Research articles

A high-throughput, chromosome-wide analysis of DNA looping reveals its contribution to the organization of chromatin, and provides insight into how nucleosomes are deposited and organised de novo.

Strong electron–electron interactions in magic-angle twisted bilayer graphene can fundamentally change the topology of the system’s flat bands, producing a hierarchy of strongly correlated topological insulators in modest magnetic fields.

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the roles of FOS and SCG2 in neural plasticity and consolidation of memories.

An integrated assessment model analysis shows that a moderately differentiated carbon price could achieve as much climate mitigation as a uniform carbon tax, avoiding concerns regarding equity between participating countries or sovereignty.

Mutations in histone H1 induce the remodelling of chromatin architecture to a more relaxed state, which leads to malignant transformation through changes in histone modifications and the expression of stem cell genes.

In the tiniest of capillaries, barely larger than a water molecule, condensation is surprisingly predictable from the macroscopic Kelvin condensation equation, a coincidence partially owing to elastic deformation of the capillary walls.

Analysis of data on species co-occurrence in the Paleobiology Database using a new machine learning algorithm reveals that mass extinctions and mass radiations are not coupled in evolutionary history.

Psychedelic alkaloids served as lead structures for the development of tabernanthalog, a non-hallucinogenic and non-toxic analogue that reduces alcohol- and heroin-seeking behaviour and produces antidepressant-like effects in rodents.

Estimates of global total biomass (the mass of all living things) and anthopogenic mass (the mass embedded in inanimate objects made by humans) over time show that we are roughly at the timepoint when anthropogenic mass exceeds total biomass.

A method in which pooled barcoded human cancer cell lines are injected into a mouse xenograft model enables simultaneous mapping of the metastatic potential of multiple cell lines, and shows that breast cancer cells that metastasize to the brain have altered lipid metabolism.

A strongly interacting gas of polar molecules is created by combining an electric field with two-dimensional optical confinement, enabling evaporative cooling and opening up the exploration of low-entropy many-body phases.

Arterial development relies on the timely and MYC-dependent suppression of endothelial metabolism and the cell cycle in pre-arterial endothelial cells through Notch signalling.

Correlations in momentum space between hadrons created by ultrarelativistic proton–proton collisions at the CERN Large Hadron Collider provide insights into the strong interaction, particularly the short-range dynamics of hyperons—baryons that contain strange quarks.

Observations from the eROSITA telescope reveal soft-X-ray-emitting bubbles extending above and below the Galactic plane, which arose from energy injected into the Galactic halo from past activity in the Galactic centre.

Structures of Mycobacterium smegmatis ATP synthase provide insights into how the enzyme conserves energy by autoinhibition of ATP hydrolysis and the mechanism of action of bedaquiline, a drug used in treatment of multidrug-resistant tuberculosis.

Experiments using a conditional triple-knockout mouse strain show that histone H1 regulates the activity of chromatin domains by controlling chromatin compaction, genome architecture and  histone methylation.

Lagerpetids, bipedal archosaurs that are thought to be related to dinosaurs, are instead a sister group to pterosaurs, and although they have no obvious flight adaptations they share numerous synapomorphies with pterosaurs across the entire skeleton.