Latest Research

  • Matters Arising |

    • Philip L. Munday
    • , Danielle L. Dixson
    • , Megan J. Welch
    • , Douglas P. Chivers
    • , Paolo Domenici
    • , Martin Grosell
    • , Rachael M. Heuer
    • , Geoffrey P. Jones
    • , Mark I. McCormick
    • , Mark Meekan
    • , Göran E. Nilsson
    • , Timothy Ravasi
    •  & Sue-Ann Watson
  • Article |

    • Leon Mutesa
    • , Pacifique Ndishimye
    • , Yvan Butera
    • , Jacob Souopgui
    • , Annette Uwineza
    • , Robert Rutayisire
    • , Ella Larissa Ndoricimpaye
    • , Emile Musoni
    • , Nadine Rujeni
    • , Thierry Nyatanyi
    • , Edouard Ntagwabira
    • , Muhammed Semakula
    • , Clarisse Musanabaganwa
    • , Daniel Nyamwasa
    • , Maurice Ndashimye
    • , Eva Ujeneza
    • , Ivan Emile Mwikarago
    • , Claude Mambo Muvunyi
    • , Jean Baptiste Mazarati
    • , Sabin Nsanzimana
    • , Neil Turok
    •  & Wilfred Ndifon
  • Article |

    Genomic integration of an adeno-associated virus vector in a mouse model of Angelman syndrome unsilences paternal Ube3a and rescues anatomical and behavioural phenotypes, suggesting a pathway towards the treatment of this neurodevelopmental disorder.

    • Justin M. Wolter
    • , Hanqian Mao
    • , Giulia Fragola
    • , Jeremy M. Simon
    • , James L. Krantz
    • , Hannah O. Bazick
    • , Baris Oztemiz
    • , Jason L. Stein
    •  & Mark J. Zylka
  • Article |

    Scalable optics co-fabricated with a cryogenic surface-electrode ion trap are used to drive high-fidelity multi-ion quantum logic gates, demonstrating a route to simultaneously scale and reduce errors in quantum processors.

    • Karan K. Mehta
    • , Chi Zhang
    • , Maciej Malinowski
    • , Thanh-Long Nguyen
    • , Martin Stadler
    •  & Jonathan P. Home
  • Article |

    Mother cells recycle parental MCMs and simultaneously synthesize nascent MCMs, both of which are inherited by daughter cells, in which the former are preferentially used to form active replisomes and the latter adjust the pace of replisome movement to minimize errors during DNA replication.

    • Hana Sedlackova
    • , Maj-Britt Rask
    • , Rajat Gupta
    • , Chunaram Choudhary
    • , Kumar Somyajit
    •  & Jiri Lukas
  • Article |

    Advances in electron cryo-microscopy allow the structure of apoferritin to be determined at a resolution that enables the visualization of individual atoms.

    • Ka Man Yip
    • , Niels Fischer
    • , Elham Paknia
    • , Ashwin Chari
    •  & Holger Stark
  • Article |

    Advances in electron cryo-microscopy hardware allow proteins to be studied at atomic resolution.

    • Takanori Nakane
    • , Abhay Kotecha
    • , Andrija Sente
    • , Greg McMullan
    • , Simonas Masiulis
    • , Patricia M. G. E. Brown
    • , Ioana T. Grigoras
    • , Lina Malinauskaite
    • , Tomas Malinauskas
    • , Jonas Miehling
    • , Tomasz Uchański
    • , Lingbo Yu
    • , Dimple Karia
    • , Evgeniya V. Pechnikova
    • , Erwin de Jong
    • , Jeroen Keizer
    • , Maarten Bischoff
    • , Jamie McCormack
    • , Peter Tiemeijer
    • , Steven W. Hardwick
    • , Dimitri Y. Chirgadze
    • , Garib Murshudov
    • , A. Radu Aricescu
    •  & Sjors H. W. Scheres
  • Article |

    Depletion of transforming growth factor-β receptor 2 (TGFBR2) in CD4+ T cells results in IL-4-dependent vascular remodelling, stopping tumour growth in a transgenic mouse model of breast cancer, suggesting that type 2 immunity could be targeted for cancer treatments.

    • Ming Liu
    • , Fengshen Kuo
    • , Kristelle J. Capistrano
    • , Davina Kang
    • , Briana G. Nixon
    • , Wei Shi
    • , Chun Chou
    • , Mytrang H. Do
    • , Efstathios G. Stamatiades
    • , Shengyu Gao
    • , Shun Li
    • , Yingbei Chen
    • , James J. Hsieh
    • , A. Ari Hakimi
    • , Ichiro Taniuchi
    • , Timothy A. Chan
    •  & Ming O. Li
  • Article |

    A high-throughput assay that introduces mismatched base pairs into the DNA sequence shows that mismatches can increase transcription factor binding affinity by prepaying some of the energetic cost of distorting the DNA.

    • Ariel Afek
    • , Honglue Shi
    • , Atul Rangadurai
    • , Harshit Sahay
    • , Alon Senitzki
    • , Suela Xhani
    • , Mimi Fang
    • , Raul Salinas
    • , Zachery Mielko
    • , Miles A. Pufall
    • , Gregory M. K. Poon
    • , Tali E. Haran
    • , Maria A. Schumacher
    • , Hashim M. Al-Hashimi
    •  & Raluca Gordân
  • Article |

    A surface-electrode ion-trap chip is demonstrated, which delivers all the wavelengths of light required for the preparation and operation of ion qubits.

    • R. J. Niffenegger
    • , J. Stuart
    • , C. Sorace-Agaskar
    • , D. Kharas
    • , S. Bramhavar
    • , C. D. Bruzewicz
    • , W. Loh
    • , R. T. Maxson
    • , R. McConnell
    • , D. Reens
    • , G. N. West
    • , J. M. Sage
    •  & J. Chiaverini
  • Article |

    4T-Trap, a bispecific molecule designed to recognize CD4 and bind TGF-β, blocks TGF-β signalling in T helper cells, causing interleukin-4-dependent vascular reorganization and cancer cell death in a mouse model of breast cancer.

    • Shun Li
    • , Ming Liu
    • , Mytrang H. Do
    • , Chun Chou
    • , Efstathios G. Stamatiades
    • , Briana G. Nixon
    • , Wei Shi
    • , Xian Zhang
    • , Peng Li
    • , Shengyu Gao
    • , Kristelle J. Capistrano
    • , Hong Xu
    • , Nai-Kong V. Cheung
    •  & Ming O. Li
  • Article |

    Exome sequences from the first 49,960 participants in the UK Biobank highlight the promise of genome sequencing in large population-based studies and are now accessible to the scientific community.

