T. Hiley
    • , Tom Lund
    • , Miljana Tanić
    • , James L. Reading
    • , Kroopa Joshi
    • , Jake Y. Henry
    • , Ehsan Ghorani
    • , Gareth A. Wilson
    • , Nicolai J. Birkbak
    • , Mariam Jamal-Hanjani
    • , Selvaraju Veeriah
    • , Zoltan Szallasi
    • , Sherene Loi
    • , Matthew D. Hellmann
    • , Andrew Feber
    • , Benny Chain
    • , Javier Herrero
    • , Sergio A. Quezada
    • , Jonas Demeulemeester
    • , Peter Van Loo
    • , Stephan Beck
    • , Nicholas McGranahan
    • , Charles Swanton
    • , Charles Swanton
    • , Mariam Jamal-Hanjani
    • , Selvaraju Veeriah
    • , Justyna Czyzewska-Khan
    • , Diana Johnson
    • , Joanne Laycock
    • , Rachel Rosenthal
    • , Pat Gorman
    • , Robert E. Hynds
    • , Gareth Wilson
    • , Nicolai J. Birkbak
    • , Thomas B. K. Watkins
    • , Nicholas McGranahan
    • , Mickael Escudero
    • , Aengus Stewart
    • , Peter Van Loo
    • , Andrew Rowan
    • , Crispin Hiley
    • , Christopher Abbosh
    • , Jacki Goldman
    • , Richard Kevin Stone
    • , Tamara Denner
    • , Sophia Ward
    • , Emma Nye
    • , Kroopa Joshi
    • , Assma Ben Aissa
    • , Yien Ning Sophia Wong
    • , Andy Georgiou
    • , Sergio Quezada
    • , John A. Hartley
    • , Helen L. Lowe
    • , Javier Herrero
    • , David Lawrence
    • , Martin Hayward
    • , Nikolaos Panagiotopoulos
    • , Mary Falzon
    • , Elaine Borg
    • , Teresa Marafioti
    • , Sam M. Janes
    • , Martin Forster
    • , Tanya Ahmad
    • , Siow Ming Lee
    • , Dionysis Papadatos-Pastos
    • , Dawn Carnell
    • , Ruheena Mendes
    • , Jeremy George
    • , Asia Ahmed
    • , Magali Taylor
    • , Junaid Choudhary
    • , Yvonne Summers
    • , Raffaele Califano
    • , Paul Taylor
    • , Rajesh Shah
    • , Piotr Krysiak
    • , Kendadai Rammohan
    • , Eustace Fontaine
    • , Richard Booton
    • , Matthew Evison
    • , Phil Crosbie
    • , Stuart Moss
    • , Leena Joseph
    • , Paul Bishop
    • , Anne Marie Quinn
    • , Helen Doran
    • , Angela Leek
    • , Phil Harrison
    • , Katrina Moore
    • , Rachael Waddington
    • , Juliette Novasio
    • , Fiona Blackhall
    • , Jane Rogan
    • , Elaine Smith
    • , Caroline Dive
    • , Jonathan Tugwood
    • , Ged Brady
    • , Dominic G. Rothwell
    • , Jackie Pierce
    • , Sakshi Gulati
    • , Babu Naidu
    • , Gerald Langman
    • , Simon Trotter
    • , Hollie Bancroft
    • , Amy Kerr
    • , Salma Kadiri
    • , Gary Middleton
    • , Madava Djearaman
    • , Dean Fennell
    • , Jacqui A. Shaw
    • , John Le Quesne
    • , David A. Moore
    • , Apostolos Nakas
    • , Sridhar Rathinam
    • , William Monteiro
    • , Hilary Marshall
    • , Louise Nelson
    • , Joan Riley
    • , Lindsay Primrose
    • , Luke Martinson
    • , Girija Anand
    • , Sajid Khan
    • , Marianne Nicolson
    • , Keith Kerr
    • , Shirley Palmer
    • , Hardy Remmen
    • , Joy Miller
    • , Keith Buchan
    • , Mahendran Chetty
    • , Lesley Gomersall
    • , Jason Lester
    • , Fiona Morgan
    • , Haydn Adams
    • , Helen Davies
    • , Malgorzata Kornaszewska
    • , Richard Attanoos
    • , Sara Lock
    • , Mairead MacKenzie
    • , Maggie Wilcox
    • , Harriet Bell
    • , Allan Hackshaw
    • , Yenting Ngai
    • , Sean Smith
    • , Nicole Gower
    • , Christian Ottensmeier
    • , Serena Chee
    • , Benjamin Johnson
    • , Aiman Alzetani
    • , Emily Shaw
    • , Eric Lim
    • , Paulo De Sousa
    • , Monica Tavares Barbosa
    • , Alex Bowman
    • , Simon Jordan
    • , Alexandra Rice
    • , Hilgardt Raubenheimer
    • , Harshil Bhayani
    • , Morag Hamilton
    • , Natalie Mensah
    • , Lyn Ambrose
    • , Anand Devaraj
    • , Hema Chavan
    • , Andrew G. Nicholson
    • , Kelvin Lau
    • , Michael Sheaff
    • , Peter Schmid
    • , John Conibear
    • , Veni Ezhil
    • , Vineet Prakash
    • , Peter Russell
    • , Teresa Light
    • , Tracey Horey
    • , Sarah Danson
    • , Jonathan Bury
    • , John Edwards
    • , Jennifer Hill
    • , Sue Matthews
    • , Yota Kitsanta
    • , Kim Suvarna
    • , Patricia Fisher
    • , Michael Shackcloth
    • , John Gosney
    • , Sarah Feeney
    • , Julius Asante-Siaw
    • , Kim Ryanna
    • , Alan Dawson
    • , Mohamad Tuffail
    • , Amrita Bajaj
    • , Jan Brozik
    • , Harriet Walter
    • , Nicolas Carey
    • , Gillian Price
    • , Kayleigh Gilbert
    • , Joanne Webb
    • , Akshay Patel
    • , Anshuman Chaturvedi
    • , Felice Granato
    • , Katie Baker
    • , Mathew Carter
    • , Lynsey Priest
    • , Matthew G. Krebs
    • , Colin Lindsay
    • , Fabio Gomes
    • , Francesca Chemie
    • , Robert George
    • , Davide Patrini
    • , Reena Khiroya
    • , Penny Shaw
    • , Marcin Skrzypski
    • , Mariana Werner Sunderland
    • , James L. Reading
    • , Carmella Beastall
    • , Nagina Mangal
    • , Karl Peggs
    • , Emilia Lim
    • , Maise Al-Bakir
    • , Neal Navani
    • , Marco Scarci
    • , Leah Ensell
    • , Dhruva Biswas
    • , Roberto Salgado
    • , Maryam Razaq
    • , Jerome Nicod
    • , Stephan Beck
    • , Saioa Lopez
    • , Ariana Huebner
    • , Michelle Dietzen
    • , Thanos Mourikis
    • , Toyin Adefila-Ideozu
    • , Sofina Begum
    • , Henriette Klein
    • , Aleksander Mani
    • , Soraia Carvalho
    • , Daniel Kaniu
    • , Cristina Realingo
    • , Mpho Malima
    • , Sarah Booth
    • , Louise Lim
    • , Jagan Rao
    • , Sara Tenconi
    • , Laura Socci
    • , Faith Kibutu
    • , Michael Agyemang
    • , Robin Young
    • , Kevin G. Blyth
    • , Craig Dick
    • , Alan Kirk
    •  & Andrew Kidd
  • Letter |

