Latest Research

  • Article |

    Branched flow of light is experimentally observed inside a thin soap membrane, where smooth variations of the membrane thickness transform the light beam into branched filaments of enhanced intensity that keep dividing as the waves propagate.

    • Anatoly Patsyk
    • , Uri Sivan
    • , Mordechai Segev
    •  & Miguel A. Bandres
  • Article |

    • Matthew S. Elitt
    • , Lilianne Barbar
    • , H. Elizabeth Shick
    • , Berit E. Powers
    • , Yuka Maeno-Hikichi
    • , Mayur Madhavan
    • , Kevin C. Allan
    • , Baraa S. Nawash
    • , Artur S. Gevorgyan
    • , Stevephen Hung
    • , Zachary S. Nevin
    • , Hannah E. Olsen
    • , Midori Hitomi
    • , Daniela M. Schlatzer
    • , Hien T. Zhao
    • , Adam Swayze
    • , David F. LePage
    • , Weihong Jiang
    • , Ronald A. Conlon
    • , Frank Rigo
    •  & Paul J. Tesar
  • Matters Arising |

    • Jing Zhao
    • , Xiao Tian
    • , Yabing Zhu
    • , Zhihui Zhang
    • , Elena Rydkina
    • , Yongxian Yuan
    • , Hongyun Zhang
    • , Bhaskar Roy
    • , Adam Cornwell
    • , Eviatar Nevo
    • , Xiaoxiao Shang
    • , Runyue Huang
    • , Karsten Kristiansen
    • , Andrei Seluanov
    • , Xiaodong Fang
    •  & Vera Gorbunova
  • Matters Arising |

    • Fazal Hadi
    • , Yavuz Kulaberoglu
    • , Kyren A. Lazarus
    • , Karsten Bach
    • , Rosemary Ugur
    • , Paul Beattie
    • , Ewan St John Smith
    •  & Walid T. Khaled
  • Article |

    Hydroxylapatite crystallites in human dental enamel show gradients in chemical composition, with a layer of magnesium enrichment on each side of a core rich in sodium, fluoride and carbonate ions.

    • Karen A. DeRocher
    • , Paul J. M. Smeets
    • , Berit H. Goodge
    • , Michael J. Zachman
    • , Prasanna V. Balachandran
    • , Linus Stegbauer
    • , Michael J. Cohen
    • , Lyle M. Gordon
    • , James M. Rondinelli
    • , Lena F. Kourkoutis
    •  & Derk Joester
  • Article |

    Fine-scale satellite data are used to quantify forest harvest rates in 26 European countries, finding an increase in harvested forest area of 49% and an increase in biomass loss of 69% between 2011–2015 and 2016–2018.

    • Guido Ceccherini
    • , Gregory Duveiller
    • , Giacomo Grassi
    • , Guido Lemoine
    • , Valerio Avitabile
    • , Roberto Pilli
    •  & Alessandro Cescatti
  • Article |

    Observations of TOI-849b reveal a radius smaller than Neptune’s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.

    • David J. Armstrong
    • , Théo A. Lopez
    • , Vardan Adibekyan
    • , Richard A. Booth
    • , Edward M. Bryant
    • , Karen A. Collins
    • , Magali Deleuil
    • , Alexandre Emsenhuber
    • , Chelsea X. Huang
    • , George W. King
    • , Jorge Lillo-Box
    • , Jack J. Lissauer
    • , Elisabeth Matthews
    • , Olivier Mousis
    • , Louise D. Nielsen
    • , Hugh Osborn
    • , Jon Otegi
    • , Nuno C. Santos
    • , Sérgio G. Sousa
    • , Keivan G. Stassun
    • , Dimitri Veras
    • , Carl Ziegler
    • , Jack S. Acton
    • , Jose M. Almenara
    • , David R. Anderson
    • , David Barrado
    • , Susana C. C. Barros
    • , Daniel Bayliss
    • , Claudia Belardi
    • , Francois Bouchy
    • , César Briceño
    • , Matteo Brogi
    • , David J. A. Brown
    • , Matthew R. Burleigh
    • , Sarah L. Casewell
    • , Alexander Chaushev
    • , David R. Ciardi
    • , Kevin I. Collins
    • , Knicole D. Colón
    • , Benjamin F. Cooke
    • , Ian J. M. Crossfield
    • , Rodrigo F. Díaz
    • , Elisa Delgado Mena
    • , Olivier D. S. Demangeon
    • , Caroline Dorn
    • , Xavier Dumusque
    • , Philipp Eigmüller
    • , Michael Fausnaugh
    • , Pedro Figueira
    • , Tianjun Gan
    • , Siddharth Gandhi
    • , Samuel Gill
    • , Erica J. Gonzales
    • , Michael R. Goad
    • , Maximilian N. Günther
    • , Ravit Helled
    • , Saeed Hojjatpanah
    • , Steve B. Howell
    • , James Jackman
    • , James S. Jenkins
    • , Jon M. Jenkins
    • , Eric L. N. Jensen
    • , Grant M. Kennedy
    • , David W. Latham
    • , Nicholas Law
    • , Monika Lendl
    • , Michael Lozovsky
    • , Andrew W. Mann
    • , Maximiliano Moyano
    • , James McCormac
    • , Farzana Meru
    • , Christoph Mordasini
    • , Ares Osborn
    • , Don Pollacco
    • , Didier Queloz
    • , Liam Raynard
    • , George R. Ricker
    • , Pamela Rowden
    • , Alexandre Santerne
    • , Joshua E. Schlieder
    • , Sara Seager
    • , Lizhou Sha
    • , Thiam-Guan Tan
    • , Rosanna H. Tilbrook
    • , Eric Ting
    • , Stéphane Udry
    • , Roland Vanderspek
    • , Christopher A. Watson
    • , Richard G. West
    • , Paul A. Wilson
    • , Joshua N. Winn
    • , Peter Wheatley
    • , Jesus Noel Villasenor
    • , Jose I. Vines
    •  & Zhuchang Zhan
  • Article |

    Structural cells implement a broad range of immune-regulatory functions beyond their roles as barriers and connective tissues, and they utilize an epigenetically encoded potential for immune gene activation in their rapid response to viral infection.

    • Thomas Krausgruber
    • , Nikolaus Fortelny
    • , Victoria Fife-Gernedl
    • , Martin Senekowitsch
    • , Linda C. Schuster
    • , Alexander Lercher
    • , Amelie Nemc
    • , Christian Schmidl
    • , André F. Rendeiro
    • , Andreas Bergthaler
    •  & Christoph Bock
  • Article |

    The small molecule GS-6207, which disrupts the function of the HIV capsid protein, shows potential as a long-acting therapeutic agent for the treatment and prevention of HIV infection.

    • John O. Link
    • , Martin S. Rhee
    • , Winston C. Tse
    • , Jim Zheng
    • , John R. Somoza
    • , William Rowe
    • , Rebecca Begley
    • , Anna Chiu
    • , Andrew Mulato
    • , Derek Hansen
    • , Eric Singer
    • , Luong K. Tsai
    • , Rujuta A. Bam
    • , Chien-Hung Chou
    • , Eda Canales
    • , Gediminas Brizgys
    • , Jennifer R. Zhang
    • , Jiayao Li
    • , Michael Graupe
    • , Philip Morganelli
    • , Qi Liu
    • , Qiaoyin Wu
    • , Randall L. Halcomb
    • , Roland D. Saito
    • , Scott D. Schroeder
    • , Scott E. Lazerwith
    • , Steven Bondy
    • , Debi Jin
    • , Magdeleine Hung
    • , Nikolai Novikov
    • , Xiaohong Liu
    • , Armando G. Villaseñor
    • , Carina E. Cannizzaro
    • , Eric Y. Hu
    • , Robert L. Anderson
    • , Todd C. Appleby
    • , Bing Lu
    • , Judy Mwangi
    • , Albert Liclican
    • , Anita Niedziela-Majka
    • , Giuseppe A. Papalia
    • , Melanie H. Wong
    • , Stephanie A. Leavitt
    • , Yili Xu
    • , David Koditek
    • , George J. Stepan
    • , Helen Yu
    • , Nikos Pagratis
    • , Sheila Clancy
    • , Shekeba Ahmadyar
    • , Terrence Z. Cai
    • , Scott Sellers
    • , Scott A. Wolckenhauer
    • , John Ling
    • , Christian Callebaut
    • , Nicolas Margot
    • , Renee R. Ram
    • , Ya-Pei Liu
    • , Rob Hyland
    • , Gary I. Sinclair
    • , Peter J. Ruane
    • , Gordon E. Crofoot
    • , Cheryl K. McDonald
    • , Diana M. Brainard
    • , Latesh Lad
    • , Swami Swaminathan
    • , Wesley I. Sundquist
    • , Roman Sakowicz
    • , Anne E. Chester
    • , William E. Lee
    • , Eric S. Daar
    • , Stephen R. Yant
    •  & Tomas Cihlar
  • Article |

    Laser-generated high-harmonic emission is used to image the valence potential and electron density in magnesium fluoride and calcium fluoride at the picometre scale, enabling direct probing of material properties.