    • Cristopher V. Van Hout
    • , Ioanna Tachmazidou
    • , Joshua D. Backman
    • , Joshua D. Hoffman
    • , Daren Liu
    • , Ashutosh K. Pandey
    • , Claudia Gonzaga-Jauregui
    • , Shareef Khalid
    • , Bin Ye
    • , Nilanjana Banerjee
    • , Alexander H. Li
    • , Colm O’Dushlaine
    • , Anthony Marcketta
    • , Jeffrey Staples
    • , Claudia Schurmann
    • , Alicia Hawes
    • , Evan Maxwell
    • , Leland Barnard
    • , Alexander Lopez
    • , John Penn
    • , Lukas Habegger
    • , Andrew L. Blumenfeld
    • , Xiaodong Bai
    • , Sean O’Keeffe
    • , Ashish Yadav
    • , Kavita Praveen
    • , Marcus Jones
    • , William J. Salerno
    • , Wendy K. Chung
    • , Ida Surakka
    • , Cristen J. Willer
    • , Kristian Hveem
    • , Joseph B. Leader
    • , David J. Carey
    • , David H. Ledbetter
    • , Lon Cardon
    • , George D. Yancopoulos
    • , Aris Economides
    • , Giovanni Coppola
    • , Alan R. Shuldiner
    • , Suganthi Balasubramanian
    • , Michael Cantor
    • , Matthew R. Nelson
    • , John Whittaker
    • , Jeffrey G. Reid
    • , Jonathan Marchini
    • , John D. Overton
    • , Robert A. Scott
    • , Gonçalo R. Abecasis
    • , Laura Yerges-Armstrong
    •  & Aris Baras
  • Article |

    The architecture of planetary systems is shown to be strongly affected by stellar clustering in position-velocity phase space; hot Jupiters occur preferentially at high density, suggesting that their extreme orbits originate from environmental perturbations.

    • Andrew J. Winter
    • , J. M. Diederik Kruijssen
    • , Steven N. Longmore
    •  & Mélanie Chevance
  • Article |

    Inverted-repeat Alu elements are the main source of drug-induced immunogenic double-stranded RNAs, which are destabilized by the RNA deaminase ADAR1, thereby limiting activation of the immune response.

    • Parinaz Mehdipour
    • , Sajid A. Marhon
    • , Ilias Ettayebi
    • , Ankur Chakravarthy
    • , Amir Hosseini
    • , Yadong Wang
    • , Fabíola Attié de Castro
    • , Helen Loo Yau
    • , Charles Ishak
    • , Sagi Abelson
    • , Catherine A. O’Brien
    •  & Daniel D. De Carvalho
  • Article |

    A jigsaw-style configuration of interlocking structures identified in the elytra of the remarkably tough diabolical ironclad beetle, Phloeodes diabolicus, is used to inspire crush-resistant multilayer composites for engineering joints.

    • Jesus Rivera
    • , Maryam Sadat Hosseini
    • , David Restrepo
    • , Satoshi Murata
    • , Drago Vasile
    • , Dilworth Y. Parkinson
    • , Harold S. Barnard
    • , Atsushi Arakaki
    • , Pablo Zavattieri
    •  & David Kisailus
  • Article |

    A approach termed ‘receptor inhibition by phosphatase recruitment’ is described for attenuating both tonic and ligand-activated cell-surface receptor signalling.

    • Ricardo A. Fernandes
    • , Leon Su
    • , Yoko Nishiga
    • , Junming Ren
    • , Aladdin M. Bhuiyan
    • , Ning Cheng
    • , Calvin J. Kuo
    • , Lora K. Picton
    • , Shozo Ohtsuki
    • , Robbie G. Majzner
    • , Skyler P. Rietberg
    • , Crystal L. Mackall
    • , Qian Yin
    • , Lestat R. Ali
    • , Xinbo Yang
    • , Christina S. Savvides
    • , Julien Sage
    • , Michael Dougan
    •  & K. Christopher Garcia
  • Article |

    Analysis of global three-dimensional shear attenuation and velocity models implies that partial melting in the seismic low-velocity zone enables motion of oceanic plates by reducing the viscosity of the asthenosphere.

    • Eric Debayle
    • , Thomas Bodin
    • , Stéphanie Durand
    •  & Yanick Ricard
  • Addendum |

    • Scott Mayer McKinney
    • , Marcin Sieniek
    • , Varun Godbole
    • , Jonathan Godwin
    • , Natasha Antropova
    • , Hutan Ashrafian
    • , Trevor Back
    • , Mary Chesus
    • , Greg S. Corrado
    • , Ara Darzi
    • , Mozziyar Etemadi
    • , Florencia Garcia-Vicente
    • , Fiona J. Gilbert
    • , Mark Halling-Brown
    • , Demis Hassabis
    • , Sunny Jansen
    • , Alan Karthikesalingam
    • , Christopher J. Kelly
    • , Dominic King
    • , Joseph R. Ledsam
    • , David Melnick
    • , Hormuz Mostofi
    • , Lily Peng
    • , Joshua Jay Reicher
    • , Bernardino Romera-Paredes
    • , Richard Sidebottom
    • , Mustafa Suleyman
    • , Daniel Tse
    • , Kenneth C. Young
    • , Jeffrey De Fauw
    •  & Shravya Shetty
  • Matters Arising |

    • Benjamin Haibe-Kains
    • , George Alexandru Adam
    • , Ahmed Hosny
    • , Farnoosh Khodakarami
    • , Thakkar Shraddha
    • , Rebecca Kusko
    • , Susanna-Assunta Sansone
    • , Weida Tong
    • , Russ D. Wolfinger
    • , Christopher E. Mason
    • , Wendell Jones
    • , Joaquin Dopazo
    • , Cesare Furlanello
    • , Levi Waldron
    • , Bo Wang
    • , Chris McIntosh
    • , Anna Goldenberg
    • , Anshul Kundaje
    • , Casey S. Greene
    • , Tamara Broderick
    • , Michael M. Hoffman
    • , Jeffrey T. Leek
    • , Keegan Korthauer
    • , Wolfgang Huber
    • , Alvis Brazma
    • , Joelle Pineau
    • , Robert Tibshirani
    • , Trevor Hastie
    • , John P. A. Ioannidis
    • , John Quackenbush
    •  & Hugo J. W. L. Aerts
  • Article |

    A robotic pipeline is used to survey a library of mutations in a Drosphila gene enhancer, showing that most mutations altered gene expression and had widespread pleiotropic effects that are likely to constrain regulatory evolution.

    • Timothy Fuqua
    • , Jeff Jordan
    • , Maria Elize van Breugel
    • , Aliaksandr Halavatyi
    • , Christian Tischer
    • , Peter Polidoro
    • , Namiko Abe
    • , Albert Tsai
    • , Richard S. Mann
    • , David L. Stern
    •  & Justin Crocker
  • Article |

    Multicriteria optimization identifies global priority areas for ecosystem restoration and estimates their benefits for biodiversity and climate, providing cost–benefit analyses that highlight the importance of optimizing spatial planning and incorporating several biomes in restoration strategies.

    • Bernardo B. N. Strassburg
    • , Alvaro Iribarrem
    • , Hawthorne L. Beyer
    • , Carlos Leandro Cordeiro
    • , Renato Crouzeilles
    • , Catarina C. Jakovac
    • , André Braga Junqueira
    • , Eduardo Lacerda
    • , Agnieszka E. Latawiec
    • , Andrew Balmford
    • , Thomas M. Brooks
    • , Stuart H. M. Butchart
    • , Robin L. Chazdon
    • , Karl-Heinz Erb
    • , Pedro Brancalion
    • , Graeme Buchanan
    • , David Cooper
    • , Sandra Díaz
    • , Paul F. Donald
    • , Valerie Kapos
    • , David Leclère
    • , Lera Miles
    • , Michael Obersteiner
    • , Christoph Plutzar
    • , Carlos Alberto de M. Scaramuzza
    • , Fabio R. Scarano
    •  & Piero Visconti
  • Article |

    High oxidation resistance, without degradation of thermal or electrical conductivity, is achieved in copper using surface modification by a solvothermal or electrochemical treatment with sodium formate and formation of a thin surface coordination layer.