    Huge X-ray structures, termed Galactic Centre ‘chimneys’, extending hundreds of parsecs above and below the Galactic plane, appear to be exhaust channels connecting the Galactic Centre region to the Fermi bubbles.

    • G. Ponti
    • , F. Hofmann
    • , E. Churazov
    • , M. R. Morris
    • , F. Haberl
    • , K. Nandra
    • , R. Terrier
    • , M. Clavel
    •  & A. Goldwurm
  • Letter |

    An inversion model for the ultraslow-spreading Mohns Ridge, combining controlled source electromagnetic and magnetotelluric data, reveals passive mantle upwelling controlled by slow and asymmetric plate movements.

    • Ståle Emil Johansen
    • , Martin Panzner
    • , Rune Mittet
    • , Hans E. F. Amundsen
    • , Anna Lim
    • , Eirik Vik
    • , Martin Landrø
    •  & Børge Arntsen
  • Letter |

    In human neuroblastoma tumours, MYCN is engaged in a USP11–BRCA1-dependent manner to suppress the accumulation of stalled RNAPII and induces both the activation and repression of genes.

    • Steffi Herold
    • , Jacqueline Kalb
    • , Gabriele Büchel
    • , Carsten P. Ade
    • , Apoorva Baluapuri
    • , Jiajia Xu
    • , Jan Koster
    • , Daniel Solvie
    • , Anne Carstensen
    • , Christina Klotz
    • , Sabrina Rodewald
    • , Christina Schülein-Völk
    • , Matthias Dobbelstein
    • , Elmar Wolf
    • , Jan Molenaar
    • , Rogier Versteeg
    • , Susanne Walz
    •  & Martin Eilers
  • Analysis |

    The characterization of missense histone mutations that occur across several cancer types provides insight into the potential role of these mutations in altering chromatin structure and potentially contributing to tumour development.

    • Benjamin A. Nacev
    • , Lijuan Feng
    • , John D. Bagert
    • , Agata E. Lemiesz
    • , JianJiong Gao
    • , Alexey A. Soshnev
    • , Ritika Kundra
    • , Nikolaus Schultz
    • , Tom W. Muir
    •  & C. David Allis
  • Letter |

    Cryo-electron microscopy structures of tau filaments from the brains of three individuals with chronic traumatic encephalopathy reveal distinct assembled tau conformers, with a novel protofilament fold enclosing hydrophobic molecules.