    • H. Lakhotia
    • , H. Y. Kim
    • , M. Zhan
    • , S. Hu
    • , S. Meng
    •  & E. Goulielmakis
  • Article |

    A systems-level map of the Arabidopsis hormone signalling network, comprising more than 2,000 binary protein–protein interactions, reveals hundreds of interpathway contact points, many of which mediate crosstalk between different hormone pathways.

    • Melina Altmann
    • , Stefan Altmann
    • , Patricia A. Rodriguez
    • , Benjamin Weller
    • , Lena Elorduy Vergara
    • , Julius Palme
    • , Nora Marín-de la Rosa
    • , Mayra Sauer
    • , Marion Wenig
    • , José Antonio Villaécija-Aguilar
    • , Jennifer Sales
    • , Chung-Wen Lin
    • , Ramakrishnan Pandiarajan
    • , Veronika Young
    • , Alexandra Strobel
    • , Lisa Gross
    • , Samy Carbonnel
    • , Karl G. Kugler
    • , Antoni Garcia-Molina
    • , George W. Bassel
    • , Claudia Falter
    • , Klaus F. X. Mayer
    • , Caroline Gutjahr
    • , A. Corina Vlot
    • , Erwin Grill
    •  & Pascal Falter-Braun
  • Article |

    During nutrient stress, ribosomal protein abundance is regulated primarily by translational and non-autophagic degradative mechanisms, but ribosome density per cell is largely maintained by reductions in cell volume and rates of cell division.

    • Heeseon An
    • , Alban Ordureau
    • , Maria Körner
    • , Joao A. Paulo
    •  & J. Wade Harper
  • Article |

    Tagging and tracking the blood plasma proteome as a discovery tool reveals widespread endogenous transport of proteins into the healthy brain and the pharmacologically modifiable mechanisms by which the brain endothelium regulates this process with age.

    • Andrew C. Yang
    • , Marc Y. Stevens
    • , Michelle B. Chen
    • , Davis P. Lee
    • , Daniel Stähli
    • , David Gate
    • , Kévin Contrepois
    • , Winnie Chen
    • , Tal Iram
    • , Lichao Zhang
    • , Ryan T. Vest
    • , Aisling Chaney
    • , Benoit Lehallier
    • , Niclas Olsson
    • , Haley du Bois
    • , Ryan Hsieh
    • , Haley C. Cropper
    • , Daniela Berdnik
    • , Lulin Li
    • , Elizabeth Y. Wang
    • , Gavin M. Traber
    • , Carolyn R. Bertozzi
    • , Jian Luo
    • , Michael P. Snyder
    • , Joshua E. Elias
    • , Stephen R. Quake
    • , Michelle L. James
    •  & Tony Wyss-Coray
  • Article |

    Dysregulation of an mTORC1 substrate-specific mechanism leads to constitutive activation of TFEB, and promotes kidney cystogenesis and tumorigenesis in a mouse model of Birt–Hogg–Dubé syndrome.

    • Gennaro Napolitano
    • , Chiara Di Malta
    • , Alessandra Esposito
    • , Mariana E. G. de Araujo
    • , Salvatore Pece
    • , Giovanni Bertalot
    • , Maria Matarese
    • , Valerio Benedetti
    • , Angela Zampelli
    • , Taras Stasyk
    • , Diletta Siciliano
    • , Alessandro Venuta
    • , Marcella Cesana
    • , Claudia Vilardo
    • , Edoardo Nusco
    • , Jlenia Monfregola
    • , Alessia Calcagnì
    • , Pier Paolo Di Fiore
    • , Lukas A. Huber
    •  & Andrea Ballabio
  • Article |

    Both piriform cortex and its sensory inputs from the olfactory bulb represent chemical odour relationships, but cortex reshapes relational information inherited from the sensory periphery to enhance odour generalization and to reflect experience.

    • Stan L. Pashkovski
    • , Giuliano Iurilli
    • , David Brann
    • , Daniel Chicharro
    • , Kristen Drummey
    • , Kevin Franks
    • , Stefano Panzeri
    •  & Sandeep Robert Datta
  • Article |

    Quantum correlations between the laser beams and the positions of the 40-kg mirrors of LIGO are confirmed experimentally, enabling high-precision measurements of both gravitational waves and macroscopic quantum states.