    • Jian Peng
    • , Bili Chen
    • , Zhichang Wang
    • , Jing Guo
    • , Binghui Wu
    • , Shuqiang Hao
    • , Qinghua Zhang
    • , Lin Gu
    • , Qin Zhou
    • , Zhi Liu
    • , Shuqin Hong
    • , Sifan You
    • , Ang Fu
    • , Zaifa Shi
    • , Hao Xie
    • , Duanyun Cao
    • , Chang-Jian Lin
    • , Gang Fu
    • , Lan-Sun Zheng
    • , Ying Jiang
    •  & Nanfeng Zheng
  • Article |

    Analysis of 97,691 high-coverage human blood DNA-derived whole-genome sequences enabled simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells, indicating that both inherited and acquired mutations are linked to age-related cancers and coronary heart disease.

    • Alexander G. Bick
    • , Joshua S. Weinstock
    • , Satish K. Nandakumar
    • , Charles P. Fulco
    • , Erik L. Bao
    • , Seyedeh M. Zekavat
    • , Mindy D. Szeto
    • , Xiaotian Liao
    • , Matthew J. Leventhal
    • , Joseph Nasser
    • , Kyle Chang
    • , Cecelia Laurie
    • , Bala Bharathi Burugula
    • , Christopher J. Gibson
    • , Amy E. Lin
    • , Margaret A. Taub
    • , Francois Aguet
    • , Kristin Ardlie
    • , Braxton D. Mitchell
    • , Kathleen C. Barnes
    • , Arden Moscati
    • , Myriam Fornage
    • , Susan Redline
    • , Bruce M. Psaty
    • , Edwin K. Silverman
    • , Scott T. Weiss
    • , Nicholette D. Palmer
    • , Ramachandran S. Vasan
    • , Esteban G. Burchard
    • , Sharon L. R. Kardia
    • , Jiang He
    • , Robert C. Kaplan
    • , Nicholas L. Smith
    • , Donna K. Arnett
    • , David A. Schwartz
    • , Adolfo Correa
    • , Mariza de Andrade
    • , Xiuqing Guo
    • , Barbara A. Konkle
    • , Brian Custer
    • , Juan M. Peralta
    • , Hongsheng Gui
    • , Deborah A. Meyers
    • , Stephen T. McGarvey
    • , Ida Yii-Der Chen
    • , M. Benjamin Shoemaker
    • , Patricia A. Peyser
    • , Jai G. Broome
    • , Stephanie M. Gogarten
    • , Fei Fei Wang
    • , Quenna Wong
    • , May E. Montasser
    • , Michelle Daya
    • , Eimear E. Kenny
    • , Kari E. North
    • , Lenore J. Launer
    • , Brian E. Cade
    • , Joshua C. Bis
    • , Michael H. Cho
    • , Jessica Lasky-Su
    • , Donald W. Bowden
    • , L. Adrienne Cupples
    • , Angel C. Y. Mak
    • , Lewis C. Becker
    • , Jennifer A. Smith
    • , Tanika N. Kelly
    • , Stella Aslibekyan
    • , Susan R. Heckbert
    • , Hemant K. Tiwari
    • , Ivana V. Yang
    • , John A. Heit
    • , Steven A. Lubitz
    • , Jill M. Johnsen
    • , Joanne E. Curran
    • , Sally E. Wenzel
    • , Daniel E. Weeks
    • , Dabeeru C. Rao
    • , Dawood Darbar
    • , Jee-Young Moon
    • , Russell P. Tracy
    • , Erin J. Buth
    • , Nicholas Rafaels
    • , Ruth J. F. Loos
    • , Peter Durda
    • , Yongmei Liu
    • , Lifang Hou
    • , Jiwon Lee
    • , Priyadarshini Kachroo
    • , Barry I. Freedman
    • , Daniel Levy
    • , Lawrence F. Bielak
    • , James E. Hixson
    • , James S. Floyd
    • , Eric A. Whitsel
    • , Patrick T. Ellinor
    • , Marguerite R. Irvin
    • , Tasha E. Fingerlin
    • , Laura M. Raffield
    • , Sebastian M. Armasu
    • , Marsha M. Wheeler
    • , Ester C. Sabino
    • , John Blangero
    • , L. Keoki Williams
    • , Bruce D. Levy
    • , Wayne Huey-Herng Sheu
    • , Dan M. Roden
    • , Eric Boerwinkle
    • , JoAnn E. Manson
    • , Rasika A. Mathias
    • , Pinkal Desai
    • , Kent D. Taylor
    • , Andrew D. Johnson
    • , Namiko Abe
    • , Christine Albert
    • , Laura Almasy
    • , Alvaro Alonso
    • , Seth Ament
    • , Peter Anderson
    • , Pramod Anugu
    • , Deborah Applebaum-Bowden
    • , Dan Arking
    • , Allison Ashley-Koch
    • , Stella Aslibekyan
    • , Tim Assimes
    • , Dimitrios Avramopoulos
    • , John Barnard
    • , R. Graham Barr
    • , Emily Barron-Casella
    • , Lucas Barwick
    • , Terri Beaty
    • , Gerald Beck
    • , Diane Becker
    • , Rebecca Beer
    • , Amber Beitelshees
    • , Emelia Benjamin
    • , Panagiotis Benos
    • , Marcos Bezerra
    • , Larry Bielak
    • , Russell Bowler
    • , Jennifer Brody
    • , Ulrich Broeckel
    • , Karen Bunting
    • , Carlos Bustamante
    • , Jonathan Cardwell
    • , Vincent Carey
    • , Cara Carty
    • , Richard Casaburi
    • , James Casella
    • , Peter Castaldi
    • , Mark Chaffin
    • , Christy Chang
    • , Yi-Cheng Chang
    • , Daniel Chasman
    • , Sameer Chavan
    • , Bo-Juen Chen
    • , Wei-Min Chen
    • , Seung Hoan Choi
    • , Lee-Ming Chuang
    • , Mina Chung
    • , Ren-Hua Chung
    • , Clary Clish
    • , Suzy Comhair
    • , Elaine Cornell
    • , Carolyn Crandall
    • , James Crapo
    • , Jeffrey Curtis
    • , Coleen Damcott
    • , Sayantan Das
    • , Sean David
    • , Colleen Davis
    • , Michael DeBaun
    • , Ranjan Deka
    • , Dawn DeMeo
    • , Scott Devine
    • , Qing Duan
    • , Ravi Duggirala
    • , Susan Dutcher
    • , Charles Eaton
    • , Lynette Ekunwe
    • , Adel El Boueiz
    • , Leslie Emery
    • , Serpil Erzurum
    • , Charles Farber
    • , Matthew Flickinger
    • , Nora Franceschini
    • , Chris Frazar
    • , Mao Fu
    • , Stephanie M. Fullerton
    • , Lucinda Fulton
    • , Stacey Gabriel
    • , Weiniu Gan
    • , Shanshan Gao
    • , Yan Gao
    • , Margery Gass
    • , Bruce Gelb
    • , Xiaoqi (Priscilla) Geng
    • , Mark Geraci
    • , Soren Germer
    • , Robert Gerszten
    • , Auyon Ghosh
    • , Richard Gibbs
    • , Chris Gignoux
    • , Mark Gladwin
    • , David Glahn
    • , Da-Wei Gong
    • , Harald Goring
    • , Sharon Graw
    • , Daniel Grine
    • , C. Charles Gu
    • , Yue Guan
    • , Namrata Gupta
    • , Jeff Haessler
    • , Michael Hall
    • , Daniel Harris
    • , Nicola L. Hawley
    • , Ben Heavner
    • , Ryan Hernandez
    • , David Herrington
    • , Craig Hersh
    • , Bertha Hidalgo
    • , Brian Hobbs
    • , John Hokanson
    • , Elliott Hong
    • , Karin Hoth
    • , Chao (Agnes) Hsiung
    • , Yi-Jen Hung
    • , Haley Huston
    • , Chii Min Hwu
    • , Rebecca Jackson
    • , Deepti Jain
    • , Cashell Jaquish
    • , Min A. Jhun
    • , Craig Johnson
    • , Rich Johnston
    • , Kimberly Jones
    • , Hyun Min Kang
    • , Shannon Kelly
    • , Michael Kessler
    • , Alyna Khan
    • , Wonji Kim
    • , Greg Kinney
    • , Holly Kramer
    • , Christoph Lange
    • , Meryl LeBoff
    • , Seunggeun Shawn Lee
    • , Wen-Jane Lee
    • , Jonathon LeFaive
    • , David Levine
    • , Joshua Lewis
    • , Xiaohui Li
    • , Yun Li
    • , Henry Lin
    • , Honghuang Lin
    • , Keng Han Lin
    • , Xihong Lin
    • , Simin Liu
    • , Yu Liu
    • , Kathryn Lunetta
    • , James Luo
    • , Michael Mahaney
    • , Barry Make
    • , Ani Manichaikul
    • , Lauren Margolin
    • , Lisa Martin
    • , Susan Mathai
    • , Susanne May
    • , Patrick McArdle
    • , Merry-Lynn McDonald
    • , Sean McFarland
    • , Daniel McGoldrick
    • , Caitlin McHugh
    • , Hao Mei
    • , Luisa Mestroni
    • , Julie Mikulla
    • , Nancy Min
    • , Mollie Minear
    • , Ryan L. Minster
    • , Matt Moll
    • , Courtney Montgomery
    • , Solomon Musani
    • , Stanford Mwasongwe
    • , Josyf C. Mychaleckyj
    • , Girish Nadkarni
    • , Rakhi Naik
    • , Take Naseri
    • , Sergei Nekhai
    • , Sarah C. Nelson
    • , Bonnie Neltner
    • , Deborah Nickerson
    • , Jeff O’Connell
    • , Tim O’Connor
    • , Heather Ochs-Balcom
    • , David Paik
    • , James Pankow
    • , George Papanicolaou
    • , Afshin Parsa
    • , Marco Perez
    • , James Perry
    • , Ulrike Peters
    • , Patricia Peyser
    • , Lawrence S. Phillips
    • , Toni Pollin
    • , Wendy Post
    • , Julia Powers Becker
    • , Meher Preethi Boorgula
    • , Michael Preuss
    • , Pankaj Qasba
    • , Dandi Qiao
    • , Zhaohui Qin
    • , Laura Rasmussen-Torvik
    • , Aakrosh Ratan
    • , Robert Reed
    • , Elizabeth Regan
    • , Muagututi‘a Sefuiva Reupena
    • , Ken Rice
    • , Carolina Roselli
    • , Ingo Ruczinski
    • , Pamela Russell
    • , Sarah Ruuska
    • , Kathleen Ryan
    • , Danish Saleheen
    • , Shabnam Salimi
    • , Steven Salzberg
    • , Kevin Sandow
    • , Christopher Scheller
    • , Ellen Schmidt
    • , Karen Schwander
    • , Frank Sciurba
    • , Christine Seidman
    • , Jonathan Seidman
    • , Vivien Sheehan
    • , Stephanie L. Sherman
    • , Amol Shetty
    • , Aniket Shetty
    • , Brian Silver
    • , Josh Smith
    • , Tanja Smith
    • , Sylvia Smoller
    • , Beverly Snively
    • , Michael Snyder
    • , Tamar Sofer
    • , Nona Sotoodehnia
    • , Adrienne M. Stilp
    • , Garrett Storm
    • , Elizabeth Streeten
    • , Jessica Lasky Su
    • , Yun Ju Sung
    • , Jody Sylvia
    • , Adam Szpiro
    • , Carole Sztalryd
    • , Daniel Taliun
    • , Hua Tang
    • , Matthew Taylor
    • , Simeon Taylor
    • , Marilyn Telen
    • , Timothy A. Thornton
    • , Machiko Threlkeld
    • , Lesley Tinker
    • , David Tirschwell
    • , Sarah Tishkoff
    • , Hemant Tiwari
    • , Catherine Tong
    • , Michael Tsai
    • , Dhananjay Vaidya
    • , David Van Den Berg
    • , Peter VandeHaar
    • , Scott Vrieze
    • , Tarik Walker
    • , Robert Wallace
    • , Avram Walts
    • , Heming Wang
    • , Karol Watson
    • , Bruce Weir
    • , Lu-Chen Weng
    • , Jennifer Wessel
    • , Cristen Willer
    • , Kayleen Williams
    • , Carla Wilson
    • , Joseph Wu
    • , Huichun Xu
    • , Lisa Yanek
    • , Rongze Yang
    • , Norann Zaghloul
    • , Yingze Zhang
    • , Snow Xueyan Zhao
    • , Wei Zhao
    • , Degui Zhi
    • , Xiang Zhou
    • , Xiaofeng Zhu
    • , Michael Zody
    • , Sebastian Zoellner
    • , Paul L. Auer
    • , Charles Kooperberg
    • , Cathy C. Laurie
    • , Thomas W. Blackwell
    • , Albert V. Smith
    • , Hongyu Zhao
    • , Ethan Lange
    • , Leslie Lange
    • , Stephen S. Rich
    • , Jerome I. Rotter
    • , James G. Wilson
    • , Paul Scheet
    • , Jacob O. Kitzman
    • , Eric S. Lander
    • , Jesse M. Engreitz
    • , Benjamin L. Ebert
    • , Alexander P. Reiner
    • , Siddhartha Jaiswal
    • , Gonçalo Abecasis
    • , Vijay G. Sankaran
    • , Sekar Kathiresan
    •  & Pradeep Natarajan
  • Article |

    PIEZO2 is expressed in the bladder urothelium and sensory neurons innervating the lower urinary tract and is a key mechanosensor for the control of urination.

    • Kara L. Marshall
    • , Dimah Saade
    • , Nima Ghitani
    • , Adam M. Coombs
    • , Marcin Szczot
    • , Jason Keller
    • , Tracy Ogata
    • , Ihab Daou
    • , Lisa T. Stowers
    • , Carsten G. Bönnemann
    • , Alexander T. Chesler
    •  & Ardem Patapoutian
  • Article |

    Room-temperature superconductivity is observed in a photochemically synthesized ternary carbonaceous sulfur hydride system at 15 °C and 267 GPa.

    • Elliot Snider
    • , Nathan Dasenbrock-Gammon
    • , Raymond McBride
    • , Mathew Debessai
    • , Hiranya Vindana
    • , Kevin Vencatasamy
    • , Keith V. Lawler
    • , Ashkan Salamat
    •  & Ranga P. Dias
  • Article |

    The authors uncover the diverse transcriptomic cell types of thirst-driving neurons in the lamina terminalis and show that unique combinations of neuron types respond to and mediate distinct thirst states.

    • Allan-Hermann Pool
    • , Tongtong Wang
    • , David A. Stafford
    • , Rebecca K. Chance
    • , Sangjun Lee
    • , John Ngai
    •  & Yuki Oka
  • Article |

    Deep learning was used to map the crown sizes of each tree in the West African Sahara, Sahel and sub-humid zone using submetre-resolution satellite imagery, revealing a relatively high density of trees in arid areas.

    • Martin Brandt
    • , Compton J. Tucker
    • , Ankit Kariryaa
    • , Kjeld Rasmussen
    • , Christin Abel
    • , Jennifer Small
    • , Jerome Chave
    • , Laura Vang Rasmussen
    • , Pierre Hiernaux
    • , Abdoul Aziz Diouf
    • , Laurent Kergoat
    • , Ole Mertz
    • , Christian Igel
    • , Fabian Gieseke
    • , Johannes Schöning
    • , Sizhuo Li
    • , Katherine Melocik
    • , Jesse Meyer
    • , Scott Sinno
    • , Eric Romero
    • , Erin Glennie
    • , Amandine Montagu
    • , Morgane Dendoncker
    •  & Rasmus Fensholt
  • Article |

    Cadmium-free blue quantum dot light-emitting diodes are constructed with a quantum yield of unity, an efficiency at the theoretical limit, high brightness and long operational lifetime.

    • Taehyung Kim
    • , Kwang-Hee Kim
    • , Sungwoo Kim
    • , Seon-Myeong Choi
    • , Hyosook Jang
    • , Hong-Kyu Seo
    • , Heejae Lee
    • , Dae-Young Chung
    •  & Eunjoo Jang
  • Article |

    Telomeric-repeat-containing RNA is recruited to telomeres by a mechanism that involves the DNA recombinase RAD51 and the formation of DNA–RNA hybrids, or R-loops—a process similar to that involved in homology-directed DNA repair.

    • Marianna Feretzaki
    • , Michaela Pospisilova
    • , Rita Valador Fernandes
    • , Thomas Lunardi
    • , Lumir Krejci
    •  & Joachim Lingner
  • Article |

    The concept of neuromorphic completeness and a system hierarchy for neuromorphic computing are presented, which could improve programming-language portability, hardware completeness and compilation feasibility of brain-inspired computing systems

    • Youhui Zhang
    • , Peng Qu
    • , Yu Ji
    • , Weihao Zhang
    • , Guangrong Gao
    • , Guanrui Wang
    • , Sen Song
    • , Guoqi Li
    • , Wenguang Chen
    • , Weimin Zheng
    • , Feng Chen
    • , Jing Pei
    • , Rong Zhao
    • , Mingguo Zhao
    •  & Luping Shi
  • Article |

    Single-cell analysis of blood vessels in the alveolus, the site of chronic disease and virus-induced lung injury, reveals two intermingled endothelial cell types with specialized gas exchange and stem cell functions.

    • Astrid Gillich
    • , Fan Zhang
    • , Colleen G. Farmer
    • , Kyle J. Travaglini
    • , Serena Y. Tan
    • , Mingxia Gu
    • , Bin Zhou
    • , Jeffrey A. Feinstein
    • , Mark A. Krasnow
    •  & Ross J. Metzger
  • Article |

    A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.

    • Erik L. Bao
    • , Satish K. Nandakumar
    • , Xiaotian Liao
    • , Alexander G. Bick
    • , Juha Karjalainen
    • , Marcin Tabaka
    • , Olga I. Gan
    • , Aki S. Havulinna
    • , Tuomo T. J. Kiiskinen
    • , Caleb A. Lareau
    • , Aitzkoa L. de Lapuente Portilla
    • , Bo Li
    • , Connor Emdin
    • , Veryan Codd
    • , Christopher P. Nelson
    • , Christopher J. Walker
    • , Claire Churchhouse
    • , Albert de la Chapelle
    • , Daryl E. Klein
    • , Björn Nilsson
    • , Peter W. F. Wilson
    • , Kelly Cho
    • , Saiju Pyarajan
    • , J. Michael Gaziano
    • , Nilesh J. Samani
    • , Aarno Palotie
    • , Mark Daly
    • , Howard Jacob
    • , Athena Matakidou
    • , Heiko Runz
    • , Sally John
    • , Robert Plenge
    • , Mark McCarthy
    • , Julie Hunkapiller
    • , Meg Ehm
    • , Dawn Waterworth
    • , Caroline Fox
    • , Anders Malarstig
    • , Kathy Klinger
    • , Kathy Call
    • , Tomi Mäkelä
    • , Jaakko Kaprio
    • , Petri Virolainen
    • , Kari Pulkki
    • , Terhi Kilpi
    • , Markus Perola
    • , Jukka Partanen
    • , Anne Pitkäranta
    • , Riitta Kaarteenaho
    • , Seppo Vainio
    • , Kimmo Savinainen
    • , Veli-Matti Kosma
    • , Urho Kujala
    • , Outi Tuovila
    • , Minna Hendolin
    • , Raimo Pakkanen
    • , Jeff Waring
    • , Bridget Riley-Gillis
    • , Athena Matakidou
    • , Heiko Runz
    • , Jimmy Liu
    • , Shameek Biswas
    • , Julie Hunkapiller
    • , Dawn Waterworth
    • , Meg Ehm
    • , Dorothee Diogo
    • , Caroline Fox
    • , Anders Malarstig
    • , Catherine Marshall
    • , Xinli Hu
    • , Kathy Call
    • , Kathy Klinger
    • , Matthias Gossel
    • , Samuli Ripatti
    • , Johanna Schleutker
    • , Markus Perola
    • , Mikko Arvas
    • , Olli Carpén
    • , Reetta Hinttala
    • , Johannes Kettunen
    • , Reijo Laaksonen
    • , Arto Mannermaa
    • , Urho Kujala
    • , Outi Tuovila
    • , Minna Hendolin
    • , Raimo Pakkanen
    • , Hilkka Soininen
    • , Valtteri Julkunen
    • , Anne Remes
    • , Reetta Kälviäinen
    • , Mikko Hiltunen
    • , Jukka Peltola
    • , Pentti Tienari
    • , Juha Rinne
    • , Adam Ziemann
    • , Jeffrey Waring
    • , Sahar Esmaeeli
    • , Nizar Smaoui
    • , Anne Lehtonen
    • , Susan Eaton
    • , Heiko Runz
    • , Sanni Lahdenperä
    • , Janet van Adelsberg
    • , Shameek Biswas
    • , John Michon
    • , Geoff Kerchner
    • , Julie Hunkapiller
    • , Natalie Bowers
    • , Edmond Teng
    • , John Eicher
    • , Vinay Mehta
    • , Padhraig Gormley
    • , Kari Linden
    • , Christopher Whelan
    • , Fanli Xu
    • , David Pulford
    • , Martti Färkkilä
    • , Sampsa Pikkarainen
    • , Airi Jussila
    • , Timo Blomster
    • , Mikko Kiviniemi
    • , Markku Voutilainen
    • , Bob Georgantas
    • , Graham Heap
    • , Jeffrey Waring
    • , Nizar Smaoui
    • , Fedik Rahimov
    • , Anne Lehtonen
    • , Keith Usiskin
    • , Joseph Maranville
    • , Tim Lu
    • , Natalie Bowers
    • , Danny Oh
    • , John Michon
    • , Vinay Mehta
    • , Kirsi Kalpala
    • , Melissa Miller
    • , Xinli Hu
    • , Linda McCarthy
    • , Kari Eklund
    • , Antti Palomäki
    • , Pia Isomäki
    • , Laura Pirilä
    • , Oili Kaipiainen-Seppänen
    • , Johanna Huhtakangas
    • , Bob Georgantas
    • , Jeffrey Waring
    • , Fedik Rahimov
    • , Apinya Lertratanakul
    • , Nizar Smaoui
    • , Anne Lehtonen
    • , David Close
    • , Marla Hochfeld
    • , Natalie Bowers
    • , John Michon
    • , Dorothee Diogo
    • , Vinay Mehta
    • , Kirsi Kalpala
    • , Nan Bing
    • , Xinli Hu
    • , Jorge Esparza Gordillo
    • , Nina Mars
    • , Tarja Laitinen
    • , Margit Pelkonen
    • , Paula Kauppi
    • , Hannu Kankaanranta
    • , Terttu Harju
    • , Nizar Smaoui
    • , David Close
    • , Steven Greenberg
    • , Hubert Chen
    • , Natalie Bowers
    • , John Michon
    • , Vinay Mehta
    • , Jo Betts
    • , Soumitra Ghosh
    • , Veikko Salomaa
    • , Teemu Niiranen
    • , Markus Juonala
    • , Kaj Metsärinne
    • , Mika Kähönen
    • , Juhani Junttila
    • , Markku Laakso
    • , Jussi Pihlajamäki
    • , Juha Sinisalo
    • , Marja-Riitta Taskinen
    • , Tiinamaija Tuomi
    • , Jari Laukkanen
    • , Ben Challis
    • , Andrew Peterson
    • , Julie Hunkapiller
    • , Natalie Bowers
    • , John Michon
    • , Dorothee Diogo
    • , Audrey Chu
    • , Vinay Mehta
    • , Jaakko Parkkinen
    • , Melissa Miller
    • , Anthony Muslin
    • , Dawn Waterworth
    • , Heikki Joensuu
    • , Tuomo Meretoja
    • , Olli Carpén
    • , Lauri Aaltonen
    • , Annika Auranen
    • , Peeter Karihtala
    • , Saila Kauppila
    • , Päivi Auvinen
    • , Klaus Elenius
    • , Relja Popovic
    • , Jeffrey Waring
    • , Bridget Riley-Gillis
    • , Anne Lehtonen
    • , Athena Matakidou
    • , Jennifer Schutzman
    • , Julie Hunkapiller
    • , Natalie Bowers
    • , John Michon
    • , Vinay Mehta
    • , Andrey Loboda
    • , Aparna Chhibber
    • , Heli Lehtonen
    • , Stefan McDonough
    • , Marika Crohns
    • , Diptee Kulkarni
    • , Kai Kaarniranta
    • , Joni Turunen
    • , Terhi Ollila
    • , Sanna Seitsonen
    • , Hannu Uusitalo
    • , Vesa Aaltonen
    • , Hannele Uusitalo-Järvinen
    • , Marja Luodonpää
    • , Nina Hautala
    • , Heiko Runz
    • , Erich Strauss
    • , Natalie Bowers
    • , Hao Chen
    • , John Michon
    • , Anna Podgornaia
    • , Vinay Mehta
    • , Dorothee Diogo
    • , Joshua Hoffman
    • , Kaisa Tasanen
    • , Laura Huilaja
    • , Katariina Hannula-Jouppi
    • , Teea Salmi
    • , Sirkku Peltonen
    • , Leena Koulu
    • , Ilkka Harvima
    • , Kirsi Kalpala
    • , Ying Wu
    • , David Choy
    • , John Michon
    • , Nizar Smaoui
    • , Fedik Rahimov
    • , Anne Lehtonen
    • , Dawn Waterworth
    • , Justin Wade Davis
    • , Bridget Riley-Gillis
    • , Danjuma Quarless
    • , Slavé Petrovski
    • , Jimmy Liu
    • , Chia-Yen Chen
    • , Paola Bronson
    • , Robert Yang
    • , Joseph Maranville
    • , Shameek Biswas
    • , Diana Chang
    • , Julie Hunkapiller
    • , Tushar Bhangale
    • , Natalie Bowers
    • , Dorothee Diogo
    • , Emily Holzinger
    • , Padhraig Gormley
    • , Xulong Wang
    • , Xing Chen
    • , Åsa Hedman
    • , Kirsi Auro
    • , Clarence Wang
    • , Ethan Xu
    • , Franck Auge
    • , Clement Chatelain
    • , Mitja Kurki
    • , Samuli Ripatti
    • , Mark Daly
    • , Juha Karjalainen
    • , Aki Havulinna
    • , Anu Jalanko
    • , Kimmo Palin
    • , Priit Palta
    • , Pietro della Briotta Parolo
    • , Wei Zhou
    • , Susanna Lemmelä
    • , Manuel Rivas
    • , Jarmo Harju
    • , Aarno Palotie
    • , Arto Lehisto
    • , Andrea Ganna
    • , Vincent Llorens
    • , Antti Karlsson
    • , Kati Kristiansson
    • , Mikko Arvas
    • , Kati Hyvärinen
    • , Jarmo Ritari
    • , Tiina Wahlfors
    • , Miika Koskinen
    • , Olli Carpén
    • , Johannes Kettunen
    • , Katri Pylkäs
    • , Marita Kalaoja
    • , Minna Karjalainen
    • , Tuomo Mantere
    • , Eeva Kangasniemi
    • , Sami Heikkinen
    • , Arto Mannermaa
    • , Eija Laakkonen
    • , Juha Kononen
    • , Lila Kallio
    • , Sirpa Soini
    • , Jukka Partanen
    • , Kimmo Pitkänen
    • , Seppo Vainio
    • , Kimmo Savinainen
    • , Veli-Matti Kosma
    • , Teijo Kuopio
    • , Anu Jalanko
    • , Risto Kajanne
    • , Ulrike Lyhs
    • , Mitja Kurki
    • , Juha Karjalainen
    • , Pietro della Briotta Parola
    • , Sina Rüeger
    • , Arto Lehistö
    • , Wei Zhou
    • , Masahiro Kanai
    • , Hannele Laivuori
    • , Aki Havulinna
    • , Susanna Lemmelä
    • , Tuomo Kiiskinen
    • , Mari Kaunisto
    • , Jarmo Harju
    • , Elina Kilpeläinen
    • , Timo P. Sipilä
    • , Georg Brein
    • , Oluwaseun A. Dada
    • , Ghazal Awaisa
    • , Anastasia Shcherban
    • , Tuomas Sipilä
    • , Kati Donner
    • , Anu Loukola
    • , Päivi Laiho
    • , Tuuli Sistonen
    • , Essi Kaiharju
    • , Markku Laukkanen
    • , Elina Järvensivu
    • , Sini Lähteenmäki
    • , Lotta Männikkö
    • , Regis Wong
    • , Hannele Mattsson
    • , Kati Kristiansson
    • , Susanna Lemmelä
    • , Tero Hiekkalinna
    • , Manuel González Jiménez
    • , Priit Palta
    • , Kalle Pärn
    • , Javier Nunez-Fontarnau
    • , Tarja Laitinen
    • , Harri Siirtola
    • , Javier Gracia Tabuenca
    • , Michelle Agee
    • , Babak Alipanahi
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , David A. Hinds
    • , Karen E. Huber
    • , Aaron Kleinman
    • , Nadia K. Litterman
    • , Jennifer C. McCreight
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A.M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Catherine H. Wilson
    • , Aviv Regev
    • , Aarno Palotie
    • , Benjamin M. Neale
    • , John E. Dick
    • , Pradeep Natarajan
    • , Christopher J. O’Donnell
    • , Mark J. Daly
    • , Michael Milyavsky
    • , Sekar Kathiresan
    •  & Vijay G. Sankaran
  • Article |

    Modelling reveals how thick diamondiferous continental mantle ‘keels’ were formed only at increased mantle temperatures when the melt-depleted, hot, ductile mantle located under subducting oceanic plates flowed backwards, underplating the continents.

    • A. L. Perchuk
    • , T. V. Gerya
    • , V. S. Zakharov
    •  & W. L. Griffin
  • Article |

    Analysis of cis-regulatory chromatin interactions, open chromatin and transcriptomes for different cell types isolated from mid-gestational human cortex samples provides insights into gene regulation during development.

    • Michael Song
    • , Mark-Phillip Pebworth
    • , Xiaoyu Yang
    • , Armen Abnousi
    • , Changxu Fan
    • , Jia Wen
    • , Jonathan D. Rosen
    • , Mayank N. K. Choudhary
    • , Xiekui Cui
    • , Ian R. Jones
    • , Seth Bergenholtz
    • , Ugomma C. Eze
    • , Ivan Juric
    • , Bingkun Li
    • , Lenka Maliskova
    • , Jerry Lee
    • , Weifang Liu
    • , Alex A. Pollen
    • , Yun Li
    • , Ting Wang
    • , Ming Hu
    • , Arnold R. Kriegstein
    •  & Yin Shen
  • Article |

    By integrating healthcare and exome-sequencing data from parent–offspring trios of patients with developmental disorders, 28 genes that had not previously been associated with developmental disorders were identified.

    • Joanna Kaplanis
    • , Kaitlin E. Samocha
    • , Laurens Wiel
    • , Zhancheng Zhang
    • , Kevin J. Arvai
    • , Ruth Y. Eberhardt
    • , Giuseppe Gallone
    • , Stefan H. Lelieveld
    • , Hilary C. Martin
    • , Jeremy F. McRae
    • , Patrick J. Short
    • , Rebecca I. Torene
    • , Elke de Boer
    • , Petr Danecek
    • , Eugene J. Gardner
    • , Ni Huang
    • , Jenny Lord
    • , Iñigo Martincorena
    • , Rolph Pfundt
    • , Margot R. F. Reijnders
    • , Alison Yeung
    • , Helger G. Yntema
    • , Silvia Borras
    • , Caroline Clark
    • , John Dean
    • , Zosia Miedzybrodzka
    • , Alison Ross
    • , Stephen Tennant
    • , Tabib Dabir
    • , Deirdre Donnelly
    • , Mervyn Humphreys
    • , Alex Magee
    • , Vivienne McConnell
    • , Shane McKee
    • , Susan McNerlan
    • , Patrick J. Morrison
    • , Gillian Rea
    • , Fiona Stewart
    • , Trevor Cole
    • , Nicola Cooper
    • , Lisa Cooper-Charles
    • , Helen Cox
    • , Lily Islam
    • , Joanna Jarvis
    • , Rebecca Keelagher
    • , Derek Lim
    • , Dominic McMullan
    • , Jenny Morton
    • , Swati Naik
    • , Mary O’Driscoll
    • , Kai-Ren Ong
    • , Deborah Osio
    • , Nicola Ragge
    • , Sarah Turton
    • , Julie Vogt
    • , Denise Williams
    • , Simon Bodek
    • , Alan Donaldson
    • , Alison Hills
    • , Karen Low
    • , Ruth Newbury-Ecob
    • , Andrew M. Norman
    • , Eileen Roberts
    • , Ingrid Scurr
    • , Sarah Smithson
    • , Madeleine Tooley
    • , Steve Abbs
    • , Ruth Armstrong
    • , Carolyn Dunn
    • , Simon Holden
    • , Soo-Mi Park
    • , Joan Paterson
    • , Lucy Raymond
    • , Evan Reid
    • , Richard Sandford
    • , Ingrid Simonic
    • , Marc Tischkowitz
    • , Geoff Woods
    • , Lisa Bradley
    • , Joanne Comerford
    • , Andrew Green
    • , Sally Lynch
    • , Shirley McQuaid
    • , Brendan Mullaney
    • , Jonathan Berg
    • , David Goudie
    • , Eleni Mavrak
    • , Joanne McLean
    • , Catherine McWilliam
    • , Eleanor Reavey
    • , Tara Azam
    • , Elaine Cleary
    • , Andrew Jackson
    • , Wayne Lam
    • , Anne Lampe
    • , David Moore
    • , Mary Porteous
    • , Emma Baple
    • , Júlia Baptista
    • , Carole Brewer
    • , Bruce Castle
    • , Emma Kivuva
    • , Martina Owens
    • , Julia Rankin
    • , Charles Shaw-Smith
    • , Claire Turner
    • , Peter Turnpenny
    • , Carolyn Tysoe
    • , Therese Bradley
    • , Rosemarie Davidson
    • , Carol Gardiner
    • , Shelagh Joss
    • , Esther Kinning
    • , Cheryl Longman
    • , Ruth McGowan
    • , Victoria Murday
    • , Daniela Pilz
    • , Edward Tobias
    • , Margo Whiteford
    • , Nicola Williams
    • , Angela Barnicoat
    • , Emma Clement
    • , Francesca Faravelli
    • , Jane Hurst
    • , Lucy Jenkins
    • , Wendy Jones
    • , V. K. Ajith Kumar
    • , Melissa Lees
    • , Sam Loughlin
    • , Alison Male
    • , Deborah Morrogh
    • , Elisabeth Rosser
    • , Richard Scott
    • , Louise Wilson
    • , Ana Beleza
    • , Charu Deshpande
    • , Frances Flinter
    • , Muriel Holder
    • , Melita Irving
    • , Louise Izatt
    • , Dragana Josifova
    • , Shehla Mohammed
    • , Aneta Molenda
    • , Leema Robert
    • , Wendy Roworth
    • , Deborah Ruddy
    • , Mina Ryten
    • , Shu Yau
    • , Christopher Bennett
    • , Moira Blyth
    • , Jennifer Campbell
    • , Andrea Coates
    • , Angus Dobbie
    • , Sarah Hewitt
    • , Emma Hobson
    • , Eilidh Jackson
    • , Rosalyn Jewell
    • , Alison Kraus
    • , Katrina Prescott
    • , Eamonn Sheridan
    • , Jenny Thomson
    • , Kirsty Bradshaw
    • , Abhijit Dixit
    • , Jacqueline Eason
    • , Rebecca Haines
    • , Rachel Harrison
    • , Stacey Mutch
    • , Ajoy Sarkar
    • , Claire Searle
    • , Nora Shannon
    • , Abid Sharif
    • , Mohnish Suri
    • , Pradeep Vasudevan
    • , Natalie Canham
    • , Ian Ellis
    • , Lynn Greenhalgh
    • , Emma Howard
    • , Victoria Stinton
    • , Andrew Swale
    • , Astrid Weber
    • , Siddharth Banka
    • , Catherine Breen
    • , Tracy Briggs
    • , Emma Burkitt-Wright
    • , Kate Chandler
    • , Jill Clayton-Smith
    • , Dian Donnai
    • , Sofia Douzgou
    • , Lorraine Gaunt
    • , Elizabeth Jones
    • , Bronwyn Kerr
    • , Claire Langley
    • , Kay Metcalfe
    • , Audrey Smith
    • , Ronnie Wright
    • , David Bourn
    • , John Burn
    • , Richard Fisher
    • , Steve Hellens
    • , Alex Henderson
    • , Tara Montgomery
    • , Miranda Splitt
    • , Volker Straub
    • , Michael Wright
    • , Simon Zwolinski
    • , Zoe Allen
    • , Birgitta Bernhard
    • , Angela Brady
    • , Claire Brooks
    • , Louise Busby
    • , Virginia Clowes
    • , Neeti Ghali
    • , Susan Holder
    • , Rita Ibitoye
    • , Emma Wakeling
    • , Edward Blair
    • , Jenny Carmichael
    • , Deirdre Cilliers
    • , Susan Clasper
    • , Richard Gibbons
    • , Usha Kini
    • , Tracy Lester
    • , Andrea Nemeth
    • , Joanna Poulton
    • , Sue Price
    • , Debbie Shears
    • , Helen Stewart
    • , Andrew Wilkie
    • , Shadi Albaba
    • , Duncan Baker
    • , Meena Balasubramanian
    • , Diana Johnson
    • , Michael Parker
    • , Oliver Quarrell
    • , Alison Stewart
    • , Josh Willoughby
    • , Charlene Crosby
    • , Frances Elmslie
    • , Tessa Homfray
    • , Huilin Jin
    • , Nayana Lahiri
    • , Sahar Mansour
    • , Karen Marks
    • , Meriel McEntagart
    • , Anand Saggar
    • , Kate Tatton-Brown
    • , Rachel Butler
    • , Angus Clarke
    • , Sian Corrin
    • , Andrew Fry
    • , Arveen Kamath
    • , Emma McCann
    • , Hood Mugalaasi
    • , Caroline Pottinger
    • , Annie Procter
    • , Julian Sampson
    • , Francis Sansbury
    • , Vinod Varghese
    • , Diana Baralle
    • , Alison Callaway
    • , Emma J. Cassidy
    • , Stacey Daniels
    • , Andrew Douglas
    • , Nicola Foulds
    • , David Hunt
    • , Mira Kharbanda
    • , Katherine Lachlan
    • , Catherine Mercer
    • , Lucy Side
    • , I. Karen Temple
    • , Diana Wellesley
    • , Lisenka E. L. M. Vissers
    • , Jane Juusola
    • , Caroline F. Wright
    • , Han G. Brunner
    • , Helen V. Firth
    • , David R. FitzPatrick
    • , Jeffrey C. Barrett
    • , Matthew E. Hurles
    • , Christian Gilissen
    •  & Kyle Retterer
  • Article |

    Cryo-electron microscopy structures of the bacterial recombination protein RecA with DNA, and of RecA–D-loop complexes, provide insights into the double-stranded DNA opening, homology search and strand-exchange processes of homologous recombination.

    • Haijuan Yang
    • , Chun Zhou
    • , Ankita Dhar
    •  & Nikola P. Pavletich
  • Article |

    • Barbara Mikulak-Klucznik
    • , Patrycja Gołębiowska
    • , Alison A. Bayly
    • , Oskar Popik
    • , Tomasz Klucznik
    • , Sara Szymkuć
    • , Ewa P. Gajewska
    • , Piotr Dittwald
    • , Olga Staszewska-Krajewska
    • , Wiktor Beker
    • , Tomasz Badowski
    • , Karl A. Scheidt
    • , Karol Molga
    • , Jacek Młynarski
    • , Milan Mrksich
    •  & Bartosz A. Grzybowski
  • Article |

    • Christopher O. Barnes
    • , Claudia A. Jette
    • , Morgan E. Abernathy
    • , Kim-Marie A. Dam
    • , Shannon R. Esswein
    • , Harry B. Gristick
    • , Andrey G. Malyutin
    • , Naima G. Sharaf
    • , Kathryn E. Huey-Tubman
    • , Yu E. Lee
    • , Davide F. Robbiani
    • , Michel C. Nussenzweig
    • , Anthony P. West Jr
    •  & Pamela J. Bjorkman
  • Author Correction |

    • David U. Gorkin
    • , Iros Barozzi
    • , Yuan Zhao
    • , Yanxiao Zhang
    • , Hui Huang
    • , Ah Young Lee
    • , Bin Li
    • , Joshua Chiou
    • , Andre Wildberg
    • , Bo Ding
    • , Bo Zhang
    • , Mengchi Wang
    • , J. Seth Strattan
    • , Jean M. Davidson
    • , Yunjiang Qiu
    • , Veena Afzal
    • , Jennifer A. Akiyama
    • , Ingrid Plajzer-Frick
    • , Catherine S. Novak
    • , Momoe Kato
    • , Tyler H. Garvin
    • , Quan T. Pham
    • , Anne N. Harrington
    • , Brandon J. Mannion
    • , Elizabeth A. Lee
    • , Yoko Fukuda-Yuzawa
    • , Yupeng He
    • , Sebastian Preissl
    • , Sora Chee
    • , Jee Yun Han
    • , Brian A. Williams
    • , Diane Trout
    • , Henry Amrhein
    • , Hongbo Yang
    • , J. Michael Cherry
    • , Wei Wang
    • , Kyle Gaulton
    • , Joseph R. Ecker
    • , Yin Shen
    • , Diane E. Dickel
    • , Axel Visel
    • , Len A. Pennacchio
    •  & Bing Ren
  • Review Article |

    The long-term success of area-based conservation—including both protected areas and other effective area-based conservation measures—after 2020 will depend on governments securing adequate funding and prioritizing biodiversity in land, water and sea management.

    • Sean L. Maxwell
    • , Victor Cazalis
    • , Nigel Dudley
    • , Michael Hoffmann
    • , Ana S. L. Rodrigues
    • , Sue Stolton
    • , Piero Visconti
    • , Stephen Woodley
    • , Naomi Kingston
    • , Edward Lewis
    • , Martine Maron
    • , Bernardo B. N. Strassburg
    • , Amelia Wenger
    • , Harry D. Jonas
    • , Oscar Venter
    •  & James E. M. Watson
  • Review Article |

    The current state of programmable photonic integrated circuits is discussed, including recent developments in their building blocks, circuit architectures, electronic control and programming strategies, as well as different application spaces.

    • Wim Bogaerts
    • , Daniel Pérez
    • , José Capmany
    • , David A. B. Miller
    • , Joyce Poon
    • , Dirk Englund
    • , Francesco Morichetti
    •  & Andrea Melloni
  • Article |

    The dynamic and reversible S-palmitoylation of the transcription factor STAT3 enhances its activation and promotes the differentiation of TH17 cells.

    • Mingming Zhang
    • , Lixing Zhou
    • , Yuejie Xu
    • , Min Yang
    • , Yilai Xu
    • , Garrison Paul Komaniecki
    • , Tatsiana Kosciuk
    • , Xiao Chen
    • , Xuan Lu
    • , Xiaoping Zou
    • , Maurine E. Linder
    •  & Hening Lin