    • Benjamin Falcon
    • , Jasenko Zivanov
    • , Wenjuan Zhang
    • , Alexey G. Murzin
    • , Holly J. Garringer
    • , Ruben Vidal
    • , R. Anthony Crowther
    • , Kathy L. Newell
    • , Bernardino Ghetti
    • , Michel Goedert
    •  & Sjors H. W. Scheres
  • Letter |

    A set of 355 self-assembling DNA ‘tiles’ can be reprogrammed to implement many different computer algorithms—including sorting, palindrome testing and divisibility by three—suggesting that molecular self-assembly could be a reliable algorithmic component in programmable chemical systems.

    • Damien Woods
    • , David Doty
    • , Cameron Myhrvold
    • , Joy Hui
    • , Felix Zhou
    • , Peng Yin
    •  & Erik Winfree
  • Letter |

    Observations of asteroid (101955) Bennu with NASA’s OSIRIS-REx spacecraft reveal an unexpected surficial diversity that poses a challenge to the success of the sample-return mission.

    • D. S. Lauretta
    • , D. N. DellaGiustina
    • , C. A. Bennett
    • , D. R. Golish
    • , K. J. Becker
    • , S. S. Balram-Knutson
    • , O. S. Barnouin
    • , T. L. Becker
    • , W. F. Bottke
    • , W. V. Boynton
    • , H. Campins
    • , B. E. Clark
    • , H. C. Connolly Jr
    • , C. Y. Drouet d’Aubigny
    • , J. P. Dworkin
    • , J. P. Emery
    • , H. L. Enos
    • , V. E. Hamilton
    • , C. W. Hergenrother
    • , E. S. Howell
    • , M. R. M. Izawa
    • , H. H. Kaplan
    • , M. C. Nolan
    • , B. Rizk
    • , H. L. Roper
    • , D. J. Scheeres
    • , P. H. Smith
    • , K. J. Walsh
    • , C. W. V. Wolner
    • , D. E. Highsmith
    • , J. Small
    • , D. Vokrouhlický
    • , N. E. Bowles
    • , E. Brown
    • , K. L. Donaldson Hanna
    • , T. Warren
    • , C. Brunet
    • , R. A. Chicoine
    • , S. Desjardins
    • , D. Gaudreau
    • , T. Haltigin
    • , S. Millington-Veloza
    • , A. Rubi
    • , J. Aponte
    • , N. Gorius
    • , A. Lunsford
    • , B. Allen
    • , J. Grindlay
    • , D. Guevel
    • , D. Hoak
    • , J. Hong
    • , D. L. Schrader
    • , J. Bayron
    • , O. Golubov
    • , P. Sánchez
    • , J. Stromberg
    • , M. Hirabayashi
    • , C. M. Hartzell
    • , S. Oliver
    • , M. Rascon
    • , A. Harch
    • , J. Joseph
    • , S. Squyres
    • , D. Richardson
    • , J. P. Emery
    • , L. McGraw
    • , R. Ghent
    • , R. P. Binzel
    • , M. M. Al Asad
    • , C. L. Johnson
    • , L. Philpott
    • , H. C. M. Susorney
    • , E. A. Cloutis
    • , R. D. Hanna
    • , H. C. Connolly Jr.
    • , F. Ciceri
    • , A. R. Hildebrand
    • , E.-M. Ibrahim
    • , L. Breitenfeld
    • , T. Glotch
    • , A. D. Rogers
    • , B. E. Clark
    • , S. Ferrone
    • , C. A. Thomas
    • , H. Campins
    • , Y. Fernandez
    • , W. Chang
    • , A. Cheuvront
    • , D. Trang
    • , S. Tachibana
    • , H. Yurimoto
    • , J. R. Brucato
    • , G. Poggiali
    • , M. Pajola
    • , E. Dotto
    • , E. Mazzotta Epifani
    • , M. K. Crombie
    • , C. Lantz
    • , M. R. M. Izawa
    • , J. de Leon
    • , J. Licandro
    • , J. L. Rizos Garcia
    • , S. Clemett
    • , K. Thomas-Keprta
    • , S. Van wal
    • , M. Yoshikawa
    • , J. Bellerose
    • , S. Bhaskaran
    • , C. Boyles
    • , S. R. Chesley
    • , C. M. Elder
    • , D. Farnocchia
    • , A. Harbison
    • , B. Kennedy
    • , A. Knight
    • , N. Martinez-Vlasoff
    • , N. Mastrodemos
    • , T. McElrath
    • , W. Owen
    • , R. Park
    • , B. Rush
    • , L. Swanson