    • Haocun Yu
    • , L. McCuller
    • , M. Tse
    • , N. Kijbunchoo
    • , L. Barsotti
    • , N. Mavalvala
    • , J. Betzwieser
    • , C. D. Blair
    • , S. E. Dwyer
    • , A. Effler
    • , M. Evans
    • , A. Fernandez-Galiana
    • , P. Fritschel
    • , V. V. Frolov
    • , F. Matichard
    • , D. E. McClelland
    • , T. McRae
    • , A. Mullavey
    • , D. Sigg
    • , B. J. J. Slagmolen
    • , C. Whittle
    • , A. Buikema
    • , Y. Chen
    • , T. R. Corbitt
    • , R. Schnabel
    • , R. Abbott
    • , C. Adams
    • , R. X. Adhikari
    • , A. Ananyeva
    • , S. Appert
    • , K. Arai
    • , J. S. Areeda
    • , Y. Asali
    • , S. M. Aston
    • , C. Austin
    • , A. M. Baer
    • , M. Ball
    • , S. W. Ballmer
    • , S. Banagiri
    • , D. Barker
    • , J. Bartlett
    • , B. K. Berger
    • , D. Bhattacharjee
    • , G. Billingsley
    • , S. Biscans
    • , R. M. Blair
    • , N. Bode
    • , P. Booker
    • , R. Bork
    • , A. Bramley
    • , A. F. Brooks
    • , D. D. Brown
    • , C. Cahillane
    • , K. C. Cannon
    • , X. Chen
    • , A. A. Ciobanu
    • , F. Clara
    • , S. J. Cooper
    • , K. R. Corley
    • , S. T. Countryman
    • , P. B. Covas
    • , D. C. Coyne
    • , L. E. H. Datrier
    • , D. Davis
    • , C. Di Fronzo
    • , K. L. Dooley
    • , J. C. Driggers
    • , P. Dupej
    • , T. Etzel
    • , T. M. Evans
    • , J. Feicht
    • , P. Fulda
    • , M. Fyffe
    • , J. A. Giaime
    • , K. D. Giardina
    • , P. Godwin
    • , E. Goetz
    • , S. Gras
    • , C. Gray
    • , R. Gray
    • , A. C. Green
    • , Anchal Gupta
    • , E. K. Gustafson
    • , R. Gustafson
    • , J. Hanks
    • , J. Hanson
    • , T. Hardwick
    • , R. K. Hasskew
    • , M. C. Heintze
    • , A. F. Helmling-Cornell
    • , N. A. Holland
    • , J. D. Jones
    • , S. Kandhasamy
    • , S. Karki
    • , M. Kasprzack
    • , K. Kawabe
    • , P. J. King
    • , J. S. Kissel
    • , Rahul Kumar
    • , M. Landry
    • , B. B. Lane
    • , B. Lantz
    • , M. Laxen
    • , Y. K. Lecoeuche
    • , J. Leviton
    • , J. Liu
    • , M. Lormand
    • , A. P. Lundgren
    • , R. Macas
    • , M. MacInnis
    • , D. M. Macleod
    • , G. L. Mansell
    • , S. Márka
    • , Z. Márka
    • , D. V. Martynov
    • , K. Mason
    • , T. J. Massinger
    • , R. McCarthy
    • , S. McCormick
    • , J. McIver
    • , G. Mendell
    • , K. Merfeld
    • , E. L. Merilh
    • , F. Meylahn
    • , T. Mistry
    • , R. Mittleman
    • , G. Moreno
    • , C. M. Mow-Lowry
    • , S. Mozzon
    • , T. J. N. Nelson
    • , P. Nguyen
    • , L. K. Nuttall
    • , J. Oberling
    • , Richard J. Oram
    • , C. Osthelder
    • , D. J. Ottaway
    • , H. Overmier
    • , J. R. Palamos
    • , W. Parker
    • , E. Payne
    • , A. Pele
    • , C. J. Perez
    • , M. Pirello
    • , H. Radkins
    • , K. E. Ramirez
    • , J. W. Richardson
    • , K. Riles
    • , N. A. Robertson
    • , J. G. Rollins
    • , C. L. Romel
    • , J. H. Romie
    • , M. P. Ross
    • , K. Ryan
    • , T. Sadecki
    • , E. J. Sanchez
    • , L. E. Sanchez
    • , T. R. Saravanan
    • , R. L. Savage
    • , D. Schaetzl
    • , R. M. S. Schofield
    • , E. Schwartz
    • , D. Sellers
    • , T. Shaffer
    • , J. R. Smith
    • , S. Soni
    • , B. Sorazu
    • , A. P. Spencer
    • , K. A. Strain
    • , L. Sun
    • , M. J. Szczepańczyk
    • , M. Thomas
    • , P. Thomas
    • , K. A. Thorne
    • , K. Toland
    • , C. I. Torrie
    • , G. Traylor
    • , A. L. Urban
    • , G. Vajente
    • , G. Valdes
    • , D. C. Vander-Hyde
    • , P. J. Veitch
    • , K. Venkateswara
    • , G. Venugopalan
    • , A. D. Viets
    • , T. Vo
    • , C. Vorvick
    • , M. Wade
    • , R. L. Ward
    • , J. Warner
    • , B. Weaver
    • , R. Weiss
    • , B. Willke
    • , C. C. Wipf
    • , L. Xiao
    • , H. Yamamoto
    • , Hang Yu
    • , L. Zhang
    • , M. E. Zucker
    •  & J. Zweizig
  • Article |

    Time-resolved cryogenic electron microscopy structures of a ribosome during the delivery of aminoacyl-tRNA by EF-Tu•GTP capture 33 ribosomal states, enabling visualization of the initial selection, proofreading and peptidyl transfer stages.

    • Anna B. Loveland
    • , Gabriel Demo
    •  & Andrei A. Korostelev
  • Article |

    Pax5 regulates contraction of the immunoglobulin heavy chain (Igh) locus—an essential step in V(D)J recombination—by promoting chromatin loop extrusion via repression of Wapl expression.

    • Louisa Hill
    • , Anja Ebert
    • , Markus Jaritz
    • , Gordana Wutz
    • , Kota Nagasaka
    • , Hiromi Tagoh
    • , Daniela Kostanova-Poliakova
    • , Karina Schindler
    • , Qiong Sun
    • , Peter Bönelt
    • , Maria Fischer
    • , Jan-Michael Peters
    •  & Meinrad Busslinger
  • Article |

    • Enrico Lavezzo
    • , Elisa Franchin
    • , Constanze Ciavarella
    • , Gina Cuomo-Dannenburg
    • , Luisa Barzon
    • , Claudia Del Vecchio
    • , Lucia Rossi
    • , Riccardo Manganelli
    • , Arianna Loregian
    • , Nicolò Navarin
    • , Davide Abate
    • , Manuela Sciro
    • , Stefano Merigliano
    • , Ettore De Canale
    • , Maria Cristina Vanuzzo
    • , Valeria Besutti
    • , Francesca Saluzzo
    • , Francesco Onelia
    • , Monia Pacenti
    • , Saverio Parisi
    • , Giovanni Carretta
    • , Daniele Donato
    • , Luciano Flor
    • , Silvia Cocchio
    • , Giulia Masi
    • , Alessandro Sperduti
    • , Lorenzo Cattarino
    • , Renato Salvador
    • , Michele Nicoletti
    • , Federico Caldart
    • , Gioele Castelli
    • , Eleonora Nieddu
    • , Beatrice Labella
    • , Ludovico Fava
    • , Matteo Drigo
    • , Katy A. M. Gaythorpe
    • , Kylie E. C. Ainslie
    • , Marc Baguelin
    • , Samir Bhatt
    • , Adhiratha Boonyasiri
    • , Olivia Boyd
    • , Lorenzo Cattarino
    • , Constanze Ciavarella
    • , Helen L. Coupland
    • , Zulma Cucunubá
    • , Gina Cuomo-Dannenburg
    • , Bimandra A. Djafaara
    • , Christl A. Donnelly
    • , Ilaria Dorigatti
    • , Sabine L. van Elsland
    • , Rich FitzJohn
    • , Seth Flaxman
    • , Katy A.M. Gaythorpe
    • , Will D. Green
    • , Timothy Hallett
    • , Arran Hamlet
    • , David Haw
    • , Natsuko Imai
    • , Benjamin Jeffrey
    • , Edward Knock
    • , Daniel J. Laydon
    • , Thomas Mellan
    • , Swapnil Mishra
    • , Gemma Nedjati-Gilani
    • , Pierre Nouvellet
    • , Lucy C. Okell
    • , Kris V. Parag
    • , Steven Riley
    • , Hayley A. Thompson
    • , H. Juliette T. Unwin
    • , Robert Verity
    • , Michaela A. C. Vollmer
    • , Patrick G. T. Walker
    • , Caroline E. Walters
    • , Haowei Wang
    • , Yuanrong Wang
    • , Oliver J. Watson
    • , Charles Whittaker
    • , Lilith K. Whittles
    • , Xiaoyue Xi
    • , Neil M. Ferguson
    • , Alessandra R. Brazzale
    • , Stefano Toppo
    • , Marta Trevisan
    • , Vincenzo Baldo
    • , Christl A. Donnelly
    • , Neil M. Ferguson
    • , Ilaria Dorigatti
    •  & Andrea Crisanti
  • Publisher Correction |

