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  • Genome-wide ancient DNA data from individuals from the Middle Bronze Age to Iron Age documents large-scale movement of people from the European continent between 1300 and 800 bc that was probably responsible for spreading early Celtic languages to Britain.

    • Nick Patterson
    • Michael Isakov
    • David Reich
    Article
  • Studies using neural ensemble recordings in rats show that cells in the piriform cortex carry a spatial representation of the environment and link locations to olfactory sensory inputs.

    • Cindy Poo
    • Gautam Agarwal
    • Zachary F. Mainen
    Article
  • A mechanism involving intracellular recycling of the morphogen Decapentaplegic (Dpp) underlies the scaling of the Dpp gradient in the Drosophila wing disc, and this is modulated by the extracellular factors Pentagone and Dally.

    • Maria Romanova-Michaelides
    • Zena Hadjivasiliou
    • Marcos Gonzalez-Gaitan
    Article
  • Two very-high-frequency quasi-periodic oscillations (at 2,132 Hz and 4,250 Hz) are detected within the initial hard spike of a magnetar giant flare originating from the galaxy NGC 253, and detailed temporal and spectral analyses are performed.

    • A. J. Castro-Tirado
    • N. Østgaard
    • S. Yang
    Article
  • The cryo-electron microscopy structure of the glucocorticoid receptor (GR)-loading complex—a complex in which Hsp70 loads GR onto Hsp90 and Hop—is described, providing insights into how the chaperones Hsp90 and Hsp70 coordinate to facilitate GR remodelling for activation.

    • Ray Yu-Ruei Wang
    • Chari M. Noddings
    • David A. Agard
    Article
  • An analysis of cancer mortality data for zoo mammals highlights marked differences across mammalian orders and an influence of diet, and shows that mortality risk is largely independent of body mass and life expectancy across species.

    • Orsolya Vincze
    • Fernando Colchero
    • Mathieu Giraudeau
    ArticleOpen Access
  • Unphosphorylated PINK1 of Pediculus humanus corporis forms a dimerized state before undergoing trans-autophosphorylation, and phosphorylated PINK1 undergoes a conformational change in the N-lobe to produce its phosphorylated, ubiquitin-binding state.

    • Zhong Yan Gan
    • Sylvie Callegari
    • David Komander
    Article
  • Studies using viral coat glycoproteins show that alphaviruses can enter cells via the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), members of an evolutionarily conserved family of lipoprotein receptors.

    • Lars E. Clark
    • Sarah A. Clark
    • Jonathan Abraham
    Article