    • , Y. Takahashi
    • , D. Velez
    • , K. Yetter
    • , C. Thayer
    • , C. Adam
    • , P. Antreasian
    • , J. Bauman
    • , C. Bryan
    • , B. Carcich
    • , M. Corvin
    • , J. Geeraert
    • , J. Hoffman
    • , J. M. Leonard
    • , E. Lessac-Chenen
    • , A. Levine
    • , J. McAdams
    • , L. McCarthy
    • , D. Nelson
    • , B. Page
    • , J. Pelgrift
    • , E. Sahr
    • , K. Stakkestad
    • , D. Stanbridge
    • , D. Wibben
    • , B. Williams
    • , K. Williams
    • , P. Wolff
    • , P. Hayne
    • , D. Kubitschek
    • , M. A. Barucci
    • , J. D. P. Deshapriya
    • , S. Fornasier
    • , M. Fulchignoni
    • , P. Hasselmann
    • , F. Merlin
    • , A. Praet
    • , E. B. Bierhaus
    • , O. Billett
    • , A. Boggs
    • , B. Buck
    • , S. Carlson-Kelly
    • , J. Cerna
    • , K. Chaffin
    • , E. Church
    • , M. Coltrin
    • , J. Daly
    • , A. Deguzman
    • , R. Dubisher
    • , D. Eckart
    • , D. Ellis
    • , P. Falkenstern
    • , A. Fisher
    • , M. E. Fisher
    • , P. Fleming
    • , K. Fortney
    • , S. Francis
    • , S. Freund
    • , S. Gonzales
    • , P. Haas
    • , A. Hasten
    • , D. Hauf
    • , A. Hilbert
    • , D. Howell
    • , F. Jaen
    • , N. Jayakody
    • , M. Jenkins
    • , K. Johnson
    • , M. Lefevre
    • , H. Ma
    • , C. Mario
    • , K. Martin
    • , C. May
    • , M. McGee
    • , B. Miller
    • , C. Miller
    • , G. Miller
    • , A. Mirfakhrai
    • , E. Muhle
    • , C. Norman
    • , R. Olds
    • , C. Parish
    • , M. Ryle
    • , M. Schmitzer
    • , P. Sherman
    • , M. Skeen
    • , M. Susak
    • , B. Sutter
    • , Q. Tran
    • , C. Welch
    • , R. Witherspoon
    • , J. Wood
    • , J. Zareski
    • , M. Arvizu-Jakubicki
    • , E. Asphaug
    • , E. Audi
    • , R.-L. Ballouz
    • , R. Bandrowski
    • , K. J. Becker
    • , T. L. Becker
    • , S. Bendall
    • , C. A. Bennett
    • , H. Bloomenthal
    • , D. Blum
    • , W. V. Boynton
    • , J. Brodbeck
    • , K. N. Burke
    • , M. Chojnacki
    • , A. Colpo
    • , J. Contreras
    • , J. Cutts
    • , C. Y. Drouet d’Aubigny
    • , D. Dean
    • , D. N. DellaGiustina
    • , B. Diallo
    • , D. Drinnon
    • , K. Drozd
    • , H. L. Enos
    • , R. Enos
    • , C. Fellows
    • , T. Ferro
    • , M. R. Fisher
    • , G. Fitzgibbon
    • , M. Fitzgibbon
    • , J. Forelli
    • , T. Forrester
    • , I. Galinsky
    • , R. Garcia
    • , A. Gardner
    • , D. R. Golish
    • , N. Habib
    • , D. Hamara
    • , D. Hammond
    • , K. Hanley
    • , K. Harshman
    • , C. W. Hergenrother
    • , K. Herzog
    • , D. Hill
    • , C. Hoekenga
    • , S. Hooven
    • , E. S. Howell
    • , E. Huettner
    • , A. Janakus
    • , J. Jones
    • , T. R. Kareta
    • , J. Kidd
    • , K. Kingsbury
    • , S. S. Balram-Knutson
    • , L. Koelbel
    • , J. Kreiner
    • , D. Lambert
    • , D. S. Lauretta
    • , C. Lewin
    • , B. Lovelace
    • , M. Loveridge
    • , M. Lujan
    • , C. K. Maleszewski
    • , R. Malhotra
    • , K. Marchese
    • , E. McDonough
    • , N. Mogk
    • , V. Morrison
    • , E. Morton
    • , R. Munoz
    • , J. Nelson
    • , M. C. Nolan
    • , J. Padilla
    • , R. Pennington
    • , A. Polit
    • , N. Ramos
    • , V. Reddy
    • , M. Riehl
    • , B. Rizk
    • , H. L. Roper
    • , S. Salazar
    • , S. R. Schwartz
    • , S. Selznick
    • , N. Shultz
    • , P. H. Smith
    • , S. Stewart
    • , S. Sutton
