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  • Sera from unvaccinated, vaccinated, and previously infected and vaccinated individuals show reduced neutralizing and spike protein-binding activity towards the Omicron (B.1.1.529) variant of SARS-CoV-2 compared to other variants.

    • Juan Manuel Carreño
    • Hala Alshammary
    • Florian Krammer
    Article
  • A high-throughput yeast display platform is used to analyse the profiles of mutations in the SARS-CoV-2 receptor-binding domain (RBD) that enable escape from antibodies, and suggests that most anti-RBD antibodies can be escaped by the Omicron variant.

    • Yunlong Cao
    • Jing Wang
    • Xiaoliang Sunney Xie
    Article Open Access
  • The SARS-CoV-2 Alpha variant suppresses innate immune responses more effectively than isolates of first-wave SARS-CoV-2, and this is a result of mutations outside of the spike coding region that lead to upregulation of viral innate immune antagonists.

    • Lucy G. Thorne
    • Mehdi Bouhaddou
    • Nevan J. Krogan
    Article Open Access
  • Pseudovirus assays and surface plasmon resonance show that the Omicron receptor-binding domain binds to human ACE2 with increased affinity relative to the ancestral virus, and that most neutralizing antibodies are considerably less potent against Omicron.

    • Elisabetta Cameroni
    • John E. Bowen
    • Davide Corti
    Article
  • Plasma from individuals vaccinated with BNT162b2 exhibits 22-fold less neutralization capacity against Omicron (B.1.1.529) than against an ancestral SARS-CoV-2 strain but residual neutralization is maintained in those with high levels of neutralization of ancestral virus.

    • Sandile Cele
    • Laurelle Jackson
    • Alex Sigal
    Article Open Access
  • Disturbances in the radiocarbon record anchor a precisely dated archaeological stratigraphy of a medieval trading emporium in Denmark in time, revealing that the Viking expansion was associated with competition for trade routes rather than with raids.

    • Bente Philippsen
    • Claus Feveile
    • Søren M. Sindbæk
    Article
  • PROTAC degrader–induced SWI/SNF inactivation abolishes DNA accessibility at enhancer elements of oncogenes and also tempers supra-physiologic expression of driver transcription factors, resulting in potent inhibition of tumour growth in mouse models.

    • Lanbo Xiao
    • Abhijit Parolia
    • Arul M. Chinnaiyan
    Article Open Access
  • Decoupling spin-polarized edge states using substitutional N-atom dopants along the edges of a zigzag graphene nanoribbon (ZGNR) reveals giant spin splitting of a N-dopant edge state, and supports the predicted emergent magnetic order in ZGNRs.

    • Raymond E. Blackwell
    • Fangzhou Zhao
    • Felix R. Fischer
    Article
  • A silicon nitride microresonator is used for coherent phase modulation of a transmission electron microscope beam, with future applications in combining high-resolution microscopy with spectroscopy, holography and metrology.

    • Jan-Wilke Henke
    • Arslan Sajid Raja
    • Tobias J. Kippenberg
    Article Open Access
  • An electric-field-induced topological phase transition from a Mott insulator to a quantum anomalous Hall insulator in near-60-degree-twisted (or AB-stacked) MoTe2/WSe2 heterobilayers is reported.

    • Tingxin Li
    • Shengwei Jiang
    • Kin Fai Mak
    Article
  • ‘Candidatus Methanoliparum’ overexpresses genes encoding alkyl-coenzyme M and methyl-coenzyme M reductases—markers of archaeal multicarbon alkane and methane metabolism—and thrives on a variety of long-chain alkanes and n-alkylcyclohexanes, and n-alkylbenzenes with long n-alkyl (C≥13) moieties.

    • Zhuo Zhou
    • Cui-jing Zhang
    • Lei Cheng
    Article