    • H. Abdalla
    • , R. Adam
    • , F. Aharonian
    • , F. Ait Benkhali
    • , E. O. Angüner
    • , M. Arakawa
    • , C. Arcaro
    • , C. Armand
    • , H. Ashkar
    • , M. Backes
    • , V. Barbosa Martins
    • , M. Barnard
    • , Y. Becherini
    • , D. Berge
    • , K. Bernlöhr
    • , R. Blackwell
    • , M. Böttcher
    • , C. Boisson
    • , J. Bolmont
    • , S. Bonnefoy
    • , J. Bregeon
    • , M. Breuhaus
    • , F. Brun
    • , P. Brun
    • , M. Bryan
    • , M. Büchele
    • , T. Bulik
    • , T. Bylund
    • , M. Capasso
    • , S. Caroff
    • , A. Carosi
    • , S. Casanova
    • , M. Cerruti
    • , T. Chand
    • , S. Chandra
    • , A. Chen
    • , S. Colafrancesco
    • , M. Curyło
    • , I. D. Davids
    • , C. Deil
    • , J. Devin
    • , P. deWilt
    • , L. Dirson
    • , A. Djannati-Ataï
    • , A. Dmytriiev
    • , A. Donath
    • , V. Doroshenko
    • , L. O’C. Drury
    • , J. Dyks
    • , K. Egberts
    • , G. Emery
    • , J.-P. Ernenwein
    • , S. Eschbach
    • , K. Feijen
    • , S. Fegan
    • , A. Fiasson
    • , G. Fontaine
    • , S. Funk
    • , M. Füßling
    • , S. Gabici
    • , Y. A. Gallant
    • , F. Gaté
    • , G. Giavitto
    • , D. Glawion
    • , J. F. Glicenstein
    • , D. Gottschall
    • , M.-H. Grondin
    • , J. Hahn
    • , M. Haupt
    • , G. Heinzelmann
    • , G. Henri
    • , G. Hermann
    • , J. A. Hinton
    • , W. Hofmann
    • , C. Hoischen
    • , T. L. Holch
    • , M. Holler
    • , D. Horns
    • , D. Huber
    • , H. Iwasaki
    • , M. Jamrozy
    • , D. Jankowsky
    • , F. Jankowsky
    • , A. Jardin-Blicq
    • , I. Jung-Richardt
    • , M. A. Kastendieck
    • , K. Katarzyński
    • , M. Katsuragawa
    • , U. Katz
    • , D. Khangulyan
    • , B. Khélifi
    • , J. King
    • , S. Klepser
    • , W. Kluźniak
    • , N. Komin
    • , K. Kosack
    • , D. Kostunin
    • , M. Kraus
    • , G. Lamanna
    • , J. Lau
    • , A. Lemière
    • , M. Lemoine-Goumard
    • , J.-P. Lenain
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    • , C. Levy
    • , T. Lohse
    • , I. Lypova
    • , J. Mackey
    • , J. Majumdar
    • , D. Malyshev
    • , V. Marandon
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    • , A. Mares
    • , C. Mariaud
    • , G. Martí-Devesa
    • , R. Marx
    • , G. Maurin
    • , P. J. Meintjes
    • , A. M. W. Mitchell
    • , R. Moderski
    • , M. Mohamed
    • , L. Mohrmann
    • , C. Moore
    • , E. Moulin
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    • , T. Murach
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    • , F. Niederwanger
    • , J. Niemiec
    • , L. Oakes
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    • , E. de Ona Wilhelmi
    • , M. Ostrowski
    • , I. Oya
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    • , C. Perennes
    • , P.-O. Petrucci
    • , B. Peyaud
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    • , A. Priyana Noel
    • , D. A. Prokhorov
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    • , G. Pühlhofer
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    • , M. Renaud
    • , F. Rieger
    • , L. Rinchiuso
    • , C. Romoli
    • , G. Rowell
    • , B. Rudak
    • , E. Ruiz-Velasco
    • , V. Sahakian
    • , S. Saito
    • , D. A. Sanchez
    • , A. Santangelo
    • , M. Sasaki
    • , R. Schlickeiser
    • , F. Schüssler
    • , A. Schulz
    • , H. M. Schutte
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    • , S. Schwemmer
    • , M. Seglar-Arroyo
    • , M. Senniappan
    • , A. S. Seyffert
    • , N. Shafi
    • , K. Shiningayamwe
    • , R. Simoni
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    • , H. Sol
    • , A. Specovius
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    • , Ł. Stawarz
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    • , C. Stegmann
    • , C. Steppa
    • , T. Takahashi
    • , T. Tavernier
    • , A. M. Taylor
    • , R. Terrier
    • , D. Tiziani
    • , M. Tluczykont
    • , C. Trichard
    • , M. Tsirou
    • , N. Tsuji
    • , R. Tuffs
    • , Y. Uchiyama
    • , D. J. van der Walt
    • , C. van Eldik
    • , C. van Rensburg
    • , B. van Soelen
    • , G. Vasileiadis
    • , J. Veh
    • , C. Venter
    • , P. Vincent
    • , J. Vink
    • , F. Voisin
    • , H. J. Völk
    • , T. Vuillaume
    • , Z. Wadiasingh
    • , S. J. Wagner
    • , R. White
    • , A. Wierzcholska
    • , R. Yang
    • , H. Yoneda
    • , M. Zacharias
    • , R. Zanin
    • , A. A. Zdziarski
    • , A. Zech
    • , A. Ziegler
    • , J. Zorn
    •  & N. Żywucka
  • Article |

    The structure of the GABAB receptor in an inactive state reveals, amongst other features, a latch between the two subunits that locks the transmembrane domain interface, and the presence of large phospholipids that may modulate receptor function.

    • Jinseo Park
    • , Ziao Fu
    • , Aurel Frangaj
    • , Jonathan Liu
    • , Lidia Mosyak
    • , Tong Shen
    • , Vesna N. Slavkovich
    • , Kimberly M. Ray
    • , Jaume Taura
    • , Baohua Cao
    • , Yong Geng
    • , Hao Zuo
    • , Yongjun Kou
    • , Robert Grassucci
    • , Shaoxia Chen
    • , Zheng Liu
    • , Xin Lin
    • , Justin P. Williams
    • , William J. Rice
    • , Edward T. Eng
    • , Rick K. Huang
    • , Rajesh K. Soni
    • , Brian Kloss
    • , Zhiheng Yu
    • , Jonathan A. Javitch
    • , Wayne A. Hendrickson
    • , Paul A. Slesinger
    • , Matthias Quick
    • , Joseph Graziano
    • , Hongtao Yu
    • , Oliver Fiehn
    • , Oliver B. Clarke
    • , Joachim Frank
    •  & Qing R. Fan
  • Article |

    Femtosecond X-ray liquidography is used to track the vibrational wavepacket trajectories of gold atoms in solution, enabling time-resolved observations of the emergence of vibrations and the evolution of the formation of covalent bonds.

    • Jong Goo Kim
    • , Shunsuke Nozawa
    • , Hanui Kim
    • , Eun Hyuk Choi
    • , Tokushi Sato
    • , Tae Wu Kim
    • , Kyung Hwan Kim
    • , Hosung Ki
    • , Jungmin Kim
    • , Minseo Choi
    • , Yunbeom Lee
    • , Jun Heo
    • , Key Young Oang
    • , Kouhei Ichiyanagi
    • , Ryo Fukaya
    • , Jae Hyuk Lee
    • , Jaeku Park
    • , Intae Eom
    • , Sae Hwan Chun
    • , Sunam Kim
    • , Minseok Kim
    • , Tetsuo Katayama
    • , Tadashi Togashi
    • , Sigeki Owada
    • , Makina Yabashi
    • , Sang Jin Lee
    • , Seonggon Lee
    • , Chi Woo Ahn
    • , Doo-Sik Ahn
    • , Jiwon Moon
    • , Seungjoo Choi
    • , Joonghan Kim
    • , Taiha Joo
    • , Jeongho Kim
    • , Shin-ichi Adachi
    •  & Hyotcherl Ihee
  • Article |

    A predicted loss-of-function germline mutation in FLT3 causes a reduction in full-length FLT3, with a compensatory increase in the levels of FLT3 ligand, leading to increased risk of autoimmune thyroid disease.

    • Saedis Saevarsdottir
    • , Thorunn A. Olafsdottir
    • , Erna V. Ivarsdottir
    • , Gisli H. Halldorsson
    • , Kristbjorg Gunnarsdottir
    • , Asgeir Sigurdsson
    • , Ari Johannesson
    • , Jon K. Sigurdsson
    • , Thorhildur Juliusdottir
    • , Sigrun H. Lund
    • , Asgeir O. Arnthorsson
    • , Edda L. Styrmisdottir
    • , Julius Gudmundsson
    • , Gerdur M. Grondal
    • , Kristjan Steinsson
    • , Lars Alfredsson
    • , Johan Askling
    • , Rafn Benediktsson
    • , Ragnar Bjarnason
    • , Arni J. Geirsson
    • , Bjorn Gudbjornsson
    • , Hallgrimur Gudjonsson
    • , Haukur Hjaltason
    • , Astradur B. Hreidarsson
    • , Lars Klareskog
    • , Ingrid Kockum
    • , Helga Kristjansdottir
    • , Thorvardur J. Love
    • , Bjorn R. Ludviksson
    • , Tomas Olsson
    • , Pall T. Onundarson
    • , Kjartan B. Orvar
    • , Leonid Padyukov
    • , Bardur Sigurgeirsson
    • , Vinicius Tragante
    • , Kristbjorg Bjarnadottir
    • , Thorunn Rafnar
    • , Gisli Masson
    • , Patrick Sulem
    • , Daniel F. Gudbjartsson
    • , Pall Melsted
    • , Gudmar Thorleifsson
    • , Gudmundur L. Norddahl
    • , Unnur Thorsteinsdottir
    • , Ingileif Jonsdottir
    •  & Kari Stefansson
  • Article |

    Depletion of the RNA-binding protein PTB (also known as PTBP1) in astrocytes reprograms these cells to become functional neurons and, in a mouse model of Parkinson’s disease, reverses the disease phenotype.

    • Hao Qian
    • , Xinjiang Kang
    • , Jing Hu
    • , Dongyang Zhang
    • , Zhengyu Liang
    • , Fan Meng
    • , Xuan Zhang
    • , Yuanchao Xue
    • , Roy Maimon
    • , Steven F. Dowdy
    • , Neal K. Devaraj
    • , Zhuan Zhou
    • , William C. Mobley
    • , Don W. Cleveland
    •  & Xiang-Dong Fu
  • Article |

    Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

    • Ernest Turro
    • , William J. Astle
    • , Karyn Megy
    • , Stefan Gräf
    • , Daniel Greene
    • , Olga Shamardina
    • , Hana Lango Allen
    • , Alba Sanchis-Juan
    • , Mattia Frontini
    • , Chantal Thys
    • , Jonathan Stephens
    • , Rutendo Mapeta
    • , Oliver S. Burren
    • , Kate Downes
    • , Matthias Haimel
    • , Salih Tuna
    • , Sri V. V. Deevi
    • , Timothy J. Aitman
    • , David L. Bennett
    • , Paul Calleja
    • , Keren Carss
    • , Mark J. Caulfield
    • , Patrick F. Chinnery
    • , Peter H. Dixon
    • , Daniel P. Gale
    • , Roger James
    • , Ania Koziell
    • , Michael A. Laffan
    • , Adam P. Levine
    • , Eamonn R. Maher
    • , Hugh S. Markus
    • , Joannella Morales
    • , Nicholas W. Morrell
    • , Andrew D. Mumford
    • , Elizabeth Ormondroyd
    • , Stuart Rankin
    • , Augusto Rendon
    • , Sylvia Richardson
    • , Irene Roberts
    • , Noemi B. A. Roy
    • , Moin A. Saleem
    • , Kenneth G. C. Smith
    • , Hannah Stark
    • , Rhea Y. Y. Tan
    • , Andreas C. Themistocleous
    • , Adrian J. Thrasher
    • , Hugh Watkins
    • , Andrew R. Webster
    • , Martin R. Wilkins
    • , Catherine Williamson
    • , James Whitworth
    • , Sean Humphray
    • , David R. Bentley
    • , Stephen Abbs
    • , Lara Abulhoul
    • , Julian Adlard
    • , Munaza Ahmed
    • , Timothy J. Aitman
    • , Hana Alachkar
    • , David J. Allsup
    • , Jeff Almeida-King
    • , Philip Ancliff
    • , Richard Antrobus
    • , Ruth Armstrong
    • , Gavin Arno
    • , Sofie Ashford
    • , William J. Astle
    • , Anthony Attwood
    • , Paul Aurora
    • , Christian Babbs
    • , Chiara Bacchelli
    • , Tamam Bakchoul
    • , Siddharth Banka
    • , Tadbir Bariana
    • , Julian Barwell
    • , Joana Batista
    • , Helen E. Baxendale
    • , Phil L. Beales
    • , David L. Bennett
    • , David R. Bentley
    • , Agnieszka Bierzynska
    • , Tina Biss
    • , Maria A. K. Bitner-Glindzicz
    • , Graeme C. Black
    • , Marta Bleda
    • , Iulia Blesneac
    • , Detlef Bockenhauer
    • , Harm Bogaard
    • , Christian J. Bourne
    • , Sara Boyce
    • , John R. Bradley
    • , Eugene Bragin
    • , Gerome Breen
    • , Paul Brennan
    • , Carole Brewer
    • , Matthew Brown
    • , Andrew C. Browning
    • , Michael J. Browning
    • , Rachel J. Buchan
    • , Matthew S. Buckland
    • , Teofila Bueser
    • , Carmen Bugarin Diz
    • , John Burn
    • , Siobhan O. Burns
    • , Oliver S. Burren
    • , Nigel Burrows
    • , Paul Calleja
    • , Carolyn Campbell
    • , Gerald Carr-White
    • , Keren Carss
    • , Ruth Casey
    • , Mark J. Caulfield
    • , Jenny Chambers
    • , John Chambers
    • , Melanie M. Y. Chan
    • , Calvin Cheah
    • , Floria Cheng
    • , Patrick F. Chinnery
    • , Manali Chitre
    • , Martin T. Christian
    • , Colin Church
    • , Jill Clayton-Smith
    • , Maureen Cleary
    • , Naomi Clements Brod
    • , Gerry Coghlan
    • , Elizabeth Colby
    • , Trevor R. P. Cole
    • , Janine Collins
    • , Peter W. Collins
    • , Camilla Colombo
    • , Cecilia J. Compton
    • , Robin Condliffe
    • , Stuart Cook
    • , H. Terence Cook
    • , Nichola Cooper
    • , Paul A. Corris
    • , Abigail Furnell
    • , Fiona Cunningham
    • , Nicola S. Curry
    • , Antony J. Cutler
    • , Matthew J. Daniels
    • , Mehul Dattani
    • , Louise C. Daugherty
    • , John Davis
    • , Anthony De Soyza
    • , Sri V. V. Deevi
    • , Timothy Dent
    • , Charu Deshpande
    • , Eleanor F. Dewhurst
    • , Peter H. Dixon
    • , Sofia Douzgou
    • , Kate Downes
    • , Anna M. Drazyk
    • , Elizabeth Drewe
    • , Daniel Duarte
    • , Tina Dutt
    • , J. David M. Edgar
    • , Karen Edwards
    • , William Egner
    • , Melanie N. Ekani
    • , Perry Elliott
    • , Wendy N. Erber
    • , Marie Erwood
    • , Maria C. Estiu
    • , Dafydd Gareth Evans
    • , Gillian Evans
    • , Tamara Everington
    • , Mélanie Eyries
    • , Hiva Fassihi
    • , Remi Favier
    • , Jack Findhammer
    • , Debra Fletcher
    • , Frances A. Flinter
    • , R. Andres Floto
    • , Tom Fowler
    • , James Fox
    • , Amy J. Frary
    • , Courtney E. French
    • , Kathleen Freson
    • , Mattia Frontini
    • , Daniel P. Gale
    • , Henning Gall
    • , Vijeya Ganesan
    • , Michael Gattens
    • , Claire Geoghegan
    • , Terence S. A. Gerighty
    • , Ali G. Gharavi
    • , Stefano Ghio
    • , Hossein-Ardeschir Ghofrani
    • , J. Simon R. Gibbs
    • , Kate Gibson
    • , Kimberly C. Gilmour
    • , Barbara Girerd
    • , Nicholas S. Gleadall
    • , Sarah Goddard
    • , David B. Goldstein
    • , Keith Gomez
    • , Pavels Gordins
    • , David Gosal
    • , Stefan Gräf
    • , Jodie Graham
    • , Luigi Grassi
    • , Daniel Greene
    • , Lynn Greenhalgh
    • , Andreas Greinacher
    • , Paolo Gresele
    • , Philip Griffiths
    • , Sofia Grigoriadou
    • , Russell J. Grocock
    • , Detelina Grozeva
    • , Mark Gurnell
    • , Scott Hackett
    • , Charaka Hadinnapola
    • , William M. Hague
    • , Rosie Hague
    • , Matthias Haimel
    • , Matthew Hall
    • , Helen L. Hanson
    • , Eshika Haque
    • , Kirsty Harkness
    • , Andrew R. Harper
    • , Claire L. Harris
    • , Daniel Hart
    • , Ahamad Hassan
    • , Grant Hayman
    • , Alex Henderson
    • , Archana Herwadkar
    • , Jonathan Hoffman
    • , Simon Holden
    • , Rita Horvath
    • , Henry Houlden
    • , Arjan C. Houweling
    • , Luke S. Howard
    • , Fengyuan Hu
    • , Gavin Hudson
    • , Joseph Hughes
    • , Aarnoud P. Huissoon
    • , Marc Humbert
    • , Sean Humphray
    • , Sarah Hunter
    • , Matthew Hurles
    • , Melita Irving
    • , Louise Izatt
    • , Roger James
    • , Sally A. Johnson
    • , Stephen Jolles
    • , Jennifer Jolley
    • , Dragana Josifova
    • , Neringa Jurkute
    • , Tim Karten
    • , Johannes Karten
    • , Mary A. Kasanicki
    • , Hanadi Kazkaz
    • , Rashid Kazmi
    • , Peter Kelleher
    • , Anne M. Kelly
    • , Wilf Kelsall
    • , Carly Kempster
    • , David G. Kiely
    • , Nathalie Kingston
    • , Robert Klima
    • , Nils Koelling
    • , Myrto Kostadima
    • , Gabor Kovacs
    • , Ania Koziell
    • , Roman Kreuzhuber
    • , Taco W. Kuijpers
    • , Ajith Kumar
    • , Dinakantha Kumararatne
    • , Manju A. Kurian
    • , Michael A. Laffan
    • , Fiona Lalloo
    • , Michele Lambert
    • , Hana Lango Allen
    • , Allan Lawrie
    • , D. Mark Layton
    • , Nick Lench
    • , Claire Lentaigne
    • , Tracy Lester
    • , Adam P. Levine
    • , Rachel Linger
    • , Hilary Longhurst
    • , Lorena E. Lorenzo
    • , Eleni Louka
    • , Paul A. Lyons
    • , Rajiv D. Machado
    • , Robert V. MacKenzie Ross
    • , Bella Madan
    • , Eamonn R. Maher
    • , Jesmeen Maimaris
    • , Samantha Malka
    • , Sarah Mangles
    • , Rutendo Mapeta
    • , Kevin J. Marchbank
    • , Stephen Marks
    • , Hugh S. Markus
    • , Hanns-Ulrich Marschall
    • , Andrew Marshall
    • , Jennifer Martin
    • , Mary Mathias
    • , Emma Matthews
    • , Heather Maxwell
    • , Paul McAlinden
    • , Mark I. McCarthy
    • , Harriet McKinney
    • , Aoife McMahon
    • , Stuart Meacham
    • , Adam J. Mead
    • , Ignacio Medina Castello
    • , Karyn Megy
    • , Sarju G. Mehta
    • , Michel Michaelides
    • , Carolyn Millar
    • , Shehla N. Mohammed
    • , Shahin Moledina
    • , David Montani
    • , Anthony T. Moore
    • , Joannella Morales
    • , Nicholas W. Morrell
    • , Monika Mozere
    • , Keith W. Muir
    • , Andrew D. Mumford
    • , Andrea H. Nemeth
    • , William G. Newman
    • , Michael Newnham
    • , Sadia Noorani
    • , Paquita Nurden
    • , Jennifer O’Sullivan
    • , Samya Obaji
    • , Chris Odhams
    • , Steven Okoli
    • , Andrea Olschewski
    • , Horst Olschewski
    • , Kai Ren Ong
    • , S. Helen Oram
    • , Elizabeth Ormondroyd
    • , Willem H. Ouwehand
    • , Claire Palles
    • , Sofia Papadia
    • , Soo-Mi Park
    • , David Parry
    • , Smita Patel
    • , Joan Paterson
    • , Andrew Peacock
    • , Simon H. Pearce
    • , John Peden
    • , Kathelijne Peerlinck
    • , Christopher J. Penkett
    • , Joanna Pepke-Zaba
    • , Romina Petersen
    • , Clarissa Pilkington
    • , Kenneth E. S. Poole
    • , Radhika Prathalingam
    • , Bethan Psaila
    • , Angela Pyle
    • , Richard Quinton
    • , Shamima Rahman
    • , Stuart Rankin
    • , Anupama Rao
    • , F. Lucy Raymond
    • , Paula J. Rayner-Matthews
    • , Christine Rees
    • , Augusto Rendon
    • , Tara Renton
    • , Christopher J. Rhodes
    • , Andrew S. C. Rice
    • , Sylvia Richardson
    • , Alex Richter
    • , Leema Robert
    • , Irene Roberts
    • , Anthony Rogers
    • , Sarah J. Rose
    • , Robert Ross-Russell
    • , Catherine Roughley
    • , Noemi B. A. Roy
    • , Deborah M. Ruddy
    • , Omid Sadeghi-Alavijeh
    • , Moin A. Saleem
    • , Nilesh Samani
    • , Crina Samarghitean
    • , Alba Sanchis-Juan
    • , Ravishankar B. Sargur
    • , Robert N. Sarkany
    • , Simon Satchell
    • , Sinisa Savic
    • , John A. Sayer
    • , Genevieve Sayer
    • , Laura Scelsi
    • , Andrew M. Schaefer
    • , Sol Schulman
    • , Richard Scott
    • , Marie Scully
    • , Claire Searle
    • , Werner Seeger
    • , Arjune Sen
    • , W. A. Carrock Sewell
    • , Denis Seyres
    • , Neil Shah
    • , Olga Shamardina
    • , Susan E. Shapiro
    • , Adam C. Shaw
    • , Patrick J. Short
    • , Keith Sibson
    • , Lucy Side
    • , Ilenia Simeoni
    • , Michael A. Simpson
    • , Matthew C. Sims
    • , Suthesh Sivapalaratnam
    • , Damian Smedley
    • , Katherine R. Smith
    • , Kenneth G. C. Smith
    • , Katie Snape
    • , Nicole Soranzo
    • , Florent Soubrier
    • , Laura Southgate
    • , Olivera Spasic-Boskovic
    • , Simon Staines
    • , Emily Staples
    • , Hannah Stark
    • , Jonathan Stephens
    • , Charles Steward
    • , Kathleen E. Stirrups
    • , Alex Stuckey
    • , Jay Suntharalingam
    • , Emilia M. Swietlik
    • , Petros Syrris
    • , R. Campbell Tait
    • , Kate Talks
    • , Rhea Y. Y. Tan
    • , Katie Tate
    • , John M. Taylor
    • , Jenny C. Taylor
    • , James E. Thaventhiran
    • , Andreas C. Themistocleous
    • , Ellen Thomas
    • , David Thomas
    • , Moira J. Thomas
    • , Patrick Thomas
    • , Kate Thomson
    • , Adrian J. Thrasher
    • , Glen Threadgold
    • , Chantal Thys
    • , Tobias Tilly
    • , Marc Tischkowitz
    • , Catherine Titterton
    • , John A. Todd
    • , Cheng-Hock Toh
    • , Bas Tolhuis
    • , Ian P. Tomlinson
    • , Mark Toshner
    • , Matthew Traylor
    • , Carmen Treacy
    • , Paul Treadaway
    • , Richard Trembath
    • , Salih Tuna
    • , Wojciech Turek
    • , Ernest Turro
    • , Philip Twiss
    • , Tom Vale
    • , Chris Van Geet
    • , Natalie van Zuydam
    • , Maarten Vandekuilen
    • , Anthony M. Vandersteen
    • , Marta Vazquez-Lopez
    • , Julie von Ziegenweidt
    • , Anton Vonk Noordegraaf
    • , Annette Wagner
    • , Quinten Waisfisz
    • , Suellen M. Walker
    • , Neil Walker
    • , Klaudia Walter
    • , James S. Ware
    • , Hugh Watkins
    • , Christopher Watt
    • , Andrew R. Webster
    • , Lucy Wedderburn
    • , Wei Wei
    • , Steven B. Welch
    • , Julie Wessels
    • , Sarah K. Westbury
    • , John-Paul Westwood
    • , John Wharton
    • , Deborah Whitehorn
    • , James Whitworth
    • , Andrew O. M. Wilkie
    • , Martin R. Wilkins
    • , Catherine Williamson
    • , Brian T. Wilson
    • , Edwin K. S. Wong
    • , Nicholas Wood
    • , Yvette Wood
    • , Christopher Geoffrey Woods
    • , Emma R. Woodward
    • , Stephen J. Wort
    • , Austen Worth
    • , Michael Wright
    • , Katherine Yates
    • , Patrick F. K. Yong
    • , Timothy Young
    • , Ping Yu
    • , Patrick Yu-Wai-Man
    • , Eliska Zlamalova
    • , Nathalie Kingston
    • , Neil Walker
    • , John R. Bradley
    • , Sofie Ashford
    • , Christopher J. Penkett
    • , Kathleen Freson
    • , Kathleen E. Stirrups
    • , F. Lucy Raymond
    •  & Willem H. Ouwehand
  • Article |

    An engineered version of IL-18 that is resistant to binding by the soluble decoy receptor IL-18BP shows strong anti-tumour activity in mouse models of cancer.

    • Ting Zhou
    • , William Damsky
    • , Orr-El Weizman
    • , Meaghan K. McGeary
    • , K. Patricia Hartmann
    • , Connor E. Rosen
    • , Suzanne Fischer
    • , Ruaidhri Jackson
    • , Richard A. Flavell
    • , Jun Wang
    • , Miguel F. Sanmamed
    • , Marcus W. Bosenberg
    •  & Aaron M. Ring
  • Article |

    Single-molecule fluorescence resonance energy transfer and real-time confocal laser tracking with fluorescence correlation spectroscopy together characterize how individual lac repressor molecules bypass operator sites while exploring the DNA surface at microsecond timescales.

    • Emil Marklund
    • , Brad van Oosten
    • , Guanzhong Mao
    • , Elias Amselem
    • , Kalle Kipper
    • , Anton Sabantsev
    • , Andrew Emmerich
    • , Daniel Globisch
    • , Xuan Zheng
    • , Laura C. Lehmann
    • , Otto G. Berg
    • , Magnus Johansson
    • , Johan Elf
    •  & Sebastian Deindl
  • Article |

    Single-molecule fluorescence in situ hybridization and live-cell imaging are used to study the contribution of transcriptional noise to stem cell heterogeneity, revealing that stochastic transcription dynamics are conducive to concomitant stem-cell maintenance and tissue homeostasis.

    • Justin C. Wheat
    • , Yehonatan Sella
    • , Michael Willcockson
    • , Arthur I. Skoultchi
    • , Aviv Bergman
    • , Robert H. Singer
    •  & Ulrich Steidl
  • Article |

    A Damascus-like steel consisting of alternating hard and soft layers is created by using a laser additive manufacturing technique and digital control of the processing parameters.

    • Philipp Kürnsteiner
    • , Markus Benjamin Wilms
    • , Andreas Weisheit
    • , Baptiste Gault
    • , Eric Aimé Jägle
    •  & Dierk Raabe
  • Article |

    A transiting planet with a period of about 8.5 days and a radius 0.4 times that of Jupiter is reported within the debris disk around the star AU Microscopii.

    • Peter Plavchan
    • , Thomas Barclay
    • , Jonathan Gagné
    • , Peter Gao
    • , Bryson Cale
    • , William Matzko
    • , Diana Dragomir
    • , Sam Quinn
    • , Dax Feliz
    • , Keivan Stassun
    • , Ian J. M. Crossfield
    • , David A. Berardo
    • , David W. Latham
    • , Ben Tieu
    • , Guillem Anglada-Escudé
    • , George Ricker
    • , Roland Vanderspek
    • , Sara Seager
    • , Joshua N. Winn
    • , Jon M. Jenkins
    • , Stephen Rinehart
    • , Akshata Krishnamurthy
    • , Scott Dynes
    • , John Doty
    • , Fred Adams
    • , Dennis A. Afanasev
    • , Chas Beichman
    • , Mike Bottom
    • , Brendan P. Bowler
    • , Carolyn Brinkworth
    • , Carolyn J. Brown
    • , Andrew Cancino
    • , David R. Ciardi
    • , Mark Clampin
    • , Jake T. Clark
    • , Karen Collins
    • , Cassy Davison
    • , Daniel Foreman-Mackey
    • , Elise Furlan
    • , Eric J. Gaidos
    • , Claire Geneser
    • , Frank Giddens
    • , Emily Gilbert
    • , Ryan Hall
    • , Coel Hellier
    • , Todd Henry
    • , Jonathan Horner
    • , Andrew W. Howard
    • , Chelsea Huang
    • , Joseph Huber
    • , Stephen R. Kane
    • , Matthew Kenworthy
    • , John Kielkopf
    • , David Kipping
    • , Chris Klenke
    • , Ethan Kruse
    • , Natasha Latouf
    • , Patrick Lowrance
    • , Bertrand Mennesson
    • , Matthew Mengel
    • , Sean M. Mills
    • , Tim Morton
    • , Norio Narita
    • , Elisabeth Newton
    • , America Nishimoto
    • , Jack Okumura
    • , Enric Palle
    • , Joshua Pepper
    • , Elisa V. Quintana
    • , Aki Roberge
    • , Veronica Roccatagliata
    • , Joshua E. Schlieder
    • , Angelle Tanner
    • , Johanna Teske
    • , C. G. Tinney
    • , Andrew Vanderburg
    • , Kaspar von Braun
    • , Bernie Walp
    • , Jason Wang
    • , Sharon Xuesong Wang
    • , Denise Weigand
    • , Russel White
    • , Robert A. Wittenmyer
    • , Duncan J. Wright
    • , Allison Youngblood
    • , Hui Zhang
    •  & Perri Zilberman
  • Article |

    The authors show that metabolic activity leads to an increase in the intracellular pH of neuromesodermal precursors, and that this increase in pH, by allowing post-translational modification of β-catenin, is required for the activation of WNT signalling and mesodermal fate acquisition.

    • Masayuki Oginuma
    • , Yukiko Harima
    • , Oscar A. Tarazona
    • , Margarete Diaz-Cuadros
    • , Arthur Michaut
    • , Tohru Ishitani
    • , Fengzhu Xiong
    •  & Olivier Pourquié
  • Article |

    Mutagenic lesions such as those that give rise to cancer frequently segregate—unrepaired—during cell division, resulting in phasing of multiple alleles across generations of daughter cells and consequent tumour heterogeneity.

    • Sarah J. Aitken
    • , Craig J. Anderson
    • , Frances Connor
    • , Oriol Pich
    • , Vasavi Sundaram
    • , Christine Feig
    • , Tim F. Rayner
    • , Margus Lukk
    • , Stuart Aitken
    • , Juliet Luft
    • , Elissavet Kentepozidou
    • , Claudia Arnedo-Pac
    • , Sjoerd V. Beentjes
    • , Susan E. Davies
    • , Ruben M. Drews
    • , Ailith Ewing
    • , Vera B. Kaiser
    • , Ava Khamseh
    • , Erika López-Arribillaga
    • , Aisling M. Redmond
    • , Javier Santoyo-Lopez
    • , Inés Sentís
    • , Lana Talmane
    • , Andrew D. Yates
    • , Sarah J. Aitken
    • , Stuart Aitken
    • , Craig J. Anderson
    • , Claudia Arnedo-Pac
    • , Frances Connor
    • , Ruben M. Drews
    • , Ailith Ewing
    • , Christine Feig
    • , Paul Flicek
    • , Vera B. Kaiser
    • , Elissavet Kentepozidou
    • , Erika López-Arribillaga
    • , Núria López-Bigas
    • , Juliet Luft
    • , Margus Lukk
    • , Duncan T. Odom
    • , Oriol Pich
    • , Tim F. Rayner
    • , Colin A. Semple
    • , Inés Sentís
    • , Vasavi Sundaram
    • , Lana Talmane
    • , Martin S. Taylor
    • , Colin A. Semple
    • , Núria López-Bigas
    • , Paul Flicek
    • , Duncan T. Odom
    •  & Martin S. Taylor
  • Article |

    Combining thermal scanning-probe lithography with templating enables the production of high-quality gratings that manipulate light through Fourier-spectrum engineering in ways that are not achievable with conventional gratings.

    • Nolan Lassaline
    • , Raphael Brechbühler
    • , Sander J. W. Vonk
    • , Korneel Ridderbeek
    • , Martin Spieser
    • , Samuel Bisig
    • , Boris le Feber
    • , Freddy T. Rabouw
    •  & David J. Norris
  • Article |

    Analysis of blood-derived DNA from participants in the UK Biobank demonstrates that clonal expansions of acquired copy-neutral loss of heterozygosity mutations act on inherited alleles along a chromosome arm by modifying their allelic dosages.

    • Po-Ru Loh
    • , Giulio Genovese
    •  & Steven A. McCarroll
  • Article |

    Serpentine subducted below the Lesser Antilles volcanic arc supplies water to the arc, controlling the location of seismicity, volcanic productivity and thickness of crust.

    • George F. Cooper
    • , Colin G. Macpherson
    • , Jon D. Blundy
    • , Benjamin Maunder
    • , Robert W. Allen
    • , Saskia Goes
    • , Jenny S Collier
    • , Lidong Bie
    • , Nicholas Harmon
    • , Stephen P. Hicks
    • , Alexander A. Iveson
    • , Julie Prytulak
    • , Andreas Rietbrock
    • , Catherine A. Rychert
    • , Jon P. Davidson
    • , George F. Cooper
    • , Colin G. Macpherson
    • , Jon D. Blundy
    • , Benjamin Maunder
    • , Robert W. Allen
    • , Saskia Goes
    • , Jenny S. Collier
    • , Lidong Bie
    • , Nicholas Harmon
    • , Stephen P. Hicks
    • , Andreas Rietbrock
    • , Catherine A. Rychert
    • , Jon P. Davidson
    • , Richard G. Davy
    • , Tim J. Henstock
    • , Michael J. Kendall
    • , David Schlaphorst
    • , Jeroen van Hunen
    • , Jamie J. Wilkinson
    •  & Marjorie Wilson
  • Article |

    Population-specific patterns of genomic mutations and selection of haematopoietic clones in Japanese and European participants predict the divergent rates of chronic lymphocytic leukaemia and T cell leukaemia in these populations.

    • Chikashi Terao
    • , Akari Suzuki
    • , Yukihide Momozawa
    • , Masato Akiyama
    • , Kazuyoshi Ishigaki
    • , Kazuhiko Yamamoto
    • , Koichi Matsuda
    • , Yoshinori Murakami
    • , Steven A. McCarroll
    • , Michiaki Kubo
    • , Po-Ru Loh
    •  & Yoichiro Kamatani
  • Article |

    Thin films of amorphous boron nitride are mechanically and electrically robust, prevent diffusion of metal atoms into semiconductors and have ultralow dielectric constants that exceed current recommendations for high-performance electronics.

    • Seokmo Hong
    • , Chang-Seok Lee
    • , Min-Hyun Lee
    • , Yeongdong Lee
    • , Kyung Yeol Ma
    • , Gwangwoo Kim
    • , Seong In Yoon
    • , Kyuwook Ihm
    • , Ki-Jeong Kim
    • , Tae Joo Shin
    • , Sang Won Kim
    • , Eun-chae Jeon
    • , Hansol Jeon
    • , Ju-Young Kim
    • , Hyung-Ik Lee
    • , Zonghoon Lee
    • , Aleandro Antidormi
    • , Stephan Roche
    • , Manish Chhowalla
    • , Hyeon-Jin Shin
    •  & Hyeon Suk Shin
  • Article |

    A fluorescent bicolour sensor is proposed as the basis of a barium-tagging technique for the detection of neutrinoless double β decay in xenon gas experiments.

    • Iván Rivilla
    • , Borja Aparicio
    • , Juan M. Bueno
    • , David Casanova
    • , Claire Tonnelé
    • , Zoraida Freixa
    • , Pablo Herrero
    • , Celia Rogero
    • , José I. Miranda
    • , Rosa M. Martínez-Ojeda
    • , Francesc Monrabal
    • , Beñat Olave
    • , Thomas Schäfer
    • , Pablo Artal
    • , David Nygren
    • , Fernando P. Cossío
    •  & Juan J. Gómez-Cadenas
  • Publisher Correction |

    • Cameron D. Griffiths
    • , Leanne M. Bilawchuk
    • , John E. McDonough
    • , Kyla C. Jamieson
    • , Farah Elawar
    • , Yuchen Cen
    • , Wenming Duan
    • , Cindy Lin
    • , Haeun Song
    • , Jean-Laurent Casanova
    • , Steven Ogg
    • , Lionel Dylan Jensen
    • , Bernard Thienpont
    • , Anil Kumar
    • , Tom C. Hobman
    • , David Proud
    • , Theo J. Moraes
    •  & David J. Marchant
  • Article |

    • Davide F. Robbiani
    • , Christian Gaebler
    • , Frauke Muecksch
    • , Julio C. C. Lorenzi
    • , Zijun Wang
    • , Alice Cho
    • , Marianna Agudelo
    • , Christopher O. Barnes
    • , Anna Gazumyan
    • , Shlomo Finkin
    • , Thomas Hägglöf
    • , Thiago Y. Oliveira
    • , Charlotte Viant
    • , Arlene Hurley
    • , Hans-Heinrich Hoffmann
    • , Katrina G. Millard
    • , Rhonda G. Kost
    • , Melissa Cipolla
    • , Kristie Gordon
    • , Filippo Bianchini
    • , Spencer T. Chen
    • , Victor Ramos
    • , Roshni Patel
    • , Juan Dizon
    • , Irina Shimeliovich
    • , Pilar Mendoza
    • , Harald Hartweger
    • , Lilian Nogueira
    • , Maggi Pack
    • , Jill Horowitz
    • , Fabian Schmidt
    • , Yiska Weisblum
    • , Eleftherios Michailidis
    • , Alison W. Ashbrook
    • , Eric Waltari
    • , John E. Pak
    • , Kathryn E. Huey-Tubman
    • , Nicholas Koranda
    • , Pauline R. Hoffman
    • , Anthony P. West Jr.
    • , Charles M. Rice
    • , Theodora Hatziioannou
    • , Pamela J. Bjorkman
    • , Paul D. Bieniasz
    • , Marina Caskey
    •  & Michel C. Nussenzweig
  • Article |

    A turnkey regime for soliton microcombs is demonstrated, in which solitons are generated by switching on a co-integrated pump laser, eliminating the need for photonic and electronic control circuitry.

    • Boqiang Shen
    • , Lin Chang
    • , Junqiu Liu
    • , Heming Wang
    • , Qi-Fan Yang
    • , Chao Xiang
    • , Rui Ning Wang
    • , Jijun He
    • , Tianyi Liu
    • , Weiqiang Xie
    • , Joel Guo
    • , David Kinghorn
    • , Lue Wu
    • , Qing-Xin Ji
    • , Tobias J. Kippenberg
    • , Kerry Vahala
    •  & John E. Bowers
  • Article |

    Molecular analyses of newly discovered, embryo-bearing ornithischian and sauropod dinosaur eggs suggest that the ancestral dinosaur egg was soft-shelled, and that hard-shelled eggs evolved independently at least three times in the major dinosaur lineages.

    • Mark A. Norell
    • , Jasmina Wiemann
    • , Matteo Fabbri
    • , Congyu Yu
    • , Claudia A. Marsicano
    • , Anita Moore-Nall
    • , David J. Varricchio
    • , Diego Pol
    •  & Darla K. Zelenitsky