    • , T. Swindle
    • , Y. H. Tang
    • , M. Westermann
    • , C. W. V. Wolner
    • , D. Worden
    • , T. Zega
    • , Z. Zeszut
    • , A. Bjurstrom
    • , L. Bloomquist
    • , C. Dickinson
    • , E. Keates
    • , J. Liang
    • , V. Nifo
    • , A. Taylor
    • , F. Teti
    • , M. Caplinger
    • , H. Bowles
    • , S. Carter
    • , S. Dickenshied
    • , D. Doerres
    • , T. Fisher
    • , W. Hagee
    • , J. Hill
    • , M. Miner
    • , D. Noss
    • , N. Piacentine
    • , M. Smith
    • , A. Toland
    • , P. Wren
    • , M. Bernacki
    • , D. Pino Munoz
    • , S.-i. Watanabe
    • , S. A. Sandford
    • , A. Aqueche
    • , B. Ashman
    • , M. Barker
    • , A. Bartels
    • , K. Berry
    • , B. Bos
    • , R. Burns
    • , A. Calloway
    • , R. Carpenter
    • , N. Castro
    • , R. Cosentino
    • , J. Donaldson
    • , J. P. Dworkin
    • , J. Elsila Cook
    • , C. Emr
    • , D. Everett
    • , D. Fennell
    • , K. Fleshman
    • , D. Folta
    • , D. Gallagher
    • , J. Garvin
    • , K. Getzandanner
    • , D. Glavin
    • , S. Hull
    • , K. Hyde
    • , H. Ido
    • , A. Ingegneri
    • , N. Jones
    • , P. Kaotira
    • , L. F. Lim
    • , A. Liounis
    • , C. Lorentson
    • , D. Lorenz
    • , J. Lyzhoft
    • , E. M. Mazarico
    • , R. Mink
    • , W. Moore
    • , M. Moreau
    • , S. Mullen
    • , J. Nagy
    • , G. Neumann
    • , J. Nuth
    • , D. Poland
    • , D. C. Reuter
    • , L. Rhoads
    • , S. Rieger
    • , D. Rowlands
    • , D. Sallitt
    • , A. Scroggins
    • , G. Shaw
    • , A. A. Simon
    • , J. Swenson
    • , P. Vasudeva
    • , M. Wasser
    • , R. Zellar
    • , J. Grossman
    • , G. Johnston
    • , M. Morris
    • , J. Wendel
    • , A. Burton
    • , L. P. Keller
    • , L. McNamara
    • , S. Messenger
    • , K. Nakamura-Messenger
    • , A. Nguyen
    • , K. Righter
    • , E. Queen
    • , K. Bellamy
    • , K. Dill
    • , S. Gardner
    • , M. Giuntini
    • , B. Key
    • , J. Kissell
    • , D. Patterson
    • , D. Vaughan
    • , B. Wright
    • , R. W. Gaskell
    • , L. Le Corre
    • , J.-Y. Li
    • , J. L. Molaro
    • , E. E. Palmer
    • , M. A. Siegler
    • , P. Tricarico
    • , J. R. Weirich
    • , X.-D. Zou
    • , T. Ireland
    • , K. Tait
    • , P. Bland
    • , S. Anwar
    • , N. Bojorquez-Murphy
    • , P. R. Christensen
    • , C. W. Haberle
    • , G. Mehall
    • , K. Rios
    • , I. Franchi
    • , B. Rozitis
    • , C. B. Beddingfield
    • , J. Marshall
    • , D. N. Brack
    • , A. S. French
    • , J. W. McMahon
    • , D. J. Scheeres
    • , E. R. Jawin
    • , T. J. McCoy
    • , S. Russell
    • , M. Killgore
    • , W. F. Bottke
    • , V. E. Hamilton
    • , H. H. Kaplan
    • , K. J. Walsh
    • , J. L. Bandfield
    • , B. C. Clark
    • , M. Chodas
    • , M. Lambert
    • , R. A. Masterson
    • , M. G. Daly
    • , J. Freemantle
    • , J. A. Seabrook
    • , O. S. Barnouin
    • , K. Craft
    • , R. T. Daly
    • , C. Ernst
    • , R. C. Espiritu
    • , M. Holdridge
    • , M. Jones
    • , A. H. Nair
    • , L. Nguyen
    • , J. Peachey
    • , M. E. Perry
    • , J. Plescia
    • , J. H. Roberts
    • , R. Steele
    • , R. Turner
    • , J. Backer
    • , K. Edmundson
    • , J. Mapel
    • , M. Milazzo
    • , S. Sides
    • , C. Manzoni
    • , B. May
    • , M. Delbo’
    • , G. Libourel
    • , P. Michel
    • , A. Ryan
    • , F. Thuillet
    •  & B. Marty
  • Letter |

    Simulation and measurement of the photoionization of atomic hydrogen at attosecond resolution confirm that the tunnelling of the ejected electron is instantaneous.

    • U. Satya Sainadh
    • , Han Xu
    • , Xiaoshan Wang
    • , A. Atia-Tul-Noor
    • , William C. Wallace
    • , Nicolas Douguet
    • , Alexander Bray
    • , Igor Ivanov
    • , Klaus Bartschat
    • , Anatoli Kheifets
    • , R. T. Sang
    •  & I. V. Litvinyuk
  • Article |

    Optical reconstruction of chromatin architecture and multiplex RNA labelling traces the DNA path in single cells and its relationship to transcription.

    • Leslie J. Mateo
    • , Sedona E. Murphy
    • , Antonina Hafner
    • , Isaac S. Cinquini
    • , Carly A. Walker
    •  & Alistair N. Boettiger
  • Letter |

    Cryo-EM structures of yeast Snf2 bound to the nucleosome in the presence of ADP or an ATP analogue reveal that Snf2 binding leads to distortion of the DNA, and a two-step mechanism underlying chromatin remodelling by Snf2 is proposed.

    • Meijing Li
    • , Xian Xia
    • , Yuanyuan Tian
    • , Qi Jia
    • , Xiaoyu Liu
    • , Ying Lu
    • , Ming Li
    • , Xueming Li
    •  & Zhucheng Chen
  • Letter |

    Microbial generation of a terminal-alkyne-containing amino acid can be encoded into E. coli and provides the potential for in vivo generation of proteins and natural products for click chemistry.

    • J. A. Marchand
    • , M. E. Neugebauer
    • , M. C. Ing
    • , C.-I. Lin
    • , J. G. Pelton
    •  & M. C. Y. Chang
  • Letter |

    A new calibration of the surface brightness–colour relation of eclipsing binary stars gives a distance to the Large Magellanic Cloud that is precise to one per cent.

    • G. Pietrzyński
    • , D. Graczyk
    • , A. Gallenne
    • , W. Gieren
    • , I. B. Thompson
    • , B. Pilecki
    • , P. Karczmarek
    • , M. Górski
    • , K. Suchomska
    • , M. Taormina
    • , B. Zgirski
    • , P. Wielgórski
    • , Z. Kołaczkowski
    • , P. Konorski
    • , S. Villanova
    • , N. Nardetto
    • , P. Kervella
    • , F. Bresolin
    • , R. P. Kudritzki
    • , J. Storm
    • , R. Smolec
    •  & W. Narloch
  • Letter |

    In serotonin-rich tissues, tissue transglutaminase 2 is able to attach serotonin to a glutamine residue in histone H3; this modification mediates permissive gene expression in these tissues.

    • Lorna A. Farrelly
    • , Robert E. Thompson
    • , Shuai Zhao
    • , Ashley E. Lepack
    • , Yang Lyu
    • , Natarajan V. Bhanu
    • , Baichao Zhang
    • , Yong-Hwee E. Loh
    • , Aarthi Ramakrishnan
    • , Krishna C. Vadodaria
    • , Kelly J. Heard
    • , Galina Erikson
    • , Tomoyoshi Nakadai
    • , Ryan M. Bastle
    • , Bradley J. Lukasak
    • , Henry Zebroski III
    • , Natalia Alenina
    • , Michael Bader
    • , Olivier Berton
    • , Robert G. Roeder
    • , Henrik Molina
    • , Fred H. Gage
    • , Li Shen
    • , Benjamin A. Garcia
    • , Haitao Li
    • , Tom W. Muir
    •  & Ian Maze
  • Letter |

    Agreement between two single-ion clocks is demonstrated experimentally at the 10−18 level over a six-month period, confirming a key postulate of Einstein’s theory of relativity with hundredfold-improved precision.

    • Christian Sanner
    • , Nils Huntemann
    • , Richard Lange
    • , Christian Tamm
    • , Ekkehard Peik
    • , Marianna S. Safronova
    •  & Sergey G. Porsev
  • Letter |

    Enzymatic catalysis of pericyclic [6+4] cycloaddition reactions to form ten-membered rings is observed during biosynthesis of the macrocyclic antibiotic streptoseomycin, and the mechanism of these transformations is established.

    • Bo Zhang
    • , Kai Biao Wang
    • , Wen Wang
    • , Xin Wang
    • , Fang Liu
    • , Jiapeng Zhu
    • , Jing Shi
    • , Ling Yu Li
    • , Hao Han
    • , Kuang Xu
    • , Hong Yun Qiao
    • , Xiao Zhang
    • , Rui Hua Jiao
    • , Kendall N. Houk
    • , Yong Liang
    • , Ren Xiang Tan
    •  & Hui Ming Ge
  • Letter |

    Even in the absence of external perturbations, waterfalls can gradually form from planar bedrock riverbeds as a result of unstable interactions between flow hydraulics, sediment transport and bedrock erosion.

    • Joel S. Scheingross
    • , Michael P. Lamb
    •  & Brian M. Fuller
  • Letter |

    A highly site-selective aromatic C–H functionalization reaction that does not require a particular directing group or arene substitution pattern provides functionalized arenes that can participate in various transformations.

    • Florian Berger
    • , Matthew B. Plutschack
    • , Julian Riegger
    • , Wanwan Yu
    • , Samira Speicher
    • , Matthew Ho
    • , Nils Frank
    •  & Tobias Ritter
  • Letter |

    Amphotericin B forms nonselective transmembrane ion channels, and restores host defences of cystic fibrosis airway epithelia independently of the regulatory function of cystic fibrosis transmembrane conductance.

    • Katrina A. Muraglia
    • , Rajeev S. Chorghade
    • , Bo Ram Kim
    • , Xiao Xiao Tang
    • , Viral S. Shah
    • , Anthony S. Grillo
    • , Page N. Daniels
    • , Alexander G. Cioffi
    • , Philip H. Karp
    • , Lingyang Zhu
    • , Michael J. Welsh
    •  & Martin D. Burke
  • Letter |

    A proof-of-concept clinical trial of patients with histiocytoses with MAPK-pathway mutations showed durable responses to treatment with the MEK1 and MEK2 inhibitor cobimetinib, which indicates that histiocytic neoplasms are dependent on MAPK signalling.

    • Eli L. Diamond
    • , Benjamin H. Durham
    • , Gary A. Ulaner
    • , Esther Drill
    • , Justin Buthorn
    • , Michelle Ki
    • , Lillian Bitner
    • , Hana Cho
    • , Robert J. Young
    • , Jasmine H. Francis
    • , Raajit Rampal
    • , Mario Lacouture
    • , Lynn A. Brody
    • , Neval Ozkaya
    • , Ahmet Dogan
    • , Neal Rosen
    • , Alexia Iasonos
    • , Omar Abdel-Wahab
    •  & David M. Hyman
  • Publisher Correction |

    • Dmitri Lodygin
    • , Moritz Hermann
    • , Nils Schweingruber
    • , Cassandra Flügel-Koch
    • , Takashi Watanabe
    • , Corinna Schlosser
    • , Arianna Merlini
    • , Henrike Körner
    • , Hsin-Fang Chang
    • , Henrike J. Fischer
    • , Holger M. Reichardt
    • , Marta Zagrebelsky
    • , Brit Mollenhauer
    • , Sebastian Kügler
    • , Dirk Fitzner
    • , Jens Frahm
    • , Christine Stadelmann
    • , Michael Haberl
    • , Francesca Odoardi
    •  & Alexander Flügel
  • Letter |

    Two classification algorithms that use the quantum state space to produce feature maps are demonstrated on a superconducting processor, enabling the solution of problems when the feature space is large and the kernel functions are computationally expensive to estimate.

    • Vojtěch Havlíček
    • , Antonio D. Córcoles
    • , Kristan Temme
    • , Aram W. Harrow
    • , Abhinav Kandala
    • , Jerry M. Chow
    •  & Jay M. Gambetta
  • Letter |

    METTL14 recognizes the trimethyl mark on lysine 36 of histone H3 that directs m6A modifications co-transcriptionally.

    • Huilin Huang
    • , Hengyou Weng
    • , Keren Zhou
    • , Tong Wu
    • , Boxuan Simen Zhao
    • , Mingli Sun
    • , Zhenhua Chen
    • , Xiaolan Deng
    • , Gang Xiao
    • , Franziska Auer
    • , Lars Klemm
    • , Huizhe Wu
    • , Zhixiang Zuo
    • , Xi Qin
    • , Yunzhu Dong
    • , Yile Zhou
    • , Hanjun Qin
    • , Shu Tao
    • , Juan Du
    • , Jun Liu
    • , Zhike Lu
    • , Hang Yin
    • , Ana Mesquita
    • , Celvie L. Yuan
    • , Yueh-Chiang Hu
    • , Wenju Sun
    • , Rui Su
    • , Lei Dong
    • , Chao Shen
    • , Chenying Li
    • , Ying Qing
    • , Xi Jiang
    • , Xiwei Wu
    • , Miao Sun
    • , Jun-Lin Guan
    • , Lianghu Qu
    • , Minjie Wei
    • , Markus Müschen
    • , Gang Huang
    • , Chuan He
    • , Jianhua Yang
    •  & Jianjun Chen
  • Letter |

    In patient-derived xenograft models of breast cancer in mice, an increase in stress hormones during progression or treatment with their synthetic derivatives activates the glucocorticoid receptor, and results in increased metastatic colonization and reduced survival.

    • Milan M. S. Obradović
    • , Baptiste Hamelin
    • , Nenad Manevski
    • , Joana Pinto Couto
    • , Atul Sethi
    • , Marie-May Coissieux
    • , Simone Münst
    • , Ryoko Okamoto
    • , Hubertus Kohler
    • , Alexander Schmidt
    •  & Mohamed Bentires-Alj
  • Letter |

    A statistical framework for breast-cancer recurrence uses long-term follow-up data and a knowledge of molecular subcategories to model distinct disease stages and to predict the risk of relapse.

    • Oscar M. Rueda
    • , Stephen-John Sammut
    • , Jose A. Seoane
    • , Suet-Feung Chin
    • , Jennifer L. Caswell-Jin
    • , Maurizio Callari
    • , Rajbir Batra
    • , Bernard Pereira
    • , Alejandra Bruna
    • , H. Raza Ali
    • , Elena Provenzano
    • , Bin Liu
    • , Michelle Parisien
    • , Cheryl Gillett
    • , Steven McKinney
    • , Andrew R. Green
    • , Leigh Murphy
    • , Arnie Purushotham
    • , Ian O. Ellis
    • , Paul D. Pharoah
    • , Cristina Rueda
    • , Samuel Aparicio
    • , Carlos Caldas
    •  & Christina Curtis
  • Letter |

    Using a thin-film lithium niobate photonic platform, an electro-optic frequency comb generator is realized that is capable of producing wide and stable spectra, spanning more frequencies than the entire telecommunications L-band.

    • Mian Zhang
    • , Brandon Buscaino
    • , Cheng Wang
    • , Amirhassan Shams-Ansari
    • , Christian Reimer
    • , Rongrong Zhu
    • , Joseph M. Kahn
    •  & Marko Lončar
  • Letter |

    Pancreatic cancer activates IL-6–STAT3 signalling in hepatocytes to induce the formation of a pro-metastatic niche in the liver.

    • Jae W. Lee
    • , Meredith L. Stone
    • , Paige M. Porrett
    • , Stacy K. Thomas
    • , Chad A. Komar
    • , Joey H. Li
    • , Devora Delman
    • , Kathleen Graham
    • , Whitney L. Gladney
    • , Xia Hua
    • , Taylor A. Black
    • , Austin L. Chien
    • , Krishna S. Majmundar
    • , Jeffrey C. Thompson
    • , Stephanie S. Yee
    • , Mark H. O’Hara
    • , Charu Aggarwal
    • , Dong Xin
    • , Abraham Shaked
    • , Mingming Gao
    • , Dexi Liu
    • , Mitesh J. Borad
    • , Ramesh K. Ramanathan
    • , Erica L. Carpenter
    • , Ailing Ji
    • , Maria C. de Beer
    • , Frederick C. de Beer
    • , Nancy R. Webb
    •  & Gregory L. Beatty
  • Article |

    Gboxin and its chemical derivatives inhibit the growth of primary human and mouse glioblastoma cells, but not of mouse embryonic fibroblasts or neonatal astrocytes, by targeting mitochondrial oxidative phosphorylation complexes.

    • Yufeng Shi
    • , S. Kyun Lim
    • , Qiren Liang
    • , Swathi V. Iyer
    • , Hua-Yu Wang
    • , Zilai Wang
    • , Xuanhua Xie
    • , Daochun Sun
    • , Yu-Jung Chen
    • , Viviane Tabar
    • , Philip Gutin
    • , Noelle Williams
    • , Jef K. De Brabander
    •  & Luis F. Parada
  • Letter |

    The E3 ubiquitin ligase TRAIP governs the choice between the NEIL3 or the Fanconi anaemia pathway for the repair of DNA interstrand crosslinks.

    • R. Alex Wu
    • , Daniel R. Semlow
    • , Ashley N. Kamimae-Lanning
    • , Olga V. Kochenova
    • , Gheorghe Chistol
    • , Michael R. Hodskinson
    • , Ravindra Amunugama
    • , Justin L. Sparks
    • , Meng Wang
    • , Lin Deng
    • , Claudia A. Mimoso
    • , Emily Low
    • , Ketan J. Patel
    •  & Johannes C. Walter
  • Letter |

    The cryo-electron microscopy structure of human TBK1 in complex with cyclic GMP–AMP-bound chicken STING reveals a binding mode that suggests that STING phosphorylation by TBK1 requires oligomerization of both proteins.

    • Conggang Zhang
    • , Guijun Shang
    • , Xiang Gui
    • , Xuewu Zhang
    • , Xiao-chen Bai
    •  & Zhijian J. Chen
  • Letter |

    Wetlands exposed to rapid sea-level rise over the late Holocene contain more soil carbon than those that experienced a long period of sea-level stability.

    • Kerrylee Rogers
    • , Jeffrey J. Kelleway
    • , Neil Saintilan
    • , J. Patrick Megonigal
    • , Janine B. Adams
    • , James R. Holmquist
    • , Meng Lu
    • , Lisa Schile-Beers
    • , Atun Zawadzki
    • , Debashish Mazumder
    •  & Colin D. Woodroffe
  • Letter |

    The transcription factor BACH1, which targets mitochondrial metabolism, is expressed at high levels in several types of cancer; reducing its expression in tumours makes them more susceptible to treatment with mitochondrial inhibitors.

    • Jiyoung Lee
    • , Ali E. Yesilkanal
    • , Joseph P. Wynne
    • , Casey Frankenberger
    • , Juan Liu
    • , Jielin Yan
    • , Mohamad Elbaz
    • , Daniel C. Rabe
    • , Felicia D. Rustandy
    • , Payal Tiwari
    • , Elizabeth A. Grossman
    • , Peter C. Hart
    • , Christie Kang
    • , Sydney M. Sanderson
    • , Jorge Andrade
    • , Daniel K. Nomura
    • , Marcelo G. Bonini
    • , Jason W. Locasale
    •  & Marsha Rich Rosner
  • Letter |

    Pressure-driven transport of aqueous salts through ångström-scale channels created from two-dimensional materials shows a transistor-like effect in which applying a tiny bias voltage can increase transport by up to 20 times.

    • T. Mouterde
    • , A. Keerthi
    • , A. R. Poggioli
    • , S. A. Dar
    • , A. Siria
    • , A. K. Geim
    • , L. Bocquet
    •  & B. Radha
  • Letter |

    Cryo-electron microscopy structures of full-length STING show that cyclic GMP–AMP induces a half-turn rotation of the ligand-binding domain relative to the transmembrane domain, forming a tetramer and higher-order oligomers for signalling.

    • Guijun Shang
    • , Conggang Zhang
    • , Zhijian J. Chen
    • , Xiao-chen Bai
    •  & Xuewu